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Introduction About VOAGE L TABLET
VOAGE L TABLET is a combination of Dapagliflozin and Linagliptin, which belongs to the group of medicines called Antidiabetic agents. It is used for the management of patients with type 2 diabetes mellitus who are inadequately controlled on metformin monotherapy.
Type II diabetes mellitus is a chronic disease characterized by abnormally high levels of glucose in the blood. It is caused by inadequate production of a hormone called insulin (produced by the pancreas to metabolize glucose) in the body or by inadequate sensitivity of body cells to the actions of insulin.
Before starting management with VOAGE L TABLET, your doctor will assess your volume status and kidney function by conducting a blood test. VOAGE L TABLET should be used with caution in patients with liver disease, heart failure, and low blood pressure. Consult your doctor before taking it.
Inform your doctor before taking this medicine if you are pregnant, think you may be pregnant, or are planning to have a baby. VOAGE L TABLET is not recommended for use by breastfeeding women as it is not known whether it may pass through breast milk. Consult your doctor for advice.
The most common side effects of taking VOAGE L TABLET are hypoglycemia, vulvovaginitis, balanitis and related genital infections, urinary tract infections, dizziness, rash, and back pain. Consult your doctor if any of the side effects worsen.
Uses Of VOAGE L TABLET
- To manage type II diabetes mellitus
How VOAGE L TABLET Works
VOAGE L TABLET effectively controls blood glucose levels, where dapagliflozin works by inhibiting sodium-glucose co-transporter 2 protein in the kidneys and managing the reabsorption of glucose from the blood into the kidneys. As a result, more glucose is excreted in urine, which helps lower blood glucose levels in the body.
Linagliptin works by inhibiting the dipeptidyl peptidase-4 (DPP-4) enzyme (a protein that helps to degrade incretin hormones) and thus increasing the concentrations of incretin hormones, stimulating the release of insulin in a glucose-dependent manner, decreasing the levels of glucagon, and reducing glucose production in the liver.
How to use VOAGE L TABLET
Take VOAGE L TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight, and disease condition.
Overdose
If you or anyone else accidentally took more VOAGE L TABLET, consult your doctor immediately or visit the nearby hospital.
Side Effects Of VOAGE L TABLET
Common side effects of VOAGE L TABLET:
- Hypoglycaemia
- vulvovaginitis, balanitis, and related genital infections
- urinary tract infection, dysuria, polyuria
- dizziness
- rash
- back pain
Stop taking VOAGE L TABLET and consult your doctor immediately if you experience any of the following side effects:
- signs and symptoms of diabetic ketoacidosis such as rapid weight loss, nausea, vomiting, stomach pain, excessive thirst, fast and deep breathing, confusion, unusual sleepiness or tiredness, a sweet smell to your breath, a sweet or metallic taste in your mouth, or a different odour to your urine or sweat
- signs and symptoms of necrotizing fasciitis of the perineum (Fournier’s Gangrene) include pain or tenderness, erythema, or swelling in the genital or perineal area, along with fever or malaise
How To Manage Side Effects
Dizziness Or Drowsiness
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
Hypoglycemia
Have foods rich in sugars, such as fruit juices, glucose drinks, candies, honey, or biscuits. Check your blood sugar after 10 minutes. If you have not reached your optimum level, take another sugary snack or drink and check your blood sugar levels once again. Contact your doctor if there is no improvement in your condition.
Skin rash Or Itching
Avoid hot baths because hot water can irritate your skin further. Do not scratch the affected area. Use sunscreen and wear protective clothing while going outside. Use unscented moisturizers to soothe and hydrate the affected area. Contact your doctor if your rashes worsen.
Warning & Precautions
Pregnancy
Consult your doctorInform your doctor before taking this medicine if you are pregnant, think you may be pregnant, or are planning to have a baby.
Breastfeeding
ContraindicatedVOAGE L TABLET is not recommended for use by breastfeeding women as it is not known whether it may pass through breast milk. Consult your doctor for advice.
Driving and Using Machines
Use with CautionDo not drive or operate any machinery if you feel dizzy after taking VOAGE L TABLET.
Alcohol
Consult your doctorAvoid excessive consumption of alcohol while taking VOAGE L TABLET, as it may increase the risk of lactic acidosis.
Kidney
ContraindicatedVOAGE L TABLET is not recommended for use if you have severe kidney disease or are on dialysis. Inform your doctor before taking VOAGE L TABLET if you have urinary tract infections or moderate kidney disease.
Liver
Use with CautionVOAGE L TABLET should be used with caution in patients with liver disease. Consult your doctor before taking it.
Allergy
ContraindicatedVOAGE L TABLET is not recommended for use if you are allergic to dapagliflozin, linagliptin, or any of the other ingredients of this medicine.
Heart Disease
Use with CautionVOAGE L TABLET should be used with caution in patients with heart failure or low blood pressure. Consult your doctor before taking it.
Use In Pediatrics
ContraindicatedVOAGE L TABLET is not recommended for use in children or adults under 18 years of age. Consult your doctor before taking it.
Use In Geriatrics
Use with CautionVOAGE L TABLET should be used with caution with elderly patients. Consult your doctor before taking it.
Other Warnings for VOAGE L TABLET
Before taking VOAGE L TABLET, inform your doctor if you:
- have genital fungal infections
- have type 1 diabetes or have a condition called diabetic ketoacidosis
- have or have had a disease of the pancreas
- have headache, drowsiness, weakness, dizziness, confusion, irritability, hunger, a fast heartbeat, sweating, and feeling jittery
- have a stuffy or runny nose and a sore throat
- have diabetic skin lesions
Drug - Drug interaction
Before taking VOAGE L TABLET, inform your doctor if you are taking any of the following medicines, such as:
- insulin or a sulphonyl urea, Ex. glimepiride or glipizide (other medicines used to manage diabetes mellitus)
- diuretics (medicines that increase urine production) (Ex. furosemide, chlorothiazide)
- rifampin (a medicine used in the management of tuberculosis)
- digoxin (a medicine used in the management of heart failure)
- topiramate or other carbonic anhydrase inhibitors (Ex. zonisamide, acetazolamide, or dichlorphenamide) (medicines used in the management of fits and glaucoma)
- ranolazine (a medicine used to manage angina)
- vandetanib (a medicine used to manage thyroid cancer)
- dolutegravir (a medicine used to manage HIV infection)
- cimetidine (a medicine used to manage stomach problems)
- corticosteroid (generally used to manage inflammation) (Ex. beclomethasone dipropionate)
Synopsis
|
Drug |
Dapagliflozin and Linagliptin |
|
Pharmacological Category |
Sodium-glucose co-transporter 2 inhibitors, DPP-4 inhibitors |
|
Therapeutic Indication |
Type II Diabetes mellitus |
|
Dosage Forms |
Tablet |
More Information
Storage
- Keep VOAGE L TABLET out of the sight and reach of children
- Store VOAGE L TABLET below 30°C
FAQs About VOAGE L TABLET
Q: What are the side effects of VOAGE L TABLET?
A: The most common side effects of taking VOAGE L TABLET are hypoglycemia, vulvovaginitis, balanitis and related genital infections, urinary tract infection, dysuria, polyuria, dizziness, rash, and back pain. Consult your doctor if any of the side effects worsen.
Q: How does VOAGE L TABLET work?
A: VOAGE L TABLET effectively controls blood glucose levels, where dapagliflozin works by inhibiting sodium-glucose co-transporter 2 protein in the kidneys and managing the reabsorption of glucose from the blood into the kidneys. As a result, more glucose is excreted in urine, which helps lower blood glucose levels in the body. Linagliptin works by inhibiting the dipeptidyl peptidase-4 (DPP-4) enzyme (a protein that helps to degrade incretin hormones) and thus increasing the concentrations of incretin hormones, stimulating the release of insulin in a glucose-dependent manner, decreasing the levels of glucagon, and reducing glucose production in the liver.
Q: Is VOAGE L TABLET safe during pregnancy?
A: There is no information on the use of VOAGE L TABLET during pregnancy. Inform your doctor if you are pregnant or planning to be pregnant before taking it.
Q: What precautions must be taken while using VOAGE L TABLET?
A: VOAGE L TABLET should be used with caution in patients with liver disease, urinary tract infections or moderate kidney disease, heart failure or low blood pressure, genital fungal infections, type 1 diabetes, a condition called diabetic ketoacidosis, a disease of the pancreas, a headache, drowsiness, weakness, dizziness, confusion, irritability, hunger, a fast heartbeat, sweating, and feeling jittery, a stuffy or runny nose and a sore throat, or have diabetic skin lesions. Consult your doctor before taking VOAGE L TABLET.
Q: What if I forget to take VOAGE L TABLET?
A: If you miss a dose of VOAGE L TABLET, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Q: Is VOAGE L TABLET safe for kidneys?
A: VOAGE L TABLET is not recommended for use if you have severe kidney disease or are on dialysis. Inform your doctor before taking VOAGE L TABLET if you have urinary tract infections or moderate kidney disease.
Q: What is VOAGE L TABLET used for?
A: VOAGE L TABLET is used for the management of patients with type 2 diabetes mellitus who are inadequately controlled on metformin alone.
Q: What should I avoid while taking VOAGE L TABLET?
A: Avoid excessive consumption of alcohol while taking VOAGE L TABLET, as it may increase the risk of lactic acidosis.
Q: Who should avoid taking VOAGE L TABLET?
A: VOAGE L TABLET is not recommended for use if you have severe kidney disease or are on dialysis, allergic to dapagliflozin, or linagliptin.
Q: Can VOAGE L TABLET be used in kids?
A: VOAGE L TABLET is not recommended for use in children or adults under 18 years of age. Consult your doctor before taking it.
References
1. KD. Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of Medical Pharmacology. Seventh Edition. 2013. Page – 301 & 294.
2. Park JW, Kim JM, Noh JH, Kim KA, Chung H, Kim E, Kang M, Park JY. Pharmacokinetics of a Fixed-Dose Combination Product of Dapagliflozin and Linagliptin and Its Comparison with Co-Administration of Individual Tablets in Healthy Humans. Pharmaceutics. March 2022. [Accessed on 5th September 2024] 
3. AstraZeneca UK Limited. Electronic Medicines Compendium (EMC) [Revised in November 2022] [Accessed on 5th September 2024] 
5. Boehringer Ingelheim Ltd. Electronic Medicines Compendium (EMC) [Revised in January 2022] [Accessed on 5th September 2024]
6. Drug bank. Dapagliflozin. [Accessed on 5th September 2024]
7. Drug bank. Linagliptin. [Accessed on 5th September 2024]
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