Zoryl 2mg Tablet 10'S

Introduction About ZORYL

ZORYL contains Glimepiride which belongs to the group of medicines called Anti-diabetic agents. It is used for the management of Type II diabetes mellitus when diet and exercise alone does not result in adequate blood sugar control. Type II diabetes mellitus is a chronic disease characterized by abnormally high levels of glucose in the blood. It is caused due to inadequate production of a hormone called insulin (produced by pancreas to metabolize glucose) in the body or due to inadequate sensitivity of body cells to the actions of insulin. Along with the therapy, your doctor might ask you to make certain lifestyle changes such as following a healthy diet, regular physical exercise and quitting alcohol consumption.

Before taking ZORYL, inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have any hormonal problems, genetic disorders (such as G6PD deficiency) or if you are malnourished, starved, on an irregular diet. ZORYL is not suitable for use in patients with type I diabetes mellitus. Consult your doctor before taking ZORYL if you are pregnant or planning to become pregnant or breastfeeding.

The most common side effect of taking ZORYL is hypoglycemia (low blood sugar levels) which can be identified through symptoms such as increased hunger, sweating, shakiness, weakness or an irregular heartbeat. To avoid this, your doctor will periodically monitor your blood sugar levels and adjust the dose of ZORYL accordingly. You can also carry a sugary snack (such as biscuits, glucose drinks or sweet candies) along with you as a precaution and have them immediately if you experience any signs of hypoglycemia. However, consult your doctor if there is no improvement in your condition.

Uses Of ZORYL

• Used to manage Type II diabetes mellitus

How ZORYL Works

ZORYL stimulates the pancreas to secrete more insulin (a hormone involved in glucose metabolism). It also makes our body more sensitive to insulin which helps in digesting the circulating sugars (glucose) in the blood, thereby reducing blood sugar levels.

How to use ZORYL

Take ZORYL preferably after meals or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. Do not stop taking ZORYL unless your doctor advice you to stop.

Side Effects Of ZORYL

How To Manage Side Effects

Hypoglycemia

Have foods rich in sugars such as fruit juices, glucose drinks, candies, honey or biscuits. Check your blood sugar after 10 minutes. If not gained optimum level, take another sugary snack, or a drink and check the blood sugar again. Consult your doctor if there is no improvement in your condition.

Warning & Precautions

Pregnancy

Contraindicated

ZORYL is not recommended for use in pregnant women. Therefore, consult your doctor before taking it.

Breastfeeding

Contraindicated

ZORYL is not recommended for use in breastfeeding women. Therefore, consult your doctor before taking it.

Driving and Using Machines

Use with Caution

Do not drive or operate any heavy tools or machines if your ability is affected by ZORYL.

Alcohol

Consult your doctor

Avoid consumption of alcohol while taking ZORYL as it may increase the risk of unwanted side effects.

Kidney

Consult your doctor

ZORYL is not recommended for use in patients with severe kidney problems. It should be used with caution in patients with other kidney problems. Therefore, consult your doctor before taking it.

Liver

Consult your doctor

ZORYL is not recommended for use in patients with severe liver problems. It should be used with caution in patients with other liver problems. Therefore, consult your doctor before taking it.

Allergy

Contraindicated

Do not take ZORYL if you are allergic to Glimepiride or to any other sulfonylureas (Ex. Glyburide, gliclazide) or sulphonamides (Ex. sulfasalazine).

Use In Pediatrics

Contraindicated

ZORYL is not recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor before taking it.

Use In Geriatrics

Use with Caution

ZORYL should be used with caution in elderly patients (aged above 65 years). Therefore, consult your doctor before taking it.

Interactions

A. Drug-Drug interactions:

Before taking ZORYL, inform your doctor if you are taking any of the following medicines:

• other medicines used to manage diabetes mellitus (such as insulin or metformin)
• medicines used for pain and inflammation (Ex. aspirin, ibuprofen, phenylbutazone, azopropazone, oxyphenbutazone)
• medicines used to manage urinary infections (amikacin, nitrofurantoin, sulfamethoxazole)
• medicines used for bacterial infections (such as tetracyclines, chloramphenicol, ciprofloxacin, clarithromycin)
• medicines used for fungal infection (Ex. fluconazole, miconazole)
• medicines used for blood clotting (Ex. warfarin)
• medicines used for muscle build-up (Ex. nandrolone, oxymethalone)
• medicines used for male sex hormone replacement therapy (Ex. testosterone)
• medicines used for depression (such as moclobemide, isocarboxazid, phenelzine, tranylcypromine, fluoxetine)
• medicines used for high blood cholesterol levels (Ex. fenofibrate, nicotinic acid, colesevelam)
• medicines used to manage high blood pressure (Ex. enalapril, lisinopril, ramipril, atenolol, propranolol, telmisartan, olmesartan, clonidine, guanethidine and reserpine)
• disopyramide (used to manage abnormal heartbeat)
• medicines used for gout (Ex. allopurinol, probenecid, sulfinpyrazone)
• medicines used for cancer (Ex. cyclophosphamide, ifosfamide, trofosfamide)
• fenfluramine (used for obesity)
• pentoxifylline (helps to improve blood flow in the body)
• medicines used to manage allergic rhinitis (Ex. tritoqualine)
• alpha blockers (medicines used to manage high blood pressure or prostate problems) Ex. prazosin, doxazosin
• hormonal replacement therapy (used for menstrual disorders in women) Ex. estradiol
• thiazide diuretics (used to manage edema and high blood pressure) Ex. hydrochlorothiazide
• levothyroxine (used for thyroid problems)
• used for mental illness (such as chlorpromazine, prochlorperazine, lithium)
• corticosteroids (for pain and inflammation) Ex. prednisolone, betamethasone
• used for asthma (Ex. salbutamol, terbutaline)
• adrenaline (used in emergency condition)
• medicines used to manage constipation (Ex. lactulose, liquid paraffin)
• medicines used to manage epilepsy (Ex. phenytoin)
• barbiturates (used to induce sleep) Ex. phenobarbital
• medicines used to reduce increased pressure in the eye (Ex. azetazolamide)
• glucagon, diazoxide (medicines used to manage signs of low blood sugar levels)
• cimetidine (a medicine used for stomach ulcers)

Overdosage:

If you or anyone else accidentally took more ZORYL, you may experience the signs of hypoglycemia (such as increased hunger, sweating, headache, feeling clammy, restless or aggressive, shakiness, fast heartbeat and confusion). To manage this, consume any sugary food immediately. If the symptom did not improve or worsens contact your doctor immediately.

Synopsis

More Information

• Keep ZORYL out of reach of children
• Store ZORYL at room temperature

FAQs About ZORYL

Q: What is ZORYL used for?

A: ZORYL is an antidiabetic medicine used to manage Type II diabetes mellitus when diet, exercise and lifestyle changes alone does not result in adequate response.

Q: How and when to take ZORYL?

A: Take ZORYL preferably after meals or as advised by your physician. Swallow the medicine with a glass of water. Do not cursh or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.

Q: How long should I take ZORYL?

A: You need to take ZORYL as long as your doctor or physician prescribes you the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.

Q: What is the best time to take ZORYL?

A: ZORYL must be taken with meals to avoid gastrointestinal side effects. Consult your doctor for advice.

Q: What to do if I forgot to take a dose of ZORYL?

A: If you forgot to take a dose of ZORYL, take it as soon as you remember. However, if it is time for the next dose of ZORYL, skip the missed dose and take the next one regularly. Do not take a double dose of ZORYL to compensate the missed ones.

Q: What are the most common side effects of taking ZORYL?

A: The most common side effects of taking ZORYL is hypoglycemia. To avoid this, your doctor will periodically monitor your blood sugar levels and adjust the dose of ZORYL accordingly. You can also carry a sugary snack (such as biscuits, glucose drinks or sweet candies) along with you as a precaution and have them immediately if you experience any signs of hypoglycemia. However, consult your doctor if there is no improvement in your condition.

Q: Can I stop taking ZORYL without consulting your doctor?

A: No. You should not stop taking ZORYL without consulting your doctor because it may lead to reversal of symptoms. If you feel better after using ZORYL, consult your doctor for advice.

Q: Will taking a higher dose of ZORYL be more effective?

A: No, taking a higher dose of ZORYL will not be effective rather it can lead to unwanted side effects. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.

Q: What precautions do I need to follow while taking ZORYL?

A: Before taking ZORYL, inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have hormonal problems, genetic problems (surgery in the gut) or if you are malnourished. ZORYL is not suitable for use in patients with type I diabetes mellitus. Consult your doctor before taking the medicine.

Q: Can I take medication for high blood pressure along with ZORYL?

A: It is not advisable to take medicines to control blood pressure while taking ZORYL without consulting your doctor. Therefore, consult your doctor before taking any antihypertensive such as beta blockers (Ex. atenolol, propranolol) along with ZORYL as they have known interactions with ZORYL.

Q: What should I do if I experience low blood sugar after taking ZORYL?

A: Low blood sugar is a common side effect of taking ZORYL. Try to have sugar rich food items such as fruit juice, glucose tablets or gel, soft drinks, honey or sugary candy. Check your blood sugar after 10 minutes. If not gained optimum level, take another sugary snack, or drink, and check the blood sugar levels once again. In case of persistent low blood sugar levels, consult your doctor immediately.

Q: Can ZORYL be taken with insulin?

A: Co-administration of ZORYL with insulin is considered risky as they are increased chances of hypoglycemia (decreased blood sugar levels). Consult your doctor before taking it.

Q: Can ZORYL be used in pregnant women?

A: ZORYL is not recommended for use in pregnant women. Therefore, consult your doctor for advice before taking it.

Q: How to take ZORYL?

A: You must take ZORYL as advised by your physician. Try to take this medicine preferably after meals and swallow it with a glass of water. Do not crush or chew the medicine.

Q: How much ZORYL should I take?

A: ZORYL should be used only under medical supervision. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body condition and severity of the disease condition.

References

1. KD. Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 270.

2. Abdul Basit, Musarrat Riaz and Asher Fawwad. Glimepiride: evidence-based facts, trends, and observations. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. August 2012. [Accessed on 14th October 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448454/

3. Brown & Burk UK Limited. Electronic Medicines Compendium (EMC). [Revised in December 2020] [Accessed on 14th October 2022] https://www.medicines.org.uk/emc/files/pil.10742.pdf

4. Sanofi India Limited. Amaryl® / Semi-Amaryl® Glimepiride Tablets IP. [Revised in April 2021] [Accessed on 14th October 2022] https://www.sanofi.in/dam/jcr:08a3cd36-a9e7-49eb-887b-9914600a6335/Amaryl%20and%20Semi-Amaryl%20%2005mg%20PI%20-%20rev%20April%202021.pdf

Useful Diagnostic Tests

• HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin
• Blood Glucose Fasting (FBS)
• Post Prandial Blood Sugar (PPBS)
• Insulin - Fasting
• Netmeds Diabetic Checkup
• Advance Diabetes Monitoring (Senior Female)
• Jaanch Diabetic Profile Basic

Author Details

Written By Dr. Janet.C - Pharm.D

Reviewed For Accuracy By Dr. Jaya Prabakaran - MBBS, MD (Diabetology and Family Medicine)

Last updated on 10 Jul 2024 | 03:45 PM(IST)