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Introduction About XOY S INJECTION
XOY S INJECTION is a combination of Ceftriaxone and Sulbactam, which belongs to the group of medicines called Antibiotics. It is used in the management of infections of the brain (meningitis), lungs, middle ear, abdomen, and abdominal wall (peritonitis), urinary tract and kidneys, bones and joints, skin or soft tissues, blood, and heart.
XOY S INJECTION can also be used to manage specific sexually transmitted infections (gonorrhoea and syphilis), patients with low white blood cell counts (neutropenia) who have fever due to bacterial infection, Lyme disease (caused by tick bites), and infections during surgery.
XOY S INJECTION is not recommended for use in premature babies and new-born babies having jaundice. Before receiving XOY S INJECTION, inform your doctor if you have liver or kidney diseases, colitis, hemolytic anemia, gallstones or kidney stones, upcoming surgeries, or pancreatitis.
XOY S INJECTION should be used with caution in pregnancy and breast feeding. Contact your doctor before receiving. XOY S INJECTION is not recommended for use in premature babies. Contact your child’s doctor. XOY S INJECTION should be used with caution in elderly patients (aged above 65 years or above). Contact your doctor before receiving.
The most common side effects of receiving XOY S INJECTION are diarrhea, rash, itching, pain at the site of injection, and inflammation of a vein caused by blood clots. Contact your doctor if any of the symptoms worsen.
Uses Of XOY S INJECTION
Manage bacterial infections involving:
- Brain (meningitis)
- Lungs
- Middle ear
- Abdomen and abdominal wall (peritonitis)
- Urinary tract and kidneys
- Bones and joints
- Skin or soft tissues
- Blood
- Heart
- Sexually transmitted infections (gonorrhoea and syphilis)
- Low white blood cell counts (neutropenia)
- Lyme disease (caused by tick bites)
- Infections during surgery
How XOY S INJECTION Works
XOY S INJECTION helps to manage infections, where Ceftriaxone is a cephalosporin antibiotic that works by inhibiting the synthesis of bacterial cell walls, leading to destruction of the bacteria, and Sulbactam is a beta-lactamase inhibitor that works by binding and inhibiting beta-lactamase (an enzyme that destroys antibiotic activity) produced by bacterial cells and thereby manages the reduction in antibacterial activity.
How to use XOY S INJECTION
XOY S INJECTION will be given to you only by a doctor or a nurse into a vein as an intravenous injection or infusion or into a muscle as an intramuscular injection. Your doctor will decide the correct dose and duration of XOY S INJECTION for you depending upon your age, body weight, and severity of the disease condition.
Side Effects Of XOY S INJECTION
Common
- Pain, tenderness, warmth, and tightness at the injection site
- Rash
- Low count of the blood cells
- Diarrhoea
- Changes in liver function tests characterized by abdominal pain, yellowing of skin or eyes, dark urine, pale stools
Uncommon
- Inflammation of the vein
- Itching
- Fever, chills
- Genital fungal infections
- Nausea, vomiting
- Changes in taste
- Headache
- Dizziness
Rare
Stop receiving XOY S INJECTION and contact your doctor immediately if you experience any of the following side effects:
- Allergic reactions such as rash, red skin, blistering of lips, eyes, and mouth, skin peeling, high fever, flu-like symptoms, increased levels of liver enzymes, and an increase in eosinophils and enlarged lymph nodes
- Sudden swelling of the throat or face causing difficulty in breathing or swallowing; sudden swelling of the hands, feet, and ankles
How To Manage Side Effects
Diarrhea
Drink lots of fluids, such as water or fruit juices, to keep you hydrated. Do not take any medicine on your own for managing diarrhea. Contact your doctor if the symptom did not improve.
Dizziness Or Drowsiness
Try to rest and relax. Get enough sleep. Avoid driving or operating any machines while you are feeling dizzy. Do not consume alcohol, as it can aggravate your dizziness. Contact your doctor if the symptom does not improve.
Headache
Rest and relax. Drink plenty of fluids, such as water or electrolytes, and apply a pain-relieving balm to the head if necessary. Do not consume alcohol. Contact your doctor if the symptom does not improve.
Nausea And Vomiting
Stick to simple meals while receiving XOY S INJECTION. Avoid eating rich or spicy food. Do not take any medication on your own. Ask for your doctor’s advice if nausea doesn’t improve. Eat light, bland foods and avoid fried, oily, or sweet foods. Avoid carbonated drinks. Ask for your doctor’s advice if vomiting doesn’t improve.
Stomach Pain
Try to rest and relax. Eat small meals but take them frequently. Keep a heat pad on your stomach. If the symptom does not improve, contact your doctor.
Warning & Precautions
Pregnancy
Use with CautionXOY S INJECTION should be used with caution in pregnant women. Consult your doctor before receiving XOY S INJECTION.
Breastfeeding
Use with CautionXOY S INJECTION should be used with caution in breastfeeding women. Consult your doctor before receiving.
Driving and Using Machines
ContraindicatedDo not drive or operate any machines if you feel dizziness after receiving XOY S INJECTION.
Kidney
Use with CautionXOY S INJECTION should be used with caution in patients with kidney disease such as kidney stones. Consult your doctor before receiving XOY S INJECTION.
Liver
Use with CautionXOY S INJECTION should be used with caution in patients with liver disease. Consult your doctor before receiving.
Allergy
ContraindicatedDo not receive XOY S INJECTION if you are allergic to ceftriaxone, sulbactam, penicillin, or similar antibiotics like carbapenems, monobactams, lidocaine, or any of the other ingredients of this medicine.
Use In Pediatrics
ContraindicatedXOY S INJECTION is not recommended for use in premature babies and new-born babies with jaundice. Ask for the advice of your child’s doctor.
Use In Geriatrics
Use with CautionXOY S INJECTION should be used with caution in elderly patients (aged 65 years or above). Your doctor might consider lowering your doses depending upon your health condition. Contact your doctor before receiving XOY S INJECTION.
Others
Tell your physician before receiving XOY S INJECTION if you have or had:
- Gut problems like colitis (inflammation of the bowel)
- Pancreatitis
- Haemolytic anaemia
- Low sodium diet
- Upcoming surgeries
- Gall bladder stones
- Blood tests (coombs test) or urine test (for glucose)
Interactions
A. Drug-Drug Interactions:
Before receiving XOY S INJECTION, inform your doctor if you are taking any of the following medicines:
- Medicine used to manage blood cancer (Ex. amacrine)
- Medicines used to manage certain infections (Ex. vancomycin, chloramphenicol, tobramycin, gentamycin)
- Medicine used to manage fungal infections (Ex. fluconazole)
- Medicines used to manage pregnancy, oral contraceptives (Ex. ethinyl estradiol, levonorgestrel)
- Medicines used to manage blood clots (Ex. dabigatran, rivaroxaban)
- Medicines used to manage gout (Ex. probenecid)
- Calcium-containing diluents (such as Ringers’ solution and Hartman’s solution)
Overdosage:
XOY S INJECTION will be administered only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if there are any unusual symptoms.
Synopsis
| Drug | : | Ceftriaxone and Sulbactam |
| Pharmacological Category | : | Cephalosporin Antibiotics and Beta-lactamase inhibitors |
| Therapeutic Indication | : | Manages Bacterial infections |
| Dosage Forms | : | Injection |
More Information
Storage
- Keep XOY S INJECTION out of reach of children
- Store XOY S INJECTION below 30°C
FAQs About XOY S INJECTION
Q: How XOY S INJECTION is given?
A: XOY S INJECTION will be given to you only by a doctor or a nurse into a vein as an intravenous injection or infusion or into a muscle as an intramuscular injection. Your doctor will decide the correct dose and duration of XOY S INJECTION for you depending upon your age, body weight, and severity of the disease condition.
Q: Can XOY S INJECTION cause diarrhea?
A: Yes. XOY S INJECTION cause diarrhea. Drink lots of fluids, such as water or fruit juices, to keep you hydrated. Do not take any medicine on your own for managing diarrhea. Contact your doctor if the symptom does not improve.
Q: Can I stop receiving XOY S INJECTION on my own?
A: Do not stop receiving XOY S INJECTION unless your doctor tells you to. Stopping early may not prove the medicine to be properly effective. If you have any further questions on the use of XOY S INJECTION, ask your doctor.
Q: Who should avoid receiving XOY S INJECTION?
A: XOY S INJECTION is not recommended for premature babies and new-borns with jaundice, or if you are allergic to ceftriaxone, sulbactam, penicillin, or similar antibiotics like carbapenems, monobactams, lidocaine, or any of the other ingredients of this medicine. Contact your doctor before receiving XOY S INJECTION.
Q: Does XOY S INJECTION cause kidney stones?
Yes. XOY S INJECTION might cause kidney stones. Also, XOY S INJECTION should be used with caution in patients with kidney stones. Consult your doctor before receiving.
Q: What is XOY S INJECTION used for?
A: XOY S INJECTION is used in the management of infections of the brain (meningitis), lungs, middle ear, abdomen and abdominal wall (peritonitis), urinary tract and kidneys, bones and joints, skin or soft tissues, blood, and heart. It can also be used to manage specific sexually transmitted infections (gonorrhoea and syphilis), patients with low white blood cell counts (neutropenia) who have fever due to bacterial infection, Lyme disease (caused by tick bites), and infections during surgery.
Q: Is XOY S INJECTION safe during pregnancy?
A: XOY S INJECTION should be used with caution in pregnant women. Consult your doctor before receiving XOY S INJECTION.
Q: Can XOY S INJECTION be used in children?
A: XOY S INJECTION is not recommended for use in premature babies and new-born babies with jaundice. Ask for the advice of your child’s doctor.
Q: What are the side effects of using XOY S INJECTION?
A: The most common side effects of receiving XOY S INJECTION are diarrhea, rash, itching, pain at the site of injection, and inflammation of a vein caused by blood clots. Contact your doctor if any of the symptoms worsen.
Q: What precautions must be taken while using XOY S INJECTION?
A: Before receiving XOY S INJECTION, inform your doctor if you have or had kidney disease such as kidney stones, liver disease, gut problems like colitis (inflammation of the bowel), pancreatitis, hemolytic anemia, low sodium diet, upcoming surgeries, gall bladder stones, or are scheduled for blood tests (coombs test) or urine tests (for glucose).
References
1. KD. Tripathi. Beta lactam antibiotics. Essentials of medical pharmacology. Seventh edition. 2013. Page – 727 to 728.
2. Patil UN, Jambulingappa KL. A Combination Strategy of Ceftriaxone, Sulbactam, and Disodium Edetate for the Treatment of Multi-Drug Resistant (MDR) Septicaemia: A Retrospective, Observational Study in Indian Tertiary Care Hospital. NIH National Library of Medicine National Centre for Biotechnology Information. Pubmed Central. November 2015. [Accessed on 25th July 2024] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668432/
3. Masoumeh Mohkam, Abdollah Karimi, Atoosa Gharib, Hamid Daneshmand, Alireza Khatami, Nozar Ghojevand, Mostafa Sharifian. Ceftriaxone associated nephrolithiasis: a prospective study in 284 children. NIH National Library of Medicine National Centre for Biotechnology Information. Pubmed.gov. May 2007. [Accessed on 25th July 2024] https://pubmed.ncbi.nlm.nih.gov/17226043/
4. Sanjay Mohan Shrivastava, Rajkumar Singh, Abu Tariq, Masoom Raza Siddiqui, Jitendar Yadav, P. S. Negi, and Manu Chaudhary. A novel high performance liquid chromatographic method for simultaneous determination of ceftriaxone and sulbactam in sulbactomax. NIH National Library of Medicine National Centre for Biotechnology Information. Pubmed Central. March 2009. [Accessed on 25th July 2024] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614746/
5. Lupin Pharmaceuticals. Ceftriaxone Injection. Dailymed. [Revised in November 2021]. [Accessed on 25th July 2024] https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=dac396fb-748d-45ea-9830-17c6eeb8834f&type=display
6. Cipla Ltd. Sulbacip IV Injection (Sulbactam Sodium). Ciplamed. [Revised in September 2013]. [Accessed on 25th July 2024] https://www.ciplamed.com/explore/resources/sulbacip-sulbactam-iv-monograph-0
7. Cipla Ltd. Cefbact-S injection (Ceftriaxone + sulbactam). Ciplamed. [Revised in April 2022] [Accessed on 25th July 2024] https://www.ciplamed.com/product-index/cefbact-s-injection
8. Cipla Ltd. Elores injection (Ceftriaxone + sulbactam). Ciplamed. [Revised in October 2019] [Accessed on 25th July 2024] https://www.ciplamed.com/product-index/elores-powder-for-infusion
9. Leeford Healthcare. Biocef-s (Ceftriaxone + sulbactam). [Accessed on 25th July 2024] https://www.leeford.in/product/164/biocef-s-375
10. Taj Pharma. Ceftriaxone + sulbactam for injection. [Accessed on 25th July 2024] https://tajpharma.in/portfolio-item/ceftriaxone-sulbactam-for-injection-187-5mg/
11. Nitin Lifesciences Ltd. Extacef XL (Ceftriaxone + sulbactam). Blue Cross Labs. [Revised in September 2022] [Accessed on 25th July 2024] https://bluecrosslabs.com/wp-content/uploads/2021/01/EXTACEF-XL1_5g-Injection-PI-Sep2022.pdf
Useful Diagnostic Tests
- Complete Blood Count (CBC)/ Hemogram
- Kidney Function Test (KFT)
- Peripheral Smear Examination By Pathologist
- Serum Electrolytes/ Electrolytes Profile
- Culture & Sensitivity, Blood
- Healthy Midlife Checkup
- Urine Routine & Microscopy
- Women Health Checkup - Essential
- Full Body Checkup – Gold
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