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Introduction About XYLOCARD 2% INFUSION
XYLOCARD 2% INFUSION contains Lignocaine which belongs to the group of medicines called Local Anesthetic agents. It is used to cause numbness (loss of sensation) of body parts at regions where it has been administered (local anesthesia). It is generally used prior to spinal anesthesia or before surgical procedures to cause temporary loss of sensation. It also helps to control heartbeat in patients having arrythmia (irregular heartbeat).
XYLOCARD 2% INFUSION will be given to you only by a trained anesthesiologist around the areas (such as hands, legs, abdomen, pelvis, spine) locally where loss of sensation (numbness) is required.
Before receiving XYLOCARD 2% INFUSION, inform your doctor if you have any liver, kidney, or heart problems. You must also inform your doctor if you have any breathing disorders, blood problems, epilepsy, glaucoma, stroke, dehydration, low blood potassium levels or muscle weakness.
XYLOCARD 2% INFUSION should be used in pregnant or breastfeeding women only if considered necessary by the physician. The most common side effects of receiving XYLOCARD 2% INFUSION are nausea, slow heart rate, dizziness, lower back pain, difficulty in walking and inability to control urine or bowel movements. Inform your doctor if any of these side effects worsen.
Uses Of XYLOCARD 2% INFUSION
- Causes numbness of body parts when used prior to spinal anesthesia or surgical procedures
- Manage arrythmia (irregular heartbeat)
How XYLOCARD 2% INFUSION Works
XYLOCARD 2% INFUSION is an anesthetic agent. It reduces pain sensation and causes numbness of body parts by blocking the flow of certain ions (sodium ions) through the nerves that causes pain sensation. As a result, it limits the transfer of pain signals from the peripheral part of the body (i.e., face, hands, legs, abdomen, pelvis) to the brain which leads to loss of sensation. It also normalizes heart rate by blocking the generation of abnormal electrical signals in the heart.
How to use XYLOCARD 2% INFUSION
XYLOCARD 2% INFUSION will be given to you only by a doctor or by a trained anesthesiologist. Your doctor/ anesthesiologist will decide the correct dose and site of administration for you depending upon your age, body weight, health condition and type of nerve block which is required to provide anesthesia or pain relief.
It can be administered locally to the region where loss of sensation (numbness) is required or can be administered in a vein, around the spinal cord or a nerve to causes numbness during surgeries (caesarean section or other major surgeries) to stop pain sensation.
Side Effects Of XYLOCARD 2% INFUSION
Common
- pain at site of injection
- low blood pressure causing dizziness, drowsiness, or lightheadedness
- nausea, vomiting
- tingling or pricking sensation (pins and needles)
- slow heartbeat, feeling faint
- changes in vision, blurred vision
- difficulty in passing urine
- pain or numbness in the legs or back
- unable to walk properly
- problems in controlling bowels and bladder
Consult your doctor immediately if you experience any of the following side effects after receiving XYLOCARD 2% INFUSION:
- signs of severe allergic reactions (such as skin rash, severe itching of the skin with raised lumps, blisters in the skin, swelling of the face, lips, tongue and/or throat with difficulty in breathing or swallowing)
- blood problems (causing bluish discoloration of the skin, headache, tiredness, weakness and shortness of breath)
- fits or convulsions
How To Manage Side Effects
Dizziness Or Drowsiness
Avoid standing or walking after surgery. Try to rest and relax. Get enough sleep. Consult your doctor if you continue to feel dizzy for a prolonged period.
Injection Site Reactions
Place an ice pack on the injected site. Do not move the affected area frequently. If the symptom worsens, consult your doctor.
Warning & Precautions
Pregnancy
Monitoring requiredXYLOCARD 2% INFUSION should be used in pregnant women only if it is considered necessary by the physician. Therefore, inform your doctor if you are pregnant or think you may be pregnant before receiving XYLOCARD 2% INFUSION.
Breastfeeding
Monitoring requiredXYLOCARD 2% INFUSION should be used in breastfeeding women only if it is considered necessary by the physician. Therefore, inform your doctor before receiving XYLOCARD 2% INFUSION if you are breastfeeding.
Driving and Using Machines
Use with CautionXYLOCARD 2% INFUSION may make you feel dizzy or drowsy for some time after administration. Therefore, do not drive or operate any heavy tools or machines if your ability is affected by XYLOCARD 2% INFUSION.
Alcohol
Consult your doctorAvoid consumption of alcohol before receiving XYLOCARD 2% INFUSION.
Kidney
Use with CautionXYLOCARD 2% INFUSION should be used with caution in patients with kidney problems. Therefore, consult your doctor before receiving it.
Liver
Use with CautionXYLOCARD 2% INFUSION should be used with caution in patients with liver problems. Therefore, consult your doctor before receiving it.
Allergy
ContraindicatedInform your doctor before receiving XYLOCARD 2% INFUSION, if you are allergic to Lignocaine or to any other local anesthetics (such as bupivacaine).
Lungs
Use with CautionXYLOCARD 2% INFUSION should be used with caution in patients with breathing disorders (such as asthma or COPD). Therefore, consult your doctor before receiving it.
Heart Disease
Consult your doctorXYLOCARD 2% INFUSION is not recommended for use in patients with heart diseases (such as heart block or abnormal or a very slow heartbeat). It should be used with caution in patients with other heart disorders. Therefore, consult your doctor before receiving it.
Use In Pediatrics
Consult your doctorXYLOCARD 2% INFUSION should be used in children and adolescents (aged below 18 years) only if it is considered necessary by the physician. It is not recommended for use in neonates aged less than 1 month. Therefore, consult your doctor for advice before administration.
Use In Geriatrics
Use with CautionXYLOCARD 2% INFUSION should be used with caution in the elderly patients. Therefore, consult your doctor for advice before receiving it.
Others
XYLOCARD 2% INFUSION is not recommended for use if you:
- have low blood volume
- have porphyria (an inherited blood disorder)
Before receiving XYLOCARD 2% INFUSION, inform your physician if you:
- are feeling sick or tired for no reason
- have epilepsy (fits)
- have glaucoma
- have low potassium levels in blood causing muscle cramps and constipation
- recently had vomiting, diarrhea or excessive blood loss
- are not drinking enough amount of water
- have too much acidity in the blood
- have any skin infection (with pus) in and around the areas where the medicine is planned to be administered
- have problems in thinking or reasoning
- have myasthenia gravis (severe muscle weakness or tenderness)
- are in stroke
- have imbalance in the constituents of the blood
- have a blood disorder
Interactions
A. Drug-Drug interactions:
Before receiving XYLOCARD 2% INFUSION, inform your doctor if you are receiving any of the following medicines:
- halothane (used to cause unconsciousness before a surgical procedure)
- medicines used to manage heart problems such as hypertension, angina, or abnormal heart rate (Ex. atenolol, propranolol, verapamil, amlodipine, nifedipine, amiodarone, mexiletine)
- diuretics (used to reduce edema and blood pressure) Ex. furosemide, spironolactone, hydrochlorothiazide
- medicines used to manage HIV infection (Ex. ritonavir, nelfinavir)
- medicines used to manage psychotic disorders (such as chlorpromazine, pimozide, sertindole, olanzapine, quetiapine, zotepine)
- suxamethonium (used to relax muscles)
- opioid analgesics (used for pain relief) Ex. morphine, pethidine, fentanyl
- dolasetron (used to manage nausea and vomiting)
- cimetidine (used to manage heartburn, and stomach ulcers)
- acetazolamide (used to manage increased eye pressure)
- quinupristin and dalfopristin (used to manage bacterial infection)
- oral contraceptives (birth control pills) Ex. drospirenone, ethinyl estradiol
Overdosage:
XYLOCARD 2% INFUSION will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms. Symptoms of overdosage might include lightheadedness, numbness of tongue or ringing sound in the ears.
Synopsis
| Drug | : | Lignocaine |
| Pharmacological Category | : | Voltage Gated Sodium Channel Blockers |
| Therapeutic Indication | : | Local anesthesia, Arrythmia |
| Dosage Forms | : | Injection, Gel, Cream, Ointment, Jelly, Topical Solution, Spray, Oral solution, Plaster |
More Information
- Keep XYLOCARD 2% INFUSION out of reach of children
- Store XYLOCARD 2% INFUSION at room temperature
FAQs About XYLOCARD 2% INFUSION
Q: How long will it take for XYLOCARD 2% INFUSION to induce numbness?
A: It may take around 2-5 minutes for XYLOCARD 2% INFUSION to create numbness of body parts. However, this period may vary from person-to-person based on the dose and amount of the XYLOCARD 2% INFUSION that is administered to you.
Q: Is XYLOCARD 2% INFUSION a narcotic medicine?
A: No. XYLOCARD 2% INFUSION is not a narcotic. It is a local anesthetic agent which is used to create loss of sensation (numbness) in certain body parts following administration.
Q: Can XYLOCARD 2% INFUSION affect blood pressure?
A: Yes. XYLOCARD 2% INFUSION may cause changes in blood pressure (high or low blood pressure) and so if you experience any unusual symptoms like feeling extremely dizzy or lightheaded after receiving XYLOCARD 2% INFUSION consult your doctor.
Q: What are the common side effects of XYLOCARD 2% INFUSION?
A: The most common side effects of receiving XYLOCARD 2% INFUSION are nausea, slow heart rate, dizziness, lower back pain, difficulty in walking and inability to control urine or bowel movements. Inform your doctor if any of these side effects worsen.
Q: What are the symptoms that could appear if I received excessive amount of XYLOCARD 2% INFUSION?
A: XYLOCARD 2% INFUSION will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms. Symptoms of overdosage might include lightheadedness, numbness of tongue or ringing sound in the ears.
Q: Can XYLOCARD 2% INFUSION be used in children?
A: Yes. XYLOCARD 2% INFUSION is used in children and in adolescents (aged between 18 years) only if it is considered necessary by the physician. It is not recommended for use in neonates aged below 1 month due to lack of safety data.
Q: Can XYLOCARD 2% INFUSION cause nerve damage?
A: Yes. XYLOCARD 2% INFUSION may cause nerve damage when administered in excess amount. Therefore, inform your doctor if you experience signs of nerve damage (such as tingling in the hands and feet) while receiving XYLOCARD 2% INFUSION.
Q: Is XYLOCARD 2% INFUSION safe for use in pregnant women?
A: XYLOCARD 2% INFUSION should be used in pregnant women only if it is considered necessary by the physician. Therefore, inform your doctor if you are pregnant or think you may be pregnant before receiving XYLOCARD 2% INFUSION.
Q: How long does the effects of XYLOCARD 2% INFUSION lasts long in the body?
A: The effects of XYLOCARD 2% INFUSION may last about 10-20 minutes after intravenous administration and for about 60-90 minutes after intramuscular administration. However, the recovery period may vary from person-to-person based on the dose and amount of the XYLOCARD 2% INFUSION that is administered to you.
References
1. KD. Tripathi. Drugs acting on peripheral (somatic) nervous system. Essentials of medical pharmacology. 8th Edition. 2019. Page – 392.
2. Weinberg L, Peake B, Tan C and Nikfarjam M. Pharmacokinetics and pharmacodynamics of lignocaine: A review. World Journal of Anesthesiology. July 2015. [Accessed on 8th September 2022] https://www.wjgnet.com/2218-6182/full/v4/i2/17.htm
3. JOSE E. USUBIAGA, WILLIAM GUSTAFSON, FRANK MOYA AND BURTON GOLDSTEIN Departments of Anesthesiology and Psychiatry, University of Miami, School of Medicine and Jackson Memorial Hospital, Miami, Florida, US.A. The Effect of Intravenous Lignocaine on Cardiac Arrhythmias During Electroconvulsive Therapy. British Journal of Anesthesia. [Accessed on 8th September 2022] https://www.bjanaesthesia.org.uk/article/S0007-0912(17)51889-9/pdf
4. Mercury Pharmaceuticals Limited. Electronic Medicines Compendium (EMC). [Revised in May 2021] [Accessed on 8th September 2022] https://www.medicines.org.uk/emc/files/pil.4781.pdf
5. Hameln pharma ltd. Electronic Medicines Compendium (EMC). [Revised in February 2022] [Accessed on 8th September 2022] https://www.medicines.org.uk/emc/files/pil.6277.pdf
6. Mercury Pharmaceuticals (Ireland) Ltd. Electronic Medicines Compendium (EMC). [Revised in
April 2016] [Accessed on 8th September 2022] https://www.hpra.ie/img/uploaded/swedocuments/2143491.PA0073_112_006.8f88df24-b092-4c3b-bf3f-294aa775a103.000001Lidocaine%20Hydrochloride%202%20PIL.170524.pdf
7. Innovative Pharmaceuticals Pvt Ltd. LIGNOCIN Injection 30ml. [Accessed on 8th September 2022] https://www.innovativepharma.in/product/lignocin-injection/
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