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Introduction About ULTRANISE TABLET
ULTRANISE TABLET is a combination of Paracetamol and Tramadol which belongs to the group of medicines called Analgesics and Opioid analgesics respectively. ULTRANISE TABLET is used in the management of moderate to severe pain.
Pain is a complex and unpleasant sensation consisting of a physiological and a psychological response to a noxious stimulus. Pain is a warning mechanism that protects us by influencing it to withdraw from harmful stimuli, which is primarily associated with injury.
Before taking ULTRANISE TABLET, inform your doctor if you have respiratory disorders, gastrointestinal obstruction, including paralytic ileus, fits or seizures, have recently suffered from a head injury, depression, intolerance to some sugars, kidney or liver problems.
ULTRANISE TABLET is not recommended for use in pregnant women and during breast-feeding more than once as it may pass through breast milk.
ULTRANISE TABLET is not recommended for use in children (under 12 years of age) and should be used with caution in elderly patients (aged 65 years and above).
The common side effects of taking ULTRANISE TABLET are nausea, dizziness, drowsiness, vomiting, gastrointestinal problems (such as constipation, flatulence, diarrhoea), stomach pain and dry mouth. Consult your physician if any of the side effects worsen.
Uses Of ULTRANISE TABLET
- Manage moderate to severe pain
How ULTRANISE TABLET Works
ULTRANISE TABLET contains Tramadol and Paracetamol. Tramadol acts on pain receptors present in the central nervous system. It blocks the nerve signals responsible for pain. Paracetamol acts as an analgesic by inhibiting the release of certain chemical mediators that produce pain. Tramadol and paracetamol, in combination, have a faster action and provide quick relief from pain.
How to use ULTRANISE TABLET
Take ULTRANISE TABLET as advised by your physician.
For tablet:
Swallow the medicine with a glass of water. Do not crush or chew the medicine.
For effervescent tablet:
Take ULTRANISE TABLET by dissolving in a glass of drinking water.
Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of ULTRANISE TABLET
Common
- nausea
- dizziness, drowsiness
- vomiting
- digestion problems (constipation, flatulence, diarrhoea)
- stomach pain
- dry mouth
- itching, sweating
- headache, shaking
- confusion, sleep disorders, mood changes (anxiety, nervousness, feeling of high spirits)
Uncommon
- increase in pulse or blood pressure increase in pulse or blood pressure, heart rate or heart rhythm disorders
- difficulty or pain on passing water/protein in the urine
- skin reactions (such as rashes, hives)
- tingling or numbness sensation in hands or feet, ringing in the ears, involuntary muscle twitching
- depression, nightmares, memory lapses
- difficulty swallowing, blood in the stools
- shivering, hot flushes, pain in the chest
Rare
- uncoordinated movements
- addiction
- blurred vision
Stop taking ULTRANISE TABLET and contact your doctor immediately if you experience any of the following side effects:
- allergic rection (signs include skin rashes, sudden swelling of the face and neck, difficulties breathing or drop of blood pressure and fainting)
- hallucinations (hearing, seeing or sensing things that are not really there)
- breathing difficulty
- fits
- transient loss of consciousness (syncope)
How To Manage Side Effects
Nausea or vomiting:
Try to take ULTRANISE TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating oil rich, fried or spicy foods. Consult your doctor if the symptom does not improve.
Diarrhoea:
Drink lot of fluids such as water or fruit juices to keep yourself hydrated. Avoid taking any medicine on your own for managing diarrhea. Consult your doctor if the symptom does not improve.
Headache:
Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the forehead if required. Do not consume too much of alcohol. Consult your doctor if the symptom does not improve.
Dry mouth:
Sip water regularly and other sugar free liquids. Do not use mouthwashes that contain alcohol because they can make your mouth dry, use mouthwash that is used only for dry mouth. Limit your caffeine intake. Avoid smoking or using tobacco products. Consult your doctor if the symptom does not improve.
Warning & Precautions
Pregnancy
ULTRANISE TABLET is generally not recommended for use in pregnant women. Consult your doctor before taking it.
Breastfeeding
ULTRANISE TABLET is not recommended for use during breast-feeding more than once as it may pass through breast milk. Consult your doctor before taking it.
Driving and Using Machines
Do not drive or operate any machines if you feel drowsy after taking ULTRANISE TABLET.
Alcohol
Avoid consumption of alcohol while taking ULTRANISE TABLET because it might make you feel drowsy and it is not recommended for use in patients with acute alcohol poisoning.
Kidney
ULTRANISE TABLET should be used with caution in patients with kidney problems. Consult your doctor before taking ULTRANISE TABLET.
Liver
ULTRANISE TABLET is not recommended for use in patients with severe liver disorder and should be used with caution in patients with liver problems or jaundice. Consult your doctor before taking ULTRANISE TABLET.
Allergy
Do not take ULTRANISE TABLET if you are allergic to Paracetamol, Tramadol or any other ingredients of this medicine.
Lungs
ULTRANISE TABLET should be used with caution in patients who have severe difficulties in breathing like asthma or severe lung problems. Consult your doctor before taking ULTRANISE TABLET.
Others
ULTRANISE TABLET is not recommended for use if you:
- have epilepsy (which is not adequately controlled by your current medicine)
- known or suspected gastrointestinal obstruction including paralytic ileus
Before taking ULTRANISE TABLET, inform your doctor if you:
- have epilepsy or already experienced fits or seizures
- have recently suffered from a head injury, shock or severe headaches associated with vomiting
- have intolerance to certain sugars
- have depression
Use in pediatrics:
ULTRANISE TABLET is not recommended for use in children (under 12 years of age). Consult your child’s doctor for advice.
Use in geriatrics:
ULTRANISE TABLET should be used with caution in elderly patients (aged 65 years and above). Consult your doctor before taking it.
Interactions
A. Drug - Drug interactions:
Before taking ULTRANISE TABLET, inform your doctor if you are taking any of the following medicines:
- medicines used to manage nausea and vomiting (Ex. metoclopramide, domperidone or ondansetron)
- medicines used against infections (Ex. ketoconazole, flucloxacillin, erythromycin)
- medicine used to reduce cholesterol in the blood (Ex. cholestyramine)
- medicine used in the management of depression or Parkinson’s disease (Ex. monoamine oxidase inhibitors such as phenelzine, isocarboxazid)
- amitriptyline (used to manage depression)
- medicine used to help stop smoking (Ex. bupropion)
- baclofen (used as muscle relaxant)
- warfarin, phenprocoumon (used to manage or manage blood clots)
- medicine used to manage epilepsy (Ex. carbamazepine)
- morphine, buprenorphine, nalbuphine or pentazocine (used to manage severe pain)
Overdosage:
If you or anyone else accidentally take too much of ULTRANISE TABLET, consult your doctor immediately or visit the nearby hospital. Overdosage symptoms of ULTRANISE TABLET includes loss of appetite, nausea, vomiting, malaise, pallor, excess sweating, respiratory depression and seizures.
Synopsis
| Drug | : | Paracetamol, Tramadol |
| Pharmacological Category | : | Analgesics, Opioid analgesics |
| Therapeutic Indication | : | Moderate to severe pain |
| Dosage Forms | : | Tablet, Injection |
More Information
- Keep ULTRANISE TABLET out of reach of children
- Store at room temperature
FAQs About ULTRANISE TABLET
What is ULTRANISE TABLET used for?
ULTRANISE TABLET is used in the management of moderate to severe pain. Tramadol and paracetamol, in combination, have a faster action and provide quick relief from pain. Your doctor may recommend this combination only when it is needed.
What are the common side effects of ULTRANISE TABLET?
The common side effects of taking ULTRANISE TABLET are nausea, dizziness, drowsiness, vomiting, digestion problems (such as constipation, flatulence, diarrhoea), stomach pain, dry mouth, itching, headache, confusion, sleep disorders and mood changes. Consult your physician if any of the side effects worsen.
Is ULTRANISE TABLET safe to use in breastfeeding women?
ULTRANISE TABLET is not recommended for use during breast-feeding more than once as it may pass through breast milk. Consult your doctor for advice before taking this medicine.
Can ULTRANISE TABLET be used in patients with liver problems?
ULTRANISE TABLET is not recommended for use in patients with severe liver disorder and should be used with caution in patients with liver problems or jaundice. Consult your doctor before taking it.
Does ULTRANISE TABLET cause dry mouth?
ULTRANISE TABLET may cause dry mouth in some individuals. To manage this effect, sip water regularly and other sugar free liquids. Do not use mouthwashes that contain alcohol because they can make your mouth dry, use mouthwash that is used only for dry mouth. Limit your caffeine intake. Avoid smoking or using tobacco products. Consult your doctor if the symptom does not improve.
References
1. KD. Tripathi. Opioid Analgesics and Antagonists. Essentials of medical pharmacology. seventh edition. 2017. Page – 469.
2. Moron Merchante I, Pergolizzi JV Jr, van de Laar M, Mellinghoff HU, Nalamachu S, O'Brien J, Perrot S, Raffa RB. Tramadol/Paracetamol fixed-dose combination for chronic pain management in family practice: a clinical review. NIH, National Library of Medicine, National center for biotechnology information. April 2013 [Accessed on 18th November 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041254/
3. Joseph V Pergolizzi, Jr, Mart van de Laar, Richard Langford, Hans-Ulrich Mellinghoff, Ignacio Moron Merchante, Srinivas Nalamachu, Joanne O’Brien, Serge Perrot, and Robert B Raffa. Tramadol/paracetamol fixed-dose combination in the management of moderate to severe pain. NIH, National Library of Medicine, National center for biotechnology information. August 2012. [Accessed on 18th November 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442743/
4. Janssen Pharmaceutica (Pty) Ltd. Tramacet Tablets (Paracetamol Plus Tramadol). [Revised in February 2016] [Accessed on 18th November 2022] https://www.sahpra.org.za/wpcontent/uploads/2020/06/TRAMACET_PI_Janssen-Pharmaceutica_MCC-Format15-February-2016.pdf
5. Ronak Exim Private Limited. Food and Drugs Authority (Ghana FDA) Paracetamol Plus Tramadol. [Revised in December 2019] [Accessed on 18th November 2022] https://fdaghana.gov.gh/img/pils/Tdrona%20Plus%20Tablets%20(Paracetamol%20and%20Tramadol%20Hydrochloride).pdf
6. Accord Healthcare Limited. Health Products Regulatory Authority (HPRA). [Revised in April 2022] [Accessed on 18th November 2022] https://www.hpra.ie/img/uploaded/swedocuments/69c7503f-69b6-4157-bb80-4c4fdbeff3ba.pdf
7. Janssen Ortho LLC. U.S. Food & Drug Administration. [Revised in August 2017] [Accessed on 18th November 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021123s014lbl.pdf
8. Grunenthal Pharma Ltd. Electronic Medicines Compendium (EMC). [Revised in January 2022] [Accessed on 18th November 2022] https://www.medicines.org.uk/emc/files/pil.455.pdf
Useful Diagnostic Tests
- Liver function test
- Kidney function test
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