CLOPILET A 75 Capsule 15's

Introduction About CLOPILET A 75 CAPSULE

CLOPILET A 75 Capsule contains a dual combination of Aspirin and Clopidogrel, two well-known antiplatelet agents used to support heart (heart attack, cardiovascular death or refractory ischemia and blood vessel health (stroke).

Follow a healthy low-fat diet as advised by doctor to achieve better results. Avoid drinking alcohol as it could increase the risk of bleeding in the gastrointestinal tract.

Do not stop taking CLOPILET A 75 CAPSULE abruptly without consulting your doctor because premature discontinuation of this medicine may increase the risk of cardiovascular events. It is not recommended for use in patients having severe liver, kidney or lung disease.

This medicine is generally not recommended for use in pregnant or breastfeeding women and in children (below 18 years). Consult your doctor for an alternative therapy.

Common side effects of taking CLOPILET A 75 CAPSULE are diarrhea, nausea, stomach pain and indigestion. Contact your doctor if any of the symptoms worsen.

Uses Of CLOPILET A 75 CAPSULE

Manages

• atherothrombotic events such as myocardial infarction, stroke, cardiovascular death or refractory ischemia

How CLOPILET A 75 CAPSULE Works

• Clopidogrel is a prodrug: It requires activation in the liver by enzymes, mainly CYP2C19, to become effective.
• It irreversibly inhibits the P2Y12 receptor: This receptor is found on the surface of platelets (blood cells involved in clotting).
• Blocking the receptor: stops ADP (adenosine diphosphate) from binding to the P2Y12 receptor, which stops the activation of platelets.
• Stops platelet aggregation: As a result, platelets do not stick together easily, reducing blood clot formation.
• Long-lasting effect: Because it irreversibly binds, the inhibition lasts for the lifespan of the platelet, about 7-10 days.
• Supports blood flow: This mechanism helps lower the risk of clots blocking blood vessels, supporting cardiovascular health.

How to use CLOPILET A 75 CAPSULE

Dosage Guidelines

• Typical dose: 75 mg once daily, or as prescribed by your doctor.
• Sometimes a one-time higher loading dose (300 to 600 mg) may be given initially.
• Dose and duration depend on your condition and doctor's advice.

How to Take this Capsule Safely

• Swallow the capsule whole with water.
• Take regularly at the same time each day.
• Preferably take after food to avoid stomach upset.
• Do not crush or chew the capsule.

CLOPILET A 75 Daily Dose and Frequency

• Usually once daily dosing.
• Maintain evenly spaced intervals between doses.
• Do not change dose or discontinue without consulting your doctor.

CLOPILET A 75 Capsule With or Without Food

• Can be taken with or without food.
• Taking with food may reduce stomach discomfort.

Precautions While Taking CLOPILET A 75 Capsule

• Inform your doctor of allergies, liver or kidney issues, bleeding disorders, pregnancy or breastfeeding.
• Avoid alcohol to reduce bleeding risk.
• Be cautious during activities that may result in cuts or injuries.
• Inform physician before any surgery.

Follow-Up and Doctor’s Advice

• Regularly visit your healthcare provider for monitoring. 
• Do not stop medicine abruptly even if feeling well.
• Report any unusual symptoms like bleeding or allergic reactions immediately.

What if I forgot to take CLOPILET A 75 CAPSULE

• Take as soon as you remember if within 12 hours of scheduled time.
• If more than 12 hours, skip missed dose and take next dose as usual.
• Do not double doses.

Overdose

If you or anyone else take too much of CLOPILET A 75 CAPSULE, contact your doctor immediately or go to a hospital. Symptoms include increased bleeding, confusion, disorientation, coma, convulsions, vomiting, tinnitus (ringing in the ears), vertigo (spinning sensation), sweating, warm extremities with bounding pulses, increased respiratory rate.

Side Effects Of CLOPILET A 75 CAPSULE

Common

• diarrhea
• stomach pain
• indigestion or heartburn

When to consult a doctor?

• fever, signs of infection or extreme tiredness
• signs of Thrombotic Thrombocytopenic Purpura (such as jaundice, bruising under the skin that can appear as red pinpoints dots under the skin, confusion, fever, unexplained extreme tiredness and/or confusion)
• signs of allergic reactions (such as skin rashes, itching with blisters, swelling of the face, lips, mouth, throat or shock)
• unusual bleeding (such as bleeding in the brain, bruising under the skin, nasal bleeds, blood in urine, bleeding in the stomach or bowel leading to coughing up blood or black stools or bleeding in other parts of the body such as eyes, lungs or joints)

How To Manage Side Effects

Constipation

• Increase dietary fiber intake gradually through fruits, vegetables, whole grains, and legumes.
• Drink plenty of water (at least 8 glasses per day) to soften stools.
• Engage in regular physical activity like walking or stretching to stimulate bowel movements.
• Avoid delaying the urge to have a bowel movement.
• If needed, use mild over-the-counter laxatives temporarily, but consult your healthcare provider before use.
• Discuss with your doctor if constipation persists or is severe.

Headache

• Drink adequate water; dehydration can cause headaches.
• Rest in a quiet, dark room if triggered by stress or lights.
• Use over-the-counter pain relievers like paracetamol or ibuprofen as directed.
• Apply a cold or warm compress to the forehead or neck to relieve tension.
• Avoid headache triggers such as caffeine withdrawal, skipping meals, or stress.
• Practice relaxation techniques like deep breathing, meditation, or gentle exercise.
• Consult a healthcare professional if headaches are frequent, severe, or unresponsive to basic care.

Nausea And Vomiting

• Take medication with food or after meals to reduce stomach irritation.
• Sip clear fluids such as water, ginger tea, or electrolyte drinks slowly throughout the day to stay hydrated.
• Eat small, frequent meals instead of large heavy ones to ease digestion.
• Avoid strong smells, greasy, spicy, or fatty foods that can worsen nausea.
• Rest in a quiet and cool environment, and avoid sudden movements.
• Over-the-counter remedies like ginger supplements or vitamin B6 may help, but consult your doctor first.
• Seek medical advice if nausea is severe, persistent, or accompanied by vomiting.

Warning & Precautions

Pregnancy

Contraindicated

CLOPILET A 75 CAPSULE is not recommended for use during pregnancy.  Consult your doctor before taking it.

Breastfeeding

Contraindicated

It is not recommended for use in breastfeeding women. Consult your doctor before taking it.

Driving and Using Machines

Use with Caution

Do not drive or operate any heavy tools or machines if your ability is affected by CLOPILET A 75 CAPSULE.

Alcohol

Consult your doctor

Avoid consumption of alcohol while taking CLOPILET A 75 CAPSULE as it could increase the risk of gastrointestinal bleeding.

Kidney

Consult your doctor

It is not recommended for use in patients having severe kidney disease and should be used with caution in patients with kidney disease. Consult your doctor before taking CLOPILET A 75 CAPSULE.

Liver

Consult your doctor

It is not recommended for use in patients having severe liver disease and it should be used with caution in patients with liver disease. Consult your doctor before taking CLOPILET A 75 CAPSULE.

Allergy

Contraindicated

Do not take CLOPILET A 75 CAPSULE if you are allergic to Aspirin or Clopidogrel or any other non-steroidal anti-inflammatory drugs (Ex. ibuprofen, celecoxib, etoricoxib).

Lungs

Contraindicated

CLOPILET A 75 CAPSULE is not recommended for use in patients having respiratory conditions such as asthma, nasal discharge (runny nose) or polyps (a type of growth in the nose). Consult your doctor before taking it.

Use In Pediatrics

Contraindicated

It is not recommended for use in children and adolescents (under 18 years of age). Consult your doctor for advice.

Use In Geriatrics

Use with Caution

It should be used with caution in elderly patients (aged 65 years and above). because of increased risk of gastro-intestinal bleeding and perforation when used for prolonged duration (if prolonged therapy is essential, patients should be reviewed regularly). Consult your doctor before taking CLOPILET A 75 CAPSULE.

Other Warnings for CLOPILET A 75 CAPSULE

Before taking CLOPILET A 75 CAPSULE, inform your physician if you:

• have stomach ulcer or severe stomach pain
• had a recent serious injury
• are going to have any upcoming surgery (including dental procedures) or already had recently
• had a recent ischemic stroke (blot clot in the artery supplying the brain)
• have a history of asthma or other allergic diseases
• are alcoholic
• have G6PD deficiency (a genetic disorder causing destruction of red blood cells in response to certain stimuli)
• have active chickenpox or shingles infection

Who should not take CLOPILET A 75 CAPSULE

CLOPILET A 75 CAPSULE is not recommended for use if you:

• have coagulation disorders (Ex. hemophilia, thrombocytopenia)
• have bleeding in the brain (Ex. intracranial hemorrhage or cerebrovascular hemorrhage)
• have bleeding in the gastrointestinal tract
• have gout
• have menorrhagia (abnormally heavy or prolonged menstrual period)

Safety Advice

• CLOPILET A 75 Capsule increases the risk of bleeding. Carefully avoid injuries during activities like shaving, cutting nails, or using sharp tools.
• Immediately inform your doctor if you experience unusual bleeding, bruising, blood in urine or stools, or prolonged bleeding.
• Follow-up with your healthcare provider for regular check-ups and blood tests to monitor medication effects and adjust therapy if needed

Diet and Lifestyle Advice

• Heart-Healthy Diet:
  Focus on fresh fruits, vegetables, whole grains, and lean proteins to support cardiovascular health. Limit saturated fats, trans fats, and excessive salt.
• Stay Hydrated:
  Drink plenty of water daily to aid circulation and overall well-being.
• Limit Alcohol:
  Avoid or minimize alcohol intake to reduce the risk of stomach bleeding and side effects.
• Avoid Foods That Increase Bleeding Risk:
  Use caution with foods like garlic, ginger, and ginkgo biloba supplements, which may increase bleeding risk.
• Regular Physical Activity:
  Engage in moderate exercise such as walking, swimming, or yoga to improve vascular health and maintain a healthy weight, with your doctor's approval.
• Quit Smoking:
  Smoking damages blood vessels and increases clotting risk, counteracting the benefits of CLOPILET A 75 Capsule.
• Manage Stress:
  Practice relaxation techniques like deep breathing, meditation, or hobbies to reduce stress, which can impact heart health.
• Monitor for Signs of Bleeding:
  Be vigilant for unusual bruising, bleeding gums, or blood in urine or stools, and report promptly.
• Follow Medication Schedule: Take your medication consistently, alongside lifestyle changes, for best results

Drug - Drug interaction

1. Other Blood Thinners & Antiplatelets:
   • Combining with medicines like warfarin, heparin, aspirin, ticagrelor, or dipyridamole can increase bleeding risk. Close monitoring is required.
2. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs):
   • Drugs like ibuprofen, naproxen may raise risk of stomach ulcers and bleeding when used with CLOPILET A 75. Use cautiously.
3. Proton Pump Inhibitors (PPIs):
   • Omeprazole, esomeprazole may reduce clopidogrel activation, lowering its effectiveness. Alternatives may be preferred.
4. Selective Serotonin Reuptake Inhibitors (SSRIs) & Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs):
   • Antidepressants such as fluoxetine, duloxetine can increase bleeding risk when combined.
5. Enzyme Modifiers (CYP3A4 Inducers/Inhibitors):
   • Drugs like rifampin, carbamazepine increase clopidogrel metabolism (may increase effect).
   • Drugs like ritonavir, conivaptan inhibit clopidogrel activation (may reduce effect).
6. Opioid Painkillers:
   • May affect clopidogrel absorption or effectiveness; discuss with your doctor.
7. Other Medicines to Watch:
   • Caution with drugs like citalopram, metoprolol, diltiazem, and some antibiotics or antifungals due to potential interactions affecting blood thinning or metabolism.

Synopsis

More Information

Symptom checklist

Coronary Artery Disease (CAD) Symptom Checklist

• Chest discomfort or pain (angina), often described as pressure, squeezing, tightness, or heaviness
• Pain spreading to shoulders, arms, neck, jaw, or back
• Shortness of breath or difficulty catching breath
• Fatigue or unusual tiredness, especially during exertion
• Dizziness or lightheadedness, sometimes fainting
• Nausea or indigestion-like feelings
• Excessive sweating (cold sweats) without physical exertion
• Swelling in ankles, feet, or legs (fluid retention)
• Persistent cough or wheezing, especially when lying down
• Irregular or rapid heartbeats (arrhythmias)
• Sudden severe chest pain or symptoms indicating a heart attack (emergency):
  • Chest pain lasting longer than 5 minutes or not relieved with rest
  • Severe nausea or vomiting
  • Sudden sweating and weakness
  • Confusion or sudden speech difficulty

Women with CAD may experience symptoms differently, such as more nausea, back or jaw pain, or shortness of breath without chest pain.

Product Comparison:

This balanced comparison helps patients and pharmacists understand that generics like CLOPILET A 75 Capsule provide effective, safe, and economical alternatives to branded clopidogrel products, supporting informed decision-making

FAQs About CLOPILET A 75 CAPSULE

References

1. KD. Tripathi. Drugs Affecting Coagulation, Bleeding and Thrombosis. Essentials of medical pharmacology. Seventh edition. 2013. Page – 629-633

2. Jeffery I. Weitz. Blood coagulation and Anticoagulant, Fibrinolytic and Antiplatelet Drugs. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 868-870

3. Gerald G. Briggs and Roger K. Freeman. C. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 888-891 & 288-29

4. Nai-Fang Chi, Chi-Pang Wen, Chung-Hsiang Liu, Jie-Yuan Li, Jiann-Shing Jeng, Chih-Hung Chen, Li-Ming Lien, Ching-Huang Lin, Yu Sun, Wei-Lun Chang, Chaur-Jong Hu, Chung Y. Hsu on behalf of and Taiwan Stroke Registry Investigators. Comparison Between Aspirin and Clopidogrel in Secondary Stroke Prevention Based on Real-World Data. Journal of American heart association. September 2018. [Accessed on 6th November 2025] 

5. S. Claiborne Johnston, J. Donald Easton, Mary Farrant, William Barsan, Robin A. Conwit, Jordan J. Elm, Anthony S. Kim, Anne S. Lindblad and Yuko Y. Palesch. Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA. The New England journal of Medicine. [Revised in July 2018]. [Accessed on 6th November 2025] 

6. Shereif H. Rezkalla and Michele Benz. Antiplatelet Therapy from Clinical Trials to Clinical Practice. NCBI; PMC US National Library of Medicine, National Institute of Health. April 2003. [Accessed on 6th November 2025] 

7. Torrent Pharmaceuticals. Deplatt A. Torrentian.com. [Revised in July 2019]. [Accessed on 6th November 2025] 

8. Cipla Ltd. Clopivas-AP Tablets (Clopidogrel + Aspirin). Ciplamed. [Revised in April 2017]. [Accessed on 6th November 2025] 

Useful Diagnostic Tests

• ECG at Home
• ECG + BP Check at Home
• Full Body Checkup with ECG & BP at Home
• Comprehensive Cardiac Risk Screening with 12 Lead ECG and BP
• Cardiac Risk Profile
• Kidney package Basic

Author Details

Written By Dr. R. Dinesh John Rajkumar - Pharm.D

Reviewed For Accuracy By Dr. Thamada Manikanta Praveen - MBBS, MD (General Medicine)

Last updated on 26 Oct 2022 | 02:36 PM(IST)