Flavedon MR 35mg Tablet 10'S

Introduction About FLAVEDON MR 35MG TABLET

What is Flavedon MR 35mg?

Flavedon MR 35mg is a medication used to manage stable angina and improve heart function. It contains Trimetazidine which helps to maintain energy metabolism in heart cells.

Flavedon Tablet helps to reduce chest pain (angina), improves heart function in ischemic conditions and helps in maintaining energy metabolism.

Take Flavedon MR 35mg as prescribed by your doctor. It is usually taken twice daily with meals.

Flavedon MR 35mg is not recommended for use if you have Parkinson disease or severe kidney problems.

This medicine should be used cautiously in elderly patients (above 75 years), pregnant, and breast-feeding mothers. Do not drive or operate any machinery if you feel dizzy after taking Flavedon MR 35mg.

The common side effects associated with Flavedon MR 35mg are dizziness, nausea, stomach pain. Consult your doctor if the any of the above side effects persists for a longer duration.

Key Composition

The active ingredient in Flavedon MR 35mg Tablet:

• Trimetazidine Dihydrochloride (35mg) – used for the management of Angina pectoris (chest pain due to reduced blood flow to the heart)

Uses Of FLAVEDON MR 35MG TABLET

• Used to manage Angina and improve heart health

Benefits of FLAVEDON MR 35MG TABLET

1. Reduce chest pain (Angina):

• Flavedon MR 35mg helps in reducing the frequency and severity of angina attacks
• It does this by optimizing heart cell metabolism, ensuring better oxygen utilization without increasing heart rate or blood pressure

2. Improves heart function in ischemic conditions:

• In conditions like Ischemic heart disease (IHD), where blood supply to the heart is reduced, Flavedon MR helps to protect heart muscles from damage
• It enhances cellular energy production, reducing further heart complications

3. Helps in maintaining energy metabolism:

• Flavedon MR works at the mitochondrial level to maintain normal energy production, especially in stressed heart and muscle tissues
• This helps in reducing fatigue, muscle weakness, and improving exercise tolerance in patients with heart conditions

How FLAVEDON MR 35MG TABLET Works

1. Shifts energy production from fatty acid oxidation to glucose oxidation:

• Trimetazidine selectively inhibits an enzyme called 3-ketoacyl-CoA thiolase (3-KAT) in fatty acid metabolism
• This reduces fatty acid oxidation and enhances glucose oxidation, which is more oxygen-efficient and beneficial for ischemic tissues

2. Maintains ATP (Energy) levels in heart cells:

• By optimizing glucose oxidation, Flavedon MR helps heart cells produce more ATP, ensuring better cell function under ischemic stress

3. Reduces calcium overload & cell decay

• Ischemia can cause calcium accumulation in heart cells, leading to mitochondrial damage and cell decay
• Flavedon MR stabilizes calcium balance, reducing oxidative stress and cell injury

How to use FLAVEDON MR 35MG TABLET

Flavedon MR is a prescription medicine which needs to be taken under medical supervision. Always consult your doctor or pharmacist if you have any questions or concerns about taking this medication.

Recommended dosage for Flavedon MR:

• Dosage: 35 mg twice daily (morning and evening) with meals

Can I take Flavedon MR on an empty stomach?

• Flavedon MR should be taken with food to enhance absorption and reduce stomach discomfort

Method of administration for Flavedon MR:

• Take Flavedon MR 35mg as prescribed by your doctor
• Swallow the medicine with a glass of water. Do not crush or chew the medicine
• Your doctor will decide the correct dose and duration for you depending upon your age, body weight, and disease condition

What if I forgot to take FLAVEDON MR 35MG TABLET

Missed a Dose? Here’s what to do:

• Take it as soon as you remember if it is not too close to the next dose
• Do not double dose to make up for a missed one
• Skip the missed dose and continue with your regular dosing schedule
• Try to take it at the same time every day to maintain stable levels in your body

Overdose

Seek emergency medical attention if:

• you experience severe drowsiness, tremors, or loss of consciousness
• irregular heartbeat or breathing difficulty
• symptoms worsen over time instead of improving

Side Effects Of FLAVEDON MR 35MG TABLET

Common side effects include:

• dizziness
• nausea
• stomach pain

When to consult a doctor?

• signs of low blood pressure such as dizziness, light headiness or fainting, malaise (feeling of being unwell), and fall flushing
• signs of low platelet count (thrombocytopenia) such as frequent bruising, superficial bleeding, and prolonged bleeding from wounds
• low white blood cell count that increases vulnerability to infections

How To Manage Side Effects

Dizziness Or Drowsiness

• When getting up from a sitting or lying position, do it slowly to reduce sudden drop in blood pressure
• Drink plenty of water throughout the day to maintain blood circulation
• Eat regular meals and include proteins complex carbs to maintain energy levels

Nausea And Vomiting

• Avoid taking medicine on an empty stomach, as it may worsen nausea
• Avoid taking fried, oily, or heavily spiced foods which can aggravate nausea
• Do not lie down immediately after meals, as this may worsen nausea and acid reflux

Stomach Pain

• Wait at least 30 minutes after taking Flavedon MR before lying down to reduce acid reflux or irritation
• Avoid carbonated, acidic, or caffeinated drinks that can increase stomach acidity
• Ginger tea, chamomile tea, or peppermint tea can help soothe stomach discomfort

Warning & Precautions

Pregnancy

Consult your doctor

There are no well-controlled clinical trials in pregnant women. Animal studies do not show direct teratogenic effects, but due to insufficient human data, its safety remains unclear. Doctors generally avoid prescribing Flavedon MR 35mg to pregnant women unless the potential benefit outweighs the risk.

Breastfeeding

Consult your doctor

There are no human studies confirming whether Trimetazidine passes into breast milk. Given the lack of safety data, it is better to avoid Flavedon MR 35mg while breastfeeding to reduce the potential risks to the baby. If the management is essential, consider switching to formula feeding under medical supervision.

Driving and Using Machines

Use with Caution

Do not drive or operate any machinery if you feel dizzy after taking Flavedon MR 35mg.

Alcohol

Consult your doctor

Avoid consumption of alcohol while taking Flavedon MR 35mg because it may make you dizzier.

Kidney

Contraindicated

Flavedon MR 35mg is not recommended for use if you are having kidney-related problems. Consult your doctor before taking the medicine.

Allergy

Contraindicated

Do not take Flavedon MR 35mg if you are allergic to Trimetazidine or any other ingredient in this medicine. Consult your doctor before taking the medicine.

Heart Disease

Consult your doctor

Flavedon MR 35mg Tablet should be used with caution in patients with heart diseases. This medicine does not manage sudden angina attacks and should not be used as a management for unstable or heart attacks. Consult your doctor before taking the medicine.

Use In Pediatrics

Contraindicated

Is Flavedon MR Safe for children?

Flavedon MR is not approved for use in children and adolescents under 18 due to a lack of clinical safety data.

Why?

• The effects of trimetazidine on a developing heart and metabolism are not well studied
• Children with heart conditions should follow alternative managements prescribed by a pediatric cardiologist

Use In Geriatrics

Use with Caution

Flavedon MR 35mg should be used with caution in elderly patients (above 75 years).

Who should not take [GBNKEYWORD

Flavedon MR 35mg Tablet is not recommended for use if you:

• have Parkinson disease

Safety Advice

• Take Flavedon MR exactly as prescribed usually one tablet twice daily with food
• It is not recommended for patients with Parkinson’s disease, severe kidney disease patients and during pregnancy & breastfeeding
• Flavedon MR 35mg is not recommended for children and adolescents (under 18 years)
• Be cautious with blood pressure medications and avoid consumption of alcohol as it may cause dizziness
• Be cautious while driving and avoid using heavy machines
• Keep in a cool, dry place away from sunlight and Store out of reach of children

Diet and Lifestyle Advice

What to avoid while taking Flavedon MR?

Lifestyle habits to Avoid:

• Skipping doses or stopping suddenly
• Smoking & alcohol
• Strenuous physical activity
• Dehydration

Foods & drinks to avoid:

• Excessive caffeine (coffee, tea, energy drinks)
• High-sodium & processed foods
• Grapefruit & grapefruit juice
• High-sugar foods

Heart-healthy diet tips for patients taking Flavedon MR:

1. Eat more heart-friendly foods

• Leafy greens (spinach, kale, broccoli)
• Fatty fish (salmon, mackerel, sardines)
• Whole grains (brown rice, oats, quinoa, whole wheat bread)
• Nuts & seeds (almonds, walnuts, chia, flaxseeds)
• Fruits (berries, apples, citrus, pomegranates)
• Legumes & beans (lentils, chickpeas, kidney beans)

2. Stay hydrated & choose heart-smart drinks

• Water
• Herbal teas (green tea, hibiscus, ginger tea)
• Fresh homemade juices (without added sugar) – pomegranate, orange, or beetroot juice

3. Portion control & eating habits

• Eat smaller, balanced meals – overeating can strain the heart and cause blood sugar spikes
• Avoid late-night eating – late meals can increase heartburn and interfere with sleep
• Chew slowly & eat mindfully – helps digestion and reduces overeating

Best exercises for Heart patients on medication:

• Walking: Start with 15-20 minutes/day, gradually increasing to 30-45 minutes most days of the week
• Cycling: 20-30 minutes, 3-5 times per week at a moderate pace
• Swimming: 20-40 minutes, 3-4 times per week at a relaxed pace
• Stretching: 15-30 minutes, 3-4 times per week
• Light strength training: 2-3 sessions per week, using light weights (1-5 kg) or resistance bands

Stress management for Angina patients:

1. Practice deep breathing & relaxation techniques

• Simple deep breathing exercise
• Inhale deeply through the nose for 4 seconds
• Hold the breath for 4 seconds
• Exhale slowly through mouth for 6-8 seconds
• Repeat 5-10 times whenever you feel stressed

2. Get enough quality sleep:

• Stick to a consistent sleep schedule
• Avoid screens (phones, TV) 30-60 min before bed
• Try a calming bedtime routine like reading, herbal tea, or meditation

Drug - Drug interaction

Before taking Flavedon MR 35mg Tablet, inform your doctor if you are taking any other medicines, including medicines obtained without the prescription:

1. Beta-blockers (e.g., Metoprolol, Atenolol, Propranolol)

• Potential Interaction: Combining Flavedon MR with beta-blockers may cause excessive fatigue, dizziness, or low heart rate
• May increase the risk of low blood pressure

2. Calcium channel blockers (e.g., Amlodipine, Diltiazem, Verapamil)

• Potential Interaction: It can cause excessive vasodilation leading to dizziness, headaches, or swelling in the legs
• It may also enhance the anti-anginal effects, which is beneficial but requires monitoring

3. Antiarrhythmic drugs (e.g., Amiodarone, Digoxin, Quinidine)

• Potential Interaction: Flavedon MR may affect heart conduction, possibly increasing the risk of irregular heartbeat
• Amiodarone + Flavedon MR can cause an additive effect on heart rate control, leading to bradycardia

4. Dopamine agonists (e.g., Levodopa, Pramipexole, Ropinirole)

• Potential Interaction: Flavedon MR may worsen Parkinsonism symptoms (tremors, rigidity, movement disorders)
• Long-term use of Flavedon MR has been linked to the development of drug-induced movement disorders

5. Strong CYP3A4 inhibitors (e.g., Ketoconazole, Ritonavir, Erythromycin, Clarithromycin)

• Potential Interaction: These drugs reduce Flavedon MR metabolism, increasing its concentration in the body
• Higher drug levels may lead to increased dizziness, nausea, or hypotension

Synopsis

More Information

Angina Pectoris:

What is Angina Pectoris?

Angina pectoris is chest pain or discomfort caused by reduced blood flow to the heart muscle. It is a symptom of coronary artery disease (CAD), where the arteries supplying blood to the heart become narrowed or blocked due to plaque buildup (atherosclerosis).

Causes of Angina: Angina occurs when the heart does not receive enough oxygen-rich blood to meet its demands. The most common causes include:

• Coronary artery disease (CAD)
• High blood pressure (hypertension)
• Anemia
• Heart valve disease
• Stress & anxiety
• Cold weather or large meals

Symptoms of Angina

• chest pain or discomfort (may spread to the arms, neck, jaw, shoulders, or back)
• shortness of breath
• fatigue or dizziness
• nausea or sweating
• pain triggered by physical exertion or stress and relieved by rest

Management of Angina

• Lifestyle changes – quit smoking, exercise regularly, manage stress, practice meditation, or deep breathing and maintain a healthy weight
• Medications for Angina: Nitrates beta-blockers, Calcium channel blockers, Antiplatelet drugs, Flavedon MR (trimetazidine)
• Medical procedures (for severe cases): Angioplasty & sent placement, Coronary artery bypass surgery (CABG)

2. Ischemic Heart Disease:

What is Ischemic Heart Disease (IHD)?

Ischemic Heart Disease (IHD), also known as Coronary Artery Disease (CAD), occurs when the heart’s blood supply is reduced due to the narrowing or blockage of coronary arteries. This is primarily caused by atherosclerosis, a condition where fatty deposits (plaque) build up inside the arteries.

Why is IHD serious?

• Reduced blood flow leads to angina (chest pain)
• Severe blockage can result in a heart attack (myocardial infarction)
• Long-term IHD can lead to heart failure or arrhythmias (irregular heartbeats)

Modifiable risk factors (Things you can control)

• High Blood Pressure  
• High Cholesterol
• Smoking
• Diabetes
• Obesity
• Physical inactivity
• Unhealthy diet
• Stress
• Excessive alcohol consumption

Non-Modifiable Risk Factors (Things you cannot control)

• Age: Risk increases after 45 years (men) and 55 years (women)
• Gender: Men are at higher risk, though postmenopausal women also face increased risk
• Family History
• Genetic Factors

Flavedon MR vs Alternative Medications:

When to expect results: How long does Flavedon MR take to work?

FAQs About FLAVEDON MR 35MG TABLET

Q: What is Flavedon MR 35mg used for?

A: Flavedon MR 35mg used is used in adult patients for the management of angina pectoris (chest pain caused by a heart disease) along with other medicines. It protects the heart cells from the effects of a reduced oxygen supply during an episode of angina.

Q: How does Flavedon MR 35mg work?

A: Flavedon MR 35mg Tablet works by optimizing metabolism of fatty acids and glucose, thereby allowing more blood flow and oxygen supply to the heart. It also reduces the thickening and scarring of heart tissue. This results in reducing chest pain due to blood vessel narrowing or blocking.  

Q: Can Flavedon MR 35mg be taken during pregnancy?

A: There is insufficient clinical data on the safety of Trimetazidine in pregnant women.

Q: Where to buy Flavedon MR 35mg Online?

A: You can purchase Flavedon MR 35mg tablets online in India through reputable pharmacy like Netmeds.

Q: Is it safe to consume alcohol while taking Flavedon MR 35mg?

A: It is not advisable to consume alcohol while taking Flavedon MR 35mg (Trimetazidine) due to potential interactions and health risks.

Q: Is Flavedon MR 35mg safe for long-term use?

A: It is safe for long-term use in most patients with chronic angina or ischemic conditions. Regular monitoring of kidney function and neurological symptoms is advised, especially in elderly patients. Consult your doctor for periodic assessments to ensure continued safety.

Q: Is Flavedon MR 35mg good for the heart?

A: Yes. Flavedon MR 35mg is good for the heart in adult patients suffering from angina pectoris (chest pain caused by a heart disease). It protects the heart cells from the effects of a reduced oxygen supply during an episode of angina.

Q: Can Flavedon MR 35mg lower blood pressure?

A: Flavedon MR 35mg can cause a fall in blood pressure on standing-up occasionally, thereby causing dizziness, light headiness or fainting, malaise (feeling of being unwell), dizziness, and fall flushing. Contact your doctor or a nearby hospital immediately.

Q: How long should I take Flavedon MR 35mg Tablet?

A: Take Flavedon MR 35mg Tablet as advised by your physician. Your doctor will decide the correct dose and duration for you depending upon your age, body weight, and disease condition.

Q: What are the common side effects of Flavedon MR 35mg Tablet?

A: The common side effects associated with Flavedon MR 35mg Tablet are dizziness, nausea, stomach pain. Consult your doctor if the condition persists for long or worsens.

Q: When should I stop taking Flavedon MR 35mg Tablet?

A: Stop taking Flavedon MR 35mg Tablet and consult your doctor immediately if you experience signs of low blood pressure (dizziness, light headiness or fainting, malaise, dizziness, and fall flushing), low platelet count (frequent bruising, superficial bleeding, and prolonged bleeding from wounds), and low white blood cell count that increases vulnerability to infections.

Q: Who should avoid taking Flavedon MR 35mg Tablet?

A: Flavedon MR 35mg Tablet is not recommended for use if you have Parkinson disease, kidney-related problems, or are allergic to trimetazidine.

Q: Is Flavedon MR 35mg Tablet safe for kids?

A: There is insufficient research on the safety and effectiveness of Flavedon MR 35mg in pediatric patients. It is primarily prescribed for adults with angina and ischemic heart disease.

References

1. KD. Tripathi. Corticosteroids. Essentials of Medical Pharmacology. Seventh edition. 2013. Page 553-554.

2. Yuri M. Pozdnyakov. Clinical Acceptability of Trimetazidine Modified Release 80 mg Once Daily Versus Trimetazidine Modified-Release 35 mg Twice Daily in Stable Angina Pectoris. National Library of Medicine. PubMed Central. June 2018. [Assessed on 14 February 2025] 

3. Kirti Gupta, Sneha Pandey, Newly Bagang, Kamalpreet Mehra, and Gaaminepreet Singh. Trimetazidine, an emerging paradigm in renal therapeutics: preclinical and clinical insights. National Library of Medicine. PubMed Central. November 2021. [Assessed on 14 February 2025]  

4. Agustin Ciapponi, Rudolf Pizarro, and Jeff Harrison. Trimetazidine for stable angina. National Library of Medicine. PubMed Central. March 2017. [Assessed on 14 February 2025]  

5. European Medicine Agency. Assessment Report for trimetazidine-containing medicinal products. [Revised in September 2012] [Assessed on 14 February 2025]  

6. Servier (Ireland) Industries Ltd. Health Product Regulatory Authority. [Revised in February 2021] [Assessed on 14 February 2025]  

7. VIANEX S.A. Health Product Regulatory Authority. [Revised in April 2016] [Assessed on 14 February 2025]  

Useful Diagnostic Tests

• Complete Blood Count (CBC)/ Hemogram
• Serum Electrolytes/ Electrolytes Profile
• Cardiac Risk Profile
• C Reactive Protein (CRP)
• Basic Heart Care
• Advance Heart Care
• Comprehensive Heart Care
• Lipid Profile Test/Cholesterol-Total, Serum
• Cardiac Risk Markers - Advanced
• Cardiac Profile - Advanced

Author Details

Written By Dr. Janet.C - Pharm.D

Reviewed For Accuracy By Dr. Thamada Manikanta Praveen - MBBS, MD (General Medicine)

Last updated on 17 Feb 2025 | 10:22 AM(IST)