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Introduction About BUTRUM NASAL SPRAY

BUTRUM NASAL SPRAY contains Butorphanol, which belongs to the group of medicines called Opioid agonist/antagonist analgesics. It is used to manage moderate to severe pain. Pain is an uncomfortable sensation in the body which stems from activation of the nervous system it generally occurs as an annoying or debilitating sensation which can be characterized as a sharp, dull, throbbing, pinching, stinging, and/or burning sensation in affected individuals.

Before taking BUTRUM NASAL SPRAY, inform your doctor if you have a head injury or increased intracranial pressure (increased pressure in the head), respiratory, hepatic, or renal impairment, and/or heart diseases (such as acute myocardial infarction, ventricular dysfunction, or coronary insufficiency).

In pregnant and breastfeeding women, BUTRUM NASAL SPRAY should be used with caution. It is not recommended for use in children and adolescents (aged below 18 years). It should be used with caution in elderly patients (those over the age of 65). The most common side effects associated with the use of BUTRUM NASAL SPRAY are excessive sleepiness, dizziness, nausea, vomiting, nasal congestion, sleeplessness, and/or lethargy. Consult your doctor if any of your symptoms get worse.

Uses Of BUTRUM NASAL SPRAY

Manage and relieve moderate to severe acute pain

How BUTRUM NASAL SPRAY Works

BUTRUM NASAL SPRAY works by blocking certain receptors (responsible for pain) in the brain and spinal cord which leads to blockage of pain transmission thus providing relief from moderate to severe acute pain in affected individuals.

How to use BUTRUM NASAL SPRAY

Take BUTRUM NASAL SPRAY as advised by your physician. It is for intranasal use only. Blow your nose. Pull the clear cover off the pump unit. Remove the protective clip. Before the initial use, prime the unit by pumping the sprayer until a fine mist appears. Insert the spray tip approximately 1 cm into one nostril, close the other nostril with your forefinger, and pump the spray unit firmly and quickly. Your doctor will determine the correct dose and duration for you depending on your age, body weight, and disease condition.

Side Effects Of BUTRUM NASAL SPRAY

Common

excessive sleepiness
dizziness
nausea and/or vomiting
nasal congestion
sleeplessness
lethargy
headache
sensation of heat
signs of dilation of vessels such as nausea, blurred vision, light-headedness, or dizziness
racing heartbeat
anorexia (an eating disorder causing weight loss)
constipation
dry mouth
stomach pain
anxiety
confusion
euphoria (feeling very happy)
floating feeling
sleeplessness
nervousness
stinging sensation
tremor
bronchitis (inflammation of the lining of a bronchial tube of the lungs)
cough
shortness of breath
nose bleeding
nasal irritation
sore throat
running nose
sinus congestion
inflammation of sinuses
signs of upper respiratory infections such as runny nose, sneezing, throat pain
sweating
itching
blurred vision
ear pain
ringing in the ears
unpleasant taste
chills
pain
chest pain
increase appetite
thirst
abnormal feelings
abnormal thinking
drowsiness
incoordination
nervousness
impaired muscle movements
stinging and burning sensation
sensation of spinning
increased appetite
double vision
hearing loss
low blood pressure

Uncommon

transient loss of consciousness
abnormal dreams
agitation
dysphoria (feeling of being unhappy)
hallucinations
hostility
withdrawal symptoms such as fatigue, anxiety, vomiting, sweating, depression
rashes/itchy welts
impaired urination
swelling due to water retention
high blood pressure
increased heart rate
depression
shallow breathing
sensation of cold
fever
accidental injury
back pain
stomach/abdominal pain
flatulence
pallor
irregular heartbeat
relaxed muscles
leg pain
feeling calmness
abnormal gait
slurred speech
reduce tolerance to sound
eye pain
eye disorder
loss of taste
petechiae (round spots on the skin)

Rare

syncope due to low blood pressure

Stop taking BUTRUM NASAL SPRAY and contact your doctor if you experience any of the following side effects:

signs of allergic reactions such as shallow breathing, rashes, and/or swelling

How To Manage Side Effects

Headache:

Take a rest and relax. Stay hydrated. Do not skip your meals. Consult your doctor if the condition persists or gets worse.

Dizziness:

Lie down until the dizziness passes and try to get up slowly. Do not bend down suddenly. Get a lot of rest. Walk slowly and carefully. Take plenty of fluids to stay hydrated. Avoid drinking coffee, alcohol, or smoking. Consult your doctor if the condition persists or gets worse.

Constipation:

Try to eat more high-fibre foods, such as fresh fruit, vegetables, and cereals, and drink plenty of water. Try doing exercise regularly (going for a daily walk or run). Consult your doctor if the condition persists or gets worse.

Nausea and vomiting:

Try to take BUTRUM NASAL SPRAY with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy foods. Consult your doctor if the symptom gets worse.

Warning & Precautions

Pregnancy

BUTRUM NASAL SPRAY should be used with caution in pregnant women only if it is considered necessary. However, it is not recommended for use during labour/delivery as its safety and risks are not known. Consult your doctor before taking the medicine.

Breastfeeding

BUTRUM NASAL SPRAY should be used with caution in breastfeeding mothers. Consult your doctor before taking the medicine.

Driving and Using Machines

Do not drive or operate machines after taking BUTRUM NASAL SPRAY as this medicine can make you feel drowsy and dizzy. Consult your doctor before taking the medicine.

Alcohol

Avoid consumption of alcohol while taking BUTRUM NASAL SPRAY because it may cause drowsiness, dizziness, and/or impaired mental function.

Kidney

BUTRUM NASAL SPRAY should be used with caution in patients with renal impairment. Consult your doctor before taking the medicine.

Liver

BUTRUM NASAL SPRAY should be used with caution in patients with liver disease such as hepatic impairment. Consult your doctor before taking the medicine.

Allergy

BUTRUM NASAL SPRAY is not recommended for use if you are allergic to butorphanol tartrate, benzethonium chloride, or any other ingredients in this medicine. Consult your doctor before taking the medicine.

Lungs

BUTRUM NASAL SPRAY should be used with caution for patients with lung problems such as respiratory impairment. Consult your doctor before taking the medicine.

Heart Disease

BUTRUM NASAL SPRAY should be used with caution in patients with heart diseases such as acute myocardial infarction, ventricular dysfunction, and coronary insufficiency only if it is necessary. Consult your doctor before taking the medicine.

Others

Before taking BUTRUM NASAL SPRAY, inform your doctor if you:

have a head injury and increased intracranial pressure (increased pressure inside the head)
are in ambulatory (inability to walk) condition

Use in Paediatrics:

BUTRUM NASAL SPRAY is not recommended to be used in children and adolescents (below 18 years of age). Consult your doctor before taking the medicine.

Use in Geriatrics:

BUTRUM NASAL SPRAY should be used with caution in elderly patients (aged above 65 years). Consult your doctor before taking the medicine.

Interactions

A. Drug-Drug Interactions:

Before taking BUTRUM NASAL SPRAY, inform your doctor, if you are taking any of the following medicine:

barbiturates (medicines used to manage sleep disorders) Ex. amobarbital
tranquillizers (medicines used to manage anxiety), such as benzodiazepines (Ex. diazepam)
antihistamines (medicines used to manage allergies) Ex. cimetidine
triptans (medicines used to manage migraine) Ex. sumatriptan
erythromycin, theophylline (medicines that can affect the metabolism of certain drugs in the liver)
oxymetazoline (a medicine used to stimulate vascular constriction in the nose)
monoamine oxidase (MAO) inhibitors (medicines used to manage psychiatric disorders) Ex. phenelzine

Overdosage:

If you or anyone else accidentally take too much of BUTRUM NASAL SPRAY, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are respiratory depression, heart failure, central nervous system depression, and coma.

Synopsis

Drug	:	Butorphanol
Pharmacological Category	:	Opioid agonist/antagonist analgesics
Therapeutic Indication	:	Moderate to severe pain
Dosage Forms	:	Nasal Spray, Injection

More Information

Keep the medicine out of reach from children
Store BUTRUM NASAL SPRAY at room temperature

FAQs About BUTRUM NASAL SPRAY

What is the function of BUTRUM NASAL SPRAY?

BUTRUM NASAL SPRAY is used to provide relief from moderate to severe pain in affected individuals, which is an uncomfortable sensation in the body that stems from activation of the nervous system and is generally characterised by symptoms such as sharp, dull, throbbing, pinching, stinging, and/or burning sensation in affected individuals.

What happens if you take more BUTRUM NASAL SPRAY than your required dose?

If you or anyone else accidentally takes too much BUTRUM NASAL SPRAY, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are respiratory depression, heart failure, depression of the central nervous system, and coma.

What are the common side effects of BUTRUM NASAL SPRAY?

The most common side effects associated with the use of BUTRUM NASAL SPRAY are excessive sleepiness, dizziness, nausea, vomiting, nasal congestion, sleeplessness, and/or lethargy. Consult your doctor if any of these symptoms worsen.

Who should avoid taking BUTRUM NASAL SPRAY?

BUTRUM NASAL SPRAY should not be used in patients who are allergic to butorphanol tartrate or benzethonium chloride. It is also not recommended for use in patients during the labour and delivery phase or in children and adolescents (aged below 18 years). Consult your doctor before taking the medicine.

Is it safe to drive after taking BUTRUM NASAL SPRAY?

Do not drive or operate machines after taking BUTRUM NASAL SPRAY since this medicine can make you feel drowsy and dizzy. Consult your doctor before taking the medicine.

Is BUTRUM NASAL SPRAY safe to use in children and the elderly?

No, BUTRUM NASAL SPRAY is not recommended to be used in children and adolescents (aged below 18 years); it should be used with caution in elderly patients (aged above 65 years) after consulting the doctor.

How does BUTRUM NASAL SPRAY work?

BUTRUM NASAL SPRAY works by blocking certain receptors (responsible for pain) in the brain and spinal cord, which leads to blockage of pain transmission and thus provides relief from moderate to severe acute pain in affected individuals.

How to use BUTRUM NASAL SPRAY?

Take BUTRUM NASAL SPRAY as advised by your physician. It is for inhalational use only. Blow your nose. Pull the clear cover off the pump unit. Remove the protective clip. Before the initial use, prime the unit by pumping the sprayer until a fine mist appears. Insert the spray tip approximately 1 cm into one nostril, close the other nostril with your forefinger, and pump the spray unit firmly and quickly. Your doctor will determine the correct dose and duration for you depending on your age, body weight, and disease condition.

References

1. KD Tripathi. Opioid Analgesics and Antagonists. Essentials of medical pharmacology. Seventh edition. 2013. Page 482.

2. Bethesda. Butorphanol. NIH National Library of Medicine. National Centre for Biotechnology Information. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. April 2019. [Assessed on 7th September 2022] https://www.ncbi.nlm.nih.gov/books/NBK547902/

3. Cephalon Inc. Food and Drug Administration (FDA). [Assessed on 7th September 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2002/19890s17lbl.pdf

4. AA Pharma Inc. Butorphanol Nasal Spray. [Revised in March 2015] [Assessed on 7th September 2022] https://www.aapharma.ca/downloads/en/PIL/2016/Butorphanol-PM.pdf

Author Details

Written By Dr. Dhivakaran R - BDS

Reviewed For Accuracy By Dr. Rajnikant - MBBS, MD (Physiology)

Last updated on 06 Dec 2022 | 05:17 PM(IST)