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Introduction About MONOSPRIN DS 60/150MG TABLET
MONOSPRIN DS 60/150MG TABLET is a combination of Aspirin and isosorbide mononitrate which belongs to the group of medicines called Anti-platelets and Nitrates. It is used for the prophylaxis management of angina and myocardial infarction in adults.
MONOSPRIN DS 60/150MG TABLET is not recommended for use in patients with lung diseases such as asthma, severe liver or kidney disease, or severe heart diseases such as constrictive pericarditis, circulatory failure, cardiogenic shock, severe hypotension, pericardial tamponade, or restrictive cardiomyopathy, hypertrophic obstructive cardiomyopathy (HOCM), low cardiac filling pressures, or aortic or mitral valve stenosis.
Before taking MONOSPRIN DS 60/150MG TABLET, inform your doctor if you have had any serious damage to your heart, such as a heart attack. MONOSPRIN DS 60/150MG TABLET is generally not recommended for use in pregnancy unless considered necessary. MONOSPRIN DS 60/150MG TABLET should not be used by breastfeeding women because it may pass through the breast milk. MONOSPRIN DS 60/150MG TABLET is not recommended for use by children.
In patients over the age of 65, MONOSPRIN DS 60/150MG TABLET should be used with caution. Alcohol consumption should be avoided because it can lower blood pressure, cause dizziness or fainting, increase the risk of gastrointestinal bleeding, and lengthen the bleeding time.
The most common side effects of MONOSPRIN DS 60/150MG TABLET are nausea, vomiting, diarrhoea, indigestion, headache, low blood pressure on standing up causing dizziness, an increased tendency for bleeding, drowsiness, sleepiness, feeling weak, tiredness, an increased or slow heart rate, and flushing. Contact your doctor if any of the symptoms worsen.
Uses Of MONOSPRIN DS 60/150MG TABLET
- Prophylaxis management of angina and myocardial infarction
How MONOSPRIN DS 60/150MG TABLET Works
MONOSPRIN DS 60/150MG TABLET helps to manage angina and myocardial infarction, where aspirin works by inhibiting cyclo-oxygenase activity in platelets, which reduces the aggregation of platelets, managing the formation of clots in blood vessels, and isosorbide mononitrate work by relaxing the blood vessels of the heart, reducing the strain on the heart and making it easier to pump blood. As a result, MONOSPRIN DS 60/150MG TABLET reduces the risk of angina and myocardial infarction.
How to use MONOSPRIN DS 60/150MG TABLET
Take this medicine as advised by your physician. Swallow this medicine as a whole with a glass of water and do not crush or chew the medicine.
Side Effects Of MONOSPRIN DS 60/150MG TABLET
Common
- nausea, vomiting, diarrhoea, indigestion
- increased tendency for bleeding
- headache, low blood pressure on standing up causing dizziness
- drowsiness, sleepiness
- feeling weak, tiredness
- increased heart rate, or slow heart rate, flushing
Uncommon
- hives or skin rash, itching
- runny noses
- looking pale
- excessive sweating
- restlessness, worsening angina
Rare
- severe bleeding in the stomach or intestines
- haemorrhage in the brain
- change in the number of blood cells
- asthma attack, pain in the lower respiratory tract
- inflammation in the blood vessels
- bruising with purple spots (cutaneous bleeding)
- reye’s syndrome
- abnormal heavy or prolonged menstrual periods
Stop taking MONOSPRIN DS 60/150MG TABLET and contact your doctor immediately if you experience any of the following side effects:
- allergic reaction such as sudden wheezing, rashes or itching over the entire body, swelling of your lips, face or body, rash-causing difficulty in breathing or swallowing or shock or fainting
- exfoliative dermatitis (serious illness with blistering of the skin, mouth, eyes and genitals) or reddening of the skin with blisters or peeling and associated with a high fever and joint pains. Severe skin reactions such as erythema multiforme, Stevens-Johnson syndrome and Lyell’s syndrome
- unusual bleeding, such as blood in urine, black stools, vomiting blood or coughing up blood
How To Manage Side Effects
Headache:
Rest and relax. Drink plenty of fluids, such as water or electrolytes, and apply a pain-relieving balm on the head if necessary. Do not consume alcohol. Contact your doctor if the symptom does not improve.
Nausea, vomiting:
Take this medicine with meals or just after meals. Stick to simple meals. Avoid eating oily or spicy foods.
Diarrhoea:
Drink lots of fluids, such as water or fruit juices, to keep you hydrated. Take no medication on your own to manage diarrhoea. Contact your doctor if the symptom does not improve.
Indigestion:
Eat smaller meals but take them frequently. Eat and exercise regularly. Contact your doctor if the symptom does not improve.
Dizziness or drowsiness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any machines while you are feeling dizzy. Do not consume alcohol, as it can aggravate your dizziness. Contact your doctor if the symptom does not improve.
Itchy skin:
Avoid hot showers because hot water can irritate the skin. Do not scratch the affected area. Use sunscreen and protective clothing when outdoors. Regularly use unscented moisturisers to soothe and hydrate the affected area. Contact your doctor if the symptom does not improve.
Warning & Precautions
Pregnancy
MONOSPRIN DS 60/150MG TABLET is generally not recommended for use in pregnancy unless considered necessary. Contact your doctor before taking it.
Breastfeeding
MONOSPRIN DS 60/150MG TABLET is generally not recommended for use in breastfeeding women as it may pass through the breast milk. Consult your doctor before taking it.
Driving and Using Machines
Do not drive or operate any machines if you feel headache, blurred vision, dizziness, and tiredness after taking [GBNEYWORD].
Alcohol
Avoid consumption of alcohol as it may lower blood pressure cause dizziness or fainting and also increase the risk of gastrointestinal bleeding and prolong bleeding time.
Kidney
MONOSPRIN DS 60/150MG TABLET is not recommended for use in patients with severe kidney disease. Contact your doctor before taking it.
Liver
MONOSPRIN DS 60/150MG TABLET is not recommended for use in patients with severe liver disease. Contact your doctor before taking it.
Allergy
Do not take MONOSPRIN DS 60/150MG TABLET if you are allergic to Aspirin, Isosorbide mononitrate, other salicylates or NSAIDs or lactose or some sugars, or other ingredients of this medicine.
Lungs
MONOSPRIN DS 60/150MG TABLET is not recommended for use in patients with lung diseases such as asthma, hay fever, nasal polyps and other chronic respiratory diseases. Contact your doctor before taking it.
Heart Disease
MONOSPRIN DS 60/150MG TABLET not recommended for use in patients with severe heart diseases such as constrictive pericarditis, circulatory failure, cardiogenic shock, severe hypotension, pericardial tamponade or restrictive cardiomyopathy, hypertrophic obstructive cardiomyopathy (HOCM), low cardiac filling pressures and aortic or mitral valve stenosis, severe heart problems causing shortness of breath and ankle swelling. MONOSPRIN DS 60/150MG TABLET should be used with caution in patients who had a heart attack. Contact your doctor before taking it.
Others
MONOSPRIN DS 60/150MG TABLET is not recommended for use if you have:
- active ulcer in the stomach or small intestine or bleeding
- stroke
- problems with blood clotting such as bleeding diathesis (like haemophilia)
- gout
- elevated intracranial pressure
- low blood volume (hypovolemia)
- severe low blood pressure (hypotension)
- severely impaired blood flow in the brain (cerebrovascular insufficiency)
- severe anaemia
- brain haemorrhage (bleeding)
- head injury (trauma)
- shock or circulatory failure or vascular collapse
- glaucoma
- hypothrombinaemia
- arterial hypoxemia
- cor pulmonale
- orthostatic disturbances of circulatory regulation
Before taking MONOSPRIN DS 60/150MG TABLET, inform your doctor if you have:
- problems with the stomach or intestine
- uncontrolled high blood pressure
- heavy menstrual periods
- glucose-6-phosphate dehydrogenase (G6PD) enzyme deficiency
- hypothyroidism
- malnourishment
- hypothermia (very low body temperature)
- very poor circulation
- surgeries
Use in pediatrics:
MONOSPRIN DS 60/150MG TABLET is not recommended for use by children. Contact your doctor before taking it.
Use in geriatrics:
MONOSPRIN DS 60/150MG TABLET should be used with caution in elderly patients (aged 65 years or above). Contact your doctor before taking it.
Interactions
A. Drug-Drug interactions:
Before taking MONOSPRIN DS 60/150MG TABLET, inform your physician, if you are using,
- medicines used to thin the blood or manage clots (Ex. warfarin, heparin, clopidogrel, alteplase)
- medicines used to manage rejection of organ after transplantation (Ex. cyclosporine, tacrolimus)
- medicines used to manage high blood pressure or heart diseases such as beta-blockers (atenolol, propranolol), calcium channel blockers (nifedipine, diltiazem), vasodilators (glycerol trinitrate, methyldopa), angiotensin receptor blockers (olmesartan medoxomil, candesartan cilexetil), Ace inhibitors like ramipril, moxonidine and diuretics like chlorothiazide, furosemide and spironolactone)
- medicines used for heart failure (digoxin)
- medicines used for the manic-depressive disorder (lithium)
- medicines used for pain (Ex. NSAIDs such as ibuprofen)
- probenecid, sulfinpyrazone (medicines used to manage gout)
- medicines used to manage epilepsy (Ex. valproate, phenytoin, phenobarbitone)
- medicines used to manage glaucoma (Ex. acetazolamide)
- medicines used to manage cancer or rheumatoid arthritis (Ex. methotrexate)
- medicines used to manage diabetes (Ex. glibenclamide, insulin)
- medicines used to manage depression such as sertraline or paroxetine
- medicines used to manage inflammation (corticosteroids like prednisone, and dexamethasone)
- medicines used to manage indigestion Ex. Antacids like magnesium carbonate
- metamizole (medicines used to manage pain and fever)
- medicines used to manage erectile dysfunction, impotence or high blood pressure in the lungs (Phosphodiesterase-5-inhibitors such as sildenafil, alprostadil, tadalafil and vardenafil )
- norepinephrine (used to manage sharp decrease in blood pressure)
- acetylcholine (medicines used in operations)
- histamine (medicines sued as a diagnostic agent)
- medicines used to manage depression (Ex. tricyclic antidepressants like amitriptyline, and clomipramine)
- medicines used to manage psychosis such as fluphenazine, haloperidol
- dihydroergotamine (medicines used to manage migraine),
- sapropterin (medicines used for the management of hyperphenylalaninaemia)
- aldesleukin (used to manage metastatic kidney cancer)
- phenylbutazone, oxyphenbutazone (medicines used to manage back pain and spondylitis)
- urinary alkaliser like potassium citrate (medicines used to correct pH, kidney diseases)
Overdosage:
If you or anyone else accidentally took too much of this medicine, consult your doctor immediately. Symptoms of overdose are a fall in blood pressure causing faintness, dizziness, feeling sick, ringing in the ears, hearing problems, headache, dizziness, confusion, nausea, vomiting, and abdominal pain. Overdose can lead to more rapid breathing than normal (hyperventilation), fever, excess sweating, restlessness, seizures, hallucinations, low blood sugar, coma, and shock.
Synopsis
| Drug | : | Aspirin, Isosorbide mononitrate |
| Pharmacological Category | : | Antiplatelet, Nitrates |
| Therapeutic Indication | : | Angina, Myocardial infarction |
| Dosage Forms | : | Tablet, Capsule |
More Information
- Keep MONOSPRIN DS 60/150MG TABLET out of reach from children
- Store MONOSPRIN DS 60/150MG TABLET below 25°C
FAQs About MONOSPRIN DS 60/150MG TABLET
Q: For what conditions is MONOSPRIN DS 60/150MG TABLET used?
A: MONOSPRIN DS 60/150MG TABLET is used to manage angina and myocardial infarction in adults. Contact your doctor before taking MONOSPRIN DS 60/150MG TABLET.
Q: How does MONOSPRIN DS 60/150MG TABLET work?
A: MONOSPRIN DS 60/150MG TABLET helps to manage angina and myocardial infarction, where aspirin works by inhibiting cyclo-oxygenase activity in platelets, which reduces the aggregation of platelets, managing the formation of clots in blood vessels, and isosorbide mononitrate work by relaxing the blood vessels of the heart, reducing the strain on the heart, and making it easier to pump blood. As a result, MONOSPRIN DS 60/150MG TABLET reduces the risk of angina and myocardial infarction.
Q: What are the side effects of taking MONOSPRIN DS 60/150MG TABLET?
A: The most common side effects of MONOSPRIN DS 60/150MG TABLET are nausea, vomiting, diarrhoea, indigestion, headache, low blood pressure on standing up causing dizziness, increased tendency for bleeding, drowsiness, sleepiness, feeling weak, tiredness, an increased or slow heart rate, and flushing. Contact your doctor if any of the symptoms worsen.
Q: Can I take alcohol while using MONOSPRIN DS 60/150MG TABLET?
A: No. Alcohol consumption should be avoided while taking MONOSPRIN DS 60/150MG TABLET, as it can lower blood pressure, cause dizziness or fainting, and increase the risk of gastrointestinal bleeding and lengthen the bleeding time.
Q: Can I use MONOSPRIN DS 60/150MG TABLET with children?
A: No, MONOSPRIN DS 60/150MG TABLET is not recommended for use by children. Contact your doctor before taking MONOSPRIN DS 60/150MG TABLET.
References
1. KD Tripathi. Drugs affecting coagulation, bleeding and thrombosis [for aspirin] & Cardiovascular drugs [for isosorbide mononitrate]. Essentials of medical pharmacology. Seventh edition. 2013. Page- 629, 544.
2. John F Gilmer, Louise M Moriarty, Dermot F Mc Cafferty, John M Clancy. Uses of Aspirin and Isosorbide mononitrate. European Journal of Pharmaceutical Sciences. October 2001. [Accessed on June 4th 2022] https://www.sciencedirect.com/science/article/abs/pii/S092809870100183X
3. Accord-UK Limited. Electronic Medicines Compendium (EMC). [Revised on March 2021] [Accessed on 4th June 2022] https://www.medicines.org.uk/emc/files/pil.2408.pdf
4. Actavis Limited. Health Products Regulatory Authority (HPRA). [Revised on December 2019] [Accessed on 4th June 2022] https://www.hpra.ie/img/uploaded/swedocuments/697b07a9-17b2-42b9-bdaa-20bc441264e4.pdf
5. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised on July 2014] [Accessed on 4th June 2022] https://www.medicines.org.uk/emc/files/pil.6114.pdf
6. Dexcel Pharma Ltd. Electronic Medicines Compendium (EMC). [Revised on December 2017] [Accessed on 4th June 2022] https://www.medicines.org.uk/emc/files/pil.2697.pdf
7. Aspirin and isosorbide mononitrate. mims.com. [Accessed on 4th June 2022] https://www.mims.com/india/drug/info/isosorbide%20mononitrate%20+%20aspirin?type=full&mtype=generic
Useful Diagnostic Tests
- Prothrombin time
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