ZONDE Injection 2ml

Introduction About ZONDE INJECTION

ZONDE INJECTION is used to provide relief from sensation of nausea and vomiting. It contains a medicine called Ondansetron which is an anti-emetic medicine. It reduces the nausea and vomiting sensation by blocking the vomiting centres of the brain.

Before receiving ZONDE INJECTION, inform your doctor if you have severe constipation, heart or liver problems, imbalance with the levels of salts in the blood, such as potassium, sodium and magnesium or if you have been scheduled for any surgery.

Consult your doctor before taking ZONDE INJECTION if you are pregnant or breastfeeding as a precaution.

The most common side effects of receiving ZONDE INJECTION includes headache, flushing and constipation. Consult your doctor if any of these above symptoms gets worse.

Uses Of ZONDE INJECTION

• Management of nausea and vomiting

How ZONDE INJECTION Works

ZONDE INJECTION is anti-emetic medicine which works by blocking the action of serotonin, a natural substance in the body that can trigger nausea and vomiting. Specifically, it targets the 5-HT3 receptors in the brain and the gastrointestinal tract. By inhibiting these receptors, ondansetron effectively reduces the signals that lead to nausea and vomiting, providing relief to patients undergoing treatments that can induce these symptoms.

How to use ZONDE INJECTION

• ZONDE INJECTION will be given to you only by a doctor or a nurse, into a vein as an intravenous infusion, or into the muscles as intramuscular injection
• Your doctor will administer the correct dose and duration for you depending upon your age, body weight and disease condition

Side Effects Of ZONDE INJECTION

Common Side Effects of ZONDE INJECTION:

• headache
• flushing (feeling of warmth)
• constipation
• Dizziness
• Diarrhea
• fits (seizures)
• irregular heartbeat (fast or slow)
• low blood pressure
• hiccups

Stop receiving ZONDE INJECTION and contact your doctor if you experience any of the following side effects:       

• sudden wheezing, chest pain or tightness
• swelling of eyelids, face, lips, mouth or tongue
• skin rash, red spots or lumps under your skin (hives) or anywhere on the body

Warning & Precautions

Pregnancy

Consult your doctor

Pregnant women should only use ZONDE INJECTION if prescribed by a doctor, after assessing the benefits and risks.

Breastfeeding

Consult your doctor

Limited data is available on the use of ondansetron during breastfeeding. While no harmful effects have been reported in breastfed infants, ondansetron is excreted in breast milk. Therefore, breastfeeding mothers should consult a doctor before using this medicine to ensure its safety for their baby.

Driving and Using Machines

Use with Caution

Do not drive or operate any machines if you feel dizzy or uneasy after receiving ZONDE INJECTION.

Liver

Use with Caution

ZONDE INJECTION should be used with caution in patients with liver problems. Consult your doctor before receiving ZONDE INJECTION.

Allergy

Contraindicated

Do not take ZONDE INJECTION if you are allergic to ondansetron, granisetron or palonosetron or to any other ingredients of this medicine.

Heart Disease

Use with Caution

ZONDE INJECTION should be used with caution in patients with heart diseases such as uneven heartbeats (arrhythmias) or congestive heart failure.

Use In Pediatrics

Monitoring required

ZONDE INJECTION can be used in children if prescribed by the physician.

Use In Geriatrics

Monitoring required

ZONDE INJECTION can be used in elderly patients if prescribed by the physician.

Interactions

A. Drug-Drug Interactions:

Before receiving ZONDE INJECTION, inform your doctor, if you are receiving any of the following medicine:

• apomorphine (used to manage Parkinson’s disease)
• Antiepileptics (Ex. phenytoin, carbamazepine)
• Anti-TB agent (Ex. rifampicin)
• Pain killers (such as tramadol, methadone)
• Antipsychotic agents (Ex. haloperidol)
• Cardiac agents (Ex. amiodarone) and/or high blood pressure (Ex. atenolol, timolol)
• cancer medicines (Ex. doxorubicin, daunorubicin, monoclonal, trastuzumab) 
• Antibiotics (such as erythromycin, ketoconazole)
• Antidepressants, Sedatives, Anxiolytics (ex. fluoxetine, paroxetine, sertraline, fluvoxamine, citalopram, venlafaxine, duloxetine escitalopram)

Overdosage:

If you or anyone else accidentally takes too much of ZONDE INJECTION, consult your doctor immediately or visit the nearby hospital.

Synopsis

FAQs About ZONDE INJECTION

Q: Is ZONDE INJECTION a chemo drug?

A: No, it is not a chemo drug. It belongs to a group of medicines called serotonin antagonists and used to manage side effects caused due to chemotherapy.

Q: What ZONDE INJECTION is used for?

A: ZONDE INJECTION is used to manage nausea and vomiting caused by medical managements like chemotherapy, radiotherapy or surgery.

Q: For how long should you take ZONDE INJECTION?

A: Your doctor will advise you on how long you should continue to take ZONDE INJECTION. Consult your doctor from time to time to review your management and assess your symptoms.

Q: What happens if you take more ZONDE INJECTION than your required dose?

A: If you or anyone else accidentally takes too much of ZONDE INJECTION, consult your doctor immediately or visit the nearby hospital.

Q: What side effects are seen with ZONDE INJECTION?

A: The most common side effects of receiving ZONDE INJECTION are headaches, flushing (feeling of warmth), constipation. Consult your doctor if above side effects got worse.

References

1. KD. Tripathi. Section 11, Gastrointestinal Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 661.

2. LTS Lohmann Therapie-Systeme AG Lohmannstrasse. Andernach GERMANY [Revised April 2022] [Accessed on 29 September 2022] click here

3. Koland M, Sandeep V, Charyulu N. Fast Dissolving Sublingual Films of Ondansetron Hydrochloride: Effect of Additives on in vitro Drug Release and Mucosal Permeation. J Young Pharm. 2010 Jul;2(3):216-22. [Accessed on 29 September 2022] click here

4. Kumria R, Gupta V, Bansal S, Wadhwa J, Nair AB. Oral buccoadhesive films of ondansetron: Development and evaluation. Int J Pharm Investig. 2013 Apr;3(2):112-8. [Accessed on 29 September 2022] click here

5. Ondansetron Soluble Films. [Accessed on 29 September 2022] click here

6. Myoclinic. [Accessed on 29 September 2022] click here

Useful Diagnostic Tests

• Complete blood count

Author Details

Written By Srilekha. R - B.Pharm

Reviewed For Accuracy By Dr. Vrushabhakumar Jitendra Shah. - MBBS

Last updated on 11 Feb 2025 | 05:01 PM(IST)