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Introduction About XYGREL 60 TABLET
XYGREL 60 TABLET contains ticagrelor which belongs to the group of medicines called antiplatelet agents. It is used to reduce the rate of cardiovascular death, myocardial infarction and stroke in patients with acute coronary syndrome (ACS) or a history of myocardial infarction. It also reduces the rate of stent thrombosis in patients who have been stented for management of ACS.
Ticagrelor stops clumping of blood cells called platelets, which is responsible for clot formation in diseased blood vessels of heart and brain and thus reduces the chances of a blood clot formation. It can be taken with or without food.
Avoid concomitant use of ticagrelor and other oral anticoagulants like heparin or warfarin, as it may increase the risk of side effects. Do not take this medicine if you are suffering from any bleeding disorders or liver problems. This medicine is not recommended for use in pregnant or breastfeeding women and in children aged below 18 years. The most common side effect of taking this medicine are bleeding and bruising.
Uses Of XYGREL 60 TABLET
- Used to reduce the rate of cardiovascular death, myocardial infarction and stroke in patients with acute coronary syndrome (ACS) or a history of myocardial infarction
How XYGREL 60 TABLET Works
Ticagrelor is a potent P2Y12 receptor antagonist. In diseased blood vessels, platelets can form thrombus (blood clot) by binding to the arterial surface. Activated platelets produces ADP3 which binds to P2Y12 receptor and propagates thrombus formation. Ticagrelor reversibly binds to P2Y12 receptor instead of ADP3 and prevents the signal transduction and platelet activation, that can lead to blood clot formation.
How to use XYGREL 60 TABLET
Take this medicine as directed by your physician. It can be taken with or without food. Your doctor will decide the correct dose for you depending upon your condition. Swallow the medicine with a glass of water. Continue to take this medicine, as long as your doctor tells you to do so, to obtain better results.
Side Effects Of XYGREL 60 TABLET
Serious
- Signs of stroke (such as headache, feeling dizzy, sudden numbness of arm, leg or face, especially if only on one side of the body, confusion, difficulty in speaking, lack of co-ordination)
- Unexpected bleeding
- Pink, red or brown urine
- Vomiting blood clots
- Red or black stools
- Fainting (syncope)
- Thrombotic Thrombocytopenic Purpura (such as fever and purplish spots on skin or in mouth, with or without yellowing of skin or eyes, unexplained extreme tiredness or confusion)
Common
- Shortness of breath
- Bleeding and bruising
- Headache, feeling dizzy
- Diarrhea, indigestion or constipation
- Nausea
- Skin rash or itching
- Gout (severe pain and swelling in joints)
- Low blood pressure
- Bleeding in the nose, stomach lining or gums
- Bleeding after surgery or from cuts
How To Manage Side Effects
Constipation
Eat fibre rich foods like fresh fruit, vegetables and cereals. Drink plenty of water. Exercise more regularly.
Diarrhea
Drink lots of fluids, such as water or juice, to avoid dehydration. Do not take any medicines without speaking to a doctor.
Headache
Apply hot or cold-water bag on your head. Take rest in a quiet and dark room. Drink tea or coffee.
Nausea And Vomiting
Try taking this medicine with, or just after meal. Stick to simple meals. Do not eat rich or spicy food.
Warning & Precautions
Pregnancy
Monitoring requiredXYGREL 60 TABLET is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.
Breastfeeding
Monitoring requiredXYGREL 60 TABLET is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.
Driving and Using Machines
Use with CautionDo not drive or operate any machines if your ability is affected by this medicine.
Alcohol
Consult your doctorAvoid consumption of alcohol while taking this medicine.
Liver
ContraindicatedDo not take XYGREL 60 TABLET if you are suffering from severe liver disease. Consult your doctor for advice.
Allergy
ContraindicatedDo not take this medicine if you are allergic to Ticagrelor.
Lungs
Use with CautionXYGREL 60 TABLET should be taken with caution in patients with asthma or other lung problems or breathing difficulties. Consult your doctor for advice.
Heart Disease
Use with CautionXYGREL 60 TABLET should be taken with caution in patients with abnormal heart rate. Consult your doctor for advice.
Others
Talk to your doctor before taking this medicine, if you:
- Have a recent serious injury, recent surgery, recent bleeding from your stomach or gut or any other bleeding disorders
- Suffer from hyperuricemia (increased uric acid levels in blood)
Interactions
Talk to your doctor, if you are taking,
- Other oral anticoagulants (e.g. heparin, warfarin)
- Medicines used to manage high cholesterol levels (e.g. simvastatin or lovastatin)
- Medicines used to manage epilepsy (e.g. phenytoin, carbamazepine and phenobarbital)
- Medicines used to manage depression (e.g. paroxetine, nefazodone, sertraline and citalopram)
- Medicines used to manage heart problems like heart failure (e.g. digoxin), abnormal heart rate (e.g. quinidine and diltiazem) or high blood pressure (e.g. propranolol, verapamil, captopril)
- Non-steroidal anti-inflammatory drugs (used to manage pain) e.g. ibuprofen and naproxen
- Rifampicin (used to manage tuberculosis)
- Cyclosporine (used to avoid graft rejection)
- Morphine and other opioids (used to manage severe pain)
- Ketoconazole (used to manage fungal infections)
- Clarithromycin (used to manage bacterial infections)
- Ritonavir and atazanavir (used to manage HIV infection)
- Cisapride (used to manage heartburn)
- Ergot alkaloids (used to manage migraine headaches)
Synopsis
| Drug | : | Ticagrelor |
| Pharmacological Category | : | Antiplatelet agent, P2Y12 receptor antagonist |
| Therapeutic Indication | : | Heart attack and stroke |
| Dosage Forms | : | Tablet |
More Information
Storage
- Store at room temperature
- Keep out of reach of children
FAQs About XYGREL 60 TABLET
Q: Can XYGREL 60 TABLET be crushed?
A: Yes. If you feel difficulty in swallowing this medicine, you can crush it and mix with half glass of water and drink it.
Q: Can XYGREL 60 TABLET cause shortness of breath?
A: Yes. This medicine may sometime cause shortness of breath in some individuals. Contact your doctor for advice.
References
1. Keith A.A. Fox, Harvey D. White, Bernard J. Gersh and Lionel H. Opie. Antithrombotic Agents: Platelet Inhibitors, Acute Anticoagulants, Fibrinolytics and Chronic Anticoagulants. Drugs for the heart. 8th Edition. 2013. Page-351-352.
2. Gerald G. Briggs, Roger K. Freeman. T. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation, Tenth Edition. 2015. Page – 3799-3800.
3. Jolanta M Siller-Matula, Bernd Jilma. Ticagrelor: from discovery to Phase III clinical trial. NIH National Library of Medicine, National center of Biotechnology information. November 2010. [Accessed 27th October 2020] https://pubmed.ncbi.nlm.nih.gov/21142630/
4. Dominick J. Angiolillo , George D. Dengas. Ticagrelor With Aspirin or Alone in High-Risk Patients After Coronary Intervention – TWILIGHT. American college of cardiology. March 2020. [Accessed 27th October 2020] https://www.acc.org/latest-in-cardiology/clinical-trials/2019/09/24/23/30/twilight
5. AstraZeneca AB; Electronic Medicines Compendium (EMC) [Revised on September 2019] Accessed 27th October 2020] https://www.medicines.org.uk/emc/files/pil.5767.pdf
6. AstraZeneca AB; Electronic Medicines Compendium (EMC) [Revised on September 2019] Accessed 27th October 2020] https://www.medicines.org.uk/emc/files/pil.7606.pdf
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