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Introduction About XYLISTIN INJECTION
XYLISTIN INJECTION contains colistin, which belongs to the group of medicines called Antibiotics. It is used to manage certain forms of serious bacterial infections when other antibiotics are not suitable. It is clinically effective in managing various infections caused by certain gram-negative bacteria, such as Aerobacter aerogenes, Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa.
A bacterial infection can be defined as a proliferation of various harmful strains of bacteria in the body. They can affect any part(s) of the body, including the respiratory tract, urinary tract, eyes, ears, skin, soft tissue, or bones.
Colistin is a polypeptide antibiotic. It binds to the susceptible bacteria and disrupts the composition (lipids and proteins) of the bacterial cell membrane. As a result, it makes the contents of the bacterial cell leak out, which subsequently leads to bacterial killing. It may also inactivate the toxins produced by the bacteria.
Before receiving XYLISTIN INJECTION, inform your doctor if you have any kidney problems. To avoid side effects, your doctor would prescribe a low dose of colistin and constantly monitor your kidney functions while receiving XYLISTIN INJECTION. You must also inform your doctor if you have any inherited blood or muscle disorders before receiving XYLISTIN INJECTION.
Do not take XYLISTIN INJECTION if you are allergic to any of the ingredients present in it. XYLISTIN INJECTION should be used in pregnant or breastfeeding women only if prescribed by the physician. The most common side effects of receiving XYLISTIN INJECTION are stomach upset, tingling sensation in the extremities, loss of sensation, fever, or dizziness. Contact your doctor if any of these side effects worsen.
Uses Of XYLISTIN INJECTION
- Manages serious bacterial infections
How XYLISTIN INJECTION Works
XYLISTIN INJECTION kills the susceptible bacteria that causes infection. It acts by disrupting the composition (lipids and proteins) of the bacterial cell membrane and enters the bacterial cell. This causes the contents of the bacterial cell to leak out, which subsequently leads to bacterial killing. It may also inactivate the effects of toxins produced by the harmful bacteria.
How to use XYLISTIN INJECTION
XYLISTIN INJECTION will be given to you only by a doctor or nurse into the vein (intravenously). Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight, and severity of infection.
Side Effects Of XYLISTIN INJECTION
Common
- Stomach upset
- Tingling sensation in the extremities or in the tongue
- Paraesthesia (loss of sensation)
- Dizziness
- Skin rash, itching
- Fever
- Breathing difficulty
- Increased kidney enzymes
Rare
Contact your doctor immediately if you experience any of the following side effects after receiving XYLISTIN INJECTION:
- Severe allergic reaction (such as skin rash, itching, or sudden swelling of the face, throat, or lips leading to wheezing or breathing difficulties)
- Inability to breathe because of paralysis of the chest muscles, sense of tingling or numbness, especially around the face, feeling dizzy, loss of balance, rapid changes in blood pressure or blood flow causing flushing or fainting, problems in speech, problems with vision, confusion, and mental problems (including loss of sense of reality)
- Kidney damage with symptoms such as little or no urination, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath
How To Manage Side Effects
Dizziness Or Drowsiness
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely if you feel dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
Skin rash Or Itching
Avoid taking hot showers, as it may further irritate your skin. Use protective clothes while going outdoors. Avoid scratching the affected area of the skin. Regularly moisturize your skin. Consult your doctor if your condition worsens.
Warning & Precautions
Pregnancy
Monitoring requiredXYLISTIN INJECTION should be used in pregnant women only if it is considered necessary by the physician. Therefore, consult your doctor before receiving it.
Breastfeeding
Use with CautionXYLISTIN INJECTION should be used with caution in breast-feeding women. Therefore, consult your doctor before receiving it.
Driving and Using Machines
ContraindicatedDo not drive or operate any heavy tools or machines if you experience dizziness, confusion, or blurred vision after receiving XYLISTIN INJECTION.
Alcohol
ContraindicatedAvoid consumption of alcohol while receiving XYLISTIN INJECTION.
Kidney
Use with CautionXYLISTIN INJECTION should be used with caution in patients suffering from kidney problems. Therefore, consult your doctor before receiving it.
Liver
Use with CautionXYLISTIN INJECTION should be used with caution in patients suffering from liver problems. Therefore, consult your doctor before receiving it.
Allergy
ContraindicatedDo not receive XYLISTIN INJECTION if you are allergic to colistin.
Use In Pediatrics
Use with CautionXYLISTIN INJECTION should be used with caution in children and adolescents (aged below 18 years). Therefore, consult your doctor before receiving it.
Use In Geriatrics
Use with CautionXYLISTIN INJECTION should be used with caution in elderly patients. Therefore, consult your doctor before receiving it.
Others
Before receiving XYLISTIN INJECTION, inform your doctor if you:
- Have myasthenia gravis (weak muscles)
- Have porphyria (an inherited blood disorder)
Interactions
A. Drug-Drug Interaction:
Before receiving XYLISTIN INJECTION, inform your doctor if you are taking any of the following medicines, such as:
- Other antibiotics such as aminoglycosides (Ex. netilmicin, gentamicin, amikacin, and tobramycin), cephalosporins (Ex. cefixime, ceftriaxone), macrolides (Ex. azithromycin, clarithromycin, or erythromycin), or fluoroquinolones (ofloxacin, norfloxacin, and ciprofloxacin)
- Muscle relaxant medications (used for relaxing muscles before surgery) Ex. atracurium, vecuronium
Overdosage:
XYLISTIN INJECTION will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms. Symptoms of overdosage might include muscle weakness and breathing difficulties.
Synopsis
| Drug | : | Colistin |
| Pharmacological Category | : | Polypeptide antibiotics |
| Therapeutic Indication | : | Bacterial infection |
| Dosage Forms | : | Injections, Syrup, Suspension, Dry suspension, Dry syrup, Tablet |
More Information
Storage
- Keep XYLISTIN INJECTION out of reach of children
- Store XYLISTIN INJECTION at room temperature
FAQs About XYLISTIN INJECTION
Q: What is the use of XYLISTIN INJECTION?
A: XYLISTIN INJECTION is an antibiotic used to manage serious bacterial infections. It is used only when other antibiotics are not suitable for you. It acts by killing the susceptible bacteria that causes infection.
Q: What XYLISTIN INJECTION does to my body?
A: XYLISTIN INJECTION kills the susceptible bacteria that causes infection. It acts by disrupting the composition (lipids and proteins) of the bacterial cell membrane and enters the bacterial cell. This causes the contents of the bacterial cell to leak out, which subsequently leads to bacterial killing. It may also inactivate the effects of toxins produced by the harmful bacteria.
Q: What are the side effects of XYLISTIN INJECTION?
A: The most common side effects of receiving XYLISTIN INJECTION are stomach upset, tingling sensation in the extremities, loss of sensation, fever, or dizziness. Contact your doctor if any of these side effects worsen.
Q: How XYLISTIN INJECTION is administered?
A: XYLISTIN INJECTION will be given to you only by a doctor or nurse into the vein (intravenously). Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight, and severity of the infection.
Q: Can XYLISTIN INJECTION be used with children?
A: Yes. XYLISTIN INJECTION can be used in children and adolescents (aged below 18 years) if prescribed by the physician. Your doctor will decide the suitable dose for your child based on their age, body weight, and severity of infection.
Q: What precautions do I need to follow while taking XYLISTIN INJECTION?
A: Before receiving XYLISTIN INJECTION, inform your doctor if you have any kidney problems. You must also inform your doctor if you have any inherited blood or muscle disorders or if you are pregnant or breastfeeding before receiving XYLISTIN INJECTION. Complete the full course of antibiotic therapy as insisted by your doctor. Regularly check your kidney functions without fail while undergoing therapy with XYLISTIN INJECTION. Consult your doctor if you experience any unusual side effects after receiving XYLISTIN INJECTION.
Q: What medicines should I avoid while taking XYLISTIN INJECTION?
A: Avoid taking other antibiotics along with XYLISTIN INJECTION without consulting your doctor. Concomitant use of antibiotics along with XYLISTIN INJECTION may potentiate the effects of XYLISTIN INJECTION and may lead to unwanted side effects.
Q: Is XYLISTIN INJECTION safe?
A: XYLISTIN INJECTION is generally safe when used in the doses recommended by your doctor. Therefore, carefully follow your doctor's instructions and inform your doctor immediately if you experience any unpleasant side effects after receiving XYLISTIN INJECTION.
Q: Can I take XYLISTIN INJECTION during pregnancy?
A: XYLISTIN INJECTION should be used in pregnant women only if it is considered necessary by the physician. Therefore, consult your doctor before receiving it.
Q: What should I avoid while using XYLISTIN INJECTION?
A: Avoid consumption of alcohol while receiving XYLISTIN INJECTION. Consult your doctor for advice.
References
1. K.D. Tripathi. Macrolide and other antibacterial antibiotics. Essentials of Medical Pharmacology. Seventh Edition. Page – 759.
2. Ferdinando F. Andrade, Daniela Silva, Acacio Rodrigues, and Cidalia Pina-Vaz. National Library of Medicine. Colistin Update on Its Mechanism of Action and Resistance, Present and Future Challenges. NIH. National Library of Medicine. National Centre of Biotechnology Information. PMC PubMed Central. November 2020. [Accessed on 11th July 2024] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692639/
3. Teva. UK Ltd. Electronic Medicines Compendium (EMC). [Revised in May 2022] [Accessed on 11th July 2024] https://www.medicines.org.uk/emc/files/pil.9664.pdf
4. Biocon Biologics India Limited. Colistimethate Sodium for Injection IP® Koolistin 1MIU/ 2MIU / 3MIU / 4.5MIU. Biocon. Ltd. [Revised in July 2019]. [Accessed on 11th July 2024] https://www.biocon.com/docs/domestic-market-pi/ccd/KOOLISTIN%201_2_3_4.5%20MIU%20Leaflet.pdf
5. Cipla Ltd. XYLISTIN 0.5 MIU Injection (Colistimethate Sodium for Injection IP (Lyophilized)). Ciplamed. [Revised in February 2020]. [Accessed on 11th July 2024] https://www.ciplamed.com/product-index/xylistin-05-miu-injection
6. Monarch Pharmaceuticals, Inc. [Revised in October 2006] [Accessed on 11th July 2024] https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/050108s026lbl.pdf
7. Pharmaceutical Partners of Canada Inc. [Revised in February 2013] [Accessed on 11th July 2024] https://pdf.hres.ca/dpd_pm/00025454.PDF
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