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Introduction About ZEPRO 40MG INJECTION
ZEPRO 40MG INJECTION is used to manage peptic ulcers, gastroesophageal reflux disease (GERD) or reflux esophagitis and its associated symptoms such as acidity, heartburn, acid reflux and pain in swallowing. It contains Pantoprazole which belongs to the group of medicines called Proton pump inhibitors.
During management with ZEPRO 40MG INJECTION your doctor will closely monitor your kidney functions, liver functions and blood magnesium levels to avoid the risk of unwanted side effects. Before receiving ZEPRO 40MG INJECTION inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have weak bones or any previous history of bleeding in the gut.
Consult your doctor before receiving ZEPRO 40MG INJECTION if you are pregnant or breastfeeding. The most common side effects of receiving ZEPRO 40MG INJECTION is pain and inflammation at the site of injection. You must also inform your doctor immediately if you experience severe tiredness with abnormal muscle movements, dizziness, confusion, disorientation and irregular heartbeat after receiving ZEPRO 40MG INJECTION, as it could be a sign of low magnesium levels in blood.
Uses Of ZEPRO 40MG INJECTION
It is used to manage:
- Peptic ulcer
- Gastrointestinal Reflux disease (GERD)
- Reflux esophagitis (inflammation of the esophagus)
- Acidity, Heartburn, Pain in swallowing
- Zollinger-Ellison syndrome (tumors in pancreas causing the stomach to secrete more acid)
How ZEPRO 40MG INJECTION Works
ZEPRO 40MG INJECTION reduces gastric acid secretion by the blocking the actions of a protein membrane called H+K+Atpase (proton pump) across the stomach lining. As a result, it manages the worsening of ulcers, heals the existing ulcers and esophageal lesions and provides relief from the unpleasant symptoms of GI tract (such as acidity, heartburn and acid reflux).
How to use ZEPRO 40MG INJECTION
- It will be administered to you only by a doctor or a nurse into the vein (intravenously)
- Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition
Side Effects Of ZEPRO 40MG INJECTION
Common side effects of ZEPRO 40MG INJECTION:
- benign polyps in the stomach
- injection site reactions (pain and inflammation)
- nausea or vomiting
- diarrhea, constipation, stomach pain, flatulence
- dry mouth
Contact your doctor immediately if you experience any of the following side effects after receiving ZEPRO 40MG INJECTION:
- severe allergic reactions (skin rash, itching, swelling of the lips, face or body and difficulty in breathing or swallowing)
- signs of liver problems (yellowing of the skin and eyes, dark urine and tiredness)
- severe skin reactions (redness, blistering, peeling of skin and bleeding in the lips, eyes, mouth, nose and genitals with fever)
- signs of kidney problem (lower back pain, painful urination)
- signs of low magnesium levels in blood (tiredness, abnormal muscle movements, dizziness, confusion, disorientation, irregular heartbeat)
- uncontrollable body movements (including eye and tongue), twisted neck and abnormal body posture
Warning & Precautions
Pregnancy
Monitoring requiredZEPRO 40MG INJECTION should be used in pregnant women only if it is considered necessary by the physician.
Breastfeeding
Monitoring requiredZEPRO 40MG INJECTION may pass through breast milk. Therefore, it should be used in breastfeeding women only if it is considered necessary by the physician.
Driving and Using Machines
Use with CautionZEPRO 40MG INJECTION does not affect your ability in driving or handling heavy tools or machines.
Alcohol
Consult your doctorAvoid consumption of alcohol while receiving ZEPRO 40MG INJECTION, as it could aggravate your existing condition.
Kidney
Use with CautionZEPRO 40MG INJECTION should be used with caution in patients with kidney problems.
Liver
Use with CautionZEPRO 40MG INJECTION should be used with caution in patients with liver problems.
Allergy
ContraindicatedDo not receive ZEPRO 40MG INJECTION if you are allergic to Pantoprazole or any other ingredients of this medicine.
Use In Pediatrics
ContraindicatedZEPRO 40MG INJECTION is not recommended for use in children and adolescents (aged below 18 years).
Use In Geriatrics
Use with CautionZEPRO 40MG INJECTION should be used with caution in elderly patients (aged 65 years and above).
Others
Before receiving ZEPRO 40MG INJECTION, inform your doctor if you:
- have osteoporosis
- have a history of bleeding in the gut
- have vitamin B12 deficiency (sore tongue, mouth ulcers, pale skin, depression)
- are going to test Chromogranin A level
Interactions
A. Drug-Drug interactions:
Before receiving ZEPRO 40MG INJECTION inform your doctor if you are receiving any of the following medicines such as:
- Antifungal (Ex. ketoconazole, itraconazole and Posaconazole)
- Anti-cancer agents (Ex. Erlotinib)
- Anticoagulants (Ex. Warfarin and phenprocoumon)
- Antimetabolites (Ex. methotrexate)
- Anti-viral agents (Ex. atazanavir)
- Antidepressants (Ex. fluvoxamine)
- Antibiotics (Ex. rifampicin)
- Herbal medicine (Ex. St. John’s wort)
Overdosage:
ZEPRO 40MG INJECTION will be administered only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms.
Synopsis
| Drug | : | Pantoprazole |
| Pharmacological Category | : | Proton pump inhibitors |
| Therapeutic Indication | : | Peptic ulcer, GERD, Reflux esophagitis |
| Dosage Forms | : | Tablet, Capsule, Injection, Infusion, Prefilled Syringe, Kit |
More Information
FAQs About ZEPRO 40MG INJECTION
Q: What is ZEPRO 40MG INJECTION used for?
A: ZEPRO 40MG INJECTION is used to manage peptic ulcers, gastroesophageal reflux disease (GERD) and reflux esophagitis and its associated symptoms such as acidity, heartburn, acid reflux and pain in swallowing. It can also be used to manage Zollinger-Ellison syndrome.
Q: How and when to take ZEPRO 40MG INJECTION?
A: ZEPRO 40MG INJECTION is not meant for self-administration. It will be given to you only by a doctor or a nurse into the vein (intravenously).
Q: What are the most common side effects of receiving ZEPRO 40MG INJECTION?
A: The most common side effects of receiving ZEPRO 40MG INJECTION are dryness of mouth, constipation and flatulence. Consult your doctor if any of these side effect bothers you.
Q: What precautions do I need to follow while receiving ZEPRO 40MG INJECTION?
A: Before receiving ZEPRO 40MG INJECTION inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have weak bones or a previous history of bleeding in the gut. Consult your doctor before receiving ZEPRO 40MG INJECTION if you are pregnant or breastfeeding. Regularly visit your doctor and take all the blood tests recommended by your doctor without fail.
Q: Can I take medication for high blood pressure along with ZEPRO 40MG INJECTION?
A: It is not advisable to take medicines to control blood pressure while receiving ZEPRO 40MG INJECTION without consulting your doctor as they have known interactions with the medicine.
Q: Can ZEPRO 40MG INJECTION be used in pregnant women?
A: ZEPRO 40MG INJECTION should be used in pregnant women only if it is considered necessary by the physician.
Q: Can ZEPRO 40MG INJECTION cause constipation?
A: Yes. Constipation is a common side effect of using ZEPRO 40MG INJECTION. Eat plenty of fiber rich foods such as fresh fruits, vegetables, cereals as well as drink plenty of water and exercise more regularly when receiving this medicine. Contact your doctor if this side effect bothers you.
Q: Can ZEPRO 40MG INJECTION cause dry mouth?
A: Yes. Dry mouth is a common side effect of using ZEPRO 40MG INJECTION.
References
1. KD Tripathi. Drugs for Peptic Ulcer and Gastroesophageal Reflux Disease. Essentials of medical pharmacology. Eighth Edition. 2019. Page –701.
2. H Wurzer, K Schutze, T Bethke, R Fischer, R Luhmann, C Riesenhuber. Efficacy and safety of pantoprazole in patients with gastroesophageal reflux disease using an intravenous-oral regimen. Austrian Intravenous Pantoprazole Study Group. NIH. National Library of Medicine. National Center for Biotechnology Information. Pubmed.gov. May-June 1999. [Accessed on 22nd October 2022] click here
3. Sun Pharmaceutical Industries Europe B.V. Electronic Medicines Compendium (EMC). [Revised in August 2021] [Accessed on 22nd October 2022] click here
4. Central Drugs Standard Control Organization. Pantoprazole. Each vial contains pantoprazole sod. Eq to Pantoprazole 40mg. S(-) Pantoprazole (as sodium) Inj 20mg/vial. [Revised in June 2006] [Accessed on 22nd October 2022] click here
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