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Introduction About UVEFROST EYE DROPS
UVEFROST EYE DROPS contains Difluprednate which belongs to the group of medicines called Corticosteroids. It is used in the management of pain and inflammation due to eye surgery.
UVEFROST EYE DROPS is also used to manage endogenous anterior uveitis (an inflammation of the middle layer of the eye which includes the iris (coloured part of the eye) and adjacent tissue, known as the ciliary body). Symptoms of anterior uveitis include red, sore and inflamed eye, blurred vision, light sensitivity, small, or irregular-shaped pupil.
You should remove the contact lenses before instilling UVEFROST EYE DROPS and can put them back after 10 minutes of use. Your doctor may need to adjust the doses of your medicines or monitor you carefully for side effects.
UVEFROST EYE DROPS is not recommended for use in patients who have bacterial, viral or fungal infection of the eye, or any other eye infections. UVEFROST EYE DROPS should be used with caution in patients who have glaucoma, diabetes, diseases causing thinning of cornea, or if you recently had a cataract surgery.
UVEFROST EYE DROPS should be used with caution in pregnant and breast-feeding women. The safety and efficacy of UVEFROST EYE DROPS have not been studied in children with endogenous anterior uveitis so, consult your child’s doctor for advice.
The most common side effects of using UVEFROST EYE DROPS are eye irritation and pain, headache, increased eye pressure, and blurred vision. Consult your doctor if any of the symptoms become bothersome.
Uses Of UVEFROST EYE DROPS
Manage:
- pain and inflammation due to eye surgery
- endogenous anterior uveitis
How UVEFROST EYE DROPS Works
UVEFROST EYE DROPS helps in relieving pain and inflammation by inhibiting the release of prostaglandins and leukotrienes (substances that causes pain and inflammation).
How to use UVEFROST EYE DROPS
Use UVEFROST EYE DROPS as advised by your doctor. It is for ophthalmic use only. Tilt your head backwards, hold the bottle upside down above the eye and dispense drops with gentle pressure. Do not let the dropper tip touch your eye surface.
After using UVEFROST EYE DROPS, press a finger into the corner of your eye, by the nose. This helps to stop the medicine from getting into other parts of the body. Wipe any extra liquid from your face with a tissue. If you are using any other eye medicines, leave at least 5 minutes between each medicine. Wash your hands to clean any medicine.
Your doctor will decide the right dose and duration of therapy for you according to your age, body weight and disease condition. Do not stop using UVEFROST EYE DROPS unless your doctor advises you to stop.
Side Effects Of UVEFROST EYE DROPS
Common
- eye irritation and pain
- headache
- increased eye pressure
- blurred vision
Rare
Stop using UVEFROST EYE DROPS and inform your doctor if you experience any of the following side effects:
- allergic reactions (hives, swelling of the face, lips, tongue, or throat, difficulty breathing)
- vision changes (sudden vision loss, blurred or tunnel vision, irritation or redness, eye pain or itching, severe headache, sensitivity to light, foreign body sensation in eye)
- symptoms of eye infection (eye swelling, weeping, drainage, crusting)
- swollen trunk and the face area with weight gain
- worsening of infection (eye redness, itching, tearing or discharge, feeling that something is in your eye, seeing floating spots, light sensitivity, red, swollen or crusty eyelids)
Warning & Precautions
Pregnancy
Consult your doctorUVEFROST EYE DROPS should be used during pregnancy only if the potential benefit justifies the potential risk to the baby. Consult your doctor before using it.
Breastfeeding
Use with CautionUVEFROST EYE DROPS should be used with caution in breastfeeding women as it is not known if it passes through the breast milk. Consult your doctor before using it.
Driving and Using Machines
ContraindicatedDo not drive or operate any machines if you experience blurred vision or any visual disturbance after using UVEFROST EYE DROPS.
Kidney
Consult your doctorThere is no proper information about the use of UVEFROST EYE DROPS in kidney patients. Consult your doctor before using it.
Liver
Consult your doctorThere is no proper information about the use of UVEFROST EYE DROPS in liver patients. Consult your doctor before using it.
Allergy
ContraindicatedDo not use UVEFROST EYE DROPS if you are allergic to Difluprednate or any of its other ingredients, or any other steroid medicines.
Use In Pediatrics
Consult your doctorUVEFROST EYE DROPS was found to be safe in children (28 days to 3 years of age) with inflammation following cataract surgery. The safety and efficacy of UVEFROST EYE DROPS have not been studied in children with endogenous anterior uveitis. Consult your child’s doctor for advice.
Use In Geriatrics
Consult your doctorThere is no proper information about the use of UVEFROST EYE DROPS in elderly patients. Consult your doctor before using it.
Others
UVEFROST EYE DROPS is not recommended for use if you:
- have eye diseases caused by viruses (Ex. herpes simplex, vaccinia, varicella) or by bacteria or fungus
- think you have any other infection of the eye
Before using UVEFROST EYE DROPS, inform your doctor if you:
- have glaucoma (excessive pressure in the eye)
- have or had herpes simplex virus (a virus that causes sores on the face, lips, genitals, and rectum and can also cause eye infections)
- currently have any kind of eye infection
- have diabetes (high blood sugar)
- recently had a cataract surgery
- have diseases causing thinning of cornea
Interactions
A. Drug – Drug Interactions:
Inform your physician if you are taking any of the following medicines before using UVEFROST EYE DROPS:
- NSAIDs such as ketorolac (used to manage pain and inflammation)
- medicines used in HIV infection (Ex ritonavir, cobicistat)
Overdosage:
If you or anyone else put too many drops of UVEFROST EYE DROPS, consult your doctor immediately or visit the nearby hospital. It can be washed out of the eye with warm water. However, consult your doctor or nurse if you experience anything unusual.
Synopsis
| Drug | : | Difluprednate |
| Pharmacological Category | : | Glucocorticoids |
| Therapeutic Indication | : | Pain and inflammation post eye surgery, Endogenous anterior uveitis |
| Dosage Forms | : | Eye Drops, Ophthalmic Emulsion |
More Information
- Keep UVEFROST EYE DROPS out of reach of children
- Store at a temperature between 15°C - 25°C
FAQs About UVEFROST EYE DROPS
Q. What is UVEFROST EYE DROPS and why is it used?
A. UVEFROST EYE DROPS contains Difluprednate which belongs to the group of medicines called Corticosteroids. It is used in the management of pain and inflammation associated with ocular surgery. UVEFROST EYE DROPS is also used to manage endogenous anterior uveitis (an inflammation of the middle layer of the eye which includes the iris (coloured part of the eye) and adjacent tissue, known as the ciliary body).
Q. Can UVEFROST EYE DROPS cause increased eye pressure?
A. Prolonged use of UVEFROST EYE DROPS can cause increased eye pressure and changes in vision. It should be used with caution in patients who already have glaucoma (increased eye pressure). Consult your doctor before using it.
Q. Is UVEFROST EYE DROPS safe to use in pregnant women?
A. UVEFROST EYE DROPS should be used during pregnancy only if the potential benefit justifies the potential risk to the baby. If you are pregnant, think you may be pregnant or are planning for pregnancy, consult your doctor before using it.
Q. Can UVEFROST EYE DROPS be used if I wear contact lens?
A. If you wear contact lenses, you should remove them before using UVEFROST EYE DROPS and can put them back after 10 minutes of use. Consult your doctor for further queries.
Q. Does UVEFROST EYE DROPS has to be kept in refrigerator?
A. Do not refrigerate UVEFROST EYE DROPS. It should be stored at a temperature between 15°C - 30°C, protected from light. Refer the package leaflet if you have further queries regarding UVEFROST EYE DROPS storage.
Q. Can UVEFROST EYE DROPS cause infection of the eye?
A. Prolonged use of UVEFROST EYE DROPS, may suppress the immune system response and thus increase the chances of secondary eye infections. In acute conditions, UVEFROST EYE DROPS may worsen an existing infection. Consult with your doctor before using this medicine if you have an existing eye infection.
References
1. Brunton L.L., Hilal-Dandan R, Knollmann B.C. Ocular Pahrmacology. Goodman & Gilman's: The Pharmacological Basis of Therapeutics. Thirteenth Edition. 2017. Page - 1262.
2. Kelly Meehan, Lori Vollmer, Joseph Sowka. Intraocular pressure elevation from topical difluprednate use. NIH. National Library of Medicine, National center for biotechnology information. Pubmed.gov. December 2010. [Accessed on 1st August 2022]. https://pubmed.ncbi.nlm.nih.gov/21111374/
3. Mark A Slabaugh, Erin Herlihy, Sharel Ongchin, Russell N van Gelder. Efficacy and potential complications of difluprednate use for pediatric uveitis. NIH. National Library of Medicine, National center for biotechnology information. Pubmed.gov. May 2012. [Accessed on 1st August 2022]. https://pubmed.ncbi.nlm.nih.gov/22265149/
4. PubChem Compound Summary for CID 443936, Difluprednate. National Center for Biotechnology Information. [Accessed on 1st August 2022]. https://pubchem.ncbi.nlm.nih.gov/compound/Difluprednate
5. Novartis Pharmaceuticals Corporation. Durezol (Difluprednate ophthalmic emulsion). [Revised in November 2020]. [Accessed on 1st August 2022]. https://www.novartis.com/us-en/sites/novartis_us/files/durezol.pdf
6. Novartis Pharmaceuticals Canada Inc. Durezol (Difluprednate ophthalmic emulsion). [Revised in July 2018]. [Accessed on 1st August 2022]. https://www.ask.novartispharma.ca/download.htm?res=durezol_scrip_e.pdf&resTitleId=1319
Useful Diagnostic Tests
- Optical coherence tomography (OCT) imaging
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