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Introduction About LEVEPSY 500MG TABLET

Levepsy 500mg Tablet is a prescription anti-epileptic medication primarily used to manage and control seizures in individuals with epilepsy. It contains levetiracetam, which works by reducing abnormal electrical activity in the brain that causes seizures. This medication is effective for various seizure types, including partial-onset seizures, myoclonic seizures, and generalized tonic-clonic seizures. By stabilizing neural activity, Levepsy helps prevent seizure episodes, improving the overall quality of life for patients.

Levepsy is ideal for adults and children over 16 years when used alone or alongside other antiepileptic drugs. It is particularly suitable for patients who require consistent seizure control with minimal drug interactions. The tablet is usually taken twice daily, with or without food, as advised by the doctor. Patients should swallow the tablet whole and maintain regular dosing times to maximize effectiveness. Missing doses or abrupt discontinuation can lead to increased seizure risk.

Important precautions include avoiding alcohol consumption during treatment, caution in patients with kidney or heart conditions, and careful use during pregnancy, where the benefits must outweigh the risks. Breastfeeding is generally not recommended due to potential side effects on the infant. Patients should not stop the medication without medical advice and should regularly consult their healthcare provider for monitoring.

Common side effects of Levepsy include drowsiness, dizziness, headache, fatigue, and mild behavioural changes such as irritability or agitation. Most side effects diminish as the body adjusts to the medication. Patients are advised to report any severe mood changes or suicidal thoughts to their doctor immediately to ensure safe and effective treatment.

Uses Of LEVEPSY 500MG TABLET

For epilepsy (seizures) management

Benefits of LEVEPSY 500MG TABLET

Levepsy 500mg Tablet for Epilepsy Management

Levepsy 500mg tablet is an effective anti-epileptic medicine formulated to help manage various types of seizures associated with epilepsy. It works by stabilizing the abnormal electrical activity in the brain, which reduces the frequency and intensity of seizure episodes. Suitable for use alone or with other medications, it supports improved quality of life by minimizing seizure-related disruptions. Consistent use as prescribed by a doctor is essential for optimal seizure control.

Levepsy 500mg Tablet for Brain Signalling Regulation

Levepsy contains levetiracetam, which modulates brain signalling by binding to synaptic vesicle protein 2A (SV2A). This action helps regulate neurotransmitter release, calming excessive electrical activity that can trigger seizures. By targeting this protein, Levepsy helps maintain balanced brain function and prevents the spread of uncontrolled neuronal bursts, making it a unique and important medication in neurological care.

Levepsy 500mg Tablet for Neurological Health Support

Levepsy 500mg tablet contributes to overall neurological health by supporting stable nerve cell activity. Its novel mechanism ensures protection against sudden surges of electrical impulses that may impair brain function. By regulating neural excitability, Levepsy aids in sustaining cognitive and motor functions, helping patients maintain everyday activities with greater confidence and safety.

How LEVEPSY 500MG TABLET Works

Mechanism of action of Levepsy 500mg tablet

Levepsy 500mg tablet works by selectively binding to the synaptic vesicle protein 2A (SV2A) in the brain. This binding modulates neurotransmitter release, helping to reduce abnormal and excessive electrical activity that leads to seizures. Unlike many anticonvulsants, Levepsy does not affect normal neuronal signalling but specifically inhibits hypersynchronized neuronal bursts. It also influences calcium channels and other neurotransmitter systems, contributing to its anticonvulsant effects. This targeted action helps control seizures effectively while maintaining normal brain function.

How to use LEVEPSY 500MG TABLET

How to Take Levepsy 500mg Tablet

Take Levepsy 500mg tablet exactly as prescribed by your doctor.
Swallow the tablet whole with a glass of water; do not crush, chew, or break it.
It can be taken with or without food but try to take it at the same times every day for consistency.
The usual dose is 500 mg twice daily, which may be adjusted by your doctor based on your response and condition.
Do not stop taking the medication suddenly without consulting your healthcare provider, as it may increase the risk of seizures.
If you miss a dose, take it as soon as you remember unless it’s almost time for the next dose; do not double the dose.
Follow all instructions given by your healthcare provider regarding dosage, timing, and duration of treatment.
Inform your doctor about all other medications and medical conditions to avoid interactions and complications.

What if I forgot to take LEVEPSY 500MG TABLET

If you forget to take a dose of Levepsy 500mg Tablet, take it as soon as you remember.
If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.
Do not take a double dose to make up for the missed one, as it may increase side effects.
Try to take the medicine at the same time every day to avoid missing future doses.
Missing doses repeatedly may reduce the effectiveness of the medicine in maintaining seizure control.
If you often forget doses, consider using reminders, alarms, or a pill organizer.
Consult your doctor if you miss multiple doses or are unsure what to do.

Overdose

If an extra dose of Levepsy 500mg tablet is accidentally taken, seek medical attention immediately by consulting your doctor or visiting the nearest hospital. Symptoms of overdose may include excessive sleepiness, increased aggression, restlessness, slowed or difficult breathing, and decreased alertness. Prompt medical care is essential to ensure safety and appropriate management.

Side Effects Of LEVEPSY 500MG TABLET

Common side effects of Levepsy 500mg tablet:

inflammation of the nose and throat, respiratory problems, cough
somnolence, headache
depression, aggression, anxiety, insomnia, nervousness, irritability
balance disorder
dizziness, tiredness
tremor (involuntary trembling), forgetfulness,
vertigo (sensation of rotation or spinning)
abdominal pain, diarrhoea, indigestion, vomiting, nausea, loss of appetite
changes in body weight
tingling and numbness
hair loss

When to Seek Medical Attention?

Stop taking this medicine and inform your doctor immediately if you experience any of the following side effects:

signs of sudden decrease of kidney function (low urine volume, tiredness, nausea, vomiting, confusion, and swelling in the legs, ankles, or feet)
signs of serious mental changes that can be symptoms of encephalopathy (confusion, sleepiness, loss of memory, forgetfulness, abnormal behaviour, involuntary or uncontrolled movements)
abnormal thoughts, feeling irritable, or reacting more aggressively
aggravation (worsening) of epilepsy

How To Manage Side Effects

Diarrhea

Maintain Hydration: Drink plenty of fluids including water, clear broths, and oral rehydration salts to replace lost fluids and electrolytes.
Eat Small, Frequent Meals: Stick to easy-to-digest foods like bananas, rice, applesauce, and toast (BRAT diet) to soothe your digestive system.
Avoid Dairy, Fatty, or Spicy Foods: These can aggravate diarrhea and should be limited until recovery.
Rest: Give your body time to heal by getting plenty of rest.
Consult a doctor if Needed: Seek medical advice if diarrhea is severe, persistent, or accompanied by fever or blood in stools.

Nausea And Vomiting

Sip Clear Fluids: Drink small sips of water, oral rehydration solution (ORS), clear broths, or herbal teas to stay hydrated.
Ginger: Ginger tea or a small piece of fresh ginger (chewed or added to warm water) may help settle the stomach.
Peppermint: Peppermint tea or inhaling peppermint oil aroma can soothe nausea
Eat Bland Foods: If you can tolerate food, choose bland options like toast, crackers, rice, or bananas (BRAT diet).
Rest in an Upright Position: Sitting up or resting with your head slightly elevated can prevent worsening nausea.
Avoid Strong Smells & Heavy Foods: Stay away from greasy, spicy, or strongly scented foods which can trigger vomiting.
Cold Compress: Placing a cool cloth on your forehead may provide some relief.

Warning & Precautions

Pregnancy

Monitoring required

Levepsy 500mg tablet should only be used in pregnant women if clearly deemed necessary by the doctor, with close medical supervision and monitoring.

Breastfeeding

Contraindicated

It is not recommended during breastfeeding due to a higher chance of side effects affecting the baby.

Driving and Using Machines

Use with Caution

Avoid driving or operating machinery if you experience drowsiness or reduced alertness after taking this medicine.

Alcohol

Contraindicated

Consult your doctor before consuming alcohol, and it is generally advised to avoid alcohol while using this medicine.

Kidney

Use with Caution

Levepsy 500mg tablet should be used cautiously in patients with kidney disease, and dose adjustments may be required under medical guidance.

Allergy

Contraindicated

Do not take this medicine if you have a known allergy to levetiracetam or any other component of the tablet.

Heart Disease

Use with Caution

Patients with a history or family history of irregular heart rhythms or heart conditions should use this medicine with caution.

Use In Pediatrics

Consult your doctor

Not recommended as monotherapy for children and adolescents under 16 years of age. However, it may be prescribed in combination with other medicines, with dosage tailored by a doctor based on age, weight, and condition.

Use In Geriatrics

Use with Caution

Elderly patients should use Levepsy 500mg tablet cautiously, strictly following the doctor’s dosing instructions.

Others

Other Warnings for LEVEPSY 500MG TABLET

Before taking this medicine, inform your doctor if you:

have salt imbalance

Safety Advice

Sudden Withdrawal: Stopping Levepsy suddenly can increase the risk of seizures. Always taper under medical supervision if your doctor advises stopping.
Medical History: Inform your doctor if you have a history of mood disorders, psychiatric illness, or kidney/liver disease before starting this medicine.
Overdose Awareness: Taking more than the prescribed dose may cause sleepiness, aggression, difficulty breathing, or fainting seek medical help immediately if this happens.
Mental Health Monitoring: Watch for mood changes, irritability, depression, or unusual behaviour and inform your doctor if they occur.
Surgery or Hospital Visits: Always inform your healthcare provider or anaesthetist that you are taking Levepsy before undergoing surgery or new treatments.

Diet and Lifestyle Advice

Diet Advice

Balanced Diet: Include fresh fruits, vegetables, whole grains, and lean proteins to support overall brain and body health.
Hydration: Drink enough water daily to prevent dehydration, especially since Levepsy is processed through the kidneys.
Limit Alcohol & Caffeine: Alcohol can worsen drowsiness and reduce seizure control; excess caffeine may trigger restlessness or sleep issues.
Avoid Skipping Meals: Sudden drops in blood sugar may sometimes trigger seizures; eat regular, balanced meals.
Nutrient-Rich Foods: Incorporate foods rich in vitamins B6, B12, folate, and magnesium, which support nervous system health.

Lifestyle Advice

Regular Sleep: Maintain a consistent sleep schedule, as lack of sleep may increase the risk of seizures.
Exercise Moderately: Engage in light to moderate physical activity (walking, yoga, stretching) to improve mood and overall well-being. Avoid overly strenuous activities without medical advice.
Stress Management: Practice relaxation techniques like meditation, deep breathing, or mindfulness, as stress may affect seizure control.
Avoid Triggers: Identify and avoid personal seizure triggers such as flashing lights, stress, or overexertion.
Safe Environment: If you are prone to seizures, ensure your surroundings are safe (avoid swimming alone, use protective gear if cycling, and inform close ones about your condition).
Routine Follow-ups: Regularly consult your doctor for dose adjustments and monitoring of side effects.

1. Levepsy 500mg Tablet vs Carbamazepine in controlling seizure episodes

Feature	Levepsy 500mg Tablet (Levetiracetam)	Carbamazepine
Effectiveness	Effective for a wide range of seizure types, including partial and generalized seizures.	Primarily effective for partial and some generalized seizures, but less broad in coverage.
Onset of Action	Shows good seizure control relatively quickly after starting treatment.	Effective but may take longer to achieve stable control due to dose adjustments.
Tolerability	Well tolerated, with fewer long-term organ-related side effects.	May cause dizziness, drowsiness, or unsteadiness more commonly.
Drug Interactions	Has fewer drug interactions, making it safer with multiple medications.	Interacts with many other medicines due to its enzyme-inducing effect.
Monitoring	Minimal monitoring needed except for kidney function.	Requires regular blood tests to monitor blood counts and liver function.
Suitability	Often preferred for patients with multiple health issues or those on many medications.	Preferred in specific seizure types but less suitable for patients with multiple comorbidities.

2. Levepsy 500mg Tablet vs Sodium Valproate

Feature	Levepsy 500mg Tablet (Levetiracetam)	Sodium Valproate
Seizure Coverage	Effective for partial, generalized, and myoclonic seizures.	Effective for a wide range of seizures, including absence, generalized, and myoclonic seizures.
Tolerability	Generally, well tolerated with fewer long-term organ-related side effects.	May cause weight gain, hair loss, tremors, and liver issues in some patients.
Cognitive Effects	Minimal impact on memory or concentration.	May cause drowsiness, confusion, or cognitive slowing in some individuals.
Drug Interactions	Fewer interactions with other medicines.	Can interact with multiple drugs, including blood thinners and other anticonvulsants.
Monitoring	Periodic kidney function check is sufficient in most cases.	Requires regular liver function tests and blood count monitoring.
Pregnancy Safety	Considered safer in terms of organ toxicity; consult doctor before use.	Higher risk of birth defects; often avoided in pregnancy unless necessary.

Drug - Drug interaction

1. Other Anti-Seizure Medicines (e.g., Phenytoin, Carbamazepine, Valproate)

Interaction: Levetiracetam does not significantly change blood levels of most other anti-seizure drugs, but combining multiple anti-seizure medicines may increase side effects like dizziness, drowsiness, or fatigue.
Management: Your doctor may monitor for side effects and adjust doses of each medicine as needed.

2. Sedatives or Sleep Medications (e.g., Benzodiazepines, Zolpidem)

Interaction: Combining with sedatives may enhance drowsiness, dizziness, or lack of coordination.
Management: Avoid driving or operating machinery. Your doctor may adjust timing or dose of either medication.

3. Antidepressants or Antipsychotics (e.g., SSRIs, Lithium, Risperidone)

Interaction: May increase the risk of mood changes, irritability, or other neuropsychiatric effects.
Management: Your doctor will monitor mood and behavior closely. Dose adjustments may be needed.

4. Painkillers (e.g., Opioids, Tramadol)

Interaction: May increase dizziness, drowsiness, or risk of sedation when taken together.
Management: Take with caution, avoid driving, and consult your doctor before starting new pain medications.

5. Other Kidney-Processed Drugs

Interaction: Levepsy is primarily eliminated through the kidneys. Drugs that affect kidney function may alter levetiracetam levels.
Management: Your doctor may adjust the dose and monitor kidney function regularly.

Drug - Food interaction

1. Caffeine (Coffee, Tea, Energy Drinks)

Interaction: Excess caffeine may worsen nervousness, irritability, or insomnia, which can indirectly affect seizure control.
Management: Limit caffeine intake and monitor how it affects your sleep and mood.

2. High-Sugar or High-Fat Meals

Interaction: Large, heavy meals may delay absorption slightly, which rarely affects overall seizure control but may cause mild stomach discomfort.
Management: Take the tablet with a light meal or snack if you experience stomach upset.

3. Herbal Supplements (e.g., St. John’s Wort, Ginkgo Biloba)

Interaction: Some herbal products may interfere with seizure control or increase side effects such as dizziness or drowsiness.
Management: Always inform your doctor before using herbal supplements to ensure safety.

4. Grapefruit and Grapefruit Juice

Interaction: Unlike many other anti-seizure medicines, levetiracetam is not significantly affected by grapefruit. No major interaction has been reported.
Management: Grapefruit can be consumed safely but always discuss with your doctor if you take multiple medications.

Synopsis

Drug	:	Levetiracetam
Pharmacological Category	:	Anticonvulsants
Therapeutic Indication	:	Epilepsy
Dosage Forms	:	Tablet, Injection, Infusion, Syrup, Suspension, Oral Suspension, Solution

More Information

FAQs About LEVEPSY 500MG TABLET

Q: What is Levepsy 500mg Tablet used for?

A: Levepsy 500mg contains levetiracetam, which helps control seizures in epilepsy. It works by stabilizing electrical activity in the brain. It is commonly prescribed for partial onset, generalized, and myoclonic seizures. It does not cure epilepsy but helps reduce the frequency and severity of seizures. Always take it under your doctor’s guidance.

Q: Can I stop Levepsy suddenly?

A: No, do not stop Levepsy suddenly, as it may trigger seizures. If your doctor wants to stop or change the dose, they will reduce it gradually. Always follow your doctor’s instructions when adjusting doses.

Q: What are the common side effects of Levepsy 500mg Tablet?

A: Some common side effects include drowsiness, dizziness, headache, fatigue, or irritability. Most are mild and may reduce over time. Contact your doctor if side effects are severe or persistent.

Q: Can Levepsy affect my mood?

A: Yes, it can sometimes cause irritability, anxiety, or depression. Inform your doctor if you notice unusual mood changes or thoughts of self-harm. Monitoring is important for mental health while on this medicine.

Q: Does Levepsy interact with other medicines?

A: Levepsy has fewer drug interactions than many anti-seizure medicines. Still, inform your doctor about all medicines, supplements, and herbal products you take. This helps prevent unwanted effects or reduced effectiveness.

Q: Do I need regular tests while on Levepsy?

A: Most patients need minimal monitoring. Your doctor may occasionally check kidney function or overall health. Regular follow-up visits ensure the medicine is working safely.

Q: Can Levepsy cause allergic reactions?

A: Although rare, allergic reactions like rash, itching, swelling, or difficulty breathing can occur. Seek immediate medical attention if you experience these symptoms.

Q: How long does Levepsy 500mg Tablet take to work?

A: Levepsy starts working within a few days, but full seizure control may take weeks. Continue taking it regularly and do not adjust the dose on your own.

Q: Can I take Levepsy 500mg Tablet with food?

A: Yes, Levepsy can be taken with or without food. Taking it with meals may reduce mild stomach upset.

Q: Can Levepsy 500mg Tablet cause weight changes?

A: Levepsy is less likely to cause weight gain compared to some other anti-seizure medicines. Maintain a balanced diet and regular exercise for overall health.

Q: Can I take Levepsy 500mg Tablet for long-term?

A: Yes, many patients take Levepsy long-term to control seizures. Regular follow-up ensures effectiveness and safety. Never stop the medicine without your doctor’s advice.

Q: Does Levepsy 500mg Tablet affect my sleep?

A: Some patients may feel drowsy or fatigued. Others may experience insomnia. Adjusting timing or dose with your doctor can help manage sleep changes.

Q: Are there lifestyle changes needed while on Levepsy?

A: Maintain a healthy diet, stay hydrated, get regular sleep, and avoid seizure triggers. Light exercise is encouraged but avoid risky activities if seizures are uncontrolled.

Q: Can Levepsy be combined with other anti-seizure medicines?

A: Yes, it is often used with other anti-seizure drugs for better control. Your doctor will adjust doses to minimize side effects and maximize effectiveness.

Q: When should I contact my doctor while taking Levepsy?

A: Contact your doctor if you experience severe side effects, mood changes, new or worsening seizures, or signs of an allergic reaction. Timely consultation ensures safety and proper seizure management.

References

1. K.D. Tripathi. Antiepileptic Drugs. Essentials of Medical Pharmacology. Seventh Edition. 2013. Page – 420.

2. Bassel Abou-Khalil. Levetiracetam in the treatment of epilepsy. NIH National Library of Medicine, National Centre for Biotechnology Information. PubMed Central. [Revised in June 2008]. [Accessed on 9th October 2025]

3. Pfizer Healthcare. Levetiracetam 500 mg Tablets. Health Products Regulatory Authority (HPRA). [Revised in 5th December 2011] [Accessed on 9th October 2025]

Useful Diagnostic Tests

Author Details

Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)

Reviewed For Accuracy By Dr. Sankara Babu Gorle - MBBS, MD (Pharmacology)

Last updated on 09 Oct 2025 | 03:54 PM(IST)