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Introduction About ZERODOL-SP TABLET
ZERODOL-SP TABLET is a pain relief combination used to provide relief from pain, inflammation and swelling associated with joint pain, muscle pain, post-operative conditions, etc.
It contains a combination of Aceclofenac, paracetamol and serratiopeptidase as active ingredients. Aceclofenac and Paracetamol are pain relieving medicines which works by blocking the release of certain chemicals in the body that causes pain, inflammation and swelling. Serratiopeptidase is a protein-breaking enzyme which breaks down the abnormal proteins at the site of inflammation, thereby healing the affected areas.
Before taking Zerodol-SP, inform your doctor if you have any stomach disease like ulcerative colitis, Crohn’s disease, bleedings or perforation in the gut, bloody stools or vomits, etc. You must also inform your doctor if you have asthma, liver, kidney or heart problems as a precaution.
Do not use this medicine if you are pregnant or breastfeeding without consulting your doctor. The most common side effects of Zerodol-SP are dizziness, nausea, vomiting, diarrhoea, constipation, mouth ulcers, increased liver enzymes in the blood, indigestion, bloating, stomach irritation, increase in blood urea or creatinine levels.
Uses Of ZERODOL-SP TABLET
- Pain, inflammation and swelling associated with joint pain, muscle pain and post-surgical conditions
How ZERODOL-SP TABLET Works
It contains a combination of Aceclofenac, Paracetamol, and Serratiopeptidase. Aceclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that blocks the enzyme (COX) responsible for producing prostaglandins, chemicals in the body that cause pain and inflammation. By inhibiting this enzyme, aceclofenac reduces pain and swelling.
Paracetamol works by reducing the intensity of pain signals sent to the brain and helps regulate body temperature, acting as both a pain reliever and fever reducer. Serratiopeptidase is an enzyme that breaks down proteins involved in inflammation and promotes the removal of dead tissue, reducing swelling and improving healing.
Together, these components help reduce pain, inflammation, and swelling effectively in conditions like arthritis, muscle pain, and joint pain.
How to use ZERODOL-SP TABLET
- Swallow this medicine with a glass of water
- Do not chew or crush the medicine
- Take the tablet as prescribed by your doctor, usually 1 to 2 times a day as advised by the physician
- It is best to take Zerodol-SP with or after food to minimize the risk of stomach upset or irritation.
- If you miss a dose, take it as soon as you remember. If it's almost time for the next dose, skip the missed one. Do not double the dose to catch up.
- Use it only for the duration prescribed by your doctor. Avoid long-term use without medical supervision to prevent side effects.
- Always consult your healthcare provider for personalized advice based on your health condition
Side Effects Of ZERODOL-SP TABLET
Common Side Effects of Zerodol-SP Tablet
- Dizziness
- Nausea or vomiting
- Diarrhoea or constipation
- Increased liver enzymes in the blood
- Wind, Inflammation or irritation of the lining of the stomach
- Mouth ulcers
- Skin rashes or Itching, skin inflammation
- Raised circular red itchy, stinging or burning patches on the skin (hives)
- Increase in blood urea levels
- Increase in blood creatinine level
Stop taking this medicine and contact your doctor if you experience any of the following side effects:
- Allergic reactions (such as fever, difficulty breathing, wheezing, abdominal pain, vomiting, swelling of the face and throat)
- Severe skin reactions with fever, peeling of skin, severe body pains and joint pains
- Symptoms include high fever, headache, vomiting, blotchy red rashes, neck stiffness, sensitivity and intolerance to light.
- Passing blood in your faeces or black tarry stools, vomiting of any blood or dark particles that look like coffee grounds.
- Indigestion or heartburn, pains in your stomach or other abnormal stomach symptoms.
- Low RBC, WBC and platelet count
Warning & Precautions
Pregnancy
ContraindicatedZERODOL-SP is not recommended for use in pregnant women unless considered necessary by your physician.
Breastfeeding
ContraindicatedIt is not recommended for use in breast-feeding women as it may pass through the breast milk.
Driving and Using Machines
ContraindicatedDo not drive or operate any machines, as you may feel dizzy after taking this medicine.
Alcohol
ContraindicatedAvoid consumption of alcohol while taking ZERODOL-SP TABLET, as it may cause liver damage.
Kidney
Consult your doctorThis medicine is not recommended for use in patients with severe kidney disease. It should be used with caution in patients with mild kidney problems.
Liver
Consult your doctorIt is not recommended for use in patients with severe liver impairment. It should be used with caution in patients with mild liver diseases.
Allergy
ContraindicatedDo not take ZERODOL SP TABLET if you are allergic to Aceclofenac, Paracetamol, Serratiopeptidase, and/or any other ingredients of this medicine.
Lungs
Consult your doctorZERODOL-SP TABLET is not recommended for use if you have an active asthma attack causing wheezing, difficulty in breathing and chest tightness. It should be used with caution in patients with a history of asthma or any other breathing problems.
Heart Disease
Consult your doctorZERODOL-SP is not recommended for use in patients with an established heart disease and/or cerebrovascular disease such as heart attack, stroke, mini-stroke or blockages to blood vessels to the heart or brain or an operation to clear or bypass blockages. It should be used with caution in patients with other heart problems like angina, high blood pressure, etc.
Use In Pediatrics
ContraindicatedZERODOL-SP TABLET is not recommended for use in children and adolescents (below 18 years).
Use In Geriatrics
Use with CautionZERODOL-SP should be used with caution with elderly patients.
Others
ZERODOL SP TABLET is not recommended for use if you:
- Have runny nose, itching and sneezing
- Raised red itchy patches on the skin
- Currently have or previous had a history of stomach ulcers
- Have any stomach condition that causes bloody stools or vomits
- Have or have had problems with your blood circulation (peripheral arterial disease)
- Have bleeding or suffer from any blood clotting disorders
Before taking this medicine, inform your doctor if you:
- Have stomach problems, stomach inflammation
- Have inflammatory bowel diseases like ulcerative colitis or Crohn’s disease
- Have ulceration, bleeding or holes in the gut
- Have problems in blood circulation to the brain
- Suffer from porphyria
- Have a habit of smoking
- Have diabetes
- Suffer from blood clots or high blood cholesterol levels
- Suffer from an auto-immune disorder called systemic lupus erythematosus)
- Are infected with chickenpox
- Are recovering from major surgery or illness
Interactions
A. Drug-Drug Interactions:
- NSAIDs (Ex. aspirin, naproxen, rofecoxib, ibuprofen, and diclofenac)
- Antihypertensives (Ex. atenolol, metoprolol)
- Diuretics (Ex. chlorothiazide, chlorthalidone)
- Cardiac glycosides (Ex. digoxin)
- Anti-manic (Ex. lithium)
- Anti-rheumatic (Ex. methotrexate)
- Immunosuppressants (Ex. ciclosporin and tacrolimus)
- Anti-progestational steroids (Ex. mifepristone)
- Corticosteroids (Ex. cortisone, prednisone, and prednisolone)
- Anticoagulants (Ex. warfarin, rivaroxaban, dalteparin, enoxaparin, heparin, and dabigatran)
- Antibiotics (Ex. ciprofloxacin and chloramphenicol)
- Anti-retroviral (Ex. zidovudine)
- Antidiabetic agents (Ex. biguanides, sulfonylureas)
- Antiglaucoma agents (Ex. acetazolamide)
- Anti-gout (Ex. probenecid)
- Antiepileptic medicines (Ex. phenytoin, phenobarbital, carbamazepine)
- Anti-tubercular (Ex. rifampicin)
- Anti-depressant (Ex. St. John's wort)
- Anti-platelet (Ex. clopidogrel)
Overdosage:
If you or anyone else accidentally takes too much of Zerodol-SP Tablets, consult your doctor immediately or visit the nearby hospital. Symptoms of an overdose are headache, pallor, nausea, vomiting, epigastric pain, gastrointestinal irritation and bleeding, diarrhea, disorientation, excitation, drowsiness, dizziness, tinnitus, hypotension, respiratory depression, fainting, convulsions, anorexia, and/or abdominal pain.
Synopsis
| Drug | : | Aceclofenac, Paracetamol, and Serratiopeptidase |
| Pharmacological Category | : | Nonsteroidal anti-inflammatory drugs, Analgesics and Antipyretics, Proteolytic enzymes |
| Therapeutic Indication | : | Pain relief |
| Dosage Forms | : | Tablet |
More Information
Storage
- Keep the medicine out of the reach of children
- Store this medicine at room temperature
FAQs About ZERODOL-SP TABLET
Q: What is Zerodol SP used for?
A: Zerodol SP is used primarily to relieve pain, inflammation, and swelling in conditions involving musculoskeletal issues, such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and joint or muscle injuries. Additionally, it is commonly prescribed to manage pain after surgeries, dental procedures, or traumatic injuries. This combination medication offers targeted relief for moderate to severe pain and associated inflammation.
Q: Is Zerodol a strong painkiller?
A: Yes, Zerodol SP is considered a strong painkiller. It combines aceclofenac (an NSAID that reduces pain and inflammation), paracetamol (a pain-reliever and fever reducer), and serratiopeptidase (an enzyme that reduces swelling and inflammation). Together, these ingredients provide potent relief from moderate to severe pain, making it effective in managing conditions where inflammation and muscle pain are present. This combination makes it stronger than medications containing only one type of pain-relief component.
Q: Can Zerodol SP be used for ear pain?
A: Zerodol SP may help relieve ear pain because of its anti-inflammatory properties, but it is not typically recommended for this type of pain without a doctor’s consultation. Ear pain can have various causes, such as infections or fluid buildup, which may require specific treatment beyond general pain relief. It’s best to consult a healthcare provider to determine if Zerodol SP is appropriate for your specific ear pain.
Q: Is Zerodol SP used for head pain?
A: Zerodol SP is generally not the first choice for headaches or migraines. It is designed to treat musculoskeletal pain, which involves inflammation and swelling of muscles and joints. Headaches and migraines are often managed with medications specifically formulated for those types of pain, such as paracetamol, ibuprofen, or migraine-specific drugs. Zerodol SP may not provide optimal relief for headaches and could have unnecessary components for that type of pain.
Q: Can Zerodol damage kidneys?
A: Long-term use of Zerodol SP can potentially damage the kidneys, especially in individuals with existing kidney conditions or those taking high doses for extended periods. Aceclofenac, an NSAID in Zerodol SP, can reduce blood flow to the kidneys, which may impair kidney function over time. It’s important to take this medication only as prescribed and to avoid long-term use without medical supervision. Regular kidney function monitoring is recommended if prolonged use is necessary.
Q: Is Zerodol SP bad for the liver?
A: Zerodol SP contains paracetamol, which can affect the liver, especially in high doses or with prolonged use. Excessive or prolonged intake of paracetamol can cause liver toxicity, so people with liver conditions should consult their doctor before using it. Following the prescribed dosage and avoiding other medications containing paracetamol while taking Zerodol SP are essential steps in protecting liver health.
Q: Does Zerodol SP make you sleepy?
A: Zerodol SP is generally not associated with causing drowsiness or sedation. However, individual responses to medications can vary, and some people might feel slightly sleepy or fatigued. If you notice significant drowsiness after taking Zerodol SP, it’s recommended to consult your doctor, as they may adjust your dosage or suggest alternative options.
Q: How many hours does Zerodol SP last?
A: Zerodol SP typically provides relief for about 6 to 8 hours, though the exact duration can vary depending on individual factors like metabolism, the severity of pain, and the condition being treated. For chronic conditions, your doctor may prescribe a specific dosage schedule to maintain consistent pain relief. Always follow the prescribed timing to prevent overlapping doses.
Q: Are Zerodol and Dolo 650 the same?
A: No, they are different medications. Zerodol SP is a combination of aceclofenac, serratiopeptidase, and paracetamol, providing anti-inflammatory, anti-swelling, and pain-relief effects. Dolo 650, on the other hand, contains only paracetamol, which is primarily used as a fever reducer and pain reliever for mild to moderate pain. While Dolo 650 can help relieve headaches, fevers, and mild pain, Zerodol SP is stronger and more effective for conditions involving significant inflammation and musculoskeletal pain.
Q: Can Zerodol be used for nerve pain?
A: Zerodol SP is not specifically used for nerve pain. Medications such as gabapentin or pregabalin are generally prescribed for nerve-related pain. Zerodol SP is more suitable for pain caused by inflammation, swelling, or injury. While it may help reduce inflammation-related pain, it is unlikely to address the underlying issues associated with nerve pain, so consulting a doctor for appropriate treatment is recommended.
Q: Does Zerodol SP cause constipation?
A: Constipation is not a common side effect of Zerodol SP, but some individuals may experience gastrointestinal side effects like constipation, stomach discomfort, or bloating. If you experience constipation, inform your doctor, as they may suggest dietary adjustments, hydration, or additional treatments to alleviate this side effect.
Q: Can Zerodol SP Tablet be taken by pregnant or breastfeeding women?
A: Zerodol SP is not recommended for use in pregnant or breastfeeding women. Its components may pose a risk to the developing fetus or nursing child, potentially leading to adverse effects. Pregnant and breastfeeding women should consult their doctor for safer alternatives. Self-medicating with Zerodol SP during pregnancy or lactation should be avoided to protect maternal and child health.
Q: Can Zerodol SP Tablet be used in diabetic patients?
A: Diabetic patients should consult their doctor before taking Zerodol SP. Some components may interact with antidiabetic medications or affect blood sugar control. It's crucial for diabetic patients to inform their doctor about all the medications they are currently taking to avoid potential interactions. The doctor may recommend regular blood sugar monitoring or adjust the dosage to ensure safe use.
References
1. KD. Tripathi. Aspects of Pharmacotherapy, Clinical Pharmacology and Drug Development, and Nonsteroidal Anti-Inflammatory Drugs and Antipyretic-Analgesics. Essentials of Medical Pharmacology. Seventh Edition. 2013. Page – 71, 204 & 206.
2. Manju Tiwari. The role of serratiopeptidase in the resolution of inflammation. NIH National Library of Medicine. National Center for Biotechnology Information. PMC PubMed Central. [Revised in May 2017] [Accessed on 19th September 2024]. click here
3. Ciplamed. MOVEXX SP Tablets [Revised in September 2023] [Accessed on 19th September 2024] click here
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