ZADIMAC PS Injection 1's

Introduction About ZADIMAC PS INJECTION

ZADIMAC PS INJECTION is a combination of Ceftazidime and Tazobactam which belongs to the group of medicines called Antibiotics. It is indicated in the management of various infections such as joint and bone infections, gynaecological infections, infections in patients suffering from Febrile Neutropenia, meningitis, lung infections (Ex. pneumonia, pseudomonal lung infection in Cystic Fibrosis), bacterial infections of the skin, lower respiratory tract infections, urinary tract infections, intra-abdominal infections, septicaemia, ear infections, vibrio infections, and perioperative prophylaxis.

Prior to the management with ZADIMAC PS INJECTION, your doctor might ask you to take certain diagnostic tests. ZADIMAC PS INJECTION is not recommended for use in patients with liver disease, seizures, or infection due to a specific bacteria (C. difficile). In pregnant and breastfeeding women, ZADIMAC PS INJECTION should be used with caution.

The most common side effects of receiving ZADIMAC PS INJECTION are injection site inflammation, rashes, fever, diarrhoea, nausea, headache, dizziness, constipation, indigestion, and pain. Inform your doctor if any of these worsen or don’t improve.

Uses Of ZADIMAC PS INJECTION

Manages,

• joint and bone infections
• gynaecological infections
• infections in patients suffering from febrile neutropenia
• meningitis
• lung infections (Ex. pneumonia, pseudomonal lung infection in Cystic Fibrosis)
• bacterial infections of the skin
• lower respiratory tract infections
• urinary tract infections
• intra-abdominal infections
• septicaemia
• ear infections
• vibrio infections
• perioperative prophylaxis

How ZADIMAC PS INJECTION Works

ZADIMAC PS INJECTION aids in the management of a variety of infections. Ceftazidime is a cephalosporin antibiotic that inhibits penicillin-binding proteins, which are essential for bacterial survival. This leads to the destruction of the bacterial cell wall and, hence, the bacteria. Tazobactam is a beta-lactamase inhibitor, which interacts with an enzyme called beta-lactamase and protects the efficiency of ceftazidime against bacteria.

How to use ZADIMAC PS INJECTION

ZADIMAC PS INJECTION will be given to you only by a doctor or a nurse into a vein or a muscle as an intravenous or intramuscular infusion. Your doctor will decide the correct dose and duration of ZADIMAC PS INJECTION for you depending upon your age, body weight and disease condition.

Side Effects Of ZADIMAC PS INJECTION

How To Manage Side Effects

Constipation

Eat plenty of fiber rich foods such as vegetables, fresh fruits, and cereals and drink plenty of water while taking ZADIMAC PS INJECTION. Exercise more regularly. If the symptom doesn’t improve, contact your doctor.

Diarrhea

Drink a lot of fluids, such as water, squash, or fruit juice to keep yourself hydrated. Do not consume any medicine by yourself with ZADIMAC PS INJECTION without consulting your doctor. If the symptom doesn’t improve, contact your doctor.

Headache

Try to take a rest. Apply a pain-relieving balm on your forehead. If the symptom doesn’t improve, contact your doctor.

Nausea And Vomiting

While receiving ZADIMAC PS INJECTION, stick to simple meals. Avoid eating rich or spicy food. If the symptom doesn’t improve, contact your doctor.

Warning & Precautions

Pregnancy

Use with Caution

ZADIMAC PS INJECTION should be used with caution in pregnant women. Consult your doctor before receiving ZADIMAC PS INJECTION.

Breastfeeding

Use with Caution

ZADIMAC PS INJECTION should be used with caution in breastfeeding women. Consult your doctor before receiving ZADIMAC PS INJECTION.

Liver

Use with Caution

ZADIMAC PS INJECTION should be used with caution in patients having liver disease. Consult your doctor before receiving it.

Allergy

Contraindicated

Tell your doctor before receiving ZADIMAC PS INJECTION if you are allergic to Ceftazidime and Tazobactam.

Use In Pediatrics

Consult your doctor

Your doctor will decide the correct dose and duration of the management with ZADIMAC PS INJECTION for your child depending upon your child’s age, diseases condition and body weight. Consult your doctor for advice.

Use In Geriatrics

Consult your doctor

Your doctor will decide the correct dose and duration of the management with ZADIMAC PS INJECTION for you depending upon your age, diseases condition and body weight. Consult your doctor for advice.

Interactions

A. Drug–Drug Interactions:

Before receiving ZADIMAC PS INJECTION, inform your doctor if you are taking any of the following medicine:

• other cephalosporins such as cefadroxil, cefepime, ceftriaxone and other penicillins such as amoxicillin, nafcillin, and ampicillin (used to manage various infections)

Overdosage:

ZADIMAC PS INJECTION will be administered to you only by a doctor or a nurse in a hospital, so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms.

Synopsis

More Information

• Keep ZADIMAC PS INJECTION out of reach from children
• Store at room temperature

FAQs About ZADIMAC PS INJECTION

Q: What is ZADIMAC PS INJECTION and why is it prescribed?

A: ZADIMAC PS INJECTION is a combination of Ceftazidime and Tazobactam, which belongs to the group of medicines called antibiotics. It is used to manage a variety of infections, including joint and bone infections, gynaecological infections, infections in patients with febrile neutropenia, meningitis, lung infections (such as pneumonia and pseudomonal lung infection in Cystic Fibrosis), bacterial skin infections, lower respiratory tract infections, urinary tract infections, intra-abdominal infections, septicaemia, ear infections, vibrio infections, and perioperative prophylaxis.

Q: How is ZADIMAC PS INJECTION administered?

A: ZADIMAC PS INJECTION will be given to you only by a doctor or a nurse into a vein or a muscle as an intravenous or intramuscular infusion. Your doctor will determine the correct dose and duration of ZADIMAC PS INJECTION for you depending on your age, body weight, and disease condition.

Q: Can ZADIMAC PS INJECTION be administered to pregnant and breastfeeding women?

A: In pregnant and breastfeeding women, ZADIMAC PS INJECTION should be used with caution. Consult your doctor before receiving ZADIMAC PS INJECTION.

Q: Can ZADIMAC PS INJECTION cause diarrhoea?

A: Diarrhoea is a common side effect of ZADIMAC PS INJECTION. Drink a lot of fluids, such as water, squash, or fruit juice, to keep yourself hydrated. Do not take any medicine containing ZADIMAC PS INJECTION without first consulting your doctor. If the symptom doesn’t improve, contact your doctor.

Q: Is ZADIMAC PS INJECTION an antibiotic?

A: Yes. ZADIMAC PS INJECTION is a combination of Ceftazidime and Tazobactam, which are antibiotics. They work by destroying the bacterial cell and managing further growth, effectively managing infections. 

References

1. KD. Tripathi. Antimicrobial Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 725, 728.

2. NIH National Library of Medicine, National center for biotechnology information. Pubchem. Ceftazidime. [Accessed on 15th July 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Ceftazidime

3. NIH National Library of Medicine, National center for biotechnology information. Pubchem. Tazobactam. [Accessed on 15th July 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Tazobactam

4. Bionova Lifesciences. Ceftadis-TB. [Accessed on 15th July 2022] https://www.bionova.co.in/ceftadis-tb-injection.html

5. Mits Healthcare Mietrex – TM. [Accessed on 15th July 2022] https://www.mitshealthcare.in/product/ceftriaxone-tazobactam-injection-manufacturers-suppliers-2

6. MIMS. Cazotaz. [Accessed on 15th July 2022] https://www.mims.com/india/drug/info/cazotaz

Useful Diagnostic Tests

• Complete Blood Count
• Urine Analysis
• Xray

Author Details

Written By Dr. Dhivakaran R - BDS

Reviewed For Accuracy By Dr. Salem Gill - MBBS

Last updated on 21 Feb 2023 | 06:32 PM(IST)