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Introduction About ZIX MR OD CAPSULE
ZIX MR OD CAPSULE is used in adults to manage painful inflammatory conditions associated with muscle spasms. It can also be used to manage pain associated with musculoskeletal (bone) disorders such as osteoarthritis, rheumatoid arthritis (inflammation of joints), or ankylosing spondylitis (back pain caused by inflammation of bones in the spine).
ZIX MR OD CAPSULE is a combination of aceclofenac and thiocolchicoside, which belong to the group of medicines called Non-Steroidal Anti-inflammatory Drugs and Muscle relaxants, respectively. It works by blocking the production of certain chemicals that cause pain and inflammation in the body. It also relaxes the muscles by blocking the action of certain chemical messengers (GABA) in the brain that cause muscle spasm. As a result, ZIX MR OD CAPSULE relieves painful muscle spasms associated with inflammatory disease conditions.
Before taking ZIX MR OD CAPSULE, inform your doctor if you have any problems in your liver, liver, kidney, heart, or stomach. You should also inform your doctor if you have diabetes, high blood cholesterol, or fits.
Do not take ZIX MR OD CAPSULE if you have asthma or varicella infection. Consult your doctor before taking ZIX MR OD CAPSULE if you are pregnant, think you may be pregnant, or are breastfeeding.
Take ZIX MR OD CAPSULE only as advised by your doctor. Do not take ZIX MR OD CAPSULE longer than recommended by your doctor, as it may cause serious side effects. Avoid smoking and consumption of alcohol while undergoing therapy with ZIX MR OD CAPSULE to achieve better results.
The most common side effects of taking ZIX MR OD CAPSULE are dizziness, drowsiness, nausea, and stomach pain. Consult your doctor if any of these side effects worsen.
Uses Of ZIX MR OD CAPSULE
It is used in adults to manage:
- Painful muscle spasms
- Pain associated with musculoskeletal disorders (such as osteoarthritis, rheumatoid arthritis, or ankylosing spondylitis)
How ZIX MR OD CAPSULE Works
ZIX MR OD CAPSULE is a muscle relaxant with anti-inflammatory and analgesic properties. It effectively reduces pain caused by muscle spasms and inflammatory bone disorders, where aceclofenac acts by blocking the release of certain chemicals (prostaglandins) that cause pain and inflammation in the body and thiocolchicoside acts by blocking the effects of certain chemical messengers (GABA) in the brain that cause painful muscle spasms. Collectively, ZIX MR OD CAPSULE relieves painful muscle spasms associated with inflammatory disease conditions.
How to use ZIX MR OD CAPSULE
Take ZIX MR OD CAPSULE as directed by your physician. Swallow the medicine with a glass of water and do not crush or chew the medicine. ZIX MR OD CAPSULE can be taken 1 hour before or 2 hours after meals. Your doctor will decide the correct dose for you depending upon your health condition.
Side Effects Of ZIX MR OD CAPSULE
Common
- Dizziness
- Drowsiness
- Indigestion, stomach pain, nausea, diarrhea
Uncommon
- Stomach bloating
- Skin rash, itching
- Constipation
- Vomiting
- Mouth ulcers
Rare
- Visual disturbance
- Heart failure
- Increased blood pressure
- Shortness of breath
- Bleeding from the stomach or bowel, blood in faces, or in vomit
- Ulceration
- Anaemia
Stop taking ZIX MR OD CAPSULE and contact your doctor immediately if you experience any of the following side effects:
- Serious allergic reactions such as skin rash, itching, swelling of the face, lips, mouth, or tongue causing difficulty in breathing or swallowing
- Mouth ulcers, skin rash, or peeling
- Difficulty breathing
- Unexpected bruising or bleeding
- Signs of liver damage (such as nausea, sudden weight loss, loss of appetite, and yellowing of eyes and skin)
- Cutaneous and soft tissue infection (skin infections)
How To Manage Side Effects
Diarrhea
Drink plenty of clear fluids like water, diluted fruit juices, or oral rehydration solutions to stay hydrated. Avoid caffeinated or alcoholic beverages, as they can worsen dehydration. Gradually take bland, low-fiber foods like bananas, rice, applesauce, and toast to help firm up stools. Probiotics, found in yogurt or supplements, may help restore the balance of gut bacteria. Practice good hand hygiene to prevent the spread of infection. Consult your doctor if diarrhea worsens.
Dizziness Or Drowsiness
Ensure proper hydration, as dehydration can cause dizziness. Avoid excessive caffeine, alcohol, and high-sodium foods, which can exacerbate symptoms. Engage in physical therapy or vestibular rehabilitation exercises designed to improve balance and reduce dizziness. Move slowly when changing positions, such as standing up or lying down, to avoid triggering dizziness. Practice relaxation techniques such as deep breathing, meditation, or yoga to manage stress, which can contribute to dizziness. Consult your doctor if dizziness persists.
Indigestion
Avoid trigger foods such as fatty, spicy, or acidic items. Eating slowly, chewing food thoroughly, and avoiding lying down immediately after meals can improve digestion. Reduce stress through relaxation techniques like meditation, yoga, or deep breathing, which can alleviate symptoms. Maintaining a healthy weight, quitting smoking, and limiting alcohol consumption are also beneficial. Drinking plenty of water helps digestion. Engaging in regular physical activity can help keep the digestive system active and reduce stress, which may improve symptoms. Consult your doctor if indigestion persists.
Nausea And Vomiting
Stay hydrated with small sips of clear fluids like water, ginger ale, or electrolyte solutions. Avoid consuming large meals; instead, opt for bland, easy-to-digest foods. Ginger, peppermint, or chamomile tea may help soothe the stomach. Rest in a comfortable position, preferably with your head elevated, to ease symptoms. Consult your doctor if nausea and vomiting persist.
Warning & Precautions
Pregnancy
ContraindicatedZIX MR OD CAPSULE is not recommended for use in pregnant women, as it may cause harm to an unborn baby. Therefore, consult your doctor before taking it. Women of childbearing age must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with ZIX MR OD CAPSULE.
Breastfeeding
ContraindicatedZIX MR OD CAPSULE is not recommended for use in breastfeeding women. Therefore, consult your doctor before taking it.
Driving and Using Machines
ContraindicatedDo not drive or handle heavy tools or machines if you feel dizzy or drowsy after taking ZIX MR OD CAPSULE.
Alcohol
ContraindicatedAvoid consumption of alcohol while taking ZIX MR OD CAPSULE to avoid the risk of side effects.
Kidney
Use with CautionZIX MR OD CAPSULE should be used with caution in patients with kidney diseases. Therefore, consult your doctor before taking it.
Liver
Use with CautionZIX MR OD CAPSULE should be used with caution in patients with liver diseases. Therefore, consult your doctor before taking it.
Allergy
ContraindicatedDo not take ZIX MR OD CAPSULE if you are allergic to aceclofenac or thiocolchicoside.
Lungs
ContraindicatedZIX MR OD CAPSULE is not recommended for use in patients with asthma. Therefore, consult your doctor before taking it.
Heart Disease
Use with CautionZIX MR OD CAPSULE should be used with caution in patients with heart diseases (such as heart failure or high blood pressure). Therefore, consult your doctor before taking it.
Use In Pediatrics
ContraindicatedZIX MR OD CAPSULE is not recommended for use in children and adolescents (below 16 years) of age. Therefore, consult your doctor before taking it.
Use In Geriatrics
Use with CautionZIX MR OD CAPSULE should be used with caution in elderly patients. Therefore, consult your doctor before taking it.
Others
ZIX MR OD CAPSULE is not recommended for use if you:
- Have a varicella infection (a viral infection)
Before taking ZIX MR OD CAPSULE, inform your doctor if you:
- Have high blood cholesterol levels
- Have diabetes mellitus
- Are smoker
- Have a history of bleeding inside the brain
- Have a history of stomach ulcer or inflammation (ulcerative colitis or Crohn's disease), particularly if complicated with hemorrhage (bleeding) or perforation
- Have epilepsy (or convulsions)
Interactions
A. Drug-Drug interactions:
- Anti-emetics (Ex. metoclopramide or domperidone)
- Anticoagulant (Ex. warfarin)
- Cardiovascular agents (Ex. enalapril, olmesartan, losartan, digoxin, digitoxin)
- Antibacterials (such as ciprofloxacin, ofloxacin, levofloxacin, or moxifloxacin)
- Anti-retroviral (such as zidovudine)
- Antidiabetics (such as glibenclamide, glycoside, and tolbutamide)
- Analgesics (such as aspirin or ibuprofen)
- Oral corticosteroids (Ex. dexamethasone)
- Proton-pump inhibitors (Ex. omeprazole)
- Antidepressants (Ex. citalopram, fluoxetine, sertraline)
- Gastrointestinal agents (Ex. misoprostol)
- Immunosuppressants (Ex. cyclosporin, tacrolimus)
- Anti-lipidemic (Ex. cholestyramine)
- Diuretics (Ex. furosemide)
- Anti-manic (Ex. lithium)
- Antineoplastic (Ex. methotrexate)
- Anti-progestational steroids (Ex. mifepristone)
Overdosage:
If you or anyone else accidentally took more ZIX MR OD CAPSULE, contact your doctor immediately. Symptoms of overdosage might include nausea, vomiting, upper stomach pain, headache, gastrointestinal bleeding, diarrhea, disorientation, excitation, coma, drowsiness, dizziness, tinnitus, hypotension, respiratory depression, fainting, and convulsions.
Synopsis
| Drug | : | Aceclofenac and Thiocolchicoside |
| Pharmacological Category | : |
Non-steroidal Anti-inflammatory Drugs,Muscle Relaxants |
| Therapeutic Indication | : | Muscle pain and spasm, Joint pain |
| Dosage Forms | : | Tablet, Capsule |
More Information
Storage
- Keep ZIX MR OD CAPSULE out of reach of children
- Store ZIX MR OD CAPSULE at room temperature
FAQs About ZIX MR OD CAPSULE
Q: Can a higher dose of ZIX MR OD CAPSULE improve my disease condition?
A: No. Do not take a higher dose of ZIX MR OD CAPSULE without consulting your doctor, as it may lead to an increased risk of unwanted side effects. Only use the dose prescribed to you by your doctor. Your doctor will decide the correct dose for you depending upon your age, body weight, and disease condition. If the prescribed dose does not result in effective pain relief, consult your doctor for advice.
Q: Can ZIX MR OD CAPSULE cure arthritis?
A: No. ZIX MR OD CAPSULE can only be used to relieve pain caused by arthritis and cannot cure arthritis. Your doctor may prescribe you other medicines along with ZIX MR OD CAPSULE to help manage your disease condition.
Q: How long should I need to take ZIX MR OD CAPSULE?
A: It is not advisable to take ZIX MR OD CAPSULE for more than 7 days, especially while taking at higher doses. This is because ZIX MR OD CAPSULE may cause chromosomal changes in the body, which might lead to unwanted side effects. Strictly follow the instructions given by your doctor regarding the duration of the therapy.
Q: Can I stop taking ZIX MR OD CAPSULE once my pain is relieved?
A: Yes. ZIX MR OD CAPSULE can be discontinued from use once pain is relieved. However, consult your doctor before doing so, as stopping ZIX MR OD CAPSULE too early may cause the pain to come back.
Q: Who should take ZIX MR OD CAPSULE?
A: ZIX MR OD CAPSULE should be used under medical supervision. Do not take ZIX MR OD CAPSULE if you are allergic to aceclofenac or thiocolchicoside or if you have asthma or a varicella infection (a viral infection). Therefore, consult your doctor before taking it.
Q: What precautions must be taken while using ZIX MR OD CAPSULE?
A: ZIX MR OD CAPSULE should be used with caution in patients with kidney diseases, liver diseases, heart diseases (such as heart failure or high blood pressure), high blood cholesterol levels, diabetes mellitus, a history of bleeding inside the brain, a history of stomach ulcers or inflammation (ulcerative colitis or Crohn's disease), or epilepsy (or convulsions). Therefore, consult your doctor before taking it.
Q: Can ZIX MR OD CAPSULE be taken with vitamin B12 supplements?
A: ZIX MR OD CAPSULE can be taken together with vitamin supplements, as vitamins tend to improve healing of inflammation and reduce pain. However, consult your doctor before taking.
Q: For what conditions ZIX MR OD CAPSULE is prescribed?
A: ZIX MR OD CAPSULE is given for reliving musculoskeletal pain associated with muscle spasms.
Q: Is ZIX MR OD CAPSULE safe for pregnant women?
A: ZIX MR OD CAPSULE is not recommended for use in pregnant women, as it may cause harm to an unborn baby. Therefore, consult your doctor before taking it. Women of childbearing age must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with ZIX MR OD CAPSULE.
Q: Can I take ZIX MR OD CAPSULE with antibiotics?
A: ZIX MR OD CAPSULE may interact with certain antibiotics (such as ciprofloxacin, ofloxacin, levofloxacin, or moxifloxacin) and may produce an altered response. Inform your doctor about the medicines that you use currently.
Q: Is ZIX MR OD CAPSULE a painkiller?
A: ZIX MR OD CAPSULE is an anti-inflammatory medicine with pain-relieving properties. It helps in reducing pain and swelling while relaxing the muscles. It can be used for reducing pain caused by muscle contractions or inflammatory bone conditions.
Q: Does ZIX MR OD CAPSULE make you feel sleepy?
A: ZIX MR OD CAPSULE may make you feel sleepy because of its sedative property. Therefore, be cautious while you drive or operate any heavy tools or machines. Do not consume alcohol or other medicine that can seduce your brain further, such as antidepressants (Ex. citalopram, sertraline). Consult your doctor if you continue to feel sleepy that interferes with your day-to-day activities.
Q: Is ZIX MR OD CAPSULE addictive?
A: ZIX MR OD CAPSULE is not a habit-forming medicine. However, you might feel better that only if you take ZIX MR OD CAPSULE. This is because ZIX MR OD CAPSULE can only reduce pain caused by inflammatory conditions. It cannot manage the actual cause of the pain. And so, if you stop taking ZIX MR OD CAPSULE, your pain may reappear once again. To avoid this, take ZIX MR OD CAPSULE only as advised by the physician for the stipulated duration.
Q: Is ZIX MR OD CAPSULE a steroid?
A: No. ZIX MR OD CAPSULE is not a steroid. It contains aceclofenac, which is a non-steroidal anti-inflammatory drug, and thiocolchicoside, which is a muscle relaxant. They act by blocking the production of certain chemicals in the body that cause pain, inflammation, and muscle spasms. As a result, it relaxes skeletal muscles and reduces pain associated with musculoskeletal disorders such as muscle spasm, arthritis, etc.
Q: Can ZIX MR OD CAPSULE be used in children?
A: No. ZIX MR OD CAPSULE is strictly not recommended for use in children aged below 16 years. Children above this age group must also consult their doctor before taking ZIX MR OD CAPSULE.
References
1. K.D. Tripathi. Nonsteroidal Anti-inflammatory Drugs and Antipyretic-Analgesics. Skeletal muscle relaxants. Essentials of Medical Pharmacology. Seventh edition. Page- 204 & 368.
2. Manish N. Maladkar, Chitra M. Tekchandani, Ashok S. Yadhav. National Library of Medicine. Targeting the Therapeutic Need in Musculoskeletal Inflammatory Pain with Thiocolchicoside and Aceclofenac Sustained Release with Combination Therapy. Aristo Pharmaceuticals Private Limited. ResearchGate. January 2019. [Accessed on 5th August 2024] https://www.researchgate.net/publication/335020828_Targeting_the_therapeutic_need_in_musculoskeletal_inflammatory_pain_with_thiocolchicoside_and_aceclofenac_sustained-release_combination_therapy
3. TORRENT PHARMACEUTICALS LTD. ZULU AT. Torrent.com. [Revised in April 2021]. [Accessed on 5th August 2024] https://www.torrentian.com/pisheet/Upload/PI_Sheet/3026.pdf
4. Cipla Ltd. IBUGESIC TH Tablets (Aceclofenac + Thiocolchicoside). Ciplamed.com. [Revised in June 2018]. [Accessed on 5th August 2024] https://ciplamed.com/content/ibugesic-th-tablets
5. Thichoren-AC. La Renon Healthcare Pvt Ltd. [Accessed on 5th August 2024] https://www.larenon.com/wp-content/uploads/2020/01/THICHOREN-2-page1.pdf
6. Novel formulations of thiocolchicoside. Patents.google.com. March 2015. [Accessed on 5th August 2024] https://patents.google.com/patent/EP2848260A1/en
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