Zerodol MR Tablet 10'S

Introduction About ZERODOL MR TABLET

Zerodol MR Tablet is a combination medicine containing Aceclofenac and Tizanidine. It is commonly prescribed for adult patients under the supervision of a healthcare professional in musculoskeletal conditions associated with muscle stiffness, inflammatory discomfort, and movement-related muscular tension. Aceclofenac belongs to the non-steroidal anti-inflammatory drug (NSAID) group, while Tizanidine belongs to the muscle relaxant group.

The two active ingredients work through different mechanisms in the body. Aceclofenac helps regulate inflammatory chemical activity associated with swelling, stiffness, and discomfort affecting muscles and joints. Tizanidine acts on the central nervous system to help regulate nerve signals involved in excessive muscle tightening and muscular spasm. Together, the combination supports muscle relaxation, flexibility, and movement-related comfort.

Zerodol MR Tablet may be recommended by healthcare professionals based on individual medical evaluation and physical condition. The suitability of this medicine may vary depending on factors such as age, medical history, liver function, kidney function, existing health conditions, and the use of other medications. Individuals with underlying medical concerns should inform their healthcare professional before using this medicine.

The tablet should be taken exactly as directed by the healthcare professional. It is intended for oral administration and should be swallowed whole with water without crushing or chewing. The dosage and duration of use may vary according to individual requirements and medical assessment. It is important to follow the prescribed instructions carefully and avoid changing the recommended dosage without medical guidance.

Some individuals may experience effects such as dizziness, drowsiness, dry mouth, stomach discomfort, nausea, or weakness while using Zerodol MR Tablet. The occurrence and intensity of these effects may vary among individuals. If any symptom persists, worsens, or becomes bothersome, medical advice should be sought promptly.

Uses Of ZERODOL MR TABLET

It is used in the management of:

• Osteoarthritis
• Rheumatoid arthritis
• Ankylosing spondylitis
• Acute low back pain
• Cervical spondylosis
• Frozen shoulder
• Sciatica
• Tennis elbow
• Muscle spasm associated with musculoskeletal disorders
• Soft tissue rheumatic conditions
• Post-traumatic pain and inflammation
• Recovery after orthopedic injuries
• Painful conditions affecting muscles, ligaments, and tendons
• Mobility limitations associated with musculoskeletal discomfort

Benefits of ZERODOL MR TABLET

Supports Relief from Muscle Tightness and Inflammatory Discomfort

Aceclofenac and Tizanidine are commonly used together in musculoskeletal conditions where muscle tightness, inflammation, and discomfort affect normal movement and flexibility.

Commonly Used for Muscle Spasm and Joint Stiffness

Healthcare professionals may prescribe this combination in conditions involving muscle spasm, swelling, restricted mobility, and discomfort affecting the back, neck, shoulders, or joints.

Provides Support During Back, Neck, and Shoulder Discomfort

This medicine combination is frequently recommended for musculoskeletal discomfort associated with lower back tightness, neck strain, shoulder stiffness, and reduced flexibility.

Helps Relax Tight Muscles Affecting Daily Activities

Muscle stiffness may interfere with walking, bending, sitting, or posture changes. Tizanidine supports muscle relaxation, while Aceclofenac helps manage inflammatory discomfort during routine activities.

Supports Comfortable Movement in Musculoskeletal Conditions

Restricted muscle movement caused by stiffness or muscular tension may affect physical comfort and mobility. This combination supports muscle relaxation and ease of movement under medical supervision.

How ZERODOL MR TABLET Works

How Zerodol MR Tablet Supports Musculoskeletal Comfort

Zerodol MR Tablet contains Aceclofenac and Tizanidine, a combination commonly used to support relief from muscle stiffness, inflammatory discomfort, and movement-related muscular tension.

Aceclofenac and Inflammatory Chemical Activity

Aceclofenac works by helping reduce the activity of inflammatory chemical messengers associated with swelling, stiffness, and discomfort affecting muscles and joints.

Tizanidine and Central Nervous System Muscle Control

Tizanidine acts through the central nervous system to help regulate nerve signals linked to excessive muscle tightening, spasm, and muscular rigidity.

Combined Mechanism of Aceclofenac and Tizanidine

The combination supports muscle comfort and flexibility by addressing both inflammatory responses and nerve-related muscle tightness involved in musculoskeletal conditions.

Regulation of Nerve Signals Affecting Muscle Tightness

Tizanidine helps control overactive nerve impulses that may contribute to restricted movement, muscle stiffness, and physical discomfort during daily activities.

Action of Zerodol MR Tablet on Muscles and Mobility

The medicine combination supports improved ease of movement by helping manage muscular tension, inflammatory discomfort, and movement-related stiffness affecting mobility.

How to use ZERODOL MR TABLET

Directions for Taking Zerodol MR Tablet

• Take Zerodol MR Tablet exactly as prescribed by the healthcare professional
• Swallow the tablet whole with a sufficient amount of water
• The medicine is intended for oral use only

Proper Method of Tablet Consumption

• Do not crush, chew, or break the tablet
• It is commonly advised to take the medicine after meals
• Follow the administration instructions provided by the doctor

Recommended Dosage as Advised by Your Doctor

• The dosage is determined by the healthcare professional based on individual medical evaluation
• Dosage duration may vary depending on the condition and patient requirements
• Always follow the prescribed dosage schedule carefully

Maintaining a Consistent Administration Schedule

• Take the medicine at the same time each day whenever possible
• Consistent usage may help maintain steady medicine levels in the body
• Avoid changing the dosage frequency without medical advice

Side Effects Of ZERODOL MR TABLET

Common Side Effects:

• Diarrhea
• Loss of appetite
• Dryness in the mouth
• Vomiting
• Nausea

How To Manage Side Effects

Diarrhea

• Stay Hydrated: Drink plenty of water and oral fluids to replace lost fluids and prevent dehydration.
• Eat Light Meals: Choose bland, easily digestible foods such as rice, toast, or bananas.
• Avoid Irritating Foods: Limit spicy, oily, or high-fiber foods until symptoms improve.
• Monitor Symptoms: Keep track of the frequency and severity of diarrhea.
• Seek Medical Advice: Consult your doctor if diarrhea persists, becomes severe, or is accompanied by dehydration symptoms.

Nausea And Vomiting

• Take Small, Frequent Meals: Eating smaller portions may help reduce stomach discomfort.
• Avoid Greasy Foods: Limit oily, spicy, or heavy meals that may worsen nausea.
• Stay Hydrated: Sip water or clear fluids regularly throughout the day.
• Rest After Meals: Avoid strenuous activities immediately after eating.
• Seek Medical Advice: Consult your doctor if nausea persists, becomes severe, or interferes with eating and drinking.

Warning & Precautions

Pregnancy

Use with Caution

Zerodol MR Tablet should be used with caution during pregnancy unless specifically prescribed by a healthcare professional. Consult your doctor before taking this medicine.

Breastfeeding

Use with Caution

Zerodol MR Tablet should be used with caution during breastfeeding and only under medical supervision. Consult your doctor before taking this medicine.

Driving and Using Machines

Use with Caution

Zerodol MR Tablet may cause dizziness, drowsiness, or reduced alertness in some individuals. If affected, avoid driving or operating machinery until you know how this medicine affects you.

Alcohol

Contraindicated

Alcohol consumption is not recommended while taking Zerodol MR Tablet, as it may increase drowsiness, dizziness, and the risk of stomach-related side effects. Consult your doctor for advice.

Kidney

Use with Caution

Zerodol MR Tablet should be used with caution in patients with kidney impairment.Consult your doctor before taking this medicine.

Liver

Use with Caution

Zerodol MR Tablet should be used with caution in patients with liver disorders. Consult your doctor before taking this medicine.

Allergy

Contraindicated

Do not use Zerodol MR Tablet if you are allergic to Aceclofenac, Tizanidine, or any other ingredients of this medicine. Seek medical attention if signs of an allergic reaction occur.

Lungs

Use with Caution

Zerodol MR Tablet should be used with caution in patients with respiratory disorders. Consult your doctor before taking this medicine.

Heart Disease

Use with Caution

Zerodol MR Tablet should be used with caution in patients with heart-related conditions. Consult your doctor before taking this medicine.

Use In Pediatrics

Contraindicated

Zerodol MR Tablet is not recommended for use in children unless specifically prescribed by a healthcare professional. Consult your doctor before taking this medicine.

Use In Geriatrics

Use with Caution

Elderly patients should use Zerodol MR Tablet with caution, as they may be more susceptible to its side effects. Medical supervision is recommended.

Other Warnings for ZERODOL MR TABLET

Before taking Zerodol MR Tablet, inform your doctor if you have:
• A history of stomach ulcers or gastrointestinal bleeding
• Low blood pressure or episodes of dizziness

Drug - Drug interaction

Antihypertensive Medicines (e.g., amlodipine, enalapril, losartan)
Interaction: Tizanidine may enhance the blood pressure-lowering effects of these medicines.
Effects: Increased risk of low blood pressure, dizziness, fainting, and weakness.
Management: Use with caution and monitor blood pressure regularly. Dose adjustments may be required.

CNS Depressants (e.g., diazepam, alprazolam, opioids, sedating antihistamines)
Interaction: Tizanidine may increase the sedative effects of these medicines.
Effects: Excessive drowsiness, dizziness, impaired concentration, and reduced alertness.
Management: Avoid activities requiring mental alertness and consult your doctor before combining these medicines.

CYP1A2 Inhibitors (e.g., ciprofloxacin, fluvoxamine)
Interaction: These medicines can significantly increase blood levels of tizanidine.
Effects: Severe drowsiness, low blood pressure, slow heart rate, and excessive muscle weakness.
Management: Concomitant use is not recommended.

Anticoagulants and Antiplatelet Medicines (e.g., warfarin, aspirin, clopidogrel)
Interaction: Aceclofenac may increase the risk of bleeding when used with these medicines.
Effects: Increased risk of bruising, gastrointestinal bleeding, and prolonged bleeding time.
Management: Use only under medical supervision and monitor for signs of bleeding.

Other NSAIDs and Corticosteroids (e.g., ibuprofen, diclofenac, prednisolone)
Interaction: Combined use may increase gastrointestinal toxicity.
Effects: Higher risk of stomach irritation, ulcers, and gastrointestinal bleeding.
Management: Concurrent use should be avoided unless specifically prescribed by a healthcare professional.

Synopsis

More Information

1.How Work-From-Home Lifestyle and Long Screen Time May Influence Muscle Stiffness

Impact of Prolonged Sitting on Muscle Flexibility

Extended sitting during work-from-home routines may reduce regular body movement and contribute to muscular tightness, stiffness, and reduced flexibility in some individuals.

Screen Time and Posture-Related Muscular Strain

Long hours of screen exposure may encourage fixed sitting positions that place additional strain on the neck, shoulders, back, and surrounding muscles.

Reduced Physical Activity During Desk-Based Work

Limited movement, fewer walking breaks, and prolonged desk work may affect muscle relaxation and overall physical comfort during daily activities.

Neck and Shoulder Tightness Associated With Device Usage

Continuous laptop or mobile device use may contribute to tension around the neck and shoulder muscles due to repetitive posture patterns.

Lower Back Discomfort During Sedentary Work Habits

Sitting for extended periods without posture variation may increase pressure on the lower back muscles and joints, influencing movement-related discomfort.

Muscle Fatigue Linked to Repetitive Work Activities

Repeated typing, screen viewing, and desk-related tasks may place continuous stress on certain muscle groups, affecting muscular ease and mobility.

2.Why Are Screen Time and Sedentary Work Habits Increasing Muscle Tightness and Neck or Back Discomfort?

Effect of Prolonged Sitting on Muscular Flexibility

Extended sitting during desk-based work may reduce regular muscle movement and contribute to tightness, stiffness, and reduced flexibility in certain muscle groups.

Screen Usage and Posture-Related Strain

Long periods of laptop, desktop, or mobile screen use may encourage fixed posture positions that place strain on the neck, shoulders, and lower back muscles.

Reduced Movement During Daily Work Routines

Sedentary work habits often involve fewer walking breaks and prolonged inactivity, which may influence muscle comfort and mobility during routine activities.

Neck and Shoulder Tension From Continuous Device Use

Repeated screen viewing and forward head posture may increase muscular tension around the neck and shoulder region during prolonged work sessions.

Lower Back Stress During Extended Desk Work

Remaining seated for long durations may increase pressure on lower back muscles and surrounding joints, contributing to movement-related discomfort.

Repetitive Work Activities and Muscle Fatigue

Typing, desk work, and continuous screen interaction may place repetitive stress on muscles, which can affect physical comfort and muscular ease over time.

FAQs About ZERODOL MR TABLET

References

1. KD. Tripathi. Autacoid and Related Drugs & Drugs Acting on Peripheral (Nervous) Somatic System. Essentials of medical pharmacology. Seventh edition. 2013. Page – 204 & 358.

2. Shirin Ghanavatian, Armen Derian. Tizanidine. NIH National Library of Medicine, National center for biotechnology information. May 2022. [Accessed on 5th June 2026]

3. Teva Pharmaceutical Works Private Limited. Tizanidine. [Revised in Oct 2021]. [Accessed on 5th June 2026]

Author Details

Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)

Reviewed For Accuracy By Dr. Sankara Babu Gorle - MBBS, MD (Pharmacology)

Last updated on 08 May 2026 | 09:57 AM(IST)