Zemiglo 50mg Tablet 14'S

Introduction About ZEMIGLO 50MG TABLET

ZEMIGLO 50MG TABLET contains Gemigliptin which belongs to the group of medicines called Antidiabetic agents. It is used as an adjunct to the diet and exercise to improve glycemic control in adults with type-2 diabetes mellitus, as an monotherapy or in combination with metformin in patients with inadequate glycemic control on metformin alone.

Diabetes mellitus is a chronic, metabolic disease characterized by elevated levels of blood glucose (or blood sugar), which leads over time to serious damage to the heart, blood vessels, eyes, kidneys, and nerves. ZEMIGLO 50MG TABLET is not recommended in patients with type 1 diabetes, diabetic ketoacidosis. Before taking inform your doctor if you have pancreatitis, liver, kidney or heart problems.

Inform your doctor before taking ZEMIGLO 50MG TABLET if you are pregnant or breastfeeding women. The common side effects of taking this medicine are headache, urinary tract infection and diarrhea. Consult your doctor if any of the above side persists for a longer duration.

Uses Of ZEMIGLO 50MG TABLET

• It is used as an adjunct to the diet and exercise to improve glycemic control in adults with type-2 diabetes mellitus, as an monotherapy or in combination with metformin in patients with inadequate glycemic control on metformin alone

How ZEMIGLO 50MG TABLET Works

ZEMIGLO 50MG TABLET enhances the level of active incretin hormones, including GLP-1 and GIP, thereby reducing blood glucose levels. Active GLP-1 and GIP promote insulin production and release from pancreatic beta cells. GLP-1 also lowers the secretion of glucagon from pancreatic alpha cells, thereby resulting in a decreased hepatic glucose production. However these incretins are rapidly degraded by the DPP-4. Hence ZEMIGLO 50MG TABLET selectively inhibits DPP-4 activity, enhancing prolonged activation of incretin hormones.

How to use ZEMIGLO 50MG TABLET

Take ZEMIGLO 50MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration depending upon your age, body weight and disease condition.

Side Effects Of ZEMIGLO 50MG TABLET

How To Manage Side Effects

Diarrhea

Drink plenty of fluids to manage dehydration. Oral rehydration drinks helps to replace lost salts and minerals.

Headache

Rest in a quiet, dark room. Apply hot or cold compresses to your head or neck.

Warning & Precautions

Pregnancy

Consult your doctor

There are no adequate and well-controlled studies in pregnant women with ZEMIGLO 50MG TABLET hence it is not recommended during pregnancy.

Breastfeeding

Consult your doctor

There is no information on excretion of ZEMIGLO 50MG TABLET into human milk. Hence it should not be used during breast-feeding.

Driving and Using Machines

Use with Caution

ZEMIGLO 50MG TABLET has no known influence on the ability to drive and use machines.

Alcohol

Contraindicated

Consumption of alcohol is not recommended while taking ZEMIGLO 50MG TABLET.

Kidney

Use with Caution

ZEMIGLO 50MG TABLET should be used with caution in patients with kidney impairment. Dosage adjustment is not necessary for patients with mild to moderate renal impairment. Consult your doctor before taking the medicine.

Liver

Use with Caution

ZEMIGLO 50MG TABLET should be used with caution in patients with liver problems. Consult your doctor before taking the medicine.

Allergy

Contraindicated

Do not take ZEMIGLO 50MG TABLET if you are allergic or hypersensitive to Gemigliptin or any other ingredients of this medicine.

Heart Disease

Use with Caution

ZEMIGLO 50MG TABLET should be used with caution in patients with heart problems. Consult your doctor before taking the medicine.

Use In Pediatrics

Consult your doctor

Safety and effectiveness in children and adolescents less than 18 years of age have not been established. Consult your doctor before taking the medicine.

Use In Geriatrics

Use with Caution

ZEMIGLO 50MG TABLET should be used with caution in elderly patient because physiological functions including liver and kidney are usually decreased in this population. Consult your doctor before taking the medicine.

Interactions

A. Drug-Drug interactions:

Before taking ZEMIGLO 50MG TABLET, inform your doctor if you are taking any prescription, non-prescription and herbal supplements.

Overdosage:

If you or anyone else accidentally took more of ZEMIGLO 50MG TABLET consult your doctor immediately or visit nearby hospital.

Synopsis

More Information

• Keep ZEMIGLO 50MG TABLET out of reach of children
• Store ZEMIGLO 50MG TABLET at room temperature

FAQs About ZEMIGLO 50MG TABLET

Q: What is ZEMIGLO 50MG TABLET used for?

A: It is used as an adjunct to the diet and exercise to improve glycemic control in adults with type-2 diabetes mellitus, as an monotherapy or in combination with metformin in patients with inadequate glycemic control on metformin alone.

Q: Can I stop taking ZEMIGLO 50MG TABLET without consulting your doctor?

A: No. do not stop taking ZEMIGLO 50MG TABLET without consulting your doctor because it may lead to unwanted side effects.

Q: Can I consume alcohol while taking ZEMIGLO 50MG TABLET?

A: Avoid consumption of alcohol during management with ZEMIGLO 50MG TABLET, as it may increase or decrease the blood sugar lowering action of ZEMIGLO 50MG TABLET. Consult your doctor for advice before taking the medicine.

Q: Will taking a higher dose of ZEMIGLO 50MG TABLET be more effective?

A: No, taking a higher dose of ZEMIGLO 50MG TABLET will not be effective. Always take the dose as advised by your physician.

Q: What precautions do I need to follow while taking ZEMIGLO 50MG TABLET?

A: ZEMIGLO 50MG TABLET is not recommended in patients with type 1 diabetes, diabetic ketoacidosis. Before taking inform your doctor if you have pancreatitis, liver, kidney or heart problems. Inform your doctor before taking ZEMIGLO 50MG TABLET if you are pregnant or breastfeeding women.

Q: What are the common side effects of ZEMIGLO 50MG TABLET?

A: The common side effects of taking this medicine are headache, urinary tract infection and diarrhea. Consult your doctor if any of the above side persists for a longer duration.

References

1. KD. Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 270.

2. Sung-Ho Kim, Jung-Hwa Yoo, Woo Je Lee, and Cheol-Young Park. Gemigliptin: An Update of Its Clinical Use in the Management of Type 2 Diabetes Mellitus. October, 2016. [Accessed on December 28th, 2023] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069390/

3. Manish Gutch, Abhay Joshi, Sukriti Kumar, Avinash Agarwal, Rajendra Kumar Pahan, and Syed Mohd Razi. Gemigliptin: Newer Promising Gliptin for Type 2 Diabetes Mellitus. November, 2017. [Accessed on December 28th, 2023] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729681/

4. Drugbank.com. [Accessed on December 28th, 2023] https://go.drugbank.com/drugs/DB12412

5. MIMS.COM. [Accessed on December 28th, 2023] https://www.mims.com/thailand/drug/info/zemiglo?type=full

6. Cayman chemical. [Accessed on December 28th, 2023] https://cdn.caymanchem.com/cdn/insert/36016.pdf

Useful Diagnostic Tests

• HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin
• Blood Glucose Fasting (FBS)
• Post Prandial Blood Sugar (PPBS)
• Insulin - Fasting
• Netmeds Diabetic Checkup
• Advance Diabetes Monitoring (Senior Female)
• Jaanch Diabetic Profile Basic

Author Details

Written By Dr. Janet.C - Pharm.D

Reviewed For Accuracy By Dr. Jaya Prabakaran - MBBS, MD (Diabetology and Family Medicine)

Last updated on 30 Dec 2023 | 06:30 PM(IST)