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Introduction About ZILAST 50MG TABLET
ZILAST 50MG TABLET contains Cilostazol which belongs to the group of medicines called Phosphodiesterase type 3 inhibitors. It is used in the management of intermittent claudication, which is defined as the cramp-like pain in the legs while walking caused by insufficient blood supply in the legs. Symptoms include pain, ache, discomfort or fatigue in muscles every time, when those muscles are used (usually the calves, thighs, buttocks, hips or feet).
Along with this management your doctor might advise you to make lifestyle modifications like increasing regular exercise and stop smoking. Prior to the management, your doctor may want you to take ankle-brachial index test to understand your existing condition.
ZILAST 50MG TABLET is not recommended for use in patients having severe heart problems (such as heart failure, heart attack), uncontrolled blood pressure, kidney or liver disease, active stomach ulcer and stroke.
Do not drink large amounts of grapefruit juice while taking ZILAST 50MG TABLET as it may reduce the effect of this medicine. ZILAST 50MG TABLET is not recommended for use among pregnant or breastfeeding women, therefore consult your doctor before taking it. This medicine is not recommended for use in children and adolescents.
The most common side effects of taking ZILAST 50MG TABLET are headache, abnormal stools, diarrhea, abdominal discomfort, dizziness, nausea and loss of appetite. Consult your doctor if any of the side effects worsen over the time.
Uses Of ZILAST 50MG TABLET
- Manage intermittent claudication
How ZILAST 50MG TABLET Works
ZILAST 50MG TABLET acts by inhibiting the activity of certain enzymes (phosphodiesterase) which helps in the increase in the level of cAMP (cellular messengers to initiate certain actions) in platelets and blood vessels. The cAMP helps in widening of some blood vessels and reducing the clotting activity of platelets inside the blood vessels. Hence increasing the blood circulation to the legs making it easier and less painful to walk.
How to use ZILAST 50MG TABLET
Take ZILAST 50MG TABLET as advised by your physician. Swallow ZILAST 50MG TABLET with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of ZILAST 50MG TABLET
Common
- headache, dizziness
- abnormal stools, diarrhea
- heart pounding
- runny nose
- abdominal pain, abdominal discomfort (indigestion), excessive burping
- nausea or vomiting, general weakness
- loss of appetite
- swelling of the ankles, feet or face
- skin allergy (rash or changes in appearance of the skin, itchy skin, patchy bleeding in the skin)
Uncommon
- shortness of breath, cough, chills
- unexpected bleeding, tendency to bleed (Ex. nose bleeding and blood in spit or urine)
- fainting, anxiety
- difficulty sleeping, unusual dreams
- allergic reaction, aches and pains
- stomachache (gastritis)
Rare
- problems with the kidneys
Stop taking ZILAST 50MG TABLET and contact your doctor immediately if you experience any of the following side effects:
- easy bruising and bleeding, fever or sore throat
- a pain or uncomfortable feeling in the chest, often spreading to the arms or neck and sometimes to the shoulders and back which may be caused by too little blood and oxygen supplying to the heart
- heart attack, irregular heartbeat, increased heart rate
- heart problems causing shortness of breath or ankle swelling
- increased blood sugar levels
- bleeding of the stomach and eyes
- pneumonia
- kidney failure
How To Manage Side Effects
Diarrhea
Drink lot of fluids such as water to keep yourself hydrated. Avoid eating high-fat or spicy foods. Avoid taking any medicine on your own for managing diarrhea. Consult your doctor if the symptom does not improve.
Dizziness Or Drowsiness
Lie down until dizziness goes away and then move slowly and carefully. Take sufficient rest and drink plenty of fluids. Rise slowly after sitting or lying down. Be careful while going up and down stairs. Consult your doctor if the symptom worsens.
Headache
Drink ample amount of water and avoid skipping meals. Get adequate rest. Try to be relaxed and stress free. Apply pain relieving balm on your forehead if necessary. Consult your doctor if the symptom does not improve.
Nausea And Vomiting
Stick to simple meals while taking this medicine. Avoid eating oily, fried and spicy foods. Do not perform any strenuous activities immediately after eating. Consult your doctor if the symptom does not improve.
Stomach Pain
Try to rest and relax. Eat and drink slowly or try to eat smaller meals more frequently. Keep a heat pad on your stomach. Consult your doctor if the symptom does not improve.
Warning & Precautions
Pregnancy
ContraindicatedZILAST 50MG TABLET is not recommended for use in pregnant women. Consult your doctor before taking ZILAST 50MG TABLET.
Breastfeeding
ContraindicatedZILAST 50MG TABLET is not recommended for use in breastfeeding women. Consult your doctor before taking ZILAST 50MG TABLET.
Driving and Using Machines
Use with CautionDo not drive or operate heavy machines if you experience dizziness while taking ZILAST 50MG TABLET.
Kidney
ContraindicatedZILAST 50MG TABLET is not recommended for use in patients with severe kidney disease. Consult your doctor before taking ZILAST 50MG TABLET.
Liver
ContraindicatedZILAST 50MG TABLET is not recommended for use in patients with moderate or severe liver disease. Consult your doctor before taking ZILAST 50MG TABLET.
Allergy
ContraindicatedDo not take ZILAST 50MG TABLET if you are allergic to Cilostazol or any other ingredients of this medicine.
Heart Disease
Consult your doctorZILAST 50MG TABLET is not recommended for use in patients with heart failure, had heart attack, persistent chest pain at rest, any heart surgery in the last 6 months, suffered from blackouts due to heart disease or any severe disturbances of the heartbeat. It should be taken with caution in patients with severe heart problem or any other problems with your heart beat and high blood pressure. Consult your doctor before taking ZILAST 50MG TABLET.
Use In Pediatrics
ContraindicatedZILAST 50MG TABLET is not recommended for use in children and adolescents. Consult your child’s doctor for advice.
Use In Geriatrics
Use with CautionZILAST 50MG TABLET should be taken with caution in elderly patients. Consult your doctor before taking ZILAST 50MG TABLET.
Others
ZILAST 50MG TABLET is not recommended for use if you:
- have any condition which increases the risk of bleeding or bruising, such as active stomach ulcers, stroke in the past six months, eye problems with diabetes and uncontrolled blood pressure
Before taking ZILAST 50MG TABLET, inform your doctor if you:
- need to have surgery (including teeth removal)
Interactions
A. Drug-Drug interactions:
Before taking ZILAST 50MG TABLET, inform your doctor if you are taking any of the following medicines:
- acetylsalicylic acid (aspirin) (used to manage painful inflammatory condition of muscle or joints)
- anticoagulant medicines (Ex. heparin, warfarin, clopidogrel, dabigatran, rivaroxaban, apixaban) (used to manage or manage blood clots)
- certain antibiotics Ex. erythromycin, clarithromycin or rifampicin (used to manage bacterial infections)
- ketoconazole (used to manage fungal infections)
- omeprazole (used to manage acidity in the stomach)
- diltiazem (used to manage high blood pressure or chest pain)
- cisapride (used to manage stomach disorders)
- medicines used to manage high cholesterol in the blood (Ex. lovastatin, simvastatin)
- halofantrine (used to manage malaria)
- protease inhibitors such as atazanavir, darunavir (used to manage HIV infection)
- pimozide (used to manage mental illnesses)
- ergot derivatives Ex. ergotamine, dihydroergotamine (used to manage or manage migraine headaches)
- st. john’s wort (herbal remedy), carbamazepine or phenytoin (used to manage convulsions)
- diuretics Ex. hydrochlorothiazide, furosemide (used to manage fluid retention)
- calcium channel blockers such as verapamil, amlodipine, angiotensin-converting-enzyme inhibitors such as captopril, lisinopril, angiotensin II receptor blockers such as valsartan, candesartan and beta blockers such as labetalol, carvedilol (used to manage high blood pressure)
B. Drug-Food interactions:
Do not drink large amounts of grapefruit juice while taking ZILAST 50MG TABLET as it may reduce the effect of this medicine and do not take together with meals as it may affects its absorption and increase the risk of side effects.
Overdosage:
If you or anyone else accidentally take too much of ZILAST 50MG TABLET, consult your doctor immediately or visit the nearby hospital. Overdosage symptoms of ZILAST 50MG TABLET includes severe headache, diarrhea, increase in heart rate and irregularities of the heartbeat.
Synopsis
| Drug | : | Cilostazol |
| Pharmacological Category | : | Platelet aggregation inhibitors |
| Therapeutic Indication | : | Intermittent claudication |
| Dosage Forms | : | Tablet |
More Information
- Keep ZILAST 50MG TABLET out of reach of children
- Store ZILAST 50MG TABLET at room temperature
FAQs About ZILAST 50MG TABLET
Q: How does ZILAST 50MG TABLET work?
A: ZILAST 50MG TABLET acts by inhibiting the activity of certain enzymes (phosphodiesterase) which helps in the increase in the level of cAMP (cellular messengers to initiate certain actions) in platelets and blood vessels. The cAMP helps in widening of some blood vessels and reducing the clotting activity of platelets inside the blood vessels. Hence increasing the blood circulation to the legs making it easier and less painful to walk.
Q: What is ZILAST 50MG TABLET used for?
A: ZILAST 50MG TABLET is used in the management of intermittent claudication, which is defined as the cramp-like pain in the legs while walking caused by insufficient blood supply in the legs. Symptoms include pain, ache, discomfort or fatigue in muscles every time, when those muscles are used (usually the calves, thighs, buttocks, hips or feet).
Q: Can I stop taking ZILAST 50MG TABLET on my own?
A: If you stop taking ZILAST 50MG TABLET the pain in your legs may come back or get worse. Therefore, you should only stop taking it if you notice side effects requiring urgent medical attention or if your doctor tells you to.
Q: What to do If I forget to take a dose of ZILAST 50MG TABLET?
A: You should take ZILAST 50MG TABLET immediately when you remember. If it is time for the next dose skip the missed dose and follow the regular dose schedule. Do not double the dose to match up the missed dose.
Q: Can ZILAST 50MG TABLET be used in pregnant or breast-feeding women?
A: ZILAST 50MG TABLET is not recommended for use in pregnant and breast-feeding women. Consult your doctor before taking this medicine if you are pregnant, planning to become pregnant or breast-feeding your child.
References
1. K.D.Tripathi, Antianginal and Other Anti-ischemic Drugs. Essentials of Medical Pharmacology. Eighth Edition.2019. Page – 601, 602.
2. Alexander M. Balinski; Charles V. Preuss. Cilostazol. NIH National Library of Medicine, National center for biotechnology information. [Revised in September 2021] [Accessed on 3rd May 2022] https://www.ncbi.nlm.nih.gov/books/NBK544363/
3. Tamara Brown, Rachel B Forster, Marcus Cleanthis, Dimitri P Mikhailidis, Gerard Stansby, Marlene Stewart. Cilostazol for intermittent claudication. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. June 2001. [Accessed on 3rd May 2022] https://pubmed.ncbi.nlm.nih.gov/34192807/#:~:text=Authors'%20conclusions%3A%20Cilostazol%20has%20been,higher%20odds%20of%20experiencing%20headache.
4. Adamed Pharma S.A. Electronic Medicines Compendium (EMC). [Revised in February 2020] [Accessed on 3rd May 2022] https://www.medicines.org.uk/emc/files/pil.2590.pdf
Useful Diagnostic Tests
- Ankle-brachial index test
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