Zyloric 100mg Tablet 10'S

Introduction About ZYLORIC 100MG TABLET

Zyloric 100mg tablet is an effective management for lowering uric acid levels in the body and reducing gout flare-ups and kidney stones. It is commonly prescribed to individuals with hyperuricemia (high uric acid levels).

Zyloric 100mg tablet should be taken after meals. Continue taking the medication as prescribed by your doctor, even when you are not experiencing a gout attack. Stopping the medication could worsen your symptoms, as it may lead to more crystals forming in your joints and kidneys. Additionally, you can support your management by making dietary changes and staying well-hydrated.

Common side effect of this medication includes nausea, dizziness, stomach pain, diarrhea, increased serum glutamic oxaloacetic transaminase, serum glutamate pyruvate transaminase, and increased alkaline phosphatase. Your doctor can assist in finding ways to reduce these symptoms. In some cases, a severe allergic reaction may occur, requiring immediate medical attention. Contact your doctor immediately if you experience symptoms of liver disease, such as persistent nausea, yellowing of the skin or eyes, or dark urine.

To ensure this medicine is safe for you, inform your doctor if you have or have had heart failure, heart issues, stroke, kidney or liver disease, or thyroid problems. Do not take this medicine if you are pregnant or breastfeeding. Regular blood tests will be required to monitor your liver function.

Uses Of ZYLORIC 100MG TABLET

• Gout
• Hyperuricemia

Benefits of ZYLORIC 100MG TABLET

01)Manage and reduce gout attacks: Zyloric is primarily used to manage gout, a form of arthritis caused by the buildup of uric acid crystals in the joints. Allopurinol (the active ingredient) helps reduce gout attacks by reducing the production of uric acid, which is responsible for the painful symptoms.

02)Reduces uric acid levels in the blood: Allopurinol works by inhibiting the enzyme xanthine oxidase, which plays a key role in producing uric acid. By lowering the levels of uric acid in the blood, it reduces the risk of uric acid crystals forming in the joints or kidneys, which can lead to gout attacks and kidney stones.

03)Helps reduce kidney stone formation: High levels of uric acid can lead to the formation of kidney stones. Zyloric helps in reducing these stones by controlling uric acid levels, especially in individuals prone to uric acid-based kidney stones. By reducing crystal formation, it can reduce the likelihood of kidney stone development.

04)Available in a convenient 100mg dosage form: The 100mg dosage of Zyloric is commonly prescribed, providing a convenient and controlled method of managing uric acid levels. The tablet form allows for easy dosing, which is important for consistent management in conditions like gout or hyperuricemia.

How ZYLORIC 100MG TABLET Works

Zyloric 100mg tablet contains allopurinol, which works by inhibiting the enzyme xanthine oxidase, responsible for converting purines into uric acid. By reducing the production of uric acid, Zyloric lowers its levels in the blood, helping to reduce the formation of uric acid crystals in the joints (which cause gout) and in the kidneys (which can lead to kidney stones). This helps reduce the frequency of gout attacks and lowers the risk of developing kidney stones, making it an effective management for hyperuricemia (high uric acid levels) associated with gout and other conditions.

How to use ZYLORIC 100MG TABLET

Follow your doctor's instructions regarding the exact dosage. Do not exceed the recommended daily dosage. It is important to follow the prescribed dosage for optimal results. Never adjust the dosage without your doctor’s approval. If you feel the medication is not working or experience side effects, consult your doctor immediately.

How to Take Zyloric 100mg Tablet?

• Take one tablet daily with or without food.
• Swallow the tablet whole with a glass of water. Do not crush or chew the medication.
• For best results, take the tablet at the same time each day.
• It is important to stay hydrated, so make sure to drink plenty of water throughout the day to reduce kidney stones and ensure the medication works effectively.

What if I forgot to take ZYLORIC 100MG TABLET

1. Take it as soon as you remember: If you realize you have missed a dose and it is not yet time for your next dose, take the missed dose as soon as you remember.
2. Skip the missed dose if it is almost time for the next dose: If it is almost time for your next dose, skip the missed dose. Do not take two doses at the same time to make up for a missed dose.
3. Consult your doctor: If you miss doses frequently or are unsure what to do, it is a good idea to check with your doctor for further guidance.

Side Effects Of ZYLORIC 100MG TABLET

Like all medicines, Zyloric 100mg tablet may cause certain side effects in some individuals, although not everybody gets them.

The most common side effects of taking Zyloric 100mg tablet are:

• Nausea
• Dizziness
• Stomach pain
• Diarrhea
• Increased serum glutamic oxaloacetic transaminase
• Increased Serum glutamate pyruvate transaminase
• Increased alkaline phosphatase level in blood

When to consult your doctor?

• Severe allergic reactions symptoms such as rash, itching, or swelling (especially of the face/tongue/throat), difficulty breathing, severe dizziness
• Liver problems symptoms such as yellowing of the skin or eyes (jaundice), dark urine, unusual tiredness, or weakness
• Kidney problems symptoms such as painful urination, blood in urine, decreased urination or difficulty urinating
• Severe skin reactions symptoms such as skin rash or blisters, peeling skin or sores, especially in the mouth, fever, or swollen lymph nodes (Stevens-Johnson Syndrome)
• Gastrointestinal problems symptoms such as persistent nausea, vomiting, or abdominal pain

How To Manage Side Effects

Warning & Precautions

Other Warnings for ZYLORIC 100MG TABLET

Before taking Zyloric 100mg tablet inform your doctor if you:

• Lesch-Nyhan syndrome
• thyroid problems
• high blood pressure
• an acute attack of gout
• cancer (especially leukaemia)
• intolerance to some sugars

Safety Advice

• Take one tablet daily with or without food.
• Swallow the tablet whole with a glass of water. Do not crush or chew the medication.
• For best results, take the tablet at the same time each day.
• Drink plenty of fluids while on Zyloric (at least 2–3 liters of water per day), as it helps reduce kidney stones and promotes proper kidney function. Dehydration can increase the risk of side effects.
• Alcohol, particularly beer and spirits, can reduce the effectiveness of Zyloric and may also raise uric acid levels. It is recommended to limit or avoid alcohol consumption while taking this medication.
• Your doctor will probably track your blood tests regularly to monitor your uric acid levels. This allows them to ensure the medication is effective and that you are not facing any negative side effects.
• Allopurinol may cause skin reactions, such as a rash. If you develop a rash or blisters, particularly with fever, it is important to contact your doctor right away, as this could indicate a severe reaction.
• Zyloric can impact liver and kidney function. To avoid potential complications, your doctor may regularly check your liver and kidney function while you are taking this medication.
• In the initial months of management with Zyloric, gout attacks may become more frequent or intense due to the redistribution of uric acid in the body. It is crucial to continue taking your medication as prescribed, even during an attack, and to follow any extra managements your doctor suggests for managing flare-ups.
• Avoid stopping Zyloric abruptly without consulting your doctor, as it could result in a worsening of gout or the development of kidney stones.
• Older adults may have an increased sensitivity to side effects, particularly those affecting the kidneys and liver, so close monitoring during management is essential.

Diet and Lifestyle Advice

Lifestyle Tips and Dietary Guidance for Managing Gout

Category	Recommendation	Explanation
Medications	Continue Zyloric (Allopurinol) 100mg as prescribed.	Allopurinol helps to lower uric acid levels, which are a primary cause of gout. Follow your doctor’s advice regarding dosage.
Hydration	Drink plenty of water (8-12 cups/day).	Helps to flush out uric acid from the body and prevent crystal formation in joints.
Alcohol	Limit or avoid alcohol, especially beer and spirits.	Alcohol can increase uric acid production and hinder its elimination. Opt for moderate wine consumption if necessary.
Purine-Rich Foods	Avoid high-purine foods (e.g., red meat, organ meats, shellfish).	Purines are broken down into uric acid, increasing the risk of gout flare-ups.
Low-Purine Alternatives	Opt for lean meats, poultry, and plant-based protein (e.g., tofu, legumes).	These have lower purine content, which helps maintain safe uric acid levels.
Dairy Products	Include low-fat or fat-free dairy (milk, yogurt, cheese).	Dairy products may help lower uric acid levels and reduce the frequency of gout attacks.
Fruits and Vegetables	Consume plenty of low-purine vegetables (e.g., leafy greens, bell peppers).	These are nutrient-rich, help manage inflammation, and do not contribute to high uric acid levels.
Whole Grains	Prefer whole grains (e.g., brown rice, quinoa, whole-wheat bread).	Whole grains are low in purines and provide fiber, which can help reduce the risk of gout flare-ups.
Vitamin C	Increase intake of vitamin C-rich foods (e.g., citrus fruits, bell peppers).	Vitamin C may help lower uric acid levels. Aim for 500mg of Vitamin C daily, through foods or supplements.
Omega-3 Fatty Acids	Include sources of omega-3s (e.g., flaxseeds, walnuts, fishlike salmon).	Omega-3s may help reduce inflammation in the joints and improve overall joint health.
Avoid Fructose	Minimize sugary foods, sodas, and high-fructose corn syrup.	High fructose levels can elevate uric acid levels and contribute to gout flare-ups.
Weight Management	Maintain a healthy weight.	Obesity is a risk factor for gout, as it can increase uric acid production. Focus on balanced eating and exercise to maintain weight.
Exercise	Engage in low-impact exercises like walking, swimming, or cycling.	Regular physical activity can help manage weight, reduce inflammation, and improve joint mobility.
Stress Management	Practice relaxation techniques (e.g., meditation, yoga, deep breathing).	Stress can exacerbate gout attacks, so finding ways to manage stress is important for overall health.
Joint Care	Avoid prolonged periods of joint strain.	Give your affected joints rest when possible and elevate them to reduce swelling. Consider using ice packs to alleviate pain.

Drug - Drug interaction

Inform your physician if you are taking any of the following medicine before taking Zyloric 100mg tablet:

1. Zyloric and Azathioprine

• Interaction: Co-administration of Zyloric (Allopurinol) with Azathioprine may significantly increase the plasma levels of Azathioprine. Allopurinol inhibits the enzyme xanthine oxidase, which is involved in the metabolism of Azathioprine, potentially leading to increased toxicity.
• Effect: Increased levels of Azathioprine can lead to severe bone marrow suppression, resulting in leukopenia (low white blood cell count), thrombocytopenia (low platelet count), and anemia.
• Management: If combined, the dose of Azathioprine should be reduced by approximately 75%. Close monitoring of blood counts (including white blood cells and platelets) is essential to detect early signs of bone marrow suppression. Alternative immunosuppressive therapy may be considered depending on the patient’s clinical condition.

2. Zyloric and Warfarin

• Interaction: Zyloric may enhance the anticoagulant effects of Warfarin, increasing the risk of bleeding. Allopurinol can interfere with the metabolism of Warfarin, potentially leading to higher levels of Warfarin in the blood.
• Effect: The enhanced anticoagulant effect increases the risk of bleeding, including symptoms like easy bruising, prolonged bleeding, and gastrointestinal bleeding, which can be life-threatening.
• Management: Close monitoring of International Normalized Ratio (INR) levels is essential when starting or adjusting doses of Zyloric. If necessary, Warfarin dose adjustments should be made to maintain therapeutic INR levels. Patients should be educated about signs of bleeding and seek immediate medical attention if any occur.

3. Zyloric and Diuretics (e.g., Hydrochlorothiazide)

• Interaction: The use of Zyloric in combination with diuretics, particularly thiazide diuretics like Hydrochlorothiazide, may increase the risk of uric acid retention and gout attacks. Diuretics reduce renal excretion of uric acid, and Zyloric works by lowering uric acid levels. The interaction may lead to an imbalance and increased risk of adverse effects.
• Effect: The combined use of these medications can lead to an increased incidence of gout flare-ups, joint pain, swelling, and inflammation due to the sudden fluctuation in uric acid levels.
• Management: When combining these drugs, careful monitoring of uric acid levels is recommended. In some cases, the dose of Zyloric may need to be adjusted. Patients should be advised to stay well-hydrated to reduce the risk of gout flares, and pain management strategies for gout should be discussed.

4. Zyloric and Amoxicillin

• Interaction: There is an increased risk of skin rashes when Zyloric is taken alongside Amoxicillin or other antibiotics like Ampicillin. This interaction may occur more frequently in patients with pre-existing renal dysfunction or those who are genetically predisposed to developing allergic reactions.
• Effect: The risk of developing a rash can be significant, especially if there is an underlying hypersensitivity reaction, which may also cause itching, hives, or even more severe reactions.
• Management: Patients taking Zyloric and Amoxicillin together should be monitored for signs of skin rash or other allergic reactions. If a rash develops, discontinuation of either medication should be considered. If the rash is severe, or if signs of anaphylaxis appear, immediate medical attention is necessary.

5. Zyloric and Vitamin C (Ascorbic Acid)

• Interaction: High doses of Vitamin C (ascorbic acid) may reduce the effectiveness of Zyloric in lowering uric acid levels. Vitamin C can increase the renal excretion of uric acid, potentially decreasing the drug's therapeutic efficacy.
• Effect: This interaction may result in insufficient lowering of uric acid levels, which could lead to the persistence of hyperuricemia and associated conditions such as gout or kidney stones.
• Management: It is advisable to limit Vitamin C supplementation to moderate levels (no more than 500mg per day) while on Zyloric. Patients should be informed of the potential interaction and encouraged to discuss any additional supplements or medications with their healthcare provider.

Synopsis

Drug	:	Allopurinol
Pharmacological Category	:	Xanthine Oxidase Inhibitor
Therapeutic Indication	:	Gout, Hyperuricemia
Dosage Forms	:	Tablet, Capsule

More Information

01.Why Choose Zyloric 100mg Tablet for Uric Acid Control?

Zyloric (with the active ingredient Allopurinol) is a medication commonly prescribed to control high levels of uric acid in the blood, which can lead to conditions like gout and kidney stones. Here’s why Zyloric might be preferred over other medications:

1. Effectively Lowers Uric Acid Levels

• Zyloric works by reducing the production of uric acid in your body. High uric acid levels can cause crystals to form in your joints (gout) or kidneys (stones). Zyloric helps prevent this from happening.

2. Long-Term Control

• While some medications only treat gout attacks as they happen, Zyloric works to prevent future attacks by controlling uric acid levels over time. It’s often used as a long-term solution.

3. Well-Understood and Trusted

• Zyloric has been in use for many years and is well-studied. Doctors are familiar with how it works and can monitor its effectiveness with regular tests.

4. Few Side Effects (in most people)

• Zyloric is generally well-tolerated. Most people don’t experience serious side effects, especially if they take it as prescribed. Like any medication, side effects are possible, but they’re rare.

5. Helps With Multiple Conditions

• Zyloric isn’t just for gout; it’s also used to treat conditions like kidney stones and certain types of cancer (where uric acid levels rise due to chemotherapy). It’s a versatile option.

6. Available in Low Dosage (100mg)

• Zyloric is available in different doses, including the 100mg tablet, making it easier to start on a lower dose and adjust as needed.

How Does Zyloric Compare to Other Drugs?

• Other medications (like pain relievers or colchicine) may only manage the symptoms of gout or lower uric acid temporarily. Zyloric, however, focuses on long-term prevention by reducing uric acid levels at the source.
• Some other uric acid-lowering drugs may come with higher risks of side effects, or they might not work as consistently over time as Zyloric.

02. Product Comparison

a) Zyloric vs. Febuxostat, Why Zyloric 100mg is More Effective?

Aspect	Zyloric (Allopurinol)	Febuxostat
Mechanism of Action	Inhibits xanthine oxidase to reduce uric acid production	Inhibits xanthine oxidase, similar to Allopurinol, but more selective
Efficacy	Effective in reducing uric acid levels	More effective in patients with renal impairment or those who fail on Allopurinol
Dosage Form	Available as oral tablets (100 mg, 300 mg)	Available as oral tablets (40 mg, 80 mg)
Side Effects	Rash, liver enzyme abnormalities, gastrointestinal issues	Nausea, liver enzyme abnormalities, cardiovascular risks
Renal Function	Requires dose adjustment in renal impairment	Preferred for patients with moderate renal impairment due to minimal dose adjustments
Cost	Generally cheaper and widely available	More expensive than Allopurinol
Long-term Use	Well-established for long-term management of gout	Newer drug with growing evidence for long-term use
Risk of Hypersensitivity	Higher risk of severe hypersensitivity reactions (e.g., SJS)	Lower risk of hypersensitivity compared to Allopurinol
Indications	First-line treatment for most gout cases	Typically used when Allopurinol is not effective or causes side effects
Drug Interactions	Many potential drug interactions (e.g., with warfarin)	Fewer drug interactions compared to Allopurinol
Effect on Serum Uric Acid	Lowers uric acid by 20-30%	Lowers uric acid more effectively, especially in severe cases
Approved for Use	Approved for chronic gout treatment and hyperuricemia	Approved for chronic gout and hyperuricemia, especially in cases of intolerance to Allopurinol

Conclusion:

Zyloric (Allopurinol) is often preferred as a first-line management due to its longer history of use, lower cost, and broad effectiveness. It works well for most patients and is generally safer for long-term use. However, Febuxostat may be considered better for those who cannot tolerate Allopurinol or have renal impairment, as it requires fewer dose adjustments. It can also be more effective in lowering serum uric acid levels for certain patients, but its higher cost and potential cardiovascular risks may limit its use.

b) Zyloric vs. Colcrys, Why Zyloric 100mg is More Effective?

 

Feature	Zyloric (Allopurinol)	Colcrys (Colchicine)
Mechanism of Action	Reduces uric acid production by inhibiting xanthine oxidase.	Reduces inflammation by inhibiting microtubule formation and neutrophil activity.
Indication	Primarily used for chronic gout and hyperuricemia management.	Primarily used for acute gout flare management.
Role in Treatment	Long-term management, helps prevent gout attacks by lowering uric acid levels.	Acute symptom relief during flare-ups; does not address uric acid production.
Duration of Use	Taken long-term for uric acid control.	Taken short-term (during acute attacks).
Effectiveness for Gout	Prevents recurrent gout attacks by lowering uric acid levels over time.	Effective in reducing symptoms of an active gout flare but does not lower uric acid levels.
Side Effects	Possible skin rash, liver issues, nausea, headache, allergic reactions.	Gastrointestinal issues (diarrhea, nausea), muscle pain, potential toxicity at high doses.
Risk of Kidney Stones	Can increase risk of kidney stones, but can be managed by adequate hydration.	No significant risk of kidney stones.
Dosing	Once daily for maintenance (may vary based on individual uric acid levels).	Multiple doses per day during acute flare-ups.
Use in Chronic Gout	First-line therapy for chronic gout due to its ability to lower uric acid over time.	Not suitable for chronic gout management; used only for acute flares.
Tolerability	Generally well-tolerated when prescribed appropriately.	Can cause significant GI side effects and is not well-tolerated by all patients.
Cost	Typically less expensive (generic available).	Can be more expensive, especially if not generic.
Approval for Uric Acid Control	Approved for chronic uric acid control in gout.	No effect on uric acid levels; used only for symptom relief.

Why Zyloric (Allopurinol) Might Be Considered Better for Gout:

• Reduction of Attacks: Zyloric is effective in reducing future gout attacks by lowering uric acid levels, which addresses the underlying cause of gout.
• Long-Term Management: Zyloric is suited for chronic management of gout, while Colcrys is only for short-term flare management.
• Cost-Effectiveness: Zyloric is generally more affordable, especially with generic versions available, making it more accessible for long-term therapy.
• Less Risk of Serious Side Effects: Although both drugs have side effects, Zyloric’s side effects are typically less severe and manageable, particularly with proper dosing.

C) Zyloric 100mg vs. Natural Gout Remedies, Why Zyloric 100mg is More Effective?

Factor	Zyloric 100mg (Allopurinol)	Natural Gout Remedies / Lifestyle Changes
Mechanism of Action	Inhibits xanthine oxidase, reducing uric acid production.	No direct effect on uric acid production. Focuses on managing symptoms and preventing flare-ups.
Effectiveness in Lowering Uric Acid	Highly effective in lowering uric acid levels in the blood.	Limited effect, depends on individual remedies. No direct mechanism for uric acid reduction.
Speed of Action	Works within days to weeks, depending on dosage and individual response.	Effects are gradual, often requiring weeks or months to see any improvement.
Preventative Ability	Prevents future gout attacks by lowering uric acid levels.	Can help prevent flare-ups but does not lower uric acid significantly.
Side Effects	Possible side effects: skin rash, liver issues, digestive disturbances, rare severe allergic reactions.	Generally safe with minimal side effects, though some remedies may interact with medications.
Reliability	High reliability in reducing uric acid and preventing gout attacks.	Variable results; no guarantee of consistent symptom control or prevention.
Lifestyle Modifications Included	Not applicable, as Zyloric is a prescription medication.	Includes dietary changes (low purine foods), hydration, weight management, stress reduction, and regular exercise.
Cost	Prescription medication, usually covered by insurance. Costs can vary based on insurance or location.	Natural remedies may incur little to no cost, depending on the approach (e.g., diet change, herbal supplements).
Long-Term Management	Long-term use can effectively control uric acid levels and prevent flare-ups.	Requires ongoing commitment to lifestyle changes and may not be sufficient on its own.
Scientific Backing	Well-researched with strong evidence supporting its efficacy.	Some remedies (e.g., cherries, vitamin C, hydration) have partial evidence, but not all are consistently supported by science.

Conclusion:

• Zyloric 100mg is more effective in reducing uric acid levels and preventing gout attacks due to its direct action on the body's metabolic processes.
• Natural remedies and lifestyle changes can be useful in managing symptoms and supporting overall joint health, but they often lack the potency and scientific backing of medications like Zyloric.

FAQs About ZYLORIC 100MG TABLET

References

1. K.D. Tripathi. Ant rheumatoid and antigout drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page-216.

2. NIH National Library of Medicine, National center for biotechnology information. Allopurinol. Statpearls. [Accessed on 18th April 2025] 

3. Proudman, C., Lester, S.E., Gonzalez-Chica, D.A. et al. Gout, flares, and allopurinol use: a population-based study. Biomed Central. Springer Link. May 2019. [Accessed on 18th April 2025]  

4. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised on December 2021] [Accessed on 18th April 2025] 

5. Elara Pharma services Ltd. Allopurinol Tablets. [Revised in March 2022]. [Accessed on 18th April 2025] 

6. Inga Laboratories. Logout – SR (Allopurinol). [Accessed on 18th April 2025] 

7. Drug Bank. Allopurinol. [Accessed on 18th April 2025] 

Useful Diagnostic Tests

• Creatinine Levels
• Uric acid
• Kidney Function Tests

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