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Introduction About URONEX D CAPSULE
Uronex D Capsule is used to manage signs and symptoms of Benign Prostatic Hyperplasia (BPH) in men. It contains a combination of Dutasteride and Tamsulosin which belongs to the group of medicines called 5-Alpha reductase inhibitors and Alpha-blockers respectively which works by reducing the production of a stress hormone called dihydrotestosterone and tamsulosin works by relaxing the muscles surrounding the prostate gland.
During this therapy, your doctor will regularly monitor your serum prostate-specific antigen (PSA) levels to detect the incidence of prostate cancer. Before taking Uronex D Capsule inform your doctor if you have any liver or kidney problems. Both pregnant women and children should avoid handling the leaking medicine, because this medicine has a high potential to get absorbed through your skin and can affect the normal development of a male baby (especially during the first 16 weeks of pregnancy).
Usage of condom during sexual intercourse is recommended among fertile men to avoid conception. Uronex D Capsule is not recommended for use in children and adolescents under 18 years of age. Uronex D Capsule should be used with caution in elderly patients above 65 years of age. The most common side effects of taking Uronex D Capsule are dizziness, enlargement of breast in men and decreased sex drive. Consult your doctor if any of the side effects bothers you.
Uses Of URONEX D CAPSULE
- Used to manage signs and symptoms of benign prostatic hyperplasia (BPH) in men
How URONEX D CAPSULE Works
Uronex D Capsule reduces the symptoms of benign prostatic hyperplasia, where Dutasteride works by reducing the production of a stress hormone called dihydrotestosterone and Tamsulosin works by relaxing the muscles surrounding the prostate gland, thus helps in shrinkage of prostate, making it easier for the urine to pass through and relieve the symptoms.
How to use URONEX D CAPSULE
Always take Uronex D Capsule as directed by your physician. Take this medicine with or without food, swallow the medicine as a whole and do not crush or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. Do not stop taking Uronex D Capsule without informing your doctor.
Side Effects Of URONEX D CAPSULE
Common
- sexual impotence (unable to achieve or maintain an erection)
- decreased sex drive
- difficulty in ejaculation
- gynecomastia (breast enlargement or tenderness)
- dizziness
Uncommon
- heart failure (shortness of breath, extreme tiredness and swelling in your ankles and legs)
- low blood pressure on standing
- weakness or loss of strength
- headache
- constipation
- diarrhea
- nausea
- vomiting
- fast heartbeat
- itchy, blocked or runny nose
- skin rash, hives, itching
- hair loss or hair growth
Rare
- swelling of the face, eyelids, lips, arms or legs
- fainting
Stop taking Uronex D Capsule and contact your doctor immediately if you experience any of the following side effects:
- signs of allergic reaction (such as skin rash, itching, hives, and swelling of face, eyelids, lips, arms, or legs)
- Stevens-johnson syndrome (a severe widespread rash with blisters and peeling skin, particularly around the mouth, nose, eyes and genitals)
How To Manage Side Effects
Constipation
Take fiber rich foods in your diet such as fresh fruits, vegetables, whole grain cereals and drink plenty of fluids. Exercise more regularly and stay active. Consult your doctor if the symptom does not improve.
Dizziness Or Drowsiness
Try to rest and relax. Get enough sleep. Avoid driving or operating any machines while you are feeling dizzy. Avoid consumption of alcohol as it can aggravate your dizziness. If the symptom persists for a longer time, contact your doctor for advice.
Headache
Apply hot or cold-water bag on your head. Try taking rest in a quiet and dark room. Drink tea or coffee. Consult your doctor if the symptom does not improve.
Nausea And Vomiting
Take this medicine with or just after a meal or snack and stick to simple meals and do not eat oil rich or spicy foods. Consult your doctor if the symptom does not improve.
Warning & Precautions
Pregnancy
ContraindicatedUronex D Capsule is intended for use only in men. Pregnant women should not come in contact with Uronex D Capsule as it may cause potential abnormalities in male foetus.
Breastfeeding
ContraindicatedUronex D Capsule is intended for use only in men and therefore should not be used in breastfeeding women.
Driving and Using Machines
Use with CautionDo not drive or operate any machines if you experience dizziness while taking Uronex D Capsule.
Alcohol
Consult your doctorAvoid consumption of alcohol while taking this medicine because it may cause excessive drowsiness. Consult your doctor before taking Uronex D Capsule.
Kidney
Use with CautionUronex D Capsule should be used with caution if you have severe kidney disease. Consult your doctor for advice before taking Uronex D Capsule.
Liver
Consult your doctorUronex D Capsule is not recommended for use in patients having severe liver disease and it should be used with caution in patients with liver problems. Consult your doctor for advice before taking Uronex D Capsule.
Allergy
ContraindicatedDo not take Uronex D Capsule if you are allergic to Tamsulosin or Dutasteride and other 5-alpha reductase inhibitors such as finasteride.
Heart Disease
ContraindicatedUronex D Capsule is not recommended for use in patients with low blood pressure (which causes dizziness, lightheadedness, or fainting (orthostatic hypotension). Consult your doctor for advice before taking Uronex D Capsule.
Use In Pediatrics
ContraindicatedUronex D Capsule is not recommended for use in children or adolescents less than 18 years of age. Consult your child’s doctor for advice.
Use In Geriatrics
Use with CautionUronex D Capsule should be used with caution in elderly patients above 65 years of age. Consult with your doctor for advice before taking Uronex D Capsule.
Others
Uronex D Capsule is not recommended for use, if you:
- are a woman (because this medicine is for men only)
Before taking Uronex D Capsule, inform your doctor if you have:
- an upcoming cataract surgery
- blood test for PSA (Prostate Specific Antigen)
Interactions
A. Drug-Drug interactions:
- Alpha blockers (Ex. prazosin, doxazosin, terazosin)
- Phosphodiesterase inhibitors (Ex. vardenafil, sildenafil and tadalafil)
- Antifungal drugs (Ex.itraconazole, ketoconazole or terbinafine)
- Calcium-channel blockers (Ex.Diltiazem or verapamil)
- Protease inhibitors (Ex. Ritonavir or indinavir)
- Antidepressants agents (Ex. Paroxetine or nefazodone)
- Antacids (Ex. Cimetidine)
- Anticoagulant agents (Ex. Warfarin)
- Antibiotics (Ex. Erythromycin)
- Non-steroidal anti-inflammatory agents (Ex. Diclofenac)
Overdosage:
If you or anyone else accidentally takes too much of Uronex D Capsule, consult your doctor immediately. Overdosage may cause acute hypotension, nausea, and vomiting.
Synopsis
| Drug | : | Dutasteride, Tamsulosin |
| Pharmacological Category | : | 5-Alpha reductase inhibitors, Alpha-blockers |
| Therapeutic Indication | : | Benign Prostatic Hyperplasia |
| Dosage Forms | : | Tablet, Capsule |
More Information
Storage
- Keep Uronex D Capsule out of reach of children
- Store at room temperature
FAQs About URONEX D CAPSULE
Q: What is the use of Uronex D Capsule?
A: Uronex D Capsule is used to manage signs and symptoms of benign prostatic hyperplasia (BPH) in men.
Q: Does Uronex D Capsule cause prostate cancer?
A: Uronex D Capsule may increase the risk of prostate cancer and so your doctor would regularly monitor your serum prostate specific antigen (PSA) which is used to detect prostate cancer, in order to avoid any untoward side effects.
Q: Can Uronex D Capsule cause infertility?
A: Yes, Uronex D Capsule may reduce sperm count, semen volume and movement also it can cause sexual impotence, decreased sex drive or difficulty in ejaculation in men. Consult your doctor if you experience any of these side effects.
Q: Can Uronex D Capsule be used for erectile dysfunction?
A: Yes, Uronex D Capsule is intended to manage signs and symptoms of benign prostatic hyperplasia (BPH) and its associated symptoms such as urinary problems and erectile dysfunction or painful ejaculation.
Q: Can Uronex D Capsule cause dizziness?
A: Yes, Uronex D Capsule can cause dizziness in some people. Try to rest and relax. Get enough sleep. Avoid driving or operating any machines while you are feeling dizzy. Avoid consumption of alcohol as it can aggravate your dizziness. If the symptom persists for a longer time, consult your doctor for advice.
Q: Is Uronex D Capsule safe to use in patients with liver disease?
A: Uronex D Capsule is not recommended for use in patients having severe liver disease and it should be used with caution in patients with liver problems. Your doctor will adjust the dose based on the severity of the impairment and will monitor your liver function test periodically during management with Uronex D Capsule. Before taking this medicine, inform your doctor if you have any liver disease.
Q: Can Uronex Capsule be used in children?
A: Uronex Capsule is not recommended for use in children or adolescents less than 18 years of age. Consult child’s doctor for advice before taking Uronex Capsule. Doctor may consider the effective management in managing the condition.
Q: Where can I purchase Uronex Capsule conveniently?
A: You can buy this medicine online through platforms like Netmeds, an online pharmacy, which offers a hassle-free way to get your medications delivered to your doorstep.
References
1. KD. Tripathi. Androgens and Drugs for Erectile Dysfunction. Essentials of medical pharmacology. Seventh edition. 2013. Page – 303.
2. KD. Tripathi. Antiadrenergic Drugs (Adrenergic Receptor Antagonists) and Drugs for Glaucoma. Essentials of medical pharmacology. Seventh edition. 2013. Page – 142.
3. Peter J. Snyder. Androgens. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 1205.
4. GlaxoSmithKline. Benign Prostatic Hyperplasia Trial With Dutasteride And Tamsulosin Combination Treatment. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in February 2017] [Accessed on 24th April 2024] https://www.clinicaltrials.gov/ct2/show/NCT00090103
5. Konstantinos Dimitropoulos and Stavros Gravas. Fixed-dose combination therapy with dutasteride and tamsulosin in the management of benign prostatic hyperplasia. NCBI; PMC US National Library of Medicine, National Institute of Health. February. [Accessed on 24th April 2024] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707422/
6. J Miller and TH Tarter. Combination therapy with dutasteride and tamsulosin for the treatment of symptomatic enlarged prostate. NCBI; PMC US National Library of Medicine, National Institute of Health. June 2009. [Accessed on 24th April 2024] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697590/
7. Sibylle Marihart, Mike Harik and Bob Djavan. Dutasteride: A Review of Current Data on a Novel Dual Inhibitor of 5α Reductase. NCBI; PMC US National Library of Medicine, National Institute of Health. 2005. [Accessed on 24th April 2024] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1550785/
8. Glenmark Pharmaceuticals Europe Limited. Laboratorios Leon Farma, SA. Electronic Medicines Compendium (EMC). [Revised in January 2020] [Accessed on 24th April 2024] https://www.medicines.org.uk/emc/files/pil.11336.pdf
9. Dr. Reddy’s Laboratories (UK) Ltd, Laboratorios Leon Farma, SA. Electronic Medicines Compendium (EMC). [Revised in January 2020] [Accessed on 24th April 2024] https://www.medicines.org.uk/emc/files/pil.11304.pdf
10. Cipla Ltd. Urimax D Tablets. Ciplamed. [Revised in December 2013] [Accessed on 24th April 2024] https://www.ciplamed.com/content/urimax-d-tablets
Useful Diagnostic Tests
- Prostate-specific antigen (PSA) test
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