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Introduction About VALVO CR 300MG TABLET
VALVO CR 300MG TABLET is a combination of Sodium valproate and Valproic acid, which belong to the group of medicines called Anticonvulsant/Antiepileptic drugs. It is used to manage epilepsy in adults and children. It is also used to manage bipolar disorders. Epilepsy is an abnormal electrical activity in the brain and nervous system. The symptoms may include temporary confusion, muscle stiffness, jerky movements in legs or arms, loss of consciousness, psychological symptoms (such as anxiety or fear), etc.
VALVO CR 300MG TABLET is not recommended for use in patients with liver problems or with a family history of liver problems, porphyria (a hereditary disease that affects the skin or nervous system), blood coagulation or clotting disorders, pancreatic diseases (inflammation of the pancreas), urea cycle disorder (a genetic disorder) or Alpers-Huttenlocher syndrome (a rare disorder that affects brain, liver & muscles), etc.
VALVO CR 300MG TABLET should be used with caution in patients with kidney problems or lung diseases (such as chronic obstructive pulmonary disease) and diabetes. VALVO CR 300MG TABLET is also not recommended for use in pregnant and breastfeeding women. It should be used with caution in children (below 2 years of age). Consult your doctor before taking the medicine.
The common side effects of taking VALVO CR 300MG TABLET may include dizziness, headache, sleep disorders, clumsiness/unsteadiness, trembling of hands and arms and nervousness. Consult your doctor if any of the symptoms worsen or persist.
Uses Of VALVO CR 300MG TABLET
- Manage epilepsy
- Manage bipolar disorders
How VALVO CR 300MG TABLET Works
VALVO CR 300MG TABLET helps in managing epilepsy, where sodium valproate and valproic acid effectively increases the GABA (a neurotransmitter/chemical messenger) concentration in the central nervous system by reducing its degradation. It also blocks certain ion channels which reduce high-frequency neuronal activity in the brain, thereby reliving seizure activity.
How to use VALVO CR 300MG TABLET
Take VALVO CR 300MG TABLET as advised by your physician. Swallow the medicine with a glass of water with or after food. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition.
Side Effects Of VALVO CR 300MG TABLET
Common
- headache
- sleep disorders
- clumsiness or unsteadiness
- trembling of hands and arms
- nervousness
- changing moods
- blurred vision
- ringing in ears
- deafness
- dizziness
- flu
- abdominal or stomach pain
- heartburn
- nausea and vomiting
- diarrhoea
- skin rash
- hair loss or thinning of hair
- back pain
- change in menstrual periods
- lack or loss of strength
- mental confusion
- aggression
- convulsion
- memory problems
- becoming unreactive
- bedwetting
- signs of liver damage such as skin and eyes that appear yellowish (jaundice), abdominal pain and swelling.
- signs of inflammation of the pancreas (pancreatitis) such as upper abdominal pain, abdomen tenderness, fever and rapid pulse
- signs of Fanconi syndrome (a disorder of kidney tubes) such as excessive thirst, urination, vomiting
- overgrown gum tissue
- agitation
- disturbance in attention
- abnormal behaviour
- hyperactivity
- learning disorder
Uncommon
- unusual bleeding or bruising
- abnormal dreams
- anxiety
- feeling sad
- irritability
- pain in joints
- cough
- constipation
- dry eyes
- spots before the eyes
- ear infection
- ear pain
- runny nose
- dental pain
- bloating
- muscle pains or stiffness
- tiredness
- weight gain or loss
- learning disorder
- coma
- loss of muscle control
- brittle bones and fractures
- shortness of breath
- chest pain
- blood clotting problems
Rare
Stop taking VALVO CR 300MG TABLET and contact your doctor if you experience any of the following side effects:
- signs of allergic reactions such as swelling of the face, lips, eyelids, throat and tongue, which may cause difficulty in breathing and swallowing
- signs of altered levels of ammonia in the blood characterized by vomiting, balance issues and lack of alertness
- signs of liver problems characterized by nausea, vomiting, tiredness, sleepiness, weakness, stomach pain, yellowing of the skin or whites of the eye
- signs of inflammation of the pancreas characterized by acute abdominal pain
- chest pain
- shortness of breath
- hallucinations
- suicidal thoughts
- psychosis (mental disorder causing disconnection from reality)
- toxic epidermal necrolysis (life-threatening skin disorder causing widespread skin pain, rashes, blisters, sores and crusting)
- Steven-Johnson syndrome (a skin disorder characterized by painful rashes and blisters on the skin)
- anaphylaxis (severe allergic reaction characterized by shortness of breath, fainting or fastened heartbeat)
- erythema multiforme (a skin condition characterized by raised red rashes on the skin)
- polycystic ovarian syndrome (a disorder of ovaries characterized by irregular periods, hair growth on the skin, acne and weight gain)
- brain diseases such as cerebral pseudo atrophy (loss of brain cells), encephalopathy (disease altering brain structure and functions) and coma (loss of consciousness)
- signs of thrombocytopenia (a condition marked by decreased platelet count) such as spontaneous bruising or bleeding
- signs of agranulocytosis (severe decrease of white blood cells or bone marrow failure) such as fever and breathing difficulty
- signs of anaemia (decreased red blood cell count) as weakness, dizziness, pale skin and shortness of breath
- signs of macrocytosis (abnormally increased red blood cell size) such as brittle nails, loss of weight or diarrhoea
- signs of pancytopenia (decreased blood cells and platelets) such as weakness, dizziness, pale skin and shortness of breath
- drowsiness
- change in consciousness level (including coma)
- confusion
- memory loss
- abnormal behaviour such as changes in attention, concentration, mood, hallucinations or fits of more frequency and severity
- signs of hypothyroidism (underactive thyroid gland) such as tiredness or weight gain
- signs of pleural effusion (build-up of fluid between the tissues that line the lungs and the chest) such as breathing difficulty and pain
- increase in the number and severity of convulsions
- signs of rhabdomyolysis (a disorder caused by the breakdown of muscle tissue) such as muscle pain and weakness
- signs of systemic lupus erythematosus (autoimmune disorder) such as joint pain, fever, fatigue or rash
- signs of increased ammonia in the blood, such as problems in balancing and co-ordination, feeling lethargic or less alert associated with vomiting
- shakiness (tremor)
- jerky muscle movements
- unsteadiness when walking due to parkinsonism (brain disorder), extrapyramidal disorder or ataxia (a disorder marked by impaired coordination)
- uncontrollable and rapid movement of the eyes
- signs of kidney disease such as renal failure, tubulointerstitial nephritis such as blood in the urine, fever, increased or decreased urine output, weakness, confusion
- signs of Fanconi syndrome (a disorder of kidney tubes) such as excessive thirst, urination and vomiting manifest as reduced urinary output or blood in the urine
- signs of decreased blood sodium levels such as confusion
- confusion that occurs due to decreased sodium levels in blood and syndrome of Inappropriate Antidiuretic Hormone (SIADH) secretion (a condition marked by high levels of the antidiuretic hormone that causes retention of water in the body)
How To Manage Side Effects
Headache:
Drink sufficient water and take plenty of rest. Do not skip meals. Do not take mental stress and strain your eyes. Consult your doctor if the condition persists or get worse in time.
Dizziness:
Lie down until the dizziness fades away and get up slowly. Do not attempt sudden head movements. Take adequate rest. Consult your doctor if the condition persists for long or gets worsened.
Diarrhoea:
Stay hydrated by consuming sufficient amount of water or fruit juice. Avoid taking medicine on your own to manage diarrhoea. Consult your doctor if the symptom gets worse or persist.
Constipation:
Consume healthy foods with high-fiber foods such as fresh fruit and vegetables, cereals and drink plenty of water. Maintain doing regular exercise, such as walking and running. Consult your doctor if the symptom gets worse or persist.
Nausea and vomiting:
Try to take VALVO CR 300MG TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating oily or spicy foods. Consult your doctor if the symptom get worse.
Warning & Precautions
Pregnancy
VALVO CR 300MG TABLET is not recommended for use by pregnant women. Women with childbearing potential should use effective contraception methods while taking VALVO CR 300MG TABLET. Consult your doctor before taking the medicine.
Breastfeeding
VALVO CR 300MG TABLET is not recommended for use by breastfeeding mothers, as it may pass through breastfed milk. Consult your doctor before taking VALVO CR 300MG TABLET.
Driving and Using Machines
Avoid driving or operating machines, if you feel drowsy or sleepy after taking VALVO CR 300MG TABLET.
Alcohol
Avoid consuming alcohol while taking VALVO CR 300MG TABLET.
Kidney
VALVO CR 300MG TABLET should be used with caution in patients with kidney diseases. Consult your doctor for advice before taking VALVO CR 300MG TABLET.
Liver
VALVO CR 300MG TABLET is not recommended for use in patients with liver problems or any family history of liver problems such as severe hepatic dysfunction, particularly due to some medicine. Consult your doctor for advice before taking VALVO CR 300MG TABLET.
Allergy
VALVO CR 300MG TABLET is not recommended for use if you are allergic to Valproic acid, Sodium valproate or any other ingredients in this medicine.
Lungs
VALVO CR 300MG TABLET should be used with caution in patients with lung diseases such as chronic obstructive pulmonary disease. Consult your doctor for advice before taking VALVO CR 300MG TABLET.
Others
VALVO CR 300MG TABLET is not recommended for use if you:
- have porphyria (a hereditary disease that affects the skin or nervous system)
- have blood coagulation or clotting disorders such as deep vein thrombosis, pulmonary embolism
- have pancreatic diseases
- have signs of urea cycle disorder (excessive ammonia build-up in the body) such as loss of appetite, vomiting and lethargy that causes excessive ammonia builds up in the body
- have a genetic disorder called Alpers-Huttenlocher syndrome (a progressive, neurodevelopmental syndrome characterized by three co-occurring clinical symptoms which are psychomotor regression (dementia); seizures; and liver disease)
Before taking VALVO CR 300MG TABLET, inform your doctor if you:
- have diabetes
- are scheduled for surgery such as dental surgery
- have systemic lupus erythematosus (a disease of the immune system that affects bones, joints and body organs)
- have a certain brain disease or any metabolic condition affecting your brain such as hypoglycaemic encephalopathy
- have a deficiency condition such as carnitine palmitoyl transferase type II deficiency (a condition that manages the body from using certain fats for energy, particularly during periods without food)
Use in Paediatrics:
VALVO CR 300MG TABLET should be used with caution in children (below 2 years of age). Consult your doctor before taking VALVO CR 300MG TABLET.
Use in Geriatrics:
VALVO CR 300MG TABLET should be used with caution in elderly patients (aged above 68 years). Consult your doctor before taking VALVO CR 300MG TABLET.
Interactions
A. Drug-Drug Interactions:
Before taking VALVO CR 300MG TABLET, inform your doctor, if you are taking any of the following medicine:
- medicines used to manage depression or Parkinson’s disease, such as monoamine oxidase inhibitors (MAOI) Ex. selegiline, phenelzin
- medicines used to manage emotional and mental conditions Ex. diazepam, olanzapine
- medicine used to manage HIV infection Ex. zidovudine
- medicines used for thinning the blood Ex. warfarin
- other medicines used to manage epilepsy Ex. phenytoin, phenobarbital, carbamazepine, primidone, rufinamide, topiramate, acetazolamide, lamotrigine and felbamate
- medicines used to manage pain and inflammation such as salicylates Ex. aspirin
- medicines used to manage malaria Ex. mefloquine, chloroquine
- medicines used to manage stomach ulcers Ex. cimetidine
- antibiotics or medicines used to manage bacterial infections such as carbapenem agents Ex. imipenem, meropenem, ertapenem, erythromycin
- medicines used to lower blood cholesterol Ex. cholestyramine
- medicines used to manage tuberculosis Ex. rifampicin
- medicines used to manage cancer Ex. temozolomide
- medicines used to manage bleeding in the brain Ex. nimodipine
- medicines used to anaesthetise Ex. Propofol
- medicines used for birth control Ex. oestrogen-containing products
- medicines used to manage pain and fever Ex. metamizole
Overdosage
If you or anyone else accidentally takes too much of VALVO CR 300MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose may include nausea, vomiting, headache, blurred vision, dizziness, poor reflexes, confusion, memory loss, tiredness, muscle weakness, fits, loss of consciousness, behavioural changes and breathing difficulties such as fast breathing or shortness of breath or chest pain.
Synopsis
| Drug | : | Sodium valproate, Valproic acid |
| Pharmacological Category | : | Anticonvulsants/Antiepileptics |
| Therapeutic Indication | : | Epilepsy, Bipolar disorder |
| Dosage Forms | : | Tablet |
More Information
- Keep VALVO CR 300MG TABLET out of reach from children
- Store VALVO CR 300MG TABLET at room temperature
FAQs About VALVO CR 300MG TABLET
What VALVO CR 300MG TABLET is used for?
VALVO CR 300MG TABLET is used to manage epilepsy in adults and children. It is also used to manage bipolar disorders in affected individuals. Epilepsy is a disorder of the brain and nervous system characterized by repeated seizures (at least two unprovoked seizures within 24 hours). Consult your doctor before taking.
What happens if you take more VALVO CR 300MG TABLET than your required dose?
If you or anyone else accidentally takes too much of VALVO CR 300MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose may include nausea, vomiting, headache, blurred vision, dizziness, poor reflexes, confusion, memory loss, tiredness, muscles weakness, fits, loss of consciousness, behavioural changes and breathing difficulties such as fast breathing or shortness of breath or chest pain.
What side effects are seen with VALVO CR 300MG TABLET?
The common side effects of taking VALVO CR 300MG TABLET are dizziness, headache, sleep disorders, clumsiness/unsteadiness, trembling of hands and arms and nervousness. Consult your doctor before taking it.
Who should avoid taking VALVO CR 300MG TABLET?
VALVO CR 300MG TABLET is not recommended for use in patients with liver problems or with history of liver problems in the family, particularly due to some medicine. It is not recommended for use in patients with porphyria (a hereditary disease that affects the skin or nervous system), blood clotting disorders or pancreatic diseases (inflammation of the pancreas). VALVO CR 300MG TABLET is also not recommended for use by pregnant and breastfeeding women. Consult your doctor before taking it.
Is VALVO CR 300MG TABLET safe to use in children?
VALVO CR 300MG TABLET should be used with caution in children (below 2 years of age) and in young girls (below 18 years of age) to ensure safety as well as efficacy. Consult your doctor before taking VALVO CR 300MG TABLET.
What if I forget to take VALVO CR 300MG TABLET?
If you or your child have forgotten to take VALVO CR 300MG TABLET at right time, take it as soon as remember. However, if it is almost time for the next dose, skip the missed dose and continue the regular dosing schedule. Do not double the dose to make up for the forgotten one.
When to stop taking VALVO CR 300MG TABLET?
Do not stop taking VALVO CR 300MG TABLET, unless as advised by your doctor or if you experience any signs of an allergy (swelling of the face, lips, eyelids, throat, tongue which may cause difficulty in breathing and swallowing), abnormal levels of ammonia in the blood (vomiting, balance issues or lack of alertness), liver problems (nausea, vomiting, tiredness, sleepiness, weakness, stomach pain, yellowing of the skin or whites of the eye), inflammation of the pancreas (acute abdominal pain) or chest pain, etc.
Can I drive or use machines after taking VALVO CR 300MG TABLET?
VALVO CR 300MG TABLET should be used with caution while driving or operating machines, as it might cause drowsiness and sleepiness. Consult your doctor before taking the medicine.
How VALVO CR 300MG TABLET works?
VALVO CR 300MG TABLET helps in managing epilepsy where sodium valproate and valproic acid effectively increase the GABA (a neurotransmitter/chemical messenger)) concentration in central nervous system by reducing its degradation. It also blocks certain ion channels which reduce high-frequency neuronal activity in the brain, thereby reliving seizures.
References
1. KD Tripathi. Antiepileptic drugs. Essentials of medical pharmacology. Seventh edition, 2013. Page – 417.
2. Masum Rahman, Hoang Nguyen. Valproic Acid. NIH National Library of Medicine. National Centre for Biotechnology Information. StatPearls [Internet]. [Revised in October 2021] [Assessed 7th July 2022] https://www.ncbi.nlm.nih.gov/books/NBK559112/
3. E Perucca, R Grimaldi, G Gatti, S Pirracchio, F Crema, G M Frigo. NIH National Library of Medicine. National Centre for Biotechnology Information. PMC PubMed Central. June 1984. [Assessed 7th July 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1463439/
4. Sanofi-Aventis. Electronic Medicine Compendium (EMC). [Revised in January 2022] [Assessed 7th July 2022] https://www.medicines.org.uk/emc/files/pil.1444.pdf
5. Intas Lifesciences Private Limited. VALPROL CR-300 CR Tablets. [Revised in August 2015] [Assessed 7th July 2022] https://www.intaspharma.com/wp-content/uploads/2018/12/Valprol-CR.pdf
6. Brimpharm SA (Pty) Ltd. NAVALPRO CR. [Revised in February 2015] [Assessed 7th July 2022] https://www.sahpra.org.za/wp-content/uploads/2020/02/Navalpro_PIL_Brimpharm_MCC-format-01-February-2015.pdf
Useful Diagnostic Tests
- Blood test
- Urine analysis
- Liver function test
- EEG (electroencephalogram)
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