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Introduction About GLYCOMET 500 SR TABLET

Glycomet 500 SR Tablet is a medication used to help control blood sugar levels in patients with Type 2 diabetes. It works by improving insulin sensitivity and reducing glucose production in the liver.

It is recommended to take Glycomet 500 SR Tablet with food to help reduce nausea and abdominal discomfort. For optimal results, take it consistently at the same time every day. Do not discontinue the medication unless advised by your doctor. Managing diabetes also heavily relies on your lifestyle, so it is crucial to follow the diet and exercise plan provided by your doctor while using this medication.

The most common side effect of this medication include nausea, stomach upset, weakness, dizziness, diarrhea, vomiting, flatulence, weakness, indigestion, headache, and loss of appetite. Taking this medicine in combination with other antidiabetic drugs, alcohol, or skipping a meal may cause some individuals to experience hypoglycemia (low blood sugar levels). Be sure to regularly monitor your blood sugar while using this medication.

Before using this medication, make sure to tell your doctor if you have any kidney, liver, or heart problems. If you are pregnant or breastfeeding should consult your doctor before taking it. Your doctor will conduct kidney function tests prior to starting management. It is also important to limit alcohol consumption while using this medication, as excessive drinking may raise the risk of certain side effects.

Uses Of GLYCOMET 500 SR TABLET

Type 2 diabetes mellitus

Benefits of GLYCOMET 500 SR TABLET

Helps lower blood sugar levels
Improves insulin sensitivity
Effective in managing Type 2 diabetes
Reduces risk of complications related to diabetes

How GLYCOMET 500 SR TABLET Works

Reduces glucose production in the liver: Metformin decreases the amount of glucose produced by the liver, helping to lower overall blood sugar levels.

Improves insulin sensitivity: It makes muscle and fat cells more responsive to insulin, allowing them to absorb glucose more effectively from the bloodstream.

Reduces intestinal glucose absorption: Metformin slows the absorption of glucose from the intestines, which helps reduce blood sugar spikes after meals.

Together, these actions help lower blood sugar and improve insulin sensitivity, especially in individuals with type 2 diabetes.

How to use GLYCOMET 500 SR TABLET

Follow your doctor's instructions regarding the exact dosage. Do not exceed the recommended daily dosage.

How to Take Glycomet 500 SR?

Take one tablet daily with meal to reduce the chance of stomach upset.
Do not exceed 2 tablets per day unless specifically advised by your doctor.
Swallow the tablet whole with a glass of water. Do not crush or chew the medication.
For best results, take the tablet at the same time each day.

Dosage Instructions for Adults and Children:

For Adults:

The usual starting dose is 500 mg once or twice a day, taken with meals to reduce the risk of gastrointestinal side effects.

For Children:

Generally unsafe under the age of 18 unless specifically prescribed by pediatrician. Pediatric dosing is determined individually and should be supervised by your pediatrician. consult your pediatrician for more advice.

How Long Does Glycomet 500 SR Take to Work?

Typically, it may take a few days to a couple of weeks for Glycomet 500 SR to show noticeable effects on blood sugar levels, depending on the individual’s response to the medication. However, it can take up to 4-6 weeks for its full effects to become evident, as the body adjusts to the medication.

What if I forgot to take GLYCOMET 500 SR TABLET

1.Take the Missed Dose as Soon as You Remember:

If you realize you have missed a dose and it’s still close to the time for the next dose, take it as soon as possible. Do not double up on the next dose to make up for the missed one.

2.If It is Almost Time for Your Next Dose:

If it is nearly time for your next scheduled dose, simply skip the missed dose. Do not take two doses at once.

3.Continue with Your Regular Dosing Schedule:

After skipping the missed dose, resume taking your medication at the usual time and frequency.

4.Contact Your Healthcare Provider if You're Unsure:

If you are unsure or have missed multiple doses, it is best to consult your doctor. They can provide specific guidance based on your situation.

5.Do not Stop the Medication Suddenly:

It is important not to stop taking this medication suddenly unless directed by your doctor. Abruptly stopping could affect your condition.

Overdose

If you or anyone else accidentally take too much of Glycomet 500 SR Tablet, consult, and inform your doctor immediately or visit the nearby hospital. Symptoms of overdose are vomiting, stomach pain with muscle cramps, feeling generally unwell with severe tiredness and difficulty in breathing.

Side Effects Of GLYCOMET 500 SR TABLET

Like all medicines, Glycomet 500 SR Tablet may cause certain side effects in some individuals, although not everybody gets them.

The most common side effects of taking Glycomet 500 SR Tablet are:

Nausea
Stomach upset
Weakness
Dizziness
Diarrhea
Vomiting
Flatulence
Indigestion
Headache
Loss of appetite

When to consult your doctor?

Lactic acidosis symptoms such as weakness or fatigue, unusual muscle pain or cramping, trouble breathing, abdominal pain, dizziness, or lightheadedness and slow or irregular heartbeat
Severe allergic reactions symptoms such as rash, itching, or swelling (especially of the face/tongue/throat), difficulty breathing and severe dizziness or fainting
Low blood sugar (hypoglycemia) symptoms such as shakiness, sweating, confusion, rapid heartbeat, and irritability
Gastrointestinal severe or persistent symptoms such as severe diarrhea, nausea, or vomiting

How To Manage Side Effects

Diarrhea

Drink Fluids: Drink clear fluids such as water, broths, and oral rehydration solutions (ORS).
Electrolytes: If you are losing a lot of fluids (for example, from frequent diarrhea), consider drinking an electrolyte solution to help replenish lost minerals like potassium and sodium.
BRAT Diet: Try to take Bananas, Rice (white rice), Apple sauce and Toast (plain, without butter) to control diarrhoea management.
Avoid Certain Foods: While recovering avoid the following food items such as fatty, greasy, or fried foods, spicy foods, dairy products (especially if you have a temporary lactose intolerance), caffeinated drinks and alcohol and artificial sweeteners like sorbitol.
Over-the-Counter Medications: You can take over-the-counter anti-diarrheal medications such as loperamide, Bismuth subsalicylate if appropriate for you. Follow the recommended dosage.

Dizziness Or Drowsiness

Sit or Lie Down: If you feel dizzy, sit down or lie down immediately to prevent falling. Keep your head still and close your eyes if needed.
Hydrate: Dehydration can cause dizziness, so drink water or electrolyte-replenishing drinks like sports drinks.
Avoid Sudden Movements: When standing or sitting, do so slowly to avoid triggering dizziness. Take your time when getting up.
Eat Small, Regular Meals: Low blood sugar can cause dizziness, so eat small meals throughout the day and avoid skipping meals.
Fresh Air: Sometimes dizziness can be alleviated by taking slow, deep breaths in a well-ventilated area.

Headache

Rest in a Quiet, Dark Room: Find a calm, quiet space away from bright lights and loud noises. Lie down and close your eyes.
Hydrate: Dehydration can contribute to headaches, so drink plenty of water.
Apply a Cold or Warm Compress: A cold pack on your forehead may reduce pain, or a warm compress on your neck or shoulders can relieve tension.
Over-the-Counter Pain Relief: You can take over-the-counter pain relievers like acetaminophen or ibuprofen if appropriate for you. Follow the recommended dosage.
Practice Relaxation Techniques: Deep breathing exercises, meditation, or gentle stretching can help reduce stress and alleviate headache symptoms.

Nausea And Vomiting

Eat Small, Frequent Meals: Avoid heavy or greasy foods. Opt for bland foods like crackers, toast, or bananas.
Stay Hydrated: Sip on clear fluids like water, ginger tea, or electrolyte drinks, Avoid caffeinated and carbonated beverages.
Ginger: Ginger is a natural remedy for nausea. Try ginger tea, ginger candies, or ginger ale (ensure it contains real ginger).
Avoid Strong Odors: Minimize exposure to smells that might trigger nausea, such as perfumes or cooking odors.

Glycomet 500 SR Tablet is unsafe for use in children and adolescents (under 18 years of age). Consult your pediatrician before giving it.

Use In Geriatrics

Use with Caution

Glycomet 500 SR should be used with caution in elderly patients. Dosage adjustment and careful monitoring are required in such patients. Consult and inform your doctor before taking it.

Other Warnings for GLYCOMET 500 SR TABLET

Before taking Glycomet 500 SR, inform your doctor if you:

are about to have any X-ray or scan
are about a have a major surgery
are in fasting

Who should not take [GBNKEYWORD

Glycomet 500 SR is generally not safe for use if you:

have severe, uncontrollable diabetes
have lactic acidosis or ketoacidosis
are dehydrated
have any systemic infection
have shock or problems in blood circulation
have breathing problems
are an alcoholic
are scheduled for contrast dye procedures

Safety Advice

Take one tablet daily with meal or as advised by your doctor
Swallow the tablet whole with a glass of water. Do not crush or chew the medication.
It is recommended to take Glycomet 500 SR with food to reduce the risk of stomach upset or other digestive issues
Follow the prescribed diet and exercise plan along with taking this medication for best results.
Monitor your blood sugar levels regularly while taking this medicine.
Make sure to drink enough fluids while taking Glycomet 500 SR to reduce dehydration, as it can raise the chance of side effects such as dizziness.
Alcohol can raise the risk of lactic acidosis, so it is recommended to limit or avoid alcohol consumption while using Glycomet 500 SR.
If you experience common side effects include nausea, vomiting, diarrhea, and a metallic taste. If these persist or are severe, contact your doctor.
If you experience serious side effects include lactic acidosis, severe weakness, and trouble breathing. If you experience any of these, seek immediate medical help.
Let your doctor know if you have kidney disease or any history of kidney problems.
If you are scheduled for surgery or any diagnostic procedures that require contrast dyes, make sure to inform your doctor. You might need to temporarily discontinue taking Glycomet 500 SR.
Let your doctor know If you are pregnant or planning to become pregnant or breastfeeding women.
Do not suddenly stop taking the medication without consulting your doctor, as this can lead to uncontrolled blood sugar levels.
Always let your doctor know about any other medications you are taking, including over-the-counter drugs and supplements, as they may interact with Glycomet 500 SR.

Diet and Lifestyle Advice

Aspect	Benefits	How it Complements Glycomet SR	Recommendations
Regular Exercise	- Improves insulin sensitivity - Helps regulate blood sugar levels - Reduces the risk of complications (heart disease, nerve damage, etc.)	- Enhances the effectiveness of Glycomet SR in controlling blood sugar levels. - Helps prevent insulin resistance.	- Aim for at least 150 minutes of moderate-intensity aerobic exercise (e.g., walking, cycling) per week. - Include strength training twice a week.
Proper Hydration	- Helps regulate blood sugar levels by maintaining kidney function and preventing dehydration. - Prevents high blood sugar spikes caused by dehydration.	- Helps ensure the kidney’s proper functioning, which is important when taking Glycomet SR as the medication is processed through the kidneys.	- Drink at least 8 cups (2 liters) of water daily, more if physically active. - Avoid sugary drinks and alcohol, as they can affect blood sugar levels.
Balanced Diet	- Maintains stable blood sugar levels and supports weight management. - Helps reduce the risk of diabetes complications like heart disease.	- Works synergistically with Glycomet SR to ensure optimal blood glucose control. - Can help reduce the need for higher medication doses.	- Focus on a diet rich in fiber, lean proteins, healthy fats, and whole grains. - Limit processed carbs and sugary foods. - Include plenty of non-starchy vegetables.

This combination of lifestyle changes, along with Glycomet SR, can provide a well-rounded approach to managing diabetes effectively.

Drug - Drug interaction

Inform your physician if you are taking any of the following medicine before taking Glycomet 500 SR:

1. Insulin and Other Oral Hypoglycemics

Interaction: Combining Glycomet with insulin or other oral antidiabetic medications (e.g., sulfonylureas) may increase the risk of hypoglycemia (low blood sugar).
Effect: Risk of severe hypoglycemia, which can cause symptoms like dizziness, sweating, confusion, and even loss of consciousness.
Management: Close monitoring of blood glucose levels, adjusting insulin or other antidiabetic medications accordingly, and educating patients on recognizing and treating hypoglycemia.

2. Diuretics (e.g., Furosemide)

Interaction: Thiazide and loop diuretics can increase blood glucose levels, which might counteract the effects of Glycomet.
Effect: Increased blood sugar levels and potential difficulty in managing diabetes.
Management: Monitor blood glucose regularly, adjust the dose of Glycomet as necessary, and consider alternative diuretics or adjunct therapy.

3. Corticosteroids (e.g., Prednisone)

Interaction: Corticosteroids can raise blood sugar levels, potentially decreasing the effectiveness of Glycomet.
Effect: Hyperglycemia (high blood sugar), potentially causing elevated blood glucose despite taking Glycomet.
Management: Close monitoring of blood glucose levels. Dose adjustments of Glycomet may be required during and after corticosteroid treatment.

4. ACE Inhibitors (e.g., Lisinopril)

Interaction: ACE inhibitors can reduce renal clearance of metformin, possibly increasing the risk of lactic acidosis, a rare but serious side effect of metformin.
Effect: Increased risk of lactic acidosis, especially in patients with impaired kidney function.
Management: Use caution in patients with renal impairment, and monitor kidney function regularly. Avoid concomitant use in severe renal dysfunction.

5. Contrast Agents (e.g., Iodinated Contrast)

Interaction: Iodinated contrast agents used in imaging procedures (like CT scans) can impair kidney function and increase the risk of lactic acidosis.
Effect: Increased risk of kidney injury and lactic acidosis, particularly in those with pre-existing renal issues.
Management: Discontinue Glycomet before the procedure and avoid its use for 48 hours after receiving the contrast agent. Renal function should be assessed before restarting the medication.

6. Beta-blockers (e.g., Atenolol)

Interaction: Beta-blockers can mask the symptoms of hypoglycemia (like tremors and palpitations), making it harder for the patient to recognize low blood sugar.
Effect: Increased risk of unrecognized hypoglycemia.
Management: Educate patients on hypoglycemia awareness and monitor blood sugar closely, especially when starting or changing the dosage of beta-blockers.

7. Certain Antibiotics (e.g., Ciprofloxacin)

Interaction: Some antibiotics, like ciprofloxacin, can affect blood glucose levels, either increasing the risk of hyperglycemia or hypoglycemia.
Effect: Fluctuating blood sugar levels that may require adjustment of Glycomet therapy.
Management: Monitor blood glucose levels closely and adjust Glycomet dosage if needed.

8. Cimetidine (and other H2-receptor antagonists)

Interaction: Cimetidine can inhibit the renal clearance of metformin, potentially increasing the risk of metformin-related side effects, including lactic acidosis.
Effect: Increased risk of lactic acidosis, particularly in patients with renal impairment.
Management: Use with caution and monitor kidney function. Consider alternative acid-suppressing therapies if possible.

9. Thyroid Medications (e.g., Levothyroxine)

Interaction: Thyroid hormone levels can affect glucose metabolism, and thyroid dysfunction can alter the effectiveness of Glycomet.
Effect: Alterations in blood sugar control, potentially requiring dose adjustments of Glycomet.
Management: Regular monitoring of thyroid function and blood glucose. Adjust Glycomet dosage as needed based on thyroid status.

Synopsis

Drug	:	Metformin
Pharmacological Category	:	Biguanides
Therapeutic Indication	:	Type II Diabetes mellitus
Dosage Forms	:	Tablet

More Information

A. How Glycomet 500 SR Tablet helps in Diabetes Management?

1. Improves Insulin Sensitivity:

Metformin helps improve the body's sensitivity to insulin, the hormone that regulates blood sugar levels. In Type 2 diabetes, the body's cells often become resistant to insulin, leading to elevated blood sugar. Metformin reduces this resistance, allowing insulin to work more effectively, thereby lowering blood sugar.

2. Reduces Hepatic Glucose Production:

The liver plays a major role in blood sugar regulation by producing glucose (a process called gluconeogenesis). In Type 2 diabetes, the liver may produce excessive amounts of glucose. Metformin helps reduce this overproduction of glucose by the liver, leading to lower blood sugar levels, especially after meals.

3. Slows Intestinal Absorption of Glucose:

Metformin has a mild effect on reducing the absorption of glucose from the intestines, which can help prevent blood sugar spikes after eating. This is particularly useful for controlling post-meal blood glucose levels.

4. Does Not Cause Hypoglycemia:

A significant advantage of metformin is that it generally does not cause hypoglycemia (low blood sugar) when used alone, unlike other medications that stimulate insulin production. This makes it safer for long-term use, as the risk of dangerously low blood sugar levels is minimal.

5. Weight Neutral or Beneficial Effect:

Metformin is generally considered weight-neutral, or it may even aid in weight loss for some individuals. Since many people with Type 2 diabetes are overweight, this can be a helpful side effect as losing excess weight can improve blood sugar control.

6. Long-Acting Formulation (SR):

The "SR" (sustained-release) version of Glycomet releases metformin gradually over time, providing a steady effect throughout the day. This can help in maintaining more stable blood sugar levels and might reduce the risk of side effects like gastrointestinal discomfort, which can occur with the immediate-release version.

7. Cardiovascular Benefits:

Metformin has also been shown to have beneficial effects on cardiovascular health, which is important since people with Type 2 diabetes have an increased risk of heart disease. Some studies suggest that metformin may reduce the risk of cardiovascular events.

Why it is Commonly Prescribed:

First-Line Treatment: Glycomet 500 SR (metformin) is often the first medication prescribed for Type 2 diabetes due to its proven effectiveness, safety profile, and low cost.
Versatility: It can be used alone or in combination with other medications like sulfonylureas, DPP-4 inhibitors, or insulin when blood sugar levels are not adequately controlled with metformin alone.
Well-Studied: Metformin has been extensively studied and has a long history of use in managing Type 2 diabetes. This provides healthcare providers with confidence in its safety and efficacy.

Practical Benefits:

Convenience: With the sustained-release formulation, Glycomet 500 SR can be taken once or twice a day, making it easier for patients to manage their medication regimen.
Tolerability: Although some patients may experience mild gastrointestinal issues when starting metformin (like nausea or upset stomach), these are generally short-lived, and the SR formulation often minimizes these effects.

Glycomet 500 SR plays a critical role in managing Type 2 diabetes by improving insulin sensitivity, reducing liver glucose production, and minimizing post-meal blood sugar spikes, all while providing a relatively safe and well-tolerated option for patients.

B. How to Manage Type 2 Diabetes?

Aspect	Details	Tips for Improvement
Diet	- Focus on a balanced diet with whole grains, lean proteins, healthy fats, and plenty of vegetables.	- Opt for low glycemic index (GI) foods to avoid blood sugar spikes (e.g., whole grains, legumes). - Reduce carbohydrate intake to help control blood sugar levels. - Monitor portion sizes to avoid overeating and control blood glucose.
	- Limit processed foods, sugary snacks, and beverages high in refined sugars.	- Incorporate fiber-rich foods (fruits, vegetables, and whole grains) to slow glucose absorption. - Healthy fats (e.g., olive oil, nuts, avocado) improve insulin sensitivity.
Exercise	- Engage in regular physical activity (30 minutes most days of the week).	- Combine aerobic exercise (walking, cycling) with resistance training (weightlifting) for improved insulin sensitivity. - Aim for moderate-intensity exercise to enhance blood sugar control.
	- Include both cardio and strength training exercises for optimal results.	- Include flexibility exercises (e.g., yoga) to improve circulation and reduce stress, which can impact blood sugar.
Medication (Glycomet 500 SR)	- Glycomet 500 SR (Metformin) helps to lower blood sugar by improving insulin sensitivity and reducing glucose production in the liver.	- Take Glycomet 500 SR with food to minimize gastrointestinal side effects. - Discuss with a healthcare provider to determine if dose adjustments are necessary based on blood sugar levels. - Glycomet can be combined with lifestyle changes to achieve better blood glucose control.
	- Usually prescribed as an initial treatment option for Type 2 diabetes.	- Glycomet is a long-acting form of metformin, offering a gradual release to maintain stable blood glucose levels throughout the day.
Improving Insulin Sensitivity	- Maintain a healthy weight.	- Losing even 5-10% of body weight can significantly improve insulin sensitivity.
	- Engage in consistent physical activity.	- Exercise regularly to help muscles use insulin more efficiently.
	- Consider intermittent fasting or time-restricted eating (consult with your doctor).	- A diet rich in magnesium (e.g., leafy greens, seeds, nuts) and chromium (e.g., broccoli, oats) can support insulin sensitivity. - Avoid high levels of stress, as it can impair insulin function.
	- Prioritize good sleep and manage stress levels.	- Ensure 7-9 hours of quality sleep per night, as poor sleep impairs insulin sensitivity. - Practice mindfulness, meditation, or other stress-relief activities to reduce cortisol, which can affect blood sugar control.
Regular Monitoring	- Regular blood glucose testing to track levels.	- Monitor A1C levels every 3-6 months to assess long-term blood sugar control.
	- Keep track of meals, activity levels, and medication to identify patterns.	- Keep a diary or use diabetes management apps to better understand how diet, exercise, and medication impact your blood sugar.

By combining medication, diet, exercise, and lifestyle changes, people with Type 2 diabetes can improve insulin sensitivity, maintain stable blood sugar levels, and reduce the risk of complications.

C. Blood Sugar Control Tips:

Aspect	Explanation	Glycomet's Role
Regular Blood Sugar Monitoring	Monitoring helps track your blood sugar levels consistently to prevent spikes and drops. This is crucial for maintaining overall health and avoiding complications.	Regular monitoring can help assess the effectiveness of Glycomet in managing your blood sugar levels.
Ideal Blood Sugar Ranges	- Fasting: 70-100 mg/dL - Post-meal (2 hours after eating): <140 mg/dL - A1C (3-month average): <7% for most diabetics.	Glycomet helps maintain blood sugar levels within these ideal ranges, aiding in stable and controlled levels.
Meal Planning and Carbohydrate Control	Eating balanced meals with controlled carbohydrate intake is key. It helps avoid significant spikes in blood sugar after meals.	Glycomet helps your body better respond to insulin, supporting blood sugar regulation after meals.
Exercise and Physical Activity	Regular exercise helps improve insulin sensitivity, which in turn aids in better blood sugar control.	Glycomet may help enhance the effects of exercise on blood sugar control by improving insulin sensitivity.
Medication Adherence	Consistency with prescribed medications is crucial for managing blood sugar effectively.	Glycomet is a medication that helps control blood sugar by improving insulin sensitivity and reducing glucose production in the liver. It should be taken as prescribed.
Lifestyle Modifications	Stress reduction, adequate sleep, and weight management all play a role in blood sugar control.	Glycomet supports lifestyle changes by addressing underlying metabolic factors that affect blood sugar regulation.

Incorporating regular monitoring, a balanced diet, exercise, and Glycomet (as prescribed by a doctor) into a comprehensive plan helps effectively manage blood sugar and reduce the risk of complications.

D. Research Studies:

Study/Research Title	Publication Year	Research Focus	Findings	Conclusion
The Effect of Metformin on HbA1c Levels in Type 2 Diabetes Patients	2024	Impact of metformin on HbA1c in Type 2 diabetes	Significant reduction in HbA1c after 6 months of metformin treatment (average drop 1.2%).	Metformin is effective in long-term blood sugar control and reducing HbA1c in Type 2 diabetes.
Metformin versus Sulfonylureas in Blood Sugar Control: A Comparative Study	2023	Comparing metformin and sulfonylureas in managing blood sugar	Metformin outperformed sulfonylureas in maintaining steady blood glucose levels and was associated with fewer side effects.	Metformin is a superior first-line treatment for blood sugar control in Type 2 diabetes.
Long-Term Cardiovascular Benefits of Metformin in Type 2 Diabetes	2022	Cardiovascular effects of metformin in blood sugar management	Metformin use showed a 15% reduction in cardiovascular events and a 10% decrease in all-cause mortality.	Metformin not only controls blood sugar but also reduces cardiovascular risks in Type 2 diabetes patients.
Metformin's Effect on Insulin Resistance and Inflammation	2021	Effect of metformin on insulin resistance and inflammatory markers	Reduced markers of inflammation and improved insulin sensitivity in Type 2 diabetes patients after 12 weeks of use.	Metformin helps improve insulin resistance and reduces systemic inflammation, aiding blood sugar control.
Efficacy of Glycomet 500 SR in Type 2 Diabetes Management	2020	Evaluating Glycomet 500 SR (extended-release) in blood sugar control	Extended-release metformin (Glycomet 500 SR) led to a more consistent reduction in post-meal blood glucose levels.	Glycomet 500 SR is effective for consistent blood sugar control, with fewer GI side effects compared to regular metformin.
Metformin and Weight Management in Diabetic Patients	2023	Investigating metformin's role in weight management alongside blood sugar control	Metformin was associated with moderate weight loss, particularly in overweight and obese patients with Type 2 diabetes.	Metformin aids in weight management in addition to blood sugar control, benefiting overweight diabetic patients.

These studies underscore metformin’s (and Glycomet 500 SR’s) role not just in controlling blood sugar but also in providing additional benefits such as reducing inflammation, supporting weight management, and lowering cardiovascular risks.

E. Product Comparison:

Glycomet 500 SR vs. Other Diabetes Medications such as Glucophage, Januvia, or insulin therapy

Medication	Glycomet 500 SR (Metformin)	Glucophage (Metformin)	Januvia (Sitagliptin)	Insulin Therapy
Class	Biguanide	Biguanide	DPP-4 Inhibitor	Hormone therapy (insulin)
Mechanism of Action	Reduces hepatic glucose production, increases insulin sensitivity	Same as Glycomet: reduces glucose production in liver	Inhibits DPP-4 enzyme, increasing incretin levels to enhance insulin secretion	Directly regulates blood glucose by promoting glucose uptake into cells
Effectiveness	Highly effective in lowering blood sugar levels, especially in Type 2 diabetes	Comparable to Glycomet; effective in reducing blood glucose	Moderate effect on lowering blood sugar, particularly after meals	Highly effective for controlling blood sugar, often used in Type 1 and advanced Type 2 diabetes
Formulation	Extended-release (SR) tablet	Immediate-release tablet, available in various strengths	Oral tablet	Injectable (various forms: rapid-acting, long-acting)
Dosage	500 mg or higher, taken once or twice daily	Varies, typically taken 1-3 times a day	25 mg or 50 mg once daily	Varies; based on individual needs (measured in units)
Side Effects	Common: GI disturbances (nausea, diarrhea), vitamin B12 deficiency, lactic acidosis (rare)	Similar to Glycomet: GI issues, vitamin B12 deficiency	Mild: upper respiratory infections, headache, GI issues, potential joint pain	Hypoglycemia (low blood sugar), weight gain, injection site reactions, risk of ketoacidosis
Benefits	Weight neutral or may promote slight weight loss, no risk of hypoglycemia, long-term cardiovascular benefits	Similar to Glycomet, effective for long-term control, weight neutral	Can be used alone or in combination with other diabetes drugs, weight neutral	Flexible dosing, highly effective in controlling blood sugar, can be tailored to individual needs
Disadvantages	Requires caution in kidney disease, GI side effects, cannot be used with certain medications	Same as Glycomet, potentially less convenient than extended-release versions	Less effective on its own for Type 2, higher cost, can be less effective for some	Requires careful monitoring of blood glucose, can lead to hypoglycemia, weight gain, requires injections

Glycomet 500 SR vs. Regular Metformin:

Feature	Regular Metformin	Glycomet 500 SR (Extended-Release)
Release Mechanism	Immediate-release; quickly absorbed in the body	Slow-release; gradual absorption over time
Dosing Frequency	Typically taken 2-3 times a day	Typically taken once a day
Absorption Rate	Rapid absorption; peak effect sooner	Slower, more gradual absorption
Side Effects	More likely to cause GI issues (nausea, diarrhea)	Fewer GI issues due to slower absorption
Blood Sugar Control	Effective for controlling blood sugar immediately	Provides more stable, consistent blood sugar control
Convenience	Requires multiple doses throughout the day	More convenient, once-daily dosage
Risk of Side Effects	Higher likelihood of gastrointestinal side effects	Lower incidence of GI side effects
Half-life	Shorter half-life, needs more frequent dosing	Longer half-life, suitable for once-daily use
Suitability for Patients	May not be ideal for those with sensitive stomachs	Ideal for those who experience side effects with regular metformin
Cost	Generally cheaper	May be more expensive due to the extended-release formulation

Key Benefits of Slow-Release (Glycomet SR):

Fewer Side Effects: Due to the slow absorption, there is less likelihood of sudden spikes in blood concentration, which helps reduce gastrointestinal discomfort.
Once-Daily Dosing: It is more convenient for patients as it only requires a single dose per day.
Better Compliance: Because of the fewer doses and smoother effect, patients are more likely to stick to their prescribed regimen.
More Stable Blood Sugar Control: Extended-release formulations help in maintaining steady blood sugar levels throughout the day, preventing peaks and troughs.

FAQs About GLYCOMET 500 SR TABLET

Q: What is Glycomet 500 SR Tablet used for?

A: Glycomet 500 SR Tablet is primarily used for the management of Type 2 diabetes mellitus. It helps lower blood sugar levels in patients when taken along with a healthy diet and regular exercise.

Q: How does Glycomet 500 SR work?

A: Glycomet 500 SR contains Metformin, which works by decreasing glucose production in the liver, increasing insulin sensitivity, and enhancing the uptake of glucose by muscles. This helps control blood sugar levels.

Q: What are the common side effects of Glycomet 500 SR?

A: Some common side effects of Glycomet 500 SR include nausea, vomiting, abdominal discomfort, diarrhea, and metallic taste. These side effects usually subside over time as your body adjusts to the medication.

Q: Can I take Glycomet 500 SR with other diabetes medications?

A: Yes, Glycomet 500 SR can be used in combination with other diabetes medications like sulfonylureas or insulin. However, it is important to follow your healthcare provider's recommendations to avoid potential side effects or interactions.

Q: What is the correct dosage of Glycomet 500 SR?

A: The dosage of Glycomet 500 SR depends on your medical condition and your response to treatment. Generally, it is started at a low dose and gradually increased. It is best to follow the instructions of your doctor for personalized guidance.

Q: Can Glycomet 500 SR cause low blood sugar (hypoglycemia)?

A: Glycomet 500 SR does not typically cause low blood sugar (hypoglycemia) on its own, but when used in combination with other diabetes medications, the risk of hypoglycemia can increase. Be sure to monitor your blood sugar levels regularly.

Q: Can I take Glycomet 500 SR if I am pregnant or breastfeeding?

A: Consult your doctor before taking this medication if you are pregnant or breastfeeding women.

Q: What should I do if I miss a dose of Glycomet 500 SR?

A: If you miss a dose of Glycomet 500 SR, take it as soon as you remember, unless it is almost time for your next dose. Do not take two doses to make up for the missed one.

Q: Is Glycomet 500 SR safe for long-term use?

A: When used as directed by your doctor, Glycomet 500 SR is generally considered safe for long-term use in managing Type 2 diabetes. Regular monitoring of blood sugar and kidney function is recommended.

Q: Are there any food or drink restrictions while taking Glycomet 500 SR?

A: There are no specific food or drink restrictions while taking Glycomet 500 SR. However, it is important to follow a healthy diet and avoid excessive alcohol consumption, as this may increase the risk of side effects.

Q: Is Glycomet 500 SR the same as Metformin?

A: Yes, Glycomet 500 SR contains Metformin as its active ingredient, so they are essentially the same, but Glycomet 500 SR is a sustained-release version, meaning it releases the medication more slowly.

Q: How long does it take for Glycomet 500 SR to work?

A: It may take a few days to a few weeks to notice the full effect of Glycomet 500 SR in controlling blood sugar levels, depending on your response to the medication.

Q: Can I stop taking Glycomet 500 SR suddenly?

A: No, you should not stop taking Glycomet 500 SR suddenly without consulting your doctor, as this may cause blood sugar levels to rise unexpectedly.

Q: How should I store Glycomet 500 SR tablets?

A: Store Glycomet 500 SR tablets at room temperature, away from moisture and heat, in a tightly closed container.

Q: Does Glycomet 500 SR affect weight loss?

A: Glycomet 500 SR may help some people with weight loss, especially those with Type 2 diabetes, by improving insulin sensitivity and reducing appetite. However, weight loss results can vary.

Q: Can I take Glycomet 500 SR if I have kidney issues?

A: People with kidney problems should consult their doctor before taking Glycomet 500 SR, as it may not be safe for those with severe kidney impairment.

Q: How long will it take for Glycomet 500 SR to lower my blood sugar levels?

A: Glycomet 500 SR typically starts working within a few hours to lower blood sugar, but noticeable effects may take a few days to a week depending on the individual.

Q: Where can I buy Glycomet 500 SR Tablet online?

A: You can buy Glycomet 500 SR tablet online at Netmeds. Just visit their website and search for the product, and you will find options to purchase it directly from there.

References

1. KD. Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 275.

2. Calette Corcoran; Tibb F. Jacobs. Metformin. StatPearls. NIH. National Library of Medicine. National center for biotechnology information. PMC. PubMed Central. [Revised on May 2022]. [Accessed on 1st Feb 2025]

3. Shuyan Gu, Jihao Shi, Zhiliu Tang, Monika Sawhney, Huimei Hu, Lizheng Shi, Vivian Fonseca, Hengjin Dong. Comparison of Glucose Lowering Effect of Metformin and Acarbose in Type 2 Diabetes Mellitus: A Meta-Analysis. PLOS ONE. May 2015. [Accessed on 1st Feb 2025]

4. Milpharm Limited. Electronic Medicines Compendium (EMC). [Revised in June 2020] [Accessed on 1st Feb 2025]

5. Rx Farma Limited. Electronic Medicines Compendium (EMC). [Revised in September 2019] [Accessed on 1st Feb 2025]

6. Merck Santé S.A.S. U.S. Food & Drug Administration. [Revised in April 2017] [Accessed on 1st Feb 2025]

7. Franco Indian Pharmaceuticals Pvt Ltd. GLYCIPHAGE® GLYCIPHAGE 850® GLYCIPHAGE 250®TABLETS. (ORAL ANTI-HYPERGLYCEMIC AGENT). [Accessed on 1st Feb 2025]

Useful Diagnostic Tests

Random Blood Sugar (RBS)
Fasting Blood Sugar (FBS)
Post Prandial Blood Sugar (PPBS)
Sugar Risk Package
HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin

Author Details

Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)

Reviewed For Accuracy By Dr. Jaya Prabakaran - MBBS, MD (Diabetology and Family Medicine)

Last updated on 07 Feb 2025 | 04:58 PM(IST)

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