Zyncet D Tablet 10'S

INTRODUCTION

ZYNCET D TABLET is a combination of Cetirizine and Phenylephrine which belongs to the group of medicines called Anti-allergics and Nasal Decongestants respectively. It is indicated for the relief of symptoms of nasal congestion and allergic rhinitis.

ZYNCET D TABLET is not recommended for use in patients with coronary artery disease, impaired liver function and severely increased blood pressure. ZYNCET D TABLET should be used with caution in patients who have spinal cord lesion, prostatic hyperplasia (enlarged prostate), epilepsy and Raynaud’s syndrome.

ZYNCET D TABLET should be used with caution in pregnant women only if advised by the doctor and it is not recommended for use in breast feeding women. This medicine is not recommended for use in children (below 12 years of age).

The side effects of taking ZYNCET D TABLET are diarrhea, general discomfort, abnormal physical weakness, rash and itching. Talk with your doctor if any of the symptoms worsen or does not improve.    

USES OF ZYNCET D TABLET

• Relieves symptoms of nasal congestion and allergic rhinitis

HOW ZYNCET D TABLET WORKS

ZYNCET D TABLET helps in relieving the symptoms of nasal congestion and allergic rhinitis where Cetirizine is a H1 receptor antagonist that works by blocking the action of a chemical messenger (histamine) responsible for runny nose, watery eyes and sneezing. It also has an anti-inflammatory action. Phenylephrine is a decongestant which acts by narrowing the small blood vessels providing temporary relief from congestion or stuffiness in the nose.

DIRECTIONS FOR USE

Always take ZYNCET D TABLET as directed by your physician. Take this medicine with or without food, swallow the medicine as a whole and do not crush or chew the medicine. Your doctor will decide the correct dose and duration of ZYNCET D TABLET for you depending upon your age, body weight and disease condition. Do not stop taking ZYNCET D TABLET without informing your doctor.  

SIDE EFFECTS OF ZYNCET D TABLET

HOW TO MANAGE SIDE EFFECTS

Diarrhoea:

Drink lot of fluids such as water or fruit juice to keep yourself hydrated. Do not consume any medicine on your own without consulting your doctor. Consult your doctor if the symptom does not improve.

Skin itching:

Avoid hot showers because hot water can irritate your skin further. Do not scratch the affected area. Avoid sun exposure or UV rays as it may sensitize your skin. Use sunscreen and protective clothing when going outdoor. Regularly moisturize your skin after consulting the doctor. Consult your doctor if the symptom does not improve.

WARNING & PRECAUTIONS

PREGNANCY

ZYNCET D TABLET should be used with caution in pregnant women only if considered clearly necessary. Consult with your doctor for advice before taking ZYNCET D TABLET.

BREASTFEEDING

ZYNCET D TABLET is not recommended for use in breast-feeding women as it passes through the breast milk. Consult with your doctor for advice before taking ZYNCET D TABLET.

ALCOHOL

Consumption of alcohol is not recommended during treatment with ZYNCET D TABLET.

KIDNEY

Dose adjustment of ZYNCET D TABLET is needed in patients having moderate or severe kidney disease. Consult with your doctor for advice before taking ZYNCET D TABLET.

LIVER

ZYNCET D TABLET is not recommended for use in patients with liver dysfunction. Consult with your doctor for advice before taking ZYNCET D TABLET.

ALLERGY

Do not take ZYNCET D TABLET if you are allergic to Cetirizine and Phenylephrine or hydroxyzine.

HEART DISEASE

ZYNCET D TABLET is not recommended for use in patients having heart diseases such as coronary artery disease (disease of the major blood vessels of the heart). Consult with your doctor for advice before taking ZYNCET D TABLET.

INTERACTIONS

A. Drug–Drug Interactions:

Before taking ZYNCET D TABLET inform to your doctor, if you are taking any of these medicines:

• monoamine oxidase inhibitors such as isocarboxazid, tricyclic antidepressants such as amitriptyline, nortriptyline (used to treat depression)
• digoxin, vasodilators such as hydralazine, minoxidil, beta blockers such as propranolol (used to treat heart problems)
• pseudoephedrine, sympathomimetic amines such as xylometazoline (used to relieve nasal congestion)
• theophylline (used to treat asthma)

Overdosage:

If you or anyone else accidentally take too much of ZYNCET D TABLET, consult your doctor immediately or visit the nearby hospital. Overdosage symptoms of ZYNCET D TABLET includes irritability, restlessness, palpitations, high blood pressure, difficulty in urination, nausea, vomiting, thirst, convulsions, confusion, diarrhoea, dizziness, tiredness, headache, general discomfort, dilated pupils, itching, sedation, sleepiness, altered consciousness, fast heart rate, tremor and urinary retention.

SYNOPSIS

MORE INFORMATION

• Keep ZYNCET D TABLET out of reach of children
• Store at room temperature

FAQs ABOUT ZYNCET D TABLET

What is ZYNCET D TABLET and why is it given?

ZYNCET D TABLET is a combination of Cetirizine and Phenylephrine which belongs to the group of medicines called Anti-allergics and Nasal Decongestants. It is indicated for the relief of symptoms of nasal congestion and allergic rhinitis.

Can ZYNCET D TABLET be given to pregnant and breast-feeding women?

ZYNCET D TABLET should be used with caution in pregnant women only if considered clearly necessary. It is not recommended for use in breast-feeding women as it passes through the breast milk. Consult with your doctor for advice before taking ZYNCET D TABLET.

Is ZYNCET D TABLET safe to use in children?

ZYNCET D TABLET should not be used in children below 12 years of age as it does not allow for appropriate dose adaptation. Consult with your child’s doctor for advice before administration of ZYNCET D TABLET to your child.

How does ZYNCET D TABLET work?

ZYNCET D TABLET helps in relieving the symptoms of nasal congestion and allergic rhinitis where Cetirizine is a H1 receptor antagonist that works by blocking the action of a chemical messenger (histamine) responsible for runny nose, watery eyes and sneezing. It also has an anti-inflammatory action. Phenylephrine is a decongestant which acts by narrowing the small blood vessels providing temporary relief from congestion or stuffiness in the nose.

What to do If I forget to take ZYNCET D TABLET?

You should take ZYNCET D TABLET immediately when you remember. If it is time for your next dose skip the dose and follow your regular dose schedule. Do not double the dose to match up your missed dose.

REFERENCES

1. KD. Tripathi. Autacoids and Related Drugs, Adrenergic System and Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 166 & 135.

2. Evan Richards; Michael J. Lopez; Christopher V. Maani. NIH National Library of Medicine, National center for biotechnology information. Bookshelf. Phenylephrine. May 2022. [Accessed on 20th June 2022] https://www.ncbi.nlm.nih.gov/books/NBK534801/

3. Aasim Naqvi; Valerie Gerriets. NIH National Library of Medicine, National center for biotechnology information. Bookshelf. Cetirizine. November 2021. [Accessed on 20th June 2022] https://www.ncbi.nlm.nih.gov/books/NBK549776/

4. N Hutton, M H Wilson, E D Mellits, R Baumgardner, L S Wissow, C Bonuccelli, N A Holtzman, C DeAngelis. Effectiveness of an antihistamine-decongestant combination for young children with the common cold: a randomized, controlled clinical trial. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. January 1991. [Accessed on 20th June 2022] https://pubmed.ncbi.nlm.nih.gov/1670783/

5. Eli O Meltzer, Fernan Caballero, Leonard M Fromer, John H Krouse, Glenis Scadding. Treatment of congestion in upper respiratory diseases. NIH National Library of Medicine, National center for biotechnology information. Pubmed central. April 2010. [Accessed on 20th June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866555/

6. Dexcel Pharma Ltd. Electronic Medicines Compendium (EMC). [Revised in June 2019]. [Accessed on 20th June 2022] https://www.medicines.org.uk/emc/files/pil.8399.pdf

7. Phenylephrine hydrochloride tablet. DailyMed; National Library of Medicine; National Institute of Health. [Revised in March 2014]. [Accessed on 20th June 2022] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8eec9d31-5f60-49bb-a427-e8163c9c8078

8. Cipla Ltd. Alerid D Tablets. Ciplamed (Cetirizine hydrochloride + Phenylephrine hydrochloride). Ciplamed [Revised in November 2013]. [Accessed on 20th June 2022] https://www.ciplamed.com/content/alerid-d-tablets

AUTHOR DETAILS

Written By Dr. R. Dinesh John Rajkumar, Pharm.D
Last updated on 12 Dec 2022 | 06:10 PM(IST)