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Torrent Pharmaceuticals Ltd

Nikoran 48mg Injection 1's

Angina
MRP ₹466.00 (Inclusive of all taxes)
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    Introduction About NIKORAN 48MG INJECTION

    NIKORAN 48MG INJECTION contains Nicorandil which belongs to the group of medicines called Antianginal drugs. It is used in adults for the management of unstable angina. Angina pectoris is a pain syndrome due to imbalance in demand and supply of oxygen in a portion of the heart muscle.   

    Prior to the management, your doctor may want you to take several blood tests to understand your existing condition.

    Avoid consumption of alcohol during management with NIKORAN 48MG INJECTION, as it may reduce your blood pressure even more.

    Before receiving NIKORAN 48MG INJECTION, inform your doctor if you have any kidney, liver or heart problems, dehydration or high blood pressure in lung vessels. NIKORAN 48MG INJECTION is not recommended for use among pregnant or breastfeeding women.

    NIKORAN 48MG INJECTION is not recommended for use in children due to lack of safety data and it should be used with caution in elderly patients.

    NIKORAN 48MG INJECTION may cause side effects such as headache, nausea, vomiting and upper abdominal discomfort. Inform your doctor if any of the side effects worsen.

    Uses Of NIKORAN 48MG INJECTION

    • For management of unstable angina

    How NIKORAN 48MG INJECTION Works

    NIKORAN 48MG INJECTION works by increasing blood flow through the heart vessels, leading to improved blood and oxygen supply to the heart muscle and thus reducing workload of the heart.

    How to use NIKORAN 48MG INJECTION

    NIKORAN 48MG INJECTION will be given to you only by a doctor or a nurse into a vein as an intravenous infusion. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

    Side Effects Of NIKORAN 48MG INJECTION

    Uncommon

    • headache
    • low blood pressure, fast heart rate
    • light-headedness, numbness in limbs
    • nausea, vomiting, upper abdominal discomfort

    How To Manage Side Effects

    Nausea:

    Take regular sips of a cold drink. Have ginger or peppermint tea. Stick to simple meals. Avoid eating oily or spicy foods. Inform your doctor if the symptom does not improve.

    Vomiting:

    Get adequate rest. Drink sufficient amount of fluids especially water. Have small sips if you feel sick. Eat when you are hungry and avoid eating oily, fried or spicy foods. Inform your doctor if the symptom does not improve.  

    Headache:

    Drink ample amount of water. Get adequate rest. Try to be relaxed and stress free. Ask your doctor before taking any medicine for headache. Inform your doctor if the symptom does not improve. 

    Warning & Precautions

    Pregnancy

    NIKORAN 48MG INJECTION is not recommended for use in pregnant women. Consult your doctor before receiving it.

    Breastfeeding

    NIKORAN 48MG INJECTION is not recommended for use in breastfeeding women as it is not known if it passes into the breast milk. Consult your doctor before receiving it.

    Alcohol

    Avoid consumption of alcohol while receiving NIKORAN 48MG INJECTION because it might drop your blood pressure.

    Kidney

    NIKORAN 48MG INJECTION is not recommended for use in patients with serious kidney dysfunction. Consult your doctor before receiving it.

    Liver

    NIKORAN 48MG INJECTION is not recommended for use in patients with serious liver dysfunction. Consult your doctor before receiving it.

    Allergy

    Do not receive NIKORAN 48MG INJECTION if you are allergic to Nicorandil or any other ingredients of this medicine.

    Lungs

    NIKORAN 48MG INJECTION is not recommended for use in patients having high blood pressure in lung vessels. Consult your doctor before receiving it.

    Heart Disease

    NIKORAN 48MG INJECTION is not recommended for use in patients having severely low blood pressure, cardiogenic shock, eisenmenger syndrome (condition that results from abnormal blood circulation caused by a defect in the heart) or right ventricular infarction. Consult your doctor before receiving it.

    Others

    NIKORAN 48MG INJECTION is not recommended for use if you:

    • have cerebral dysfunction
    • are dehydrated
    • have neurocirculatory asthenia (trouble breathing, fast, uneven heartbeat, dizziness, sleep disturbances)
    • closed-angle glaucoma (high pressure in eye)

    Use in pediatrics:

    NIKORAN 48MG INJECTION is not recommended for use in children as its safety has not been established in this population. Consult your child’s doctor for advice.

    Use in geriatrics:

    NIKORAN 48MG INJECTION should be used with caution in elderly patients. Consult your doctor before receiving it.

    Interactions

    A. Drug - Drug interactions:

    Before receiving NIKORAN 48MG INJECTION, inform your doctor if you are taking any of the following medicines:

    • medicines used to manage depression (Ex. amitriptyline, nortriptyline)
    • medicines used to relax blood vessels (Ex. nitroglycerin, nitroprusside)

    Overdosage:

    NIKORAN 48MG INJECTION will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor if you experience any unusual symptoms such as peripheral vasodilation, low blood pressure and fast heartbeat.

    Synopsis

    Drug :   Nicorandil
    Pharmacological Category :   Potassium channel activators
    Therapeutic Indication :   Angina pectoris
    Dosage Forms :   Tablet, Injection

    More Information

    • Store in a refrigerator (2 - 8°C), do not freeze or at room temperature (based on manufacturer’s recommendation)

    FAQs About NIKORAN 48MG INJECTION

    Can NIKORAN 48MG INJECTION be used in elderly patients?

    NIKORAN 48MG INJECTION should be used with caution in elderly patients as their physiology may increase the risk of an adverse event. Your doctor may monitor your blood pressure and other cardiac functions frequently and adjust the dose accordingly.

    Does NIKORAN 48MG INJECTION cause headache?

    NIKORAN 48MG INJECTION might cause headache in some individuals. If you experience headache, drink ample amount of water and get adequate rest. Try to be relaxed and stress free. Ask your doctor before taking any medicine for headache. Inform your doctor if you have continuous headache.

    Can NIKORAN 48MG INJECTION be used on infants?

    No, NIKORAN 48MG INJECTION is used for adults and not recommended for children as its safety has not been established in this population. Your child’s doctor will decide the correct dose or select a suitable alternative therapy for your child.

    What precautions do I need to follow while receiving NIKORAN 48MG INJECTION?

    Patients receiving NIKORAN 48MG INJECTION must inform their doctor about their pre-existing disease conditions like kidney, liver or heart problems. Patients should also inform if they are pregnant, breast-feeding, having any allergies, high blood pressure in lung vessels or dehydration. Inform your doctor immediately if you have any unusual symptoms.

    Does NIKORAN 48MG INJECTION cause vomiting?

    NIKORAN 48MG INJECTION might cause vomiting in some individuals. In such case, get adequate rest and drink sufficient amount of fluids, especially water. Have small sips if you feel sick. Eat when you are hungry and avoid eating oily, fried or spicy foods. Inform your doctor if you have continuous vomiting.

    References

    1. KD. Tripathi. Antianginal and other Anti-ischemic Drugs. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 539.

    2. Jason M Tarkin, Juan Carlos Kaski. Nicorandil and long-acting nitrates: vasodilator therapies for the management of chronic stable angina pectoris.  European Cardiology Review. July 2018. [Accessed on 24th November 2022] https://www.ecrjournal.com/articles/nicorandil-and-long-acting-nitrates-vasodilator-therapies-management-chronic-stable-angina

    3. Korea University Anam Hospital. A Study to Evaluate the Impact of Pre-procedural Intracoronary Nicorandil Injection to PREVENT reduction Of decreased TIMI FLOW in Patients Who Undergoing Percutaneous Coronary Intervention for the Coronary Artery Disease. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in October 2022] [Accessed on 24th November 2022] https://clinicaltrials.gov/ct2/show/NCT05427786

    4. Dexcel Pharma Ltd. Electronic Medicines Compendium (EMC). [Revised in January 2022] [Accessed on 24th November 2022] https://www.medicines.org.uk/emc/files/pil.652.pdf

    5. Torrent Pharmaceuticals Ltd. Nikoran I.V. (Nicorandil). [Revised in May 2014] [Accessed on 24th November 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/175.pdf

    6. Central Drugs Standard Control Organization (CDSCO). [Accessed on 24th November 2022] https://cdscoonline.gov.in/CDSCO/Drugs

    Useful Diagnostic Tests

    • Electrocardiogram (ECG)
    • Coronary angiography
    • Complete Blood Count (CBC)

    Author Details

    Written By Dr. R. Dinesh John Rajkumar - Pharm.D
    Reviewed For Accuracy By Dr. Thamada Manikanta Praveen - MBBS, MD (General Medicine)
    Last updated on 28 Nov 2022 | 10:29 AM(IST)
    Lab updated