Zivast L 10/25mg Tablet 10'S

Introduction About ZIVAST L 10/25MG TABLET

ZIVAST L 10/25MG TABLET is a combination of Atorvastatin and Losartan which belongs to the group of medicines called Antihyperlipidemics and Antihypertensives respectively. It is used to manage hypertension (high blood pressure) and hyperlipidemia (high blood cholesterol levels) in patients who have both co-existing medical conditions. It can also be used to manage the risk of heart attack, stroke and other heart problems.

Before taking ZIVAST L 10/25MG TABLET inform your doctor if you have any lung, liver, kidney or heart problems (apart from hypertension such as heart failure). You must also inform your doctor if you have diabetes, thyroid disorders, muscle problems, alcoholism or severe dehydration as a precaution.

ZIVAST L 10/25MG TABLET is not recommended for use in pregnant or breastfeeding women as it may cause serious harm to the growing baby or the nursing baby. The most common side effects of taking ZIVAST L 10/25MG TABLET are dizziness, headache, nausea, constipation, high blood potassium levels and high blood sugar levels. Consult your doctor if any of these side effect worsens.

Uses Of ZIVAST L 10/25MG TABLET

It is used to:

• Manage high blood pressure
• Manage high blood cholesterol levels
• Prevent the risk of heart attack or stroke

How ZIVAST L 10/25MG TABLET Works

ZIVAST L 10/25MG TABLET effectively reduces high blood pressure and high blood cholesterol levels. It contains two medicines namely, losartan and atorvastatin. Losartan relaxes the blood vessels supplying the heart and other vital organs of the body. As a result, it improves blood flow and oxygen supply to the heart which reduces strain on the heart and improves heart functions.

Atorvastatin is a lipid-lowering medicine. It blocks the release of certain enzymes (HMG-CoA reductase) that is involved in cholesterol formation within the body. It also reduces the amount of cholesterol produced by the liver and improves the excretion of lipids from the body via faeces.

Collectively, this medicine reduces blood pressure and blood cholesterol levels and manages you from their associated risks.

How to use ZIVAST L 10/25MG TABLET

Take ZIVAST L 10/25MG TABLET as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. ZIVAST L 10/25MG TABLET can be taken with or without meals. Try to take ZIVAST L 10/25MG TABLET at the same time each day.

Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and health condition. Continue to take ZIVAST L 10/25MG TABLET for the stipulated duration instructed by your doctor without interruption to achieve better results.

Side Effects Of ZIVAST L 10/25MG TABLET

How To Manage Side Effects

Nausea and vomiting:

Take ZIVAST L 10/25MG TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if your nausea worsens.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.

Headache:  

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.

Warning & Precautions

Interactions

A. Drug-Drug interactions:

Before taking ZIVAST L 10/25MG TABLET inform your doctor, if you are taking any of the following medicines such as:

• other medicines used to manage elevated blood pressure (such as aliskiren, captopril, enalapril, lisinopril, telmisartan, valsartan)
• antidepressants (used to manage depression) such as sertraline, fluoxetine, escitalopram, amitriptyline, nortriptyline, imipramine
• baclofen (a medicine used for relaxing muscles)
• amifostine (a kidney protectant used along with chemotherapeutic agents)
• non-steroidal anti-inflammatory drugs (used for pain relief) such as indomethacin, celecoxib, ibuprofen, aspirin
• lithium, St. John’s wort (medicines used to manage depression)
• other medicines used to reduce blood cholesterol levels (Ex. gemfibrozil, ezetimibe, colestipol, colesevelam)
• medicines used to manage angina or other heart problems (Ex. amlodipine, diltiazem, verapamil, amiodarone, and digoxin)
• potassium supplements or potassium-sparing diuretics such as spironolactone, triamterene or amiloride (used to retain or increase potassium levels in the body)
• medicines to manage graft rejection (Ex. cyclosporin, tacrolimus, sirolimus)
• medicines used to manage Hepatitis C infection (Ex. telaprevir, boceprevir and combination of elbasvir/grazoprevir)
• medicines used to manage fungal infection (Ex. ketoconazole, itraconazole, voriconazole, fluconazole, posaconazole)
• medicines used to manage bacterial infections (Ex. fusidic acid, erythromycin, clarithromycin, telithromycin, trimethoprim)
• medicines used to manage HIV infection (Ex. ritonavir, lopinavir, atazanavir, indinavir, darunavir)
• warfarin, heparin (used to manage or manage blood clots)
• letermovir (a medicine used to manage cytomegalovirus)
• phenazone (a pain killer)
• oral contraceptives (birth control pill) Ex. levonorgestrel, ethinylestradiol
• cimetidine (a medicine used to manage heartburn and stomach ulcers)
• colchicine (a medicine used to manage gout)
• antacids (used to neutralize stomach acid) Ex. aluminium hydroxide, milk of magnesia
• stiripentol (a medicine used to manage fits)

B. Drug-Food interactions:

While taking ZIVAST L 10/25MG TABLET, avoid drinking grapefruit juice as it may interact with ZIVAST L 10/25MG TABLET and reduce its effectiveness.

Overdosage:

If you or anyone else accidentally take too much of this medicine, consult your doctor immediately.

Synopsis

Drug	:	Atorvastatin, Losartan
Pharmacological Category	:	HMG-CoA reductase inhibitors, Angiotensin-II receptor blockers
Therapeutic Indication	:	High blood pressure, High blood cholesterol levels, Prevention of heart attack or stroke
Dosage Forms	:	Tablet

More Information

• Keep ZIVAST L 10/25MG TABLET out of reach of children
• Store ZIVAST L 10/25MG TABLET at room temperature

FAQs About ZIVAST L 10/25MG TABLET

Q: What are the uses of ZIVAST L 10/25MG TABLET?

A: ZIVAST L 10/25MG TABLET is used to manage hypertension (high blood pressure) and hyperlipidemia (high blood cholesterol levels) in patients who have both co-existing medical conditions. It can also be used to manage the risk of heart attack, stroke, angina and other heart problems.

Q: Can the use of ZIVAST L 10/25MG TABLET cause diabetes?

A: Yes. ZIVAST L 10/25MG TABLET may increase blood sugar levels in some patients. This is most predominantly seen in patients who already have diabetes along with obesity and/or hypertension. Therefore, consult your doctor before taking this medicine if you are diabetic, obese or have hypertension. Your doctor will closely monitor your blood sugar levels while undergoing therapy with ZIVAST L 10/25MG TABLET to avoid any unwanted side effects.

Q: What is the best time to take ZIVAST L 10/25MG TABLET?

A: Take ZIVAST L 10/25MG TABLET as advised by your physician. Your doctor will decide the best time for you to take ZIVAST L 10/25MG TABLET. Try to take this medicine at the same time each day. It can be taken with or without food.

Q: What are the side effects of taking ZIVAST L 10/25MG TABLET?

A: The most common side effects of taking ZIVAST L 10/25MG TABLET are dizziness, headache, nausea, constipation, high blood potassium levels and high blood sugar levels. Consult your doctor if any of these side effect worsens.

Q: Can I consume alcohol along with ZIVAST L 10/25MG TABLET?

A: ZIVAST L 10/25MG TABLET should be used with caution in patients who consume large amounts of alcohol. It is advisable to avoid alcohol consumption while taking this medicine to achieve maximum benefits.

Q: Can the use of ZIVAST L 10/25MG TABLET make me feel more tired?

A: Yes. The use of ZIVAST L 10/25MG TABLET can make you feel more tired, because it acts by reducing the supply of energy to the muscles present in your body. However, you may also feel tired due to other reasons such as severe liver damage. Consult your doctor if you experience excessive tiredness with muscle pain.

Q: Who should not take ZIVAST L 10/25MG TABLET?

A: ZIVAST L 10/25MG TABLET is not recommended for use in patients with severe liver damage. It is also not suitable for use in patients having muscle problems and in women in who are pregnant or breastfeeding. Before taking ZIVAST L 10/25MG TABLET inform your doctor if you have diabetes or any kidney or heart problems. Do not take this medicine if you are undergoing therapy with antibiotics such as fusidic acid.

Q: What are the dietary restrictions that I need to follow while taking ZIVAST L 10/25MG TABLET?

A: While taking ZIVAST L 10/25MG TABLET, follow a low-cholesterol diet as instructed by your doctor and avoid excessive alcohol intake. Avoid eating oil rich or deep-fried foods. Limit your sugar intake by avoid eating biscuits, cakes, soft drinks, or pastries. Stick to a simple nutritious diet. Avoid consumption of grapefruit while taking ZIVAST L 10/25MG TABLET as it may reduce its effectiveness.

Q: What should I do if I forget to take a dose of ZIVAST L 10/25MG TABLET?

A: If you forget to take a dose of ZIVAST L 10/25MG TABLET, take it as soon as you remember. However, if it is time to take the next dose of ZIVAST L 10/25MG TABLET, skip the missed dose and take the next one at regular times. Do not take a double dose of ZIVAST L 10/25MG TABLET to compensate the missed dose, as it could lead to toxicity.

Q: Can I stop taking ZIVAST L 10/25MG TABLET once my symptom subsides?

A: Do not stop taking this medicine without consulting your doctor, as it could once again increase your blood pressure and cholesterol levels once again. ZIVAST L 10/25MG TABLET can only control your hypertension and blood cholesterol levels and cannot manage them completely, therefore, it is important to take this medicine until your doctor advises you to stop.

Q: Can I take ZIVAST L 10/25MG TABLET if I am diabetic?

A: ZIVAST L 10/25MG TABLET may increase blood sugar levels in some patients. This is most predominantly seen in patients who already have diabetes along with obesity and/or hypertension. Therefore, consult your doctor before taking ZIVAST L 10/25MG TABLET if you are diabetic, obese or have hypertension.

Q: Does ZIVAST L 10/25MG TABLET cause muscle pain?

A: ZIVAST L 10/25MG TABLET may cause a rare but serious side effect of unexplained muscle pain or weakness called rhabdomyolysis. Therefore, consult your doctor if you experience any signs of muscle problems after taking ZIVAST L 10/25MG TABLET. Also, talk to your doctor before taking ZIVAST L 10/25MG TABLET if you already have weak muscles or have a family history of any muscle disorders.

Q: How ZIVAST L 10/25MG TABLET controls cholesterol levels in the body?

A: ZIVAST L 10/25MG TABLET is a lipid-lowering medicine. It blocks the release of certain enzymes (HMG-CoA reductase) that is involved in cholesterol formation within the body. It also reduces the amount of cholesterol produced by the liver and improves the excretion of lipids from the body via faeces.

Q: How long should I take ZIVAST L 10/25MG TABLET to manage high cholesterol?

A: You should take ZIVAST L 10/25MG TABLET as long as your doctor advises you to take. Because ZIVAST L 10/25MG TABLET will only help you in managing your blood pressure and cholesterol levels and cannot completely manage them. If you stop using ZIVAST L 10/25MG TABLET, your symptoms may raise once again.

Q: Can ZIVAST L 10/25MG TABLET be taken by pregnant or breast-feeding women?

A: ZIVAST L 10/25MG TABLET is not recommended for use in pregnant or in breast-feeding women. Therefore, consult your doctor before taking it. Women of childbearing age must use a reliable contraceptive method to avoid pregnancy while undergoing therapy with this medicine. However, if you accidentally become pregnant while taking this medicine, stop taking it and consult your doctor immediately.

Q: Can I take ZIVAST L 10/25MG TABLET daily?

A: Take ZIVAST L 10/25MG TABLET as advised by your physician. Your doctor will evaluate your health condition and suggests whether can you take ZIVAST L 10/25MG TABLET every day or not.

Q: Can ZIVAST L 10/25MG TABLET cause ankle swelling?

A: ZIVAST L 10/25MG TABLET may cause edema or swelling of ankles in few patients. If you experience ankle swelling, keep your legs on a table or slightly elevated from the ground level. If this symptom bothers you, contact your doctor.

Q: Can the use of ZIVAST L 10/25MG TABLET affect the liver?

A: Yes. ZIVAST L 10/25MG TABLET may affect the way your liver work. Therefore, it is not recommended for use in patients with severe liver problems (such as jaundice, cholestasis or biliary obstruction). It should be used with caution in patients with other liver problems. Consult your doctor before taking it.

References

1. K.D. Tripathi. Drugs affecting renin angiotensin system and plasma kinins & Hypolipidaemic Drugs and Plasma Expanders. Essentials of medical pharmacology. Seventh edition. 2013. Page –507 & 637.

2. Lindsey A. McIver; Momin S. Siddique. Atorvastatin. StatPearls. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. September 2022. [Accessed on 5th January 2023] https://www.ncbi.nlm.nih.gov/books/NBK430779/

3. Sana Mulla; Waqas J. Siddiqui. Losartan. StatPearls. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. July 2022. [Accessed on 5th January 2023] https://www.ncbi.nlm.nih.gov/books/NBK526065/

4. Sun Pharmaceutical Industries Europe B.V. Electronic Medicines Compendium (EMC). [Revised in April 2022] [Accessed on 5th January 2023] https://www.medicines.org.uk/emc/files/pil.4339.pdf

5. Dexcel Pharma Ltd. Electronic Medicines Compendium (EMC). [Revised in July 2019] [Accessed on 5th January 2023] https://www.medicines.org.uk/emc/files/pil.9045.pdf

Useful Diagnostic Tests

• Kidney function tests
• CBC
• Lipid Profile
• Liver Function Test
• Echocardiography

 

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