Ivabrad 5 mg Tablet 15'S

Introduction About IVABRAD 5MG TABLET

Ivabrad 5 mg tablet is commonly prescribed for patients who require heart rate regulation in conditions like stable angina or certain types of heart rhythm irregularities. It is ideal for individuals where slowing the heart rate is beneficial, especially in cases where beta-blockers or other heart medications might not be suitable. It works by specifically targeting the sinoatrial node the natural pacemaker of the heart to help slow down the heart rate without significantly affecting blood pressure.    

Ivabrad 5 mg tablet is typically taken once or twice daily depending on your doctor’s guidance, with or without food. It is important to follow the dosage instructions provided by your healthcare provider to ensure proper heart rate management. Always take Ivabradine exactly as prescribed to achieve the desired results.  

Before starting Ivabradine, inform your doctor if you have any pre-existing conditions such as liver problems, kidney issues, or irregular heart rhythms. Ivabradine should be used cautiously in patients with low blood pressure or heart failure. It is important not to stop taking the medication without consulting your healthcare provider. Common side effects may include dizziness, fatigue, slow heart rate or visual disturbances though not everyone experiences these.

Ivabradine is generally not recommended during pregnancy unless clearly advised by the doctor. Breastfeeding mothers should avoid using Ivabradine as it is not known whether this medication passes into breast milk. Always consult with your healthcare provider before taking this medication during pregnancy or while breastfeeding.

Uses Of IVABRAD 5MG TABLET

• Helps manage elevated resting heart rate
• Supports regulation of irregular heartbeat patterns
• Effective in stable heart conditions requiring heart rate control

Benefits of IVABRAD 5MG TABLET

Ivabrad 5 mg role in heart rate control

Ivabrad 5 mg is often considered in clinical routines where guided heart rate regulation is necessary. It works by selectively influencing the activity of the sinoatrial node, a natural pacemaker within the heart, helping to achieve a more consistent resting heart rate.

This approach is especially relevant in individuals who may not tolerate certain other heart rate-modifying options. By focusing solely on the heart rate without significantly altering blood pressure.

Ivabradine advantages in long-term use

Ivabradine is frequently included in long-term heart rate management plans due to its targeted action and consistent profile. Its selective approach allows for pulse regulation while minimizing the influence on other cardiovascular parameters like blood pressure. This makes it a suitable option for patients requiring sustained heart rate control without systemic effects. Over time, its usage can be aligned with lifestyle adjustments and other supportive measures, allowing for a more tailored and well-monitored approach to cardiac rhythm support.

How IVABRAD 5MG TABLET Works

Ivabrad 5 mg role in heart rate control

Ivabrad 5 mg is often considered in clinical routines where guided heart rate regulation is necessary. It works by selectively influencing the activity of the sinoatrial node, a natural pacemaker within the heart, helping to achieve a more consistent resting heart rate.

This approach is especially relevant in individuals who may not tolerate certain other heart rate-modifying options. By focusing solely on the heart rate without significantly altering blood pressure.

Ivabradine advantages in long-term use

Ivabradine is frequently included in long-term heart rate management plans due to its targeted action and consistent profile. Its selective approach allows for pulse regulation while minimizing the influence on other cardiovascular parameters like blood pressure. This makes it a suitable option for patients requiring sustained heart rate control without systemic effects. Over time, its usage can be aligned with lifestyle adjustments and other supportive measures, allowing for a more tailored and well-monitored approach to cardiac rhythm support.

How to use IVABRAD 5MG TABLET

Ivabradine recommended dose

• The typical starting dose for adults is 5 mg twice daily.
• After 2–4 weeks, the dose may be adjusted based on resting heart rate: 
• Increase to 7.5 mg twice daily if heart rate > 60 bpm.
• Maintain at 5 mg twice daily if heart rate is 50–60 bpm.
• Reduce to 2.5 mg twice daily or discontinue if heart rate < 50 bpm or symptoms of bradycardia occur.

When to take Ivabrad 5 mg – before or after food

• Take Ivabrad 5 mg with meals to enhance absorption and reduce variability in drug levels.
• Preferably taken at consistent times daily, morning and evening, to maintain stable blood levels.

Ivabrad dosage for elderly patients

• In patients aged 75 years and above, start with a lower dose of 2.5 mg twice daily.
• Dose will be cautiously adjusted based on heart rate and tolerability.
• Regular monitoring is essential due to increased risk of bradycardia and other side effects.
• Adjust dose gradually, not exceeding 7.5 mg twice daily, only if well-tolerated.

What if I forgot to take IVABRAD 5MG TABLET

If you forget to take your scheduled dose of Ivabrad 5 mg Tablet, take it as soon as you remember on the same day. If it's almost time for your next dose, skip the missed one and return to your regular dosing schedule. Do not take two doses at the same time or extra doses to make up for the missed one, as this may increase the risk of side effects like a slower-than-usual heart rate or dizziness.

To stay on track, try to take Ivabrad at the same time each day. Using a medication reminder or setting an alarm can help you remember your daily dose. If you frequently miss doses, speak with your healthcare provider to discuss the best way to maintain consistency in your dosing routine.

Overdose

What to Know About Accidental Overdose

Taking more than the recommended dose of Ivabrad 5 mg Tablet can affect heart rate control and may lead to symptoms such as unusually slow heartbeat (bradycardia), dizziness, tiredness or shortness of breath. In some cases, the effects may not be immediately noticeable, making it important to act promptly.

How to Avoid Accidental Overuse of Ivabrad 5 mg Tablet

To reduce the risk of taking an extra dose:

• Take Ivabrad at the same time every day.
• Use a pill organizer or reminder app.
• Do not share your medication with others.
• Keep it out of reach of children or anyone for whom it is not prescribed.

What to Do in Case of Overdosage of Ivabrad 5 mg Tablet

If you suspect that you or someone else has taken an extra dose of Ivabrad 5 mg Tablet:

• Do not wait for symptoms to appear.
• Contact a healthcare professional or visit the nearest medical center immediately.
• If possible, carry the medication strip or prescription along with you for reference.

Prompt attention helps healthcare providers assess the situation and offer appropriate support.

Side Effects Of IVABRAD 5MG TABLET

Ivabrad 5 mg Tablet common side effects

• brief moments of increased brightness (due to sudden changes in light intensity)
• slow heart rate
• signs of atrial fibrillation (irregular rapid contraction of the heart) such as chest pain, pounding heartbeat, and tiredness
• uncontrolled blood pressure
• headache, dizziness, blurred vision

How long do side effects of Ivabradine last?

The duration of Ivabradine side effects generally varies between individuals. Most common side effects, like visual disturbances (flashes of light) or bradycardia (slow heart rate), tend to be temporary and usually subside within a few days to weeks as the body adjusts to the medication. Headaches and gastrointestinal discomfort may also improve within a short period.

If side effects persist or worsen, such as significant dizziness or fatigue, dosage adjustments or discontinuation may be necessary. For more serious issues, it's important to consult a healthcare provider promptly. Regular monitoring of heart rate and symptoms can help manage side effects effectively.

When to Seek Medical Attention?

It is important to seek medical attention if you experience any of the following while taking Ivabrad 5 mg:

• Severe bradycardia (slow heart rate): If your resting heart rate drops below 50 bpm or if you experience symptoms like dizziness, fatigue, or fainting, contact your healthcare provider immediately.
• Visual disturbances: If you experience persistent or bothersome flashes of light or other visual changes that interfere with daily activities, notify your doctor.
• Signs of heart failure worsening: Increased shortness of breath, swelling in the legs, or rapid weight gain may indicate worsening heart failure, requiring prompt medical evaluation.
• Severe chest pain or discomfort: Though Ivabradine is used to treat angina, if you experience new or worsening chest pain, seek medical help right away.
• Allergic reactions: If you develop signs of an allergic reaction such as rash, itching, swelling (especially of the face, tongue, or throat), or difficulty breathing, seek immediate medical attention.
• Unusual symptoms: If you feel unusually weak, confused, or experience any side effects that are not typical, contact your healthcare provider for advice.

Early intervention can help prevent complications, so it's crucial to stay in regular contact with your healthcare team while on Ivabradine.

Warning & Precautions

Other Warnings for IVABRAD 5MG TABLET

Before taking Ivabrad Tablet, inform your doctor if you:

• had a recent stroke (cerebral attack)
• suffer from mild to moderate low blood pressure (after change in antihypertensive management)
• have chronic eye retinal disease

Who should not take [GBNKEYWORD

Ivabrad Tablet is not recommended for use if you:

• suffer from very low blood pressure
• have unstable angina (a severe form of chest pain

Safety Advice

Expert Advice: Ivabrad 5 mg tablet safety guidelines

• Monitor Heart Rate Regularly: Check your resting heart rate frequently. If it drops below 50 bpm, contact your healthcare provider for possible dose adjustments.
• Avoid Abrupt Discontinuation: Do not stop Ivabradine suddenly without medical guidance, as this could lead to worsened symptoms or rebound effects.
• Use with Caution in Certain Conditions: If you have severe liver or kidney problems, your doctor may adjust the dose or monitor you more closely.
• Consult Before Combining with Other Medications: Always inform your healthcare provider about other medications you're taking, especially those affecting heart rate or blood pressure, to avoid potential interactions.
• Pregnancy and Breastfeeding: Ivabradine is not recommended during pregnancy or breastfeeding unless deemed absolutely necessary by your doctor.

Diet and Lifestyle Advice

Ivabradine and heart-healthy lifestyle

When taking Ivabrad 5 mg Tablet (Ivabradine), adopting a heart-healthy lifestyle is essential for optimizing its effectiveness and supporting overall cardiovascular health. Ivabradine works by regulating your heart rate, and pairing this with a healthy lifestyle can help achieve better results in managing heart health. Here are some key lifestyle practices to support your treatment:

1. Regular Physical Activity

• Exercise plays a vital role in heart health. Moderate-intensity activities like walking, swimming, or cycling can help improve cardiovascular function and keep your heart strong.
• Avoid intense workouts or activities that cause excessive strain on your heart, especially if your heart rate is significantly affected by Ivabradine.

2. Healthy Diet

• A heart-healthy diet rich in fruits, vegetables, and whole grains helps manage cholesterol, blood pressure, and overall heart function. Include foods like omega-3 fatty acids (found in fish), fiber, and antioxidants in your daily meals.
• Focus on lean proteins such as chicken, turkey, tofu, and fish, and choose healthy fats like olive oil and avocado.

3. Stress Management

• Chronic stress can increase heart rate and negatively affect heart health. Practicing stress-relieving techniques such as yoga, meditation, or simple deep breathing exercises can complement Ivabradine’s action.

4. Weight Management

• Maintaining a healthy weight helps lower the risk of heart disease. Regular physical activity, combined with a balanced diet, is essential in managing your weight effectively.

5. Adequate Sleep

• Ensure that you get 7-8 hours of quality sleep each night, as insufficient sleep can increase your heart rate and blood pressure.

By combining Ivabradine with a heart-healthy lifestyle, you enhance the benefits of the medication while promoting long-term cardiovascular wellness.

Low-Sodium Diet Recommendations for Ivabrad 5 mg Tablet Users

Following a low-sodium diet is an essential step for those using Ivabrad 5 mg Tablet (Ivabradine), as it helps to improve heart health, prevent fluid retention, and maximize the effectiveness of the medication. Here are four key recommendations for maintaining a low-sodium diet:

• Limit Processed and Canned Foods: Processed and canned foods, such as soup, frozen meals, and deli meats, are often high in sodium. Choose fresh, whole foods like fruits, vegetables, and lean meats to control your sodium intake.
• Use Fresh Herbs and Spices: Instead of using salt for seasoning, enhance the flavor of your meals with fresh herbs (e.g., basil, oregano) and spices (e.g., cumin, turmeric). This can add flavor without the extra sodium.
• Opt for Low-Sodium Alternatives: Look for low-sodium versions of common pantry staples like soy sauce, broths, and snack foods. These alternatives allow you to maintain a flavorful diet without increasing sodium intake.
• Prepare Meals at Home: Cooking meals at home gives you full control over the ingredients, helping you keep sodium levels low. Focus on whole foods like grilled chicken, steamed vegetables, and brown rice to create heart-healthy dishes.

By following these guidelines, you can help improve heart health and support the effectiveness of Ivabradine while managing your sodium intake.

How does Ivabrad 5 mg benefit daily heart function

Ivabrad 5 mg helps improve daily heart function by lowering the heart rate in a targeted way, allowing the heart to pump more efficiently with less strain. It reduces oxygen demand without affecting blood pressure or heart strength, making it ideal for patients with angina. This leads to fewer symptoms, better exercise tolerance, and improved quality of life.

Ivabradine vs beta-blockers

Parameter	Ivabradine	Beta-Blockers
Mechanism of Action	Selective inhibition of the If current in SA node	Blocks beta-adrenergic receptors
Primary Effect	Reduces heart rate only	Reduces heart rate and blood pressure
Effect on Blood Pressure	Minimal to none	Significant blood pressure reduction
Effect on Contractility	No negative inotropic effect	May reduce myocardial contractility
Ideal Use Case	Patients with low BP or intolerance to beta-blockers	First-line in heart failure and post-MI care
Respiratory Safety	Safe in asthma/COPD	May worsen asthma (especially non-selective blockers)
Common Side Effects	Bradycardia, visual brightness (phosphenes)	Fatigue, cold extremities, bradycardia
Use in Heart Failure	Add-on therapy when HR ≥ 70 bpm despite beta-blocker	First-line therapy in most heart failure cases
Contraindications	Acute decompensated HF, bradycardia, atrial fibrillation	Severe bradycardia, AV block, asthma (non-selective)
Monitoring Requirement	Heart rate and visual symptoms	HR, BP, glucose (in diabetics), bronchospasm signs

Drug - Drug interaction

Ivabrad 5 mg Tablet (Ivabradine) may interact with certain other medications, which could affect its role in heart rate control or increase the risk of side effects such as excessive slowing of the pulse. It's important to inform your healthcare provider about all medications, supplements, or herbal products you are currently taking.

1. Heart Rate-Lowering Medications
   • Examples: Beta-blockers (e.g., metoprolol, atenolol), diltiazem, verapamil
   • Interaction: May cause a significant drop in heart rate when used together
   • Management: Monitor heart rate closely; dosage adjustments may be required
2. Antifungal Agents (Azoles)
   • Examples: Ketoconazole, itraconazole
   • Interaction: May increase blood levels of Ivabradine, raising side effect risk
   • Management: Avoid concurrent use unless specifically advised by your doctor
3. Macrolide Antibiotics
   • Examples: Clarithromycin, erythromycin
   • Interaction: Can enhance Ivabradine’s effect on the heart, potentially leading to irregular rhythms
   • Management: Alternative antibiotics may be considered
4. HIV Protease Inhibitors
   • Examples: Ritonavir, nelfinavir
   • Interaction: Can significantly elevate Ivabradine plasma levels
   • Management: Avoid concurrent use unless under strict medical supervision
5. Antidepressants and Anti-seizure Drugs
   • Examples: Phenytoin, carbamazepine, St. John’s Wort
   • Interaction: May lower the effectiveness of Ivabrad by increasing metabolism
   • Management: Monitor heart rate response; dose change may be needed

Drug - Food interaction

While Ivabrad 5 mg Tablet (Ivabradine) is generally safe when taken as directed, certain foods and beverages can influence its absorption and activity. Being aware of these interactions can help maintain stable heart rate control and avoid unwanted effects.

Grapefruit and Grapefruit Juice

• • Interaction: Grapefruit contains compounds that can increase Ivabradine levels in the blood by inhibiting its breakdown in the liver.
  • Effect: Higher blood levels may enhance the medicine’s effect on the heart, potentially leading to excessive slowing of the pulse or visual disturbances.
  • Management Tip: Avoid regular or large amounts of grapefruit or grapefruit juice while using Ivabrad 5 mg Tablet.

High-Fat Meals

• • Interaction: Consuming Ivabrad with a high-fat meal may increase its absorption.
  • Effect: This can lead to a slightly stronger effect on heart rate.
  • Management Tip: Take the tablet with food, preferably at the same time daily, but avoid high-fat meals immediately before or after the dose to maintain consistency.

Caffeine-Containing Products (in excess)

• • Interaction: While not a direct interaction, high caffeine intake can increase heart rate, counteracting Ivabradine's role in heart rate control.
  • Effect: May reduce the desired effect of the medicine.
  • Management Tip: Limit intake of caffeinated beverages (e.g., coffee, energy drinks) if advised by your healthcare provider.

Synopsis

Drug	:	Ivabradine
Pharmacological Category	:	Hyperpolarization-activated cyclic nucleotide-gated channel blockers
Therapeutic Indication	:	Symptomatic stable angina, Chronic Heart failure
Dosage Forms	:	Tablet

More Information

 

 

FAQs About IVABRAD 5MG TABLET

Q: What is Ivabradine 5 mg Tablet used for?

A: Ivabradine 5 mg Tablet is primarily used to manage chronic stable angina. It works by lowering the heart rate, thereby reducing the heart's oxygen demand and helping alleviate symptoms like chest pain and shortness of breath.

Q: How long does it take for Ivabradine to work?

A: Ivabradine may take a few days to weeks to show its full effect. It's important to follow up with your doctor regularly to assess your heart rate and adjust the dosage as needed.

Q: What should I do if I experience visual disturbances while taking Ivabradine?

A: Visual disturbances like flashes of light are a common but typically mild side effect of Ivabradine. If these disturbances are bothersome or persist, consult your doctor. Dose adjustments may be needed.

Q: Can I drink alcohol while taking Ivabradine?

A: While moderate alcohol consumption is not strictly contraindicated, it is advisable to limit alcohol intake as it may enhance side effects such as dizziness and fainting, especially when combined with Ivabradine.

Q: Can Ivabradine cause low blood pressure?

A: Ivabradine does not directly lower blood pressure, but if combined with other blood pressure-lowering medications, it could potentially enhance the effects of those drugs. It is important to monitor both blood pressure and heart rate during treatment.

Q: How often should I see my doctor while taking Ivabrad 5 mg Tablet?

A: Regular check-ups are essential while on Ivabradine, particularly to monitor your heart rate, symptoms, and potential side effects. Typically, you'll need a follow-up visit within a few weeks of starting the medication, and then regularly as prescribed by your doctor.

Q: Can Ivabradine be taken long-term?

A: Yes, Ivabradine is generally prescribed for long-term use in patients with stable angina or chronic heart failure, but it should be regularly monitored by a healthcare provider.

Q: What should I do if I experience a slow heart rate while taking Ivabradine?

A: If your heart rate drops below 50 bpm, you should contact your healthcare provider immediately. The dosage of Ivabradine may need to be adjusted.

Q: Can Ivabrad dosage be changed based on symptoms?

A: Yes, Ivabradine dosage can be adjusted based on your symptoms and heart rate. If side effects occur or your heart rate becomes too slow, your doctor may reduce the dosage.

Q: When to take Ivabrad 5 mg – morning or night?

A: Ivabradine should be taken twice daily, typically in the morning and evening, with food to enhance absorption and reduce side effects.

Q: Is Ivabradine safe for long-term use without side effects?

A: Ivabradine is generally safe for long-term use but side effects like bradycardia, fatigue and visual disturbances can occur. Regular monitoring by your doctor is recommended.

Q: Can Ivabradine cause shortness of breath?

A: Ivabradine typically does not cause shortness of breath. However, if it slows the heart rate too much (bradycardia), it can affect heart function, potentially worsening symptoms of heart failure, including shortness of breath. If you experience this, consult your doctor immediately to adjust the dosage or treatment. Regular monitoring is important to avoid this complication.

Q: Can Ivabradine be taken with other heart medications?

A: Ivabradine can be taken with other heart medications like ACE inhibitors, beta-blockers, and diuretics, but caution is required when combining it with other drugs that affect the heart rate. Always consult your doctor before combining Ivabradine with other treatments.

Q: Can I stop taking Ivabrad 5 mg Tablet suddenly?

A: Ivabradine should not be stopped suddenly unless advised by a healthcare provider, as doing so may worsen symptoms like angina or heart failure. If you need to stop taking Ivabradine, your doctor will guide you on how to gradually reduce the dosage.

Q: Can Ivabradine cause dizziness or lightheadedness?

Ivabradine can cause dizziness or lightheadedness, especially due to its effect of lowering the heart rate. This may be more noticeable when standing up quickly or during the initial days of treatment. If symptoms persist or worsen, consult your doctor.

Q: Can Ivabradine be used during pregnancy and breastfeeding?

A: Ivabradine is not recommended during pregnancy due to potential risks to the unborn baby. It should also be avoided while breastfeeding as the drug may pass into breast milk. Always consult your doctor if you're pregnant or planning to breastfeed.

Q: Can Ivabradine affect exercise tolerance?

A: Ivabradine can improve exercise tolerance in patients with stable angina or irregular heart rhythm pattern by lowering the heart rate and reducing the heart’s workload. This may help reduce symptoms like fatigue or chest discomfort during physical activity.

Q: Can Ivabradine be taken if I have a pacemaker?

A: Ivabradine is generally not recommended for patients who are pacemaker-dependent, as the drug works by reducing the natural heart rate. If your heart rhythm is controlled solely by a pacemaker, Ivabradine may not be effective or appropriate. Always discuss with your cardiologist.

References

1. Ivabradine Prescribing Information USFDA. Revised on April 2019. [Accessed on 5th May 2025].
2. Ivabradine Statpearls Revised on 15th February 2025. [Accessed on 5th May 2025].
3. Gaidaa M Dogheim Ibtsam Khairat, Gamal A Omran, Sahar M El-Haggar, Ahmed M El Amrawy, Rehab H Werida. Clinical comparative study assessing the effect of ivabradine on neopterin and NT-Pro BNP against standard treatment in chronic heart failure patients. NIH. National Library of Medicine. . Published on 3rd March 2022. [Accessed on 5th May 2025].
4. Mirembe Reed; Connor C. Kerndt; Diala Nicolas. Ivabradine. NIH National Library of Medicine. National Center for Biotechnology Information. Stat Pearls [Internet]. [Revised in May 2022] [Accessed on 5th May 2025]  
5. Lupin Limited. IVABRAD OD 10MG, IVABRAD OD 15MG. [Accessed on 5th May 2025]  
6. Alniche Life Sciences Pvt. Ltd. Ivaniche. [Accessed on 5th May 2025]
7. Noucor Health S.A. Electronic Medicines Compendium (EMC). [Revised in July 2022] [Accessed on 5th May 2025]    

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