UDAPA M XR 500 Tablet 10's
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Introduction About UDAPA M XR 500 TABLET
What is Udapa M XR 500 Tablet?
Udapa M XR 500 Tablet is a combination medication containing Dapagliflozin and Metformin XR, used to manage type 2 diabetes by lowering high blood sugar levels.
Dapagliflozin helps remove excess glucose through urine, while Metformin XR decreases glucose production in the liver and improves insulin sensitivity, leading to better blood sugar control.
Take Udapa M XR 500 Tablet once daily, preferably with evening meal. Swallow the tablet whole without crushing or chewing. Consult your doctor before use if you have kidney or liver issues.
Inform your healthcare provider about all medications you take to avoid interactions, particularly with diuretics, insulin, or other antidiabetics.
The common side effects include urinary tract infections, increased urination, and gastrointestinal discomfort. Rarely, there may be a risk of lactic acidosis; seek medical attention if symptoms like muscle pain, difficulty breathing, or fatigue occur.
Uses Of UDAPA M XR 500 TABLET
- Used in the management of type-2 diabetes mellitus
Benefits of UDAPA M XR 500 TABLET
- Helps manage type 2 diabetes mellitus when diet and exercise alone are insufficient
- Extended-release formulation allows once-daily dosing for steady blood sugar control
- Reduces risks of diabetes complications such as kidney damage, eye issues, nerve damage, and cardiovascular problems
- May aid in weight management and cardiovascular risk reduction
How UDAPA M XR 500 TABLET Works
Dapagliflozin helps remove excess glucose through urine, while Metformin XR decreases glucose production in the liver and improves insulin sensitivity, leading to better blood sugar control.
How to use UDAPA M XR 500 TABLET
Take Udapa M XR 500 Tablet once daily, preferably with evening meal. Swallow the tablet whole without crushing or chewing.
Recommended dosage and timing
Take Udapa M XR 500 Tablet once daily, usually in the morning or as prescribed by your doctor. The dosage depends on your medical condition and response to treatment. Consistency at the same time each day is important for effective blood sugar control.
Taking Udapa M XR 500 Tablet with or without food
It is recommended to take Udapa M XR 500 Tablet with meals, preferably with the evening meal, to improve absorption and reduce gastrointestinal side effects.
What if I forgot to take UDAPA M XR 500 TABLET
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.
Overdose
If you or anyone else accidentally took too much of this medicine, consult your doctor immediately. Symptoms of overdose are hypoglycaemia and lactic acidosis.
Side Effects Of UDAPA M XR 500 TABLET
Common side effects of UDAPA M XR 500 TABLET:
- urinary tract infections
- increased urination
- gastrointestinal discomfort.
When to consult a doctor?
- Rarely, there may be a risk of lactic acidosis; seek medical attention if symptoms like muscle pain, difficulty breathing, or fatigue occur
Warning & Precautions
Pregnancy
Monitoring requiredUDAPA M XR 500 TABLET should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Breastfeeding
Consult your doctorIt is not known whether UDAPA M XR 500 TABLET pass through the breast milk, contact your doctor before taking the medicine.
Driving and Using Machines
Use with CautionDo not drive or operate any machines if you experience symptoms of hypoglycaemia such as weakness, dizziness, increased sweating, fast heartbeat, change in vision, difficulty in concentration, weakness, sleepiness, light-headedness after taking UDAPA M XR 500 TABLET.
Alcohol
Consult your doctorAvoid consumption of alcohol while taking UDAPA M XR 500 TABLET as it increases the risk of lactic acidosis.
Kidney
Consult your doctorUDAPA M XR 500 TABLET is not recommended for use in patients with moderate to severe kidney disease. It should be used with caution in patients with acute kidney injury.
Liver
Use with CautionUDAPA M XR 500 TABLET should be used with caution in patients with liver disease.
Allergy
ContraindicatedDo not take UDAPA M XR 500 TABLET if you are allergic to Dapagliflozin, Metformin or to any other ingredients of this medicine.
Heart Disease
Consult your doctorUDAPA M XR 500 TABLET is not recommended for use in patients with recent heart attack or acute myocardial infarction, heart failure, cardiovascular shock. It should be used with caution in patients with hypotension.
Use In Pediatrics
Consult your doctorIt is not known whether UDAPA M XR 500 TABLET is safe and effective in children and adolescents below 18 years of age.
Use In Geriatrics
Use with CautionUDAPA M XR 500 TABLET should be used with caution in elderly patients (aged above 65 years).
Other Warnings for UDAPA M XR 500 TABLET
Before taking UDAPA M XR 500 TABLET, inform your doctor if you:
- have to undergo intravascular radiocontrast study with iodinated materials for X-ray procedure
- had any surgical procedure
- have acute febrile illness
- are taking reduced intake of food
- had prolonged fasting due to acute illness or post-surgery
- have pancreatic diseases
- have urinary tract infections
- have low blood sugar
- are debilitated, or malnourished
- have adrenal or pituitary insufficiency
- have vitamin B12 deficiency
- have genital mycotic infections
- have or had bladder cancer
- have serious illness
- are on low salt diet
- had stroke
Who should not take UDAPA M XR 500 TABLET
UDAPA M XR 500 TABLET is not recommended for use if you have:
- septicemia or severe infection
- diabetic ketoacidosis or type 1 diabetes
- dehydration from diarrhoea, vomiting and excessive heat exposure
- uncontrolled diabetes
- lactic acidosis
Diet and Lifestyle Advice
- Balanced diet: Focus on a diet rich in vegetables, fruits, whole grains, and lean proteins to help regulate blood sugar and support overall health. Limit refined sugars and processed foods.
- Hydration: Drink plenty of water throughout the day, especially important with dapagliflozin as it promotes glucose excretion through urine, increasing fluid loss.
- Regular exercise: Engage in moderate physical activity such as walking, cycling, or yoga most days of the week to improve insulin sensitivity and cardiovascular health.
- Weight management: Maintaining a healthy weight enhances medication effectiveness and reduces diabetes complications.
- Limit alcohol: Alcohol can affect blood sugar control and interact with medication side effects.
- Monitor blood sugar: Regular glucose monitoring helps track medication effectiveness and lifestyle impact.
- Avoid smoking: Smoking worsens diabetes outcomes and increases cardiovascular risk.
- Follow medication adherence: Take Udapa M XR 500 Tablet as prescribed, typically with the evening meal, for consistent blood sugar control.
Drug - Drug interaction
|
Drug/Class |
Interaction Description |
Potential Effect |
Precaution / Advice |
|
Insulin and other antidiabetics |
Increased risk of hypoglycemia when combined with Udapa M |
Low blood sugar symptoms |
Monitor blood glucose; adjust doses if needed |
|
Diuretics (e.g., furosemide) |
Increased risk of dehydration and electrolyte imbalance |
Dizziness, low blood pressure |
Monitor hydration and electrolytes closely |
|
ACE inhibitors and ARBs |
Enhanced blood pressure lowering, risk of kidney impairment |
Hypotension, kidney function changes |
Closely monitor blood pressure and kidney status |
|
Contrast agents (iodinated dyes) |
Risk of lactic acidosis if kidney function impaired |
Severe metabolic complications |
Stop medication before imaging as advised |
|
CYP3A4 inhibitors (ketoconazole) |
May increase dapagliflozin levels |
Increased risk of side effects |
Monitor closely; dose adjustment may be necessary |
|
Lithium |
May increase lithium levels leading to toxicity |
Lithium toxicity |
Monitor lithium blood levels |
Synopsis
| Drug | : | Dapagliflozin, Metformin |
| Pharmacological Category | : | Antidiabetics |
| Therapeutic Indication | : | Type II diabetes mellitus |
| Dosage Forms | : | Tablet |
More Information
Impact on weight and weight loss:
Udapa M XR 500 Tablet may lead to modest weight loss primarily due to dapagliflozin promoting glucose excretion through urine, which results in calorie loss. This effect can be beneficial for overweight patients with type 2 diabetes. However, weight loss magnitude varies among individuals. Metformin also supports weight management by improving insulin sensitivity but does not typically cause significant weight loss alone.
Long-term safety and lifelong use:
Udapa M XR 500 is generally considered safe for long-term use under medical supervision. Long-term therapy helps maintain blood sugar control and reduce diabetes complications. Regular monitoring of kidney and liver function is essential during treatment, as dose adjustments may be required. Patients should adhere to prescribed doses and consult their healthcare provider for ongoing assessment. Lifelong use is common in chronic diabetes management but should be personalized based on patient response and tolerance.
FAQs About UDAPA M XR 500 TABLET
Q: What UDAPA M XR 500 TABLET used for?
A: UDAPA M XR 500 TABLET is used to manage type-2 diabetes mellitus along with diet and exercise when diabetes cannot be controlled with other medicines. It is also used in combination with insulin or GLP-1 receptor agonist like liraglutide.
Q: Can I take this medication during pregnancy?
A: Consult your doctor before taking UDAPA M XR 500 TABLET.
Q: What if I miss a dose?
A: Take it as soon as remembered or skip if near next dose.
Q: Is dose adjustment necessary for kidney problems?
A: Always consult your healthcare provider.
Q: Who should not take UDAPA M XR 500 TABLET?
A: UDAPA M XR 500 TABLET is not recommended for use in patients with allergic history to dapagliflozin, metformin, liver disease, moderate to severe kidney disease, recent heart attack or acute myocardial infarction, heart failure, cardiovascular collapse (shock), septicaemia or severe infection, diabetic ketoacidosis dehydration, hypoxemia, diabetic coma, uncontrolled diabetes, and lactic acidosis.
Q: Can I take alcohol while taking UDAPA M XR 500 TABLET?
A: No. Avoid consumption of alcohol while taking UDAPA M XR 500 TABLET as it may increase the risk of lactic acidosis.
Q: How does UDAPA M XR 500 TABLET work?
A: UDAPA M XR 500 TABLET contains two antidiabetic medicines Metformin and Dapagliflozin which lowers the blood sugar levels in type 2 diabetes mellitus by eliminating excess sugars through urine and also by increasing the activity of insulin.
Q: Can I use UDAPA M XR 500 TABLET with other diabetic medications?
A: Your doctor may advise UDAPA M XR 500 TABLET with or without other medications to control your blood sugar levels. However, it is advised to maintain a proper diet and exercise to achieve the controlled blood sugar levels while using this medicine with or without other antidiabetic medications.
Q: Does UDAPA M XR 500 TABLET cause low blood sugar?
A: Yes. UDAPA M XR 500 TABLET may cause low blood sugar. Stop taking UDAPA M XR 500 TABLET and contact your doctor if you experience any unusual symptoms like weakness, shaking, sweating, drowsiness, dizziness, feeling very anxious, fast heartbeat, hunger, headache, change in vision, change in mood or confusion, and irritability. Consult your doctor for advice.
Q: Who can take UDAPA M XR 500 TABLET?
A: UDAPA M XR 500 TABLET is prescribed for adults with type 2 diabetes when diet, exercise, and either drug alone do not provide adequate blood sugar control. It is particularly beneficial for overweight patients or those at risk of heart and kidney disease. It is not recommended for type 1 diabetes, diabetic ketoacidosis, or individuals with severe kidney impairment. Always consult a doctor to determine suitability.
Q: Can UDAPA M XR 500 TABLET cause weight loss?
A: Yes, UDAPA M XR 500 TABLET may lead to weight loss, primarily due to dapagliflozin's ability to excrete excess glucose in urine. This feature makes the combination particularly helpful for overweight patients with type 2 diabetes. However, weight loss may vary between individuals.
Q: Can UDAPA M XR 500 TABLET be taken during pregnancy or breastfeeding?
A: This medicine is not recommended during pregnancy due to insufficient safety data and the potential risk of harm to the unborn baby. If you are pregnant or planning to conceive, consult your doctor for alternative options. Similarly, it is not advised during breastfeeding, as dapagliflozin may affect the infant's kidney development.
Q: Can UDAPA M XR 500 TABLET cause hypoglycemia (low blood sugar)?
A: UDAPA M XR 500 TABLET does not typically cause hypoglycemia when used alone. However, if taken with other diabetes medications like sulfonylureas (e.g., glimepiride) or insulin, the risk of hypoglycemia increases. Be cautious and monitor blood sugar regularly if combining with other drugs.
References
1. K.D. Tripathi. Insulin, oral hypoglycaemic drugs and glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page-278, 275.
2. Clifford J Bailey, Jorge L Gross, Delphine Hennicken, Nayyar Iqbal, Traci A Mansfield, James F List. Uses of metformin and dapagliflozin. Biomed Central (BMC). February 2013. [Accessed on 27th November 2025]
3. AstraZeneca UK Ltd. Electronic Medicines Compendium (EMC). [Revised in May 2021] [Accessed on 27th November 2025] 
4. AstraZeneca Pharmaceuticals. U.S. Food & Drug Administration. [Revised in July 2017] [Accessed on 27th November 2025]
5. AstraZeneca Pharmaceuticals LP. Dapagliflozin and Metformin. [Revised in April 2022] [Accessed on 27th November 2025]
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