ISOLAZINE Tablet 15's

Introduction About ISOLAZINE TABLET

ISOLAZINE TABLET is a combination of Hydralazine and Isosorbide dinitrate which belongs to the group of medicines called Vasodilators. ISOLAZINE Tablet is a prescription-based medicine used under specific healthcare guidance. It is known to support cardiovascular health parameters like heart failure. Commonly suggested in wellness routines by medical professionals, it is essential to follow the advised regimen.

During course of the management your doctor might regularly monitor your blood pressure to avoid any side effects. The safety and effectiveness of ISOLAZINE TABLET in children have not been established.

Before taking ISOLAZINE TABLET, consult your doctor if you have any kidney, heart, lung or liver problems, too much sweating, fluid loss, vomiting or diarrhea or if you consume alcohol.

ISOLAZINE TABLET is not studied in pregnant and breastfeeding women, so consult your doctor before taking the medicine. The most common side effects of taking ISOLAZINE TABLET are headache and dizziness. Consult your doctor if any of the side effects worsen.

Key Composition

Each ISOLAZINE Tablet contains:

• Hydralazine: A vasodilator that supports healthy circulation
• Isosorbide Dinitrate: Helps optimize oxygen supply in cardiovascular processes

Uses Of ISOLAZINE TABLET

• Used to manage heart failure

Benefits of ISOLAZINE TABLET

• Formulated with a combination of Hydralazine and Isosorbide Dinitrate
• Taken as per healthcare provider’s recommendation
• Often included in heart-focused health strategies
• Available in oral tablet format for easy intake

How ISOLAZINE TABLET Works

Why Hydralazine is combined with Isosorbide Dinitrate

The combination supports the function of the circulatory system through dual-action vasodilation. Each working on different types of blood vessels.

Hydralazine:

• Primarily acts on arteries
• Helps relax and widen arterial walls, making it easier for the heart to pump blood forward

Isosorbide Dinitrate

• Primarily acts on veins
• Helps reduce the amount of blood returning to the heart, which lowers the pressure the heart has to work against. It increases nitric oxide levels in the body, which relaxes venous smooth muscles, helping to reduce pressure buildup in the heart.

How to use ISOLAZINE TABLET

How to take ISOLAZINE Tablet: Step-by-Step Guidance

Taking ISOLAZINE Tablet correctly helps ensure the medicine works as intended. Here is a simple guide to follow:

1. Follow Your Doctor’s Instructions: Always take the tablet exactly as prescribed by your healthcare provider
2. Use the Same Time Every Day: Consistency helps maintain stable levels in your system
3. Swallow Whole: Take the tablet with a full glass of water
4. Do Not Crush or Break: To maintain effectiveness, avoid breaking the tablet unless advised
5. Monitor for Any Unusual Reactions: If you notice dizziness or headache, sit or lie down until it passes

Recommended Dosage and Frequency of ISOLAZINE

The dosage of ISOLAZINE Tablet can vary based on individual health needs, but general guidelines include:

• Usually taken two to three times daily at evenly spaced intervals
• Your healthcare provider may start you on a low dose and adjust it based on your response
• Do not change your dose without consulting your doctor

Timing and Food Considerations

• ISOLAZINE Tablet can be taken with or without food but taking it with meals may help reduce the chance of stomach discomfort
• Avoid taking the tablet just before activities requiring full alertness, as it may cause dizziness in some people
• Alcohol consumption is generally advised to be avoided or limited while using ISOLAZINE, as it can increase side effects

What if I forgot to take ISOLAZINE TABLET

• If you forget to take a dose, take it as soon as you remember
• If it is almost time for your next dose, skip the missed dose
• Do not take two doses at once to make up for the missed one
• Maintaining a regular schedule helps to manage missed doses

Overdose

• If you or anyone else accidentally took too much of ISOLAZINE TABLET, contact your doctor immediately. Symptoms of overdose include headache, confusion, fast heartbeat, generalized skin flushing, reduced cardiac output, low blood pressure, irregular heartbeat and shock

Side Effects Of ISOLAZINE TABLET

Commonly Reported Side Effects of ISOLAZINE Tablet:

• headache
• dizziness

When to Inform a Healthcare Professional?

• allergic reaction (signs include rash, hives, itching, red, swollen, blistered or peeling skin, wheezing, tightness in the chest or throat, difficulty breathing, swallowing or talking, unusual hoarseness or swelling of the mouth, face, lips, tongue or throat)
• lupus-like rash on the cheeks or other body parts, easy sunburn, muscle or joint pain, chest pain or breathlessness or swelling in the arms or legs
• low blood pressure (very bad dizziness or passing out)
• fever
• insufficient oxygen supply to heart muscle and angina (chest pain or pressure or a fast heartbeat)
• peripheral neuritis (numbness, prickling and tingling sensation)

How long do ISOLAZINE side effects typically last?

The duration of side effects after taking ISOLAZINE Tablet can vary depending on the individual and the specific reaction. The most common side effects such as dizziness, headache, or flushing usually appear soon after taking the medicine and may last from a few minutes to a few hours

• Mild side effects often improve as your body adjusts during the first few days of treatment
• If side effects persist beyond a week or become bothersome, it is important to consult your healthcare provider
• Serious or unusual reactions require prompt medical advice

How To Manage Side Effects

Warning & Precautions

Other Warnings for ISOLAZINE TABLET

Before taking ISOLAZINE TABLET, inform your doctor if you:

• have too much sweating, fluid loss, vomiting or diarrhea

Drug - Drug interaction

Common Interactions Include:

1. Other Blood Pressure Medications

• Combining ISOLAZINE with other medicines that lower blood pressure (like beta-blockers, ACE inhibitors, or calcium channel blockers) may increase the chance of low blood pressure, dizziness, or fainting
• Always inform your doctor about all blood pressure medications you are using

2. Nitrates and Nitric Oxide Donors

• Using ISOLAZINE with other nitrate-containing drugs or nitric oxide donors can lead to excessive blood vessel dilation and sudden drops in blood pressure
• Avoid combining ISOLAZINE with medications such as nitroglycerin or recreational drugs like sildenafil unless directed by a healthcare professional

3. Diuretics (Water Pills)

• Diuretics can alter electrolyte levels and blood pressure. When combined with ISOLAZINE, close monitoring by your healthcare provider is important

4. Medications Affecting Heart Rhythm

• Some drugs can influence heart rate or rhythm. Combining these with ISOLAZINE requires medical supervision to avoid unwanted effects

5. Other Vasodilators or Muscle Relaxants

• Combining with other vasodilators or muscle relaxants may amplify effects like dizziness or headache

Synopsis

Drug	:	Hydralazine, Isosorbide dinitrate
Pharmacological Category	:	Vasodilators
Therapeutic Indication	:	As adjunct to standard management in heart failure
Dosage Forms	:	Tablet

More Information

Things your doctor may consider before prescribing ISOLAZINE Tablet

Before prescribing ISOLAZINE Tablet, your healthcare provider will evaluate several important factors to ensure it is a suitable option for you:

1. Your Overall Heart and Circulatory Health

Doctors assess your heart function and blood vessel condition to understand how ISOLAZINE might support your circulation.

2. Current Medications and Potential Interactions

Your doctor reviews all medications and supplements you are taking to avoid harmful interactions.

3. Kidney and Liver Function

Since the body processes medicines through these organs, your doctor may check their function to determine appropriate dosing and safety.

4. Blood Pressure Levels

ISOLAZINE affects blood pressure, so your current readings and history help guide its use

5. History of Allergies or Sensitivities

Any known allergies to the ingredients or similar medicines are considered

6. Pregnancy or Breastfeeding Status

Special considerations apply if you are pregnant, planning to become pregnant, or breastfeeding

7. Other Health Conditions

Conditions like headaches, dizziness, or low blood pressure may influence the decision to prescribe ISOLAZINE.

Myths vs Facts About ISOLAZINE Tablet:

Myth 1:

ISOLAZINE can be stopped suddenly without any problems.

Fact:

It is important to follow your doctor’s advice about stopping or changing your dose. Sudden changes may cause unwanted effects or affect how your heart functions.

Myth 2:

ISOLAZINE works immediately after the first dose.

Fact:

ISOLAZINE may take some time to show its full effects. Consistent use as prescribed is key to achieving benefits.

Myth 3:

ISOLAZINE can be taken with alcohol without any issues.

Fact:

Alcohol can increase side effects like dizziness or headache when taking ISOLAZINE, so it is best to avoid or limit alcohol consumption.

Myth 5:

Only people with severe conditions need ISOLAZINE.

Fact:

Your doctor may recommend ISOLAZINE based on your specific health needs, even early in managing certain circulatory conditions.

FAQs About ISOLAZINE TABLET

References

1. Barbara G. Wells, Joseph T. DiPiro, Terry L. Shwinghammer, Cecily V. DiPiro. Heart Failure. Pharmacotherapy Handbook. Ninth edition. Page- 75.

2. Anne L Taylor, Susan Ziesche, Clyde Yancy, Peter Carson, Ralph D'Agostino Jr, Keith Ferdinand, Malcolm Taylor, Kirkwood Adams, Michael Sabolinski, Manuel Worcel, Jay N Cohn; African-American Heart Failure Trial Investigators. Combination of isosorbide dinitrate and hydralazine in blacks with heart failure. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. November 2004. [Accessed on 4th July 2025] 

3. Arbor Pharmaceuticals. LLC. U.S. Food & Drug Administration. [Revised in April 2015] [Accessed on 4th July 2025] 

4. Memorial Sloan Kettering Cancer Centre. Hydralazine + Isosorbide dinitrate. [Revised in September 2020] [Accessed on 4th July 2025] 

Author Details