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Introduction About ZYLULI CREAM
ZYLULI CREAM is used in the management of various fungal infections such as tinea pedis (fungal infection between the toes), tinea cruris (red and itchy rash in the warm and moist areas of the body), and tinea corporis (ringworm fungal infection).
It contains a medicine called Luliconazole, which belongs to the group of medicines called Topical Antifungal agents. It works by stopping the growth of the fungus causing these infections.
ZYLULI CREAM is not recommended for use by pregnant and breastfeeding women unless considered clearly necessary. It is not recommended for use in children 12 years of age and below unless clearly necessary. This medicine should be used with caution in elderly patients (aged 65 years or older).
Avoid applying ZYLULI CREAM to the eyes, mouth, or vaginal region. The most common side effects of this medicine are application site reactions such as irritation, itching, and stinging. Contact your physician if any of the symptoms worsen.
Uses Of ZYLULI CREAM
ZYLULI CREAM is used to manage various fungal infections such as:
How ZYLULI CREAM Works
ZYLULI CREAM works by damaging the cell membranes of the fungus (essential for the survival of the fungus as they manage the entry of unwanted substances into the cells and stop the leakage of cell contents) and works against the fungi. As a result, ZYLULI CREAM relieves discomfort, itching and irritation on the skin.
How to use ZYLULI CREAM
- Apply this medicine as directed by your physician.
- It is for external use only.
- Clean and dry the skin to be managed.
- Wash your hands with soap and water and apply a thin layer of the medicine to the affected area of the skin and rub it gently.
- Avoid contact with the eyes, mouth, or vaginal area.
- Do not cover, wrap, or bandage the skin unless directed by the doctor.
Overdose
If you or anyone else accidentally use too much of ZYLULI CREAM or if you or a child accidentally swallow the medicine, consult your doctor immediately or visit the nearby hospital.
Side Effects Of ZYLULI CREAM
Common Side Effects of ZYLULI CREAM:
- Application site reactions such as irritation, itching, and stinging
Stop taking ZYLULI CREAM and contact your doctor immediately if you experience any of the following side effects:
- Allergic reaction (symptoms like skin rash, itching or hives, swelling of the face, lips, or tongue)
- Increased inflammation
- Redness and pain
Warning & Precautions
Pregnancy
ContraindicatedZYLULI CREAM is generally not recommended for use in pregnant women unless considered necessary.
Breastfeeding
ContraindicatedZYLULI CREAM is generally not recommended for use in breastfeeding women as it may pass through breast milk.
Allergy
ContraindicatedDo not take ZYLULI CREAM if you are allergic to luliconazole or any of the other ingredients of this medicine.
Use In Pediatrics
Consult your doctorZYLULI CREAM is generally not recommended to use in children under 12 years of age unless clearly necessary.
Use In Geriatrics
Use with CautionZYLULI CREAM should be used with caution in elderly patients (above 65 years of age).
Drug - Drug interaction
Tell your doctor if you are applying or have recently taken any other medicines, including medicines obtained without a prescription, vitamin supplements, or herbal products.
Synopsis
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Drug |
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Pharmacological Category |
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Topical Antifungals |
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Therapeutic Indication |
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Dosage Forms |
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Cream, Gel, Lotion, Ointment, Spray, Soap, Dusting Powder |
FAQs About ZYLULI CREAM
Q: Can I use ZYLULI CREAM in children?
A: No. ZYLULI CREAM is not recommended for use in children 12 years of age and below unless clearly necessary. Contact your doctor before applying it.
Q: How to apply ZYLULI CREAM?
A: Apply ZYLULI CREAM as directed by your physician. It is for external use only. Clean and dry the skin to be managed. Wash your hands with soap and water, and apply a thin layer of the medicine to the affected area of the skin and rub it gently. Avoid contact with the eyes, mouth, or vaginal area. Do not cover, wrap, or bandage the skin unless directed by the doctor.
Q: When to seek medical emergency while using ZYLULI CREAM?
A: Stop taking ZYLULI CREAM and contact your doctor immediately if you experience an allergic reaction (symptoms like skin rash, itching or hives, swelling of the face, lips, or tongue), increased inflammation, redness, and pain.
Q: How does ZYLULI CREAM work?
A: ZYLULI CREAM works by causing holes in the cell membranes of the fungus (essential for the survival of the fungus as they manage the entry of unwanted substances into the cells and stop the leakage of cell contents) and killing fungi. In this way, Luliconazole relieves discomfort, itching, and irritation on the skin.
Q: What is the use of ZYLULI CREAM?
A: ZYLULI CREAM is used in the management of various fungal infections such as tinea pedis (athlete's foot), tinea cruris (jock itch), and tinea corporis (ringworm). Please consult your physician before using ZYLULI CREAM.
Q: Is it safe to take ZYLULI CREAM in pregnant and breastfeeding women?
A: ZYLULI CREAM is not recommended for use among women who are pregnant and breastfeeding unless considered necessary. Please consult your physician before using ZYLULI CREAM.
Q: What are the common side effects of ZYLULI CREAM?
A: The most common side effects of this medicine are application site reactions such as irritation, itching, and stinging. Contact your physician if any of the symptoms worsen.
Q: Who should avoid using ZYLULI CREAM?
A: Do not take ZYLULI CREAM if you are allergic to luliconazole or any of the other ingredients of this medicine.
Q: What precautions must be taken while using ZYLULI CREAM?
A: Before using ZYLULI CREAM, inform your doctor if you have liver, kidney, heart disease, or any other pre-existing conditions; avoid contact with the eyes; and do not use it on open wounds unless advised by your physician.
Q: How long should I use ZYLULI CREAM?
A: The duration of use depends on the type and severity of the fungal infection. Follow your doctor's instructions, and don’t stop using the cream even if symptoms improve without consulting a doctor.
References
1. P. David Rogers and Damian J. Krysan. Antifungal Agents. Goodman & Gilman’s: The Pharmacological Basics of Therapeutics. 13th Edition. New York McGraw Hill Medical 2018. Page – 1087-1104.
2. Deepshikha Khanna and Subhash Bharti. Luliconazole for the treatment of fungal infections: an evidence-based review. Journal of Core Evidence. September 2014 [Accessed on 22nd April 2026] 
3. Manjot Kaur, Guru Nanak Dev, Kanwardeep Singh, and Subheet Kumar Jain. Luliconazole vesicular-based gel formulations for its enhanced topical delivery. Journal of Liposome Research. October 2019. [Accessed on 22nd April 2026] 
4. Hiroyasu Koga, Yasuko Nanjoh, Koichi Makimura, Ryoji Tsuboi. In vitro antifungal activities of luliconazole, a new topical imidazole. Journal of Medical Mycology. September 2009. [Accessed on 22nd April 2026]
5. Medicis Pharmaceuticals. US Food and Drug Administration. [Revised in November 2013] [Accessed on 22nd April 2026]
6. Bausch Health Companies Inc. Luliconazole. [Revised in April 2020] [Accessed on 22nd April 2026]
7. DM Pharma. Luliconazole. [Accessed on 22nd April 2026]
8. Glamris Derma care. Luliconazole. [Accessed on 22nd April 2026]