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INTRODUCTION
LINAPRIDE M 500 TABLET is a combination of Metformin and Linagliptin which belongs to the group of medicines called Antidiabetic agents. It is used to treat Type II diabetes mellitus among adult patients when diet, exercise and treatment with other conventional medicines does not result in adequate sugar control. It is used as an adjunct therapy along with proper diet and exercise to achieve better results.
Type II diabetes mellitus is a chronic disease characterized by abnormally high levels of glucose in the blood. It is caused either due to inadequate production of a hormone called insulin (produced by pancreas to metabolize glucose) in the body or due to inadequate sensitivity of body cells to the actions of insulin.
Take LINAPRIDE M 500 TABLET preferably with meals. During therapy with LINAPRIDE M 500 TABLET, your doctor might regularly monitor your blood sugar levels and kidney functions to avoid the risk of unwanted side effects.
Before taking LINAPRIDE M 500 TABLET inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have problems in blood circulation or are severely dehydrated due to excessive vomiting or diarrhea recently.
LINAPRIDE M 500 TABLET is not recommended for use in patients with severe uncontrollable diabetes. It is also not suitable for use in patients with alcoholism and in patients with severe systemic infections.
Consult your doctor before taking LINAPRIDE M 500 TABLET if you are pregnant or breastfeeding. The most common side effects of taking LINAPRIDE M 500 TABLET are nausea, diarrhea, stomach pain, constipation, loss of appetite and metallic taste. Consult your doctor if any of these side effects trouble you.
USES OF LINAPRIDE M 500 TABLET
- Treats Type II diabetes mellitus in adults
HOW LINAPRIDE M 500 TABLET WORKS
LINAPRIDE M 500 TABLET is an antidiabetic medicine. It contains two medicines namely metformin and Linagliptin. Metformin makes the body more sensitive to insulin (a hormone involved in glucose metabolism). This helps our body cells to utilize more amount of the circulating blood glucose. Additionally, it can stop glucose production by the liver and reduces its absoprtion in the body.
Linagliptin controls blood sugar levels by blocking the actions of an enzyme called dipeptidyl peptidase (DPP)-4 that reduces insulin secretion in the body. Collectively, LINAPRIDE M 500 TABLET controls blood sugar levels and improve glycemic control in patients with type II diabetes.
DIRECTIONS FOR USE
Take LINAPRIDE M 500 TABLET preferably after meals or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. Do not stop taking LINAPRIDE M 500 TABLET unless your doctor advice you to stop.
SIDE EFFECTS OF LINAPRIDE M 500 TABLET
COMMON
- nausea
- diarrhea, stomach pain
- changes in taste (metallic taste)
- increased lipase levels in blood
UNCOMMON
- inflamed nose or throat, cough
- constipation, loss of appetite
- vomiting
- increased amylase levels in blood
- skin itchiness
RARE
Stop taking LINAPRIDE M 500 TABLET and consult your doctor immediately if you experience any of the following side effects:
- Signs of severe decrease in blood sugar levels (such as increased sweating, feeling shaky, anxiety, blurred vision, tingling sensation in the lips, pale skin, mood changes or confusion)
- serious allergic reaction (such as hives, swelling of the face, lips, tongue or throat causing difficulty in breathing or swallowing)
- severe skin rashes with redness and blistering of the skin
- signs of lactic acidosis (cold hands or feet, dizziness or light-headedness, slow or irregular heartbeat, weakness or tiredness, unusual muscle pain, trouble breathing, sleepiness or drowsiness, stomach pains, nausea or vomiting)
- signs of liver damage (such as tiredness, loss of appetite, weight loss, with or without yellowing of the skin or whites of the eyes)
- inflammation of the pancreas causing severe persistent stomach pain which radiates towards your back along with nausea and vomiting
HOW TO MANAGE SIDE EFFECTS
Nausea and vomiting:
Take LINAPRIDE M 500 TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if your condition worsens.
Constipation:
Taking LINAPRIDE M 500 TABLET with meals may reduce the chances of constipation. However, if you experience constipation, eat plenty of fiber rich foods such as fresh fruits, vegetables and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.
WARNING & PRECAUTIONS
PREGNANCY
It is not known whether the use of LINAPRIDE M 500 TABLET could affect the unborn baby. Therefore, it should not be used during pregnancy unless recommended by your doctor.
BREASTFEEDING
It is not known whether the use of LINAPRIDE M 500 TABLET could pass through the breast milk. Therefore, it should be used in breastfeeding only if considered necessary by the physician.
DRIVING AND USING MACHINES
LINAPRIDE M 500 TABLET has no influence on your ability to drive or handle heavy tools or machines. However, do not drive or operate any machines if your ability is affected by LINAPRIDE M 500 TABLET.
ALCOHOL
Avoid consumption of alcohol while taking LINAPRIDE M 500 TABLET as it may increase the risk of unwanted side effects.
KIDNEY
LINAPRIDE M 500 TABLET is not recommended for use in patients with severely reduced kidney functions. Therefore, consult your doctor before taking it.
LIVER
LINAPRIDE M 500 TABLET is not recommended for use in patients with severe liver problems. It should be used with caution in patients with gall stones. Therefore, consult your doctor before taking it.
ALLERGY
Do not take LINAPRIDE M 500 TABLET if you are allergic to Metformin or Linagliptin.
LUNGS
LINAPRIDE M 500 TABLET is not recommended for use in patients with severe infections of the lungs or respiratory tract. Therefore, consult your doctor before taking it.
HEART DISEASE
LINAPRIDE M 500 TABLET is not recommended for use in patients with severe heart problems (such as acute heart failure, recent heart attack, arrythmia, prolonged QT interval). Therefore, consult your doctor before taking it
OTHERS
LINAPRIDE M 500 TABLET is not recommended for use if you:
- have severe, uncontrollable diabetes
- have diabetic coma or precoma
- have nausea, vomiting, diarrhea or rapid weight loss
- have lactic acidosis or ketoacidosis (buildup of lactic acid or ketones in the body)
- are dehydrated (due to drinking less fluid or had severe vomiting or diarrhea during the recent days)
- have any severe systemic infections
- have shock or problems in blood circulation
- are an alcoholic
Before taking LINAPRIDE M 500 TABLET, inform your doctor if you:
- have type I diabetes mellitus (insulin-dependent diabetes)
- have a need for any surgery
Use in Pediatrics:
LINAPRIDE M 500 TABLET is not generally recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor before taking it.
Use in Geriatrics:
LINAPRIDE M 500 TABLET should be used with caution among the elderly patients (aged 65 years or above). Therefore, consult your doctor before taking it.
INTERACTIONS
A. Drug - Drug interactions:
Before taking LINAPRIDE M 500 TABLET, inform your doctor if you are taking any of the following medicines such as:
- other medicines used to treat diabetes (Ex. glimepiride, glyburide, gliclazide, rosiglitazone, pioglitazone)
- medicines used to treat asthma (Ex. salbutamol or terbutaline)
- corticosteroids (used to treat pain and inflammation) Ex. hydrocortisone, prednisolone
- diuretics (used to reduce edema and to treat hypertension) Ex. furosemide, hydrochlorothiazide
- medicines used to treat pain and inflammation (such as ibuprofen and celecoxib)
- medicines used to treat high blood pressure (such as atenolol, propranolol, captopril, enalapril, ramipril, lisinopril, losartan, valsartan, olmesartan, telmisartan)
- cimetidine (a medicine used to treat stomach ulcer)
- dolutegravir (a medicine used to treat HIV infection)
- verapamil (a medicine used to treat heart problems)
- rifampicin (a medicine used to treat tuberculosis)
- ranolazine (a medicine used to treat chest pain)
- trimethoprim (a medicine used to treat bacterial infection)
- medicines used to treat cancer (Ex. vandetanib, crizotinib and Olaparib)
- isavuconazole (a medicine used to treat fungal infections)
Overdosage:
If you or anyone else accidentally took more LINAPRIDE M 500 TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are feeling cold or uncomfortable, severe nausea or vomiting, stomach pain, severe tiredness, difficulty in breathing, unexplained weight loss, muscular cramps and fast breathing.
SYNOPSIS
| Drug | : | Metformin, Linagliptin |
| Pharmacological Category | : | Biguanides, DPP-4 Inhibitors |
| Therapeutic Indication | : | Type II Diabetes mellitus |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep LINAPRIDE M 500 TABLET out of the sight and reach of children
- Store LINAPRIDE M 500 TABLET below 30°C
FAQs ABOUT LINAPRIDE M 500 TABLET
What is LINAPRIDE M 500 TABLET used for?
LINAPRIDE M 500 TABLET is an antidiabetic medicine used as an adjunct to diet and exercise to control blood sugar levels in patients with Type II diabetes mellitus.
How and when to take LINAPRIDE M 500 TABLET?
Take LINAPRIDE M 500 TABLET preferably after meals or as advised by your physician. Swallow the medicine with a glass of water. Do not cursh or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
How long should I take LINAPRIDE M 500 TABLET?
You need to take LINAPRIDE M 500 TABLET as long as your doctor prescribes you the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition
What is the best time to take LINAPRIDE M 500 TABLET?
LINAPRIDE M 500 TABLET must be taken with meals to avoid gastrointestinal side effects.
What to do if I forgot to take a dose of LINAPRIDE M 500 TABLET?
If you forgot to take a dose of LINAPRIDE M 500 TABLET, take it as soon as you remember. However, if it is time for the next dose of LINAPRIDE M 500 TABLET, skip the missed dose and take the next one regularly. Do not take a double dose of LINAPRIDE M 500 TABLET to compensate the missed ones.
What are the most common side effects of taking LINAPRIDE M 500 TABLET?
The most common side effects of taking LINAPRIDE M 500 TABLET are nausea, diarrhea, stomach pain, constipation, loss of appetite and metallic taste. Consult your doctor if any of these side effects trouble you.
Can I stop taking LINAPRIDE M 500 TABLET without consulting your doctor?
No. You should not stop taking LINAPRIDE M 500 TABLET without consulting your doctor because it may lead to reversal of symptoms. If you feel better after using LINAPRIDE M 500 TABLET, consult your doctor for advice.
Will taking a higher dose of LINAPRIDE M 500 TABLET be more effective?
No, taking a higher dose of LINAPRIDE M 500 TABLET will not be effective rather it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.
What precautions do I need to follow while taking LINAPRIDE M 500 TABLET?
Before taking LINAPRIDE M 500 TABLET inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have severe systemic infections or are severely dehydrated due to excessive vomiting or diarrhea recently. Along with the therapy, follow the diet and lifestyle changes advised by your doctor to achieve better results. Consult your doctor before taking LINAPRIDE M 500 TABLET if you are pregnant or breastfeeding.
Can I take medication for high blood pressure along with LINAPRIDE M 500 TABLET?
It is not advisable to take medicines to control blood pressure while taking LINAPRIDE M 500 TABLET without consulting your doctor. Therefore, consult your doctor before taking any antihypertensive medications along with LINAPRIDE M 500 TABLET as they have known interactions with LINAPRIDE M 500 TABLET.
What should I do if I experience low blood sugar after taking LINAPRIDE M 500 TABLET?
Low blood sugar is a common side effect of taking LINAPRIDE M 500 TABLET. If you experience any signs of low blood sugar levels (such as increased hunger, sweating, shakiness, weakness or an irregular heartbeat), consume a sugary snack or sugar drink immediately. Consult your doctor if the symptom did not improve.
Can LINAPRIDE M 500 TABLET be taken with insulin?
Co-administration of LINAPRIDE M 500 TABLET with insulin is considered risky as they are increased chances of hypoglycemia (decreased blood sugar levels). Therefore, consult your doctor before taking it.
Can LINAPRIDE M 500 TABLET be used in pregnant women?
LINAPRIDE M 500 TABLET should not be used in pregnant women unless recommended by the physician. Therefore, consult your doctor for advice.
How to take LINAPRIDE M 500 TABLET?
You must take LINAPRIDE M 500 TABLET as advised by your physician. Try to take this medicine preferably after meals and swallow it with a glass of water. Do not crush or chew the medicine.
How much LINAPRIDE M 500 TABLET should I take?
LINAPRIDE M 500 TABLET should be used only under medical supervision. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body condition and severity of the disease condition.
Can LINAPRIDE M 500 TABLET cause constipation?
Yes. Constipation is a common side effect of using LINAPRIDE M 500 TABLET. Eat plenty of fiber rich foods such as fresh fruits, vegetables, cereals as well as drink plenty of water and exercise more regularly while taking this medicine. Contact your doctor if this side effect bothers you.
REFERENCES
1. KD. Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 275.
2. Thomas Haak. Combination of Linagliptin and Metformin for the Treatment of Patients with Type 2 Diabetes. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. January 2015. [Accessed on 13th December 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284079/
3. Dragenopharm Apotheker Püschl GmbH. Electronic Medicines Compendium (EMC). [Revised in February 2021] [Accessed on 13th December 2022] https://www.medicines.org.uk/emc/files/pil.7697.pdf
4. Rx Farma Limited. Electronic Medicines Compendium (EMC). [Revised in September 2019] [Accessed on 13th December 2022] https://www.medicines.org.uk/emc/files/pil.11951.pdf
5. Central Drugs Standard Control Organization. Linagliptin 2.5mg/2.5mg/2.5mg + Metformin 500mg/850mg/1000mg Film coated Tablet. July 2013. [Accessed on 13th December 2022] https://cdsco.gov.in/opencms/resources/UploadCDSCOWeb/2018/UploadApprovalNewDrugs/dciApprovedfdc.pdf
USEFUL DIAGNOSTIC TESTS
- Glucose - Fasting Blood
- Glucose - Postprandial Blood
- Glycosylated Hemoglobin
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