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INTRODUCTION
RANCV 500 TABLET contains Ranolazine which belongs to the group of medicines called Antianginals. It is used to treat chronic angina.
Angina pectoris can be defined as a sudden, sharp and severe chest pain that originates from the apex of the heart and radiates to the left shoulder. It can be characterized by the presence of severe and crushing pain along with a feeling of pressure and suffocation, especially behind the breastbone.
RANCV 500 TABLET is not recommended for use in patients with severe kidney disease, moderate to severe liver disease. Contact your doctor before taking.
RANCV 500 TABLET should be used with caution in patients with mild to moderate kidney disease, mild liver disease and moderate to severe heart failure, abnormal ECG changes like like QT prolongation or long QT syndrome. Contact your doctor before taking.
RANCV 500 TABLET is generally not recommended for use in pregnant women unless considered clearly necessary. Contact your doctor before taking. RANCV 500 TABLET is not recommended for use in breastfeeding women as it is not known whether it may pass through the breast milk. Contact your doctor before taking it.
RANCV 500 TABLET is not recommended for use in children and adolescents under 18 years of age. Contact your doctor before taking.
RANCV 500 TABLET should be used with caution in elderly patients aged 65 years or above. Contact your doctor before taking.
Avoid drinking grapefruit juice as it may lead to unwanted effects. The most common side effects of taking RANCV 500 TABLET are nausea, vomiting, constipation, dizziness headache and weakness. Contact your doctor if any of the above side effects worsen.
USES OF RANCV 500 TABLET
- Used to treat chronic angina
HOW RANCV 500 TABLET WORKS
RANCV 500 TABLET works by inhibiting the entry of sodium and potassium into the heart cells, thereby preventing the calcium influx causing vasodilation and reduces ventricular tension, myocardial oxygen demand. Thus, relieving angina symptoms.
DIRECTIONS FOR USE
Take RANCV 500 TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your physician will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF RANCV 500 TABLET
COMMON
- nausea, vomiting
- constipation
- dizziness
- headache
- weakness
UNCOMMON
- altered sensation
- anxiety
- difficulty sleeping
- confusion
- hallucination
- blurred vision, visual disturbance
- changes in sensation (touch or taste)
- tremors
- feeling tired or sluggish
- sleepiness or drowsiness
- fainting
- dark urine, blood in urine, difficulty in urination
- difficulty in breathing
- cough, nose bleed
- excessive sweating, itching
- feeling swollen or bloated
- hot flushes, low blood pressure
- increase in creatinine
- increase in urea in blood
- increase in blood platelets count and white blood cells
- changes in ECG heart tracing
- joint swelling, pain in extremity
- loss of appetite and/or weight loss
- muscle cramp or weakness
- ringing in the ears or spinning sensation
- stomach pain, discomfort, indigestion
- dry mouth
RARE
- paraesthesia in mouth and lips
- rashes
- problems with coordination
- decrease in blood pressure upon standing
- disorientation
- coldness in hands and legs
- hives, allergic skin reaction
- impotence
- inability to walk due to imbalance
- inflammation of pancreas or intestine
- loss of memory
- throat tightness
- low sodium levels in the blood (hyponatremia) causing tiredness, confusion, muscle twitching, cramps
Stop taking RANCV 500 TABLET and contact your doctor immediately if you experience any of the following side effects:
- symptoms of angioedema or allergic reaction such as hives, swelling of the face, tongue or throat causing difficulty in breathing or swallowing
HOW TO MANAGE SIDE EFFECTS
Headache:
Rest and relax. Drink plenty of fluids such as water and electrolytes. Apply a pain-relieving balm on the head if necessary. Do not consume alcohol. Contact your doctor if the symptom did not improve.
Nausea and Vomiting:
Take the medicine, with or just after a meal. Stick to simple meals. Avoid eating oily or spicy food.
Constipation:
Eat plenty of fibre rich foods such as fresh fruits, vegetables and cereals. Drink plenty of water and exercise more regularly.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operate any machines while you are feeling dizzy. Do not consume alcohol, as it can aggravate your dizziness. Contact your doctor if the symptom did not improve.
WARNING & PRECAUTIONS
PREGNANCY
RANCV 500 TABLET is not recommended for use in pregnant women unless considered clearly necessary. Contact your doctor before taking RANCV 500 TABLET.
BREASTFEEDING
RANCV 500 TABLET is not recommended for use in breastfeeding women as it is not known whether it may pass through the breast milk. Contact your doctor before taking RANCV 500 TABLET.
DRIVING AND USING MACHINES
Do not drive or operate any machines if you feel dizziness, lightheadedness, faintness, blurred vision, confusion, hallucination, double vision and coordination problems after taking RANCV 500 TABLET.
KIDNEY
RANCV 500 TABLET is not recommended for use in patients with severe kidney disease and should be used with caution in mild to moderate kidney disease. Contact your doctor before taking RANCV 500 TABLET.
LIVER
RANCV 500 TABLET is not recommended for use in patients with moderate to severe liver disease and should be used with caution in mild liver disease. Contact your doctor before taking RANCV 500 TABLET.
ALLERGY
Do not take RANCV 500 TABLET if you are allergic to Ranolazine or to lactose or other sugars or to any other ingredients of this medicine.
HEART DISEASE
RANCV 500 TABLET should be used with caution in patients with moderate to severe heart failure, abnormal ECG changes like QT prolongation or long QT syndrome. Contact your doctor before taking RANCV 500 TABLET.
OTHERS
RANCV 500 TABLET is not recommended for use if you have:
- rare hereditary problems like galactose intolerance, the Lapp lactase deficiency and glucose-galactose malabsorption
Use in pediatrics:
RANCV 500 TABLET is not recommended for use in children and adolescents under 18 years of age. Contact your doctor before taking RANCV 500 TABLET.
Use in geriatrics:
RANCV 500 TABLET should be used with caution in elderly patients aged 65 years or above. Contact your doctor before taking RANCV 500 TABLET.
INTERACTIONS
A. Drug - Drug interactions:
Before taking RANCV 500 TABLET, inform your doctor if you are taking any of the following medicine:
- medicines used to treat bacterial infections (Ex. clarithromycin, telithromycin, erythromycin)
- medicines used to treat fungal infections (Ex. itraconazole, ketoconazole, fluconazole, voriconazole, posaconazole)
- medicines used to treat HIV infection (atazanavir, nelfinavir, ritonavir, indinavir, saquinavir tenofovir disoproxil and efavirenz)
- nefazodone (used for depression)
- medicines used to treat heart problems or heart rhythm disorders (Ex. quinidine, dofetilide, sotalol, metoprolol, diltiazem, verapamil, procainamide, disopyramide)
- medicine used to prevent rejection of a transplanted organ (cyclosporine, tacrolimus, sirolimus, everolimus)
- medicines used to treat epilepsy (Ex. phenytoin, carbamazepine or phenobarbital)
- medicines used to treat tuberculosis (Ex. rifampicin, rifampin, rifabutin, rifapentine)
- St. John's Wort (herbal medicine used for depression)
- digoxin (medicines used for heart failure)
- medicines used to treat allergies (Ex. terfenadine, astemizole, mizolastine)
- medicines to treat psychoses (Ex. bupropion, imipramine, doxepin, amitriptyline, paroxetine)
- medicines used to treat cancer (Ex. cyclophosphamide)
- medicines to treat elevated cholesterol levels in the blood (Ex. simvastatin, lovastatin, atorvastatin)
- cimetidine (medicine used for stomach ulcers)
- metformin (medicines used to treat diabetes mellitus)
B. Drug - Food interaction:
Avoid drinking grapefruit juice with this medicine as it may lead to unwanted effects. Consult your doctor for advice.
Overdosage:
If you or anyone else accidentally takes too much of RANCV 500 TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are dizziness, nausea and vomiting.
SYNOPSIS
| Drug | : | Ranolzine |
| Pharmacological Category | : | Antianginals |
| Therapeutic Indication | : | Chronic angina |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep RANCV 500 TABLET out of the sight and reach of children
- Store RANCV 500 TABLET below 25°C
FAQs ABOUT RANCV 500 TABLET
Who should avoid taking RANCV 500 TABLET?
RANCV 500 TABLET is not recommended for use in patients with allergic history to Ranolazine or lactose or rare hereditary problems like galactose intolerance, the Lapp lactase deficiency and glucose-galactose malabsorption, severe kidney disease, moderate to severe liver disease. Contact your doctor before taking RANCV 500 TABLET.
How RANCV 500 TABLET works?
RANCV 500 TABLET works by inhibiting the entry of sodium and potassium into the heart cells, thereby preventing the calcium influx causing vasodilation and reduces ventricular tension, myocardial oxygen demand. Thus, relieving angina symptoms.
What are the side effects of taking RANCV 500 TABLET?
The most common side effects of taking RANCV 500 TABLET are nausea, vomiting, constipation, dizziness headache and feeling weak. Contact your doctor if any of the symptoms worsen.
Does RANCV 500 TABLET cause hyponatremia?
Yes. RANCV 500 TABLET may cause hyponatremia. Contact your doctor if you experience any unusual symptoms like tiredness, confusion, muscle twitching, cramps.
Can I take grapefruit juice while taking RANCV 500 TABLET?
No. Avoid drinking grapefruit juice with this medicine as it may lead to unwanted effects. Contact your doctor before taking.
REFERENCES
1. KD. Tripathi. Cardiovascular drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page -554.
2. Robert J. Kizior, Keith J. Hodgson. Ranolazine. Saunders Nursing Drug Handbook 2021. 28th edition. 2021. page-1000.
3. Menarini. Pharmaceuticals Ltd. Electronic Medicines Compendium (EMC). [Revised on December 2021] [Accessed on 4th June 2022] https://www.medicines.org.uk/emc/files/pil.6442.pdf
4. Gilead Sciences, Inc. U.S. Food & Drug Administration. [Revised on January 2016] [Accessed on 4th June 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021526s029lbl.pdf
5. Gilead Sciences, Inc. Ranolazine. [Revised on April 2010] [Accessed on 4th June 2022] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8d442b8c-97a8-40a9-8603-f9cd0542cedc
6. Ranolazine. Torrent Pharmaceuticals ltd. [Revised on July 2019] [Accessed on 4th June 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/1344.pdf
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