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Introduction About ZYLORIC 300MG TABLET
ZYLORIC 300MG TABLET contains Allopurinol which belongs to a group of medicines called Enzyme inhibitors. It is used to manage gout, kidney stones, enzyme disorders (Lesch-Nyhan Syndrome), and high levels of uric acid caused by certain cancer medications.
Gout is a form of arthritis due to high levels of uric acid in the body and this uric acid builds up in the joints and tendons as crystals causing severe pain, redness and tenderness in joints.
Before taking ZYLORIC 300MG TABLET, inform your doctor if you have kidney or liver problems, high blood pressure or heart problems, thyroid, cancer or Lesch-Nyhan syndrome, gout attack, lactose or galactose intolerance and glucose-galactose malabsorption.
ZYLORIC 300MG TABLET should be used with caution in pregnant women and it is not recommended for use in breastfeeding women as it passes through the breast milk. Consult your doctor before taking it.
ZYLORIC 300MG TABLET is not recommended for use in children below children under 15 years of age except in some types of cancer such as leukaemia and certain enzyme disorders such as Lesch-Nyhan syndrome. ZYLORIC 300MG TABLET should be used with caution in elderly patients above 65years of age. Consult your doctor before taking it.
The most common side effects of taking ZYLORIC 300MG TABLET are skin rash and increased levels of thyroid stimulation hormone in blood. Consult with your doctor if any of these worsens or doesn’t improve.
Uses Of ZYLORIC 300MG TABLET
Manages,
- gout
- kidney stones formation
- certain types of kidney diseases
- some types of cancer (especially leukemia)
- Lesch-Nyhan syndrome
How ZYLORIC 300MG TABLET Works
ZYLORIC 300MG TABLET works by stopping the enzyme (xanthine oxidase) which is responsible for production of uric acid. Thus lowering the levels of uric acid in blood and urine and decreases the incidence of gout symptoms.
How to use ZYLORIC 300MG TABLET
Take ZYLORIC 300MG TABLET as advised by your physician. Swallow the medicines with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of ZYLORIC 300MG TABLET
Common
- skin rash
- increased thyroid-stimulating hormone levels in the blood.
Uncommon
- nausea, vomiting
- diarrhoea
- abdominal pain
- abnormal liver tests
Rare
- liver problems (liver inflammation, jaundice)
Stop taking ZYLORIC 300MG TABLET and contact your doctor immediately if you experience any of the following side effects:
- allergic reaction symptoms such as flaking skin, boils or sore lips and mouth, sudden wheeziness, fluttering or tightness in the chest and collapse
- serious hypersensitivity reactions characterised by fever, joint pain, abnormalities in blood, bleeding in the lips, mouth, eyes, nose or genitals, ulcers of the mouth, throat, nose, genitals, conjunctivitis (red and swollen eyes), widespread blisters or peeling
How To Manage Side Effects
Itchy rash:
Avoid hot showers because hot water can irritate the skin. Do not scratch the affected area. Use sunscreen and protective clothing when outdoors. Regularly use moisturizer to soothe and hydrate the affected area. If the symptom does not improve, contact your doctor.
Nausea or vomiting:
Try to take this medicine with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. If the symptom does not improve, contact your doctor.
Diarrhoea:
Drink lots of fluids, such as water or fruit juices to keep you hydrated. Do not take any medicine on your own for managing diarrhea. Contact your doctor if the symptom did not improve.
Stomach pain:
Rest and relax. Eat and drink slowly or try to have smaller meals. Keep a heat pad on your stomach. Do not self-manage and contact your doctor if the symptom did not improve.
Warning & Precautions
Pregnancy
ZYLORIC 300MG TABLET should be used with caution in pregnant women. Consult with your doctor before taking.
Breastfeeding
ZYLORIC 300MG TABLET is not recommended for use in breastfeeding women as it passes through the breast milk. Consult your doctor before taking it.
Driving and Using Machines
Do not drive or operate any machines if you feel drowsy, giddy or have problems with co-ordination after taking ZYLORIC 300MG TABLET.
Kidney
ZYLORIC 300MG TABLET should be used with caution in patients with kidney problems. Consult your doctor before taking.
Liver
ZYLORIC 300MG TABLET should be used with caution in patients with liver problems. Consult your doctor before taking.
Allergy
Do not take ZYLORIC 300MG TABLET if you are allergic to Allopurinol or any other ingredients of this medicine.
Heart Disease
ZYLORIC 300MG TABLET should be used with caution in patients with heart problems. Consult your doctor before taking.
Others
Before taking ZYLORIC 300MG TABLET inform your doctor if you have:
- Lesch-Nyhan syndrome
- thyroid problems
- high blood pressure
- an acute attack of gout
- cancer (especially leukaemia)
- intolerance to some sugars
Use in paediatrics:
ZYLORIC 300MG TABLET is not recommended in children below 15 years of age except in some types of cancer (leukaemia) and certain enzyme disorders such as Lesch-Nyhan syndrome. Consult with your child’s doctor before giving it to your child.
Use in geriatrics:
ZYLORIC 300MG TABLET should be used with caution in elderly patients (aged above 65 years). Consult your doctor before taking.
Interactions
A. Drug - Drug interactions:
Before taking ZYLORIC 300MG TABLET, inform your doctor if you are taking any of the following medicine:
- aspirin (medicine used to manage heart diseases, pain)
- theophylline (medicine used for asthma and breathing disorders)
- medicines used to manage epilepsy (Ex. phenytoin, carbamazepine).
- vidarabine (used to manage herpes simplex or chicken pox)
- medicines used to manage bacterial infections (Ex. ampicillin and amoxicillin)
- didanosine (used to manage HIV infection)
- medicines used to manage diabetes (Ex. chlorpropamide and tolbutamide)
- cytostatics (medicines stop the cell growth in cancer). Ex. cyclophosphamide, doxorubicin, bleomycin, procarbazine, alkyl halogenides
- azathioprine (medicines used for rheumatoid arthritis and after organ transplants)
- medicines used to manage high blood pressure, heart failure (Ex. captopril)
- medicines used to thin the blood (Ex. dicoumarol, phenprocoumon, and warfarin)
- medicines used to reduce uric acid levels, gout (Ex. probenecid, salicylate).
- aluminium hydroxide (medicines used to manage acidity)
Overdosage:
If you or anyone else accidentally take too much of ZYLORIC 300MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are nausea, vomiting, diarrhoea and dizziness.
Synopsis
| Drug | : | Allopurinol |
| Pharmacological Category | : | Xanthine Oxidase Inhibitor |
| Therapeutic Indication | : | Gout, Kidney stones, Leukaemia, Lesch-Nyhan syndrome |
| Dosage Forms | : | Tablet, Capsule |
More Information
- Keep ZYLORIC 300MG TABLET out of the sight and reach of children
- Store ZYLORIC 300MG TABLET below 25°C
FAQs About ZYLORIC 300MG TABLET
How ZYLORIC 300MG TABLET works?
ZYLORIC 300MG TABLET works by stopping the enzyme (xanthine oxidase) which is responsible for production of uric acid. Thus, lowering the levels of uric acid in blood and urine and decreases the incidence of gout symptoms.
Does ZYLORIC 300MG TABLET affect kidney?
Yes. ZYLORIC 300MG TABLET might affect the kidney. Inform your doctor priorly if you have any kidney diseases or are on dialysis. Your doctor might consider adjusting the dose of ZYLORIC 300MG TABLET for you. Consult your doctor before taking
What happens if I suddenly stop taking ZYLORIC 300MG TABLET?
Do not stop ZYLORIC 300MG TABLET unless you told by doctor. If you stop taking ZYLORIC 300MG TABLET suddenly, there is a high risk of gout attack or you will get serious side effects. Consult your doctor before stopping.
Can ZYLORIC 300MG TABLET cause joint pain?
Yes. ZYLORIC 300MG TABLET can cause joint pain. But it is a rare side effect. If you develop any of these symptoms stop the medication and contact your healthcare provide.
Does ZYLORIC 300MG TABLET affect my ability to drive?
Do not drive or operate any machines if you feel drowsy, giddy or have problems with co-ordination after taking ZYLORIC 300MG TABLET. You can resume with your activities after you feel normal again.
If I am having a gout attack, will an extra dose of ZYLORIC 300MG TABLET help me?
No. ZYLORIC 300MG TABLET is not a pain reliever and does not show its effect immediately. If you have an attack of gout while taking ZYLORIC 300MG TABLET, keep taking it at the same dose. Do not stop taking it. Your doctor may advise you to take a pain reliever medicine You can also apply icepacks or cold compress and rest the affected joint, to reduce pain. See your doctor if the pain and inflammation does not show improvement in 24 hours.
References
1. K.D.Tripathi. Ant rheumatoid and antigout drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page - 216.
2. NIH National Library of Medicine, National center for biotechnology information. Allopurinol. Statpearls. [Accessed on 23rd April 2022]. https://www.ncbi.nlm.nih.gov/books/NBK499942/
3. Proudman, C., Lester, S.E., Gonzalez-Chica, D.A. et al. Gout, flares, and allopurinol use: a population-based study. Biomed Central. Springer Link. May 2019. [Accessed on 23rd April 2022]. https://arthritis-research.biomedcentral.com/articles/10.1186/s13075-019-1918-7
4. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised on December 2021] [Accessed on 23rd April 2022]. https://www.medicines.org.uk/emc/files/pil.6006.pdf
5. Elara Pharmaservices Ltd. Allopurinol Tablets. [Revised in March 2022]. [Accessed on 23rd April 2022]. https://www.zistapharma.com/downloadmedia.aspx?e=ProdDoc&ID=4&ProdName=Allopurinol%20Tablets&inline=1
6. Inga Laboratories. Logout – SR (Allopurinol). [Accessed on 23rd April 2022]. https://ingalabs.com/product-logout-sr-tablets.html
7. Drug Bank. Allopurinol. [Accessed on 23rd April 2022]. https://go.drugbank.com/drugs/DB00437
Useful Diagnostic Tests
- Creatinine Levels
- Uric acid
- Kidney Function Tests
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