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Introduction About ROSUMAC GOLD 20MG CAPSULE
ROSUMAC GOLD 20MG CAPSULE is used in the management of acute coronary syndrome, myocardial infarction, angina and stroke. It is a combination of Aspirin, Clopidogrel and Rosuvastatin which belongs to the group of medicines called Non-Steroidal Anti-Inflammatory Drugs, Antiplatelets and HMG-CoA reductase inhibitors respectively.
Along with ROSUMAC GOLD 20MG CAPSULE management follow a healthy low-fat diet as advised by doctor to achieve better results. Avoid drinking alcohol during the therapy, as it could increase the risk of bleeding in the gastrointestinal tract. It is not recommended for use in patients having severe liver, kidney, or heart disease.
ROSUMAC GOLD 20MG CAPSULE is generally not recommended for use in pregnant or breastfeeding women and in children (below 18 years). The most common side effects are increased bleeding tendency, nausea, indigestion, diarrhea, stomach pain, constipation, muscle pain, dizziness and headache. Contact your doctor if any of these symptoms worsen.
Uses Of ROSUMAC GOLD 20MG CAPSULE
It is used to manage:
- acute coronary syndrome
- myocardial infarction
- angina
- stroke
How ROSUMAC GOLD 20MG CAPSULE Works
ROSUMAC GOLD 20MG CAPSULE effectively improves cardiac function and reduces the risk of heart problems, where clopidogrel acts by inhibiting platelet aggregation in the coronary arteries, aspirin acts by blocking the actions of an enzyme called cyclo-oxygenase which is believed to be responsible for catalyzing the synthesis of platelets and rosuvastatin acts by inhibiting the action of an enzyme called HMG-CoA reductase, which is required to catalyze the formation of cholesterol, thus managing clot or plaque formation in the coronary arteries leading to an uninterrupted supply of oxygen and blood to the heart.
How to use ROSUMAC GOLD 20MG CAPSULE
- Take ROSUMAC GOLD 20MG CAPSULE as advised by your physician
- Swallow the with a glass of water. Do not crush or chew the medicine
- Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition
Side Effects Of ROSUMAC GOLD 20MG CAPSULE
Common side effects of ROSUMAC GOLD 20MG CAPSULE:
- indigestion, diarrhea, stomach pain, nausea, constipation
- dizziness, headache
- muscle cramps or pain
- tingling or numbness sensation
Stop taking ROSUMAC GOLD 20MG CAPSULE and contact your doctor immediately if you experience any of the following side effects:
- severe allergic reactions (skin rash, itching, swelling of the face, lips, throat and neck, difficulty in breathing or swallowing)
- symptoms of pancreatitis (severe abdominal pain, nausea, vomiting, fever, rapid heart rate)
- jaundice (yellowing of eyes, skin, and urine with fever)
- flu-like symptoms (fever, cough, sore throat, headache and extreme tiredness)
- hemorrhagic vasculitis (inflammation of the blood vessels with bleeding)
Warning & Precautions
Pregnancy
ContraindicatedROSUMAC GOLD 20MG CAPSULE is not recommended for use during pregnancy. Women of child-bearing potential should use suitable contraceptive method to avoid pregnancy while taking the medicine.
Breastfeeding
ContraindicatedROSUMAC GOLD 20MG CAPSULE is not recommended for use in breastfeeding women.
Driving and Using Machines
Use with CautionROSUMAC GOLD 20MG CAPSULE does not affect your ability to drive or operate machines. However, if you experience dizziness during management with the medicine. Do not drive or operate any machines.
Alcohol
Consult your doctorAvoid consumption of alcohol while taking ROSUMAC GOLD 20MG CAPSULE as it may increase the risk of stomach bleeding and aggravate your existing condition.
Kidney
Consult your doctorROSUMAC GOLD 20MG CAPSULE is not recommended for use in patients having moderate-to-severe kidney disease. It should be used with caution in patients with kidney problems.
Liver
Consult your doctorROSUMAC GOLD 20MG CAPSULE is not recommended for use in patients having severe liver disease and active liver disease (including persistent elevations of serum transaminases exceeding three times the upper limit). It should be used with caution in patients with history of liver disease.
Allergy
ContraindicatedDo not take ROSUMAC GOLD 20MG CAPSULE if you are allergic to Clopidogrel, Rosuvastatin, Aspirin or prostaglandin synthetase inhibitors (Ex. naproxen, ibuprofen, mefenamic acid, and indomethacin).
Lungs
Use with CautionROSUMAC GOLD 20MG CAPSULE should be used with caution in patients with interstitial lung disease or severe respiratory failure.
Heart Disease
ContraindicatedROSUMAC GOLD 20MG CAPSULE is not recommended for use in patients with recent ischemic stroke.
Use In Pediatrics
Monitoring requiredROSUMAC GOLD 20MG CAPSULE is not recommended for use in children and adolescents (under 18 years of age) unless prescribed by your physician due to increased risk of bleeding.
Use In Geriatrics
Use with CautionROSUMAC GOLD 20MG CAPSULE should be used with caution in elderly patients (aged 70 years or above) because of increased risk of gastro-intestinal bleeding and perforation when used for prolonged duration (if prolonged therapy is essential, patients should be reviewed regularly).
Others
It is not recommended for use if you:
- have or had any repeated or unexplained muscle pains
- have family history of hereditary muscular disorders
- have family history of muscle problems following management with cholesterol-lowering medicines
- have an underactive thyroid gland
- have gastrointestinal problems (such as peptic ulcer, or bleeding in the gut)
- have bleeding disorders (Ex. bleeding in the brain, hemophilia, or others)
- have thrombocytopenia (decreased platelet count)
- have gout
- have lactose intolerance
- have diabetes
- have dehydration
- have menorrhagia (abnormally heavy bleeding during menstruation)
Before taking ROSUMAC GOLD 20MG CAPSULE, inform your doctor if you have:
- upcoming planned surgery (including dental surgery)
Interactions
A. Drug-Drug interactions:
Before taking the medicine, inform to your doctor, if you are taking any of these medicines:
- Anticoagulants (Ex. warfarin, coumarin, heparin, phenindione)
- Anti-lipidemic agents (Ex. clofibrate, gemfibrozil, fenofibrate, ezetimibe)
- Non-steroidal anti-inflammatory drugs (Ex. ibuprofen, paracetamol)
- Anti-viral agents (Ex. ritonavir with lopinavir and/or atazanavir or sofosbuvir with velpatasvir and voxilaprevir)
- selective serotonin reuptake inhibitors (Ex. fluoxetine, sertraline, paroxetine, or fluvoxamine)
- Antacids (Ex. aluminium hydroxide, magnesium hydroxide)
- proton-pump inhibitors (Ex. omeprazole or esomeprazole)
- medicines used during percutaneous coronary intervention (Ex. abciximab, eptifibatide, and tirofiban)
- antibiotics (Ex. azithromycin, erythromycin, roxithromycin, and clarithromycin, fusidic acid)
- Anticonvulsants (Ex. phenytoin, valproic acid)
- Anti-diabetic agents (Ex. insulin, glipizide, glimepiride)
- Immunosuppressants (Ex. ciclosporin or tacrolimus, methotrexate)
- nicotinic acid
- antifungal agents (Ex. clotrimazole, fluconazole)
- Cardiac glycosides (Ex. digoxin)
- Anti-cancer agents (Ex. darolutamide, regorafenib)
- Anti-gout agents (Ex. probenecid or sulfinpyrazone)
- Antiplatelet agents (Ex. dipyridamole)
- Anti-maniac agents (Ex. lithium)
- corticosteroids (Ex. prednisolone, dexamethasone)
- acetazolamide
- Contraceptive (Ex. mifepristone)
- Anti-emetic agents (Ex. metoclopramide)
Overdosage:
If you or anyone else take too much of ROSUMAC GOLD 20MG CAPSULE, contact your doctor immediately or go to a hospital straight away. Overdosage symptoms might include increased bleeding, confusion, disorientation, convulsions, vomiting, tinnitus (ringing in the ears), vertigo (spinning sensation), sweating, warm extremities with bounding pulses, increased respiratory rate and hyperventilation.
Synopsis
| Drug | : | Aspirin, Clopidogrel, Rosuvastatin |
| Pharmacological Category | : | Non-Steroidal Anti-inflammatory Drugs, Antiplatelets, HMG-CoA reductase inhibitors |
| Therapeutic Indication | : | Acute coronary syndrome, Myocardial infarction, Angina, Stroke |
| Dosage Forms | : | Capsule, Tablet |
More Information
FAQs About ROSUMAC GOLD 20MG CAPSULE
Q: Can ROSUMAC GOLD 20MG CAPSULE make me bleed more?
A: Yes. ROSUMAC GOLD 20MG CAPSULE may increase your tendency to bleed and therefore it should be used with caution in patients having bleeding disorders like hemophilia, bleeding in the gut, brain or under the skin or others. While taking ROSUMAC GOLD 20MG CAPSULE if you experience any symptoms like blood in vomit or urine, coughing up blood, black stools, or purple spots under the skin, contact your doctor immediately as it could be a sign of severe internal bleeding.
Q: Can ROSUMAC GOLD 20MG CAPSULE be taken during periods?
A: ROSUMAC GOLD 20MG CAPSULE generally can increase your tendency to bleed and if taken during periods, it may cause heavy menstrual bleeding.
Q: Can I continue to take ROSUMAC GOLD 20MG CAPSULE before any planned surgeries?
A: No. Avoid taking ROSUMAC GOLD 20MG CAPSULE if you are going to undergo any surgery (including dental surgery) because this medicine can make you bleed more than usual.
Q: Can ROSUMAC GOLD 20MG CAPSULE be used in children?
A: No. ROSUMAC GOLD 20MG CAPSULE is not recommended for use in children and adolescents (under 18 years) unless prescribed by your physician. It is strictly not recommended for use in children aged less than 6 years due to risk of increased side effects.
Q: Can I try to get pregnant while taking ROSUMAC GOLD 20MG CAPSULE?
A: No. ROSUMAC GOLD 20MG CAPSULE should be discontinued from use if you are trying to get pregnant because, it may cause severe abnormalities to the growing fetus. Also, it is advised that women of child-bearing potential should use suitable contraceptive method to avoid pregnancy while taking the medicine.
Q: Can I consume alcohol while taking ROSUMAC GOLD 20MG CAPSULE?
A: No. Avoid consumption of alcohol while taking ROSUMAC GOLD 20MG CAPSULE as it could aggravate your existing disease condition and increase the risk of bleeding. Before taking the medicine, inform your doctor if you are alcoholic or have history of alcohol abuse.
References
1. KD. Tripathi. Drugs Affecting Coagulation, Bleeding and Thrombosis and Hypolipidemic Drugs and Plasma Expanders. Essentials of medical pharmacology. Seventh edition. 2013. Page – 629-633 & 636-638.
2. Jeffery I. Weitz. Blood coagulation and Anticoagulant, Fibrinolytic and Antiplatelet Drugs. Thomas P. Bersot. Drug therapy for hypercholesterolemia and dyslipidemia. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 868-870 & 892-898.
3. Gerald G. Briggs and Roger K. Freeman. A. C. & R. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 888-891, 288-298 & 3463-3465.
4. Susan Smyth. Early Use of Rosuvastatin in Acute Coronary Syndromes: Targeting Platelet-Leukocyte Interactions. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in March 2017] [Accessed on 7th October 2021] click here
5. Michael J. Lim, Frederick A. Spencer, Joel M. Gore, Omar H. Dabbous, Giancarlo Agnelli, Eva M. Kline-Rogers, Donna DiBenedetto, Kim A. Eagle, Rajendra H. Mehta. Impact of combined pharmacologic treatment with clopidogrel and a statin on outcomes of patients with non-ST-segment elevation acute coronary syndromes: perspectives from a large multinational registry. European Heart Journal. Oxford Academic. February 2005. [Accessed on 7th October 2021] click here
6. Charles H Hennekens Danielle Hollar, Arthur S Agatston. Aspirin and Statins to Decrease Risks of Cardiovascular Disease – The Need for Wider Utilization. US Cardiology reviews. 2004. [Accessed on 7th October 2021] click here
7. Travis R. Sexton, Eric L. Wallace, Tracy E. Macaulay, Richard J. Charnigo, Virgilio Evangelista, Charles L. Campbell, Alison L. Bailey and Susan S. Smyth. The effect of rosuvastatin on thrombo inflammation in the setting of acute coronary syndrome. NCBI; PMC US National Library of Medicine, National Institute of Health. October 2014. [Accessed on 7th October 2021] click here
8. Ke An, Rong Huang, Sai Tian, Dan Guo, Jiaqi Wang, Hongyan Lin, and Shaohua Wang. Statins significantly reduce mortality in patients receiving clopidogrel without affecting platelet activation and aggregation: a systematic review and meta-analysis. NCBI; PMC US National Library of Medicine, National Institute of Health. May 2019. [Accessed on 7th October 2021] click here
9. P. Maggi, G. V. De Socio, S. Cicalini, M. D’Abbraccio, G. Dettorre, A. Di Biagio, C. Martinelli, G. Nunnari, S. Rusconi, L. Sighinolfi, V. Spagnuolo, and N. Squillace. Statins and aspirin in the prevention of cardiovascular disease among HIV-positive patients between controversies and unmet needs: review of the literature and suggestions for a friendly use. NCBI; PMC US National Library of Medicine, National Institute of Health. May 2019. [Accessed on 7th October 2021] click here
10. Torrent Pharmaceuticals Ltd. Unistar Gold / Rozucor Gold. Torrentian.com. [Revised in March 2021] [Accessed on 7th October 2021] click here
11. Cipla Ltd. Rosulip Gold Capsules (Rosuvastatin calcium + Clopidogrel + Aspirin). Ciplamed.com. [Revised in January 2019] [Accessed on 7th October 2021] click here
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