TRUDOL PLUS Tablet 10's

Introduction About TRUDOL PLUS TABLET

TRUDOL PLUS TABLET is a combination of Diclofenac and Tramadol which belongs to the group of medicines called Non-steroidal anti-inflammatory drugs and Opiate analgesics respectively. TRUDOL PLUS TABLET is used in the management of pain and inflammation (redness and swelling). Pain is an unpleasant sensation that occurs with tissue damage. It helps the body to react and manage further tissue damage. It can be short-term (acute) or long-term (chronic) and the perception of pain can differ from one person to other.

Before taking TRUDOL PLUS TABLET, inform your doctor if you have stomach ulcers, gastric bleeding, severe heart failure, high blood pressure, and liver or kidney disease. TRUDOL PLUS TABLET is not recommended in pregnant women, children and adolescents below 12 years of age. Consult your doctor before taking. TRUDOL PLUS TABLET is excreted into breast milk so it not recommended in breastfeeding women, but if deemed necessary you should stop breast-feeding during the management with TRUDOL PLUS TABLET.

It should be used with caution in elderly patients (above 65 years of age). Avoid consumption of alcohol while taking TRUDOL PLUS TABLET because it might make you dizzier. The common side effects of TRUDOL PLUS TABLET nausea, loss of appetite, vomiting, dizziness, indigestion, sleepiness, constipation, heartburn, stomach pain and dryness in the mouth. If any of these side effects become worsen, contact your doctor for advice.

Uses Of TRUDOL PLUS TABLET

• Used to manage pain and inflammation (redness and swelling)

How TRUDOL PLUS TABLET Works

TRUDOL PLUS TABLET contains Diclofenac and Tramadol. Diclofenac works by blocking the release of certain chemical messengers, which are responsible for causing pain and inflammation. Tramadol acts on pain receptors present in the central nervous system which blocks the nerve signals responsible for pain. 

How to use TRUDOL PLUS TABLET

Take TRUDOL PLUS TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the right dose depends on your age, body weight and severity of the condition.

Side Effects Of TRUDOL PLUS TABLET

How To Manage Side Effects

Constipation

Eat more fibre-rich foods like green leafy vegetables and fruits. Drink lot of water. Consult your doctor if the symptom does not improve.

Nausea And Vomiting

Take this medicine with, or just after meals. Stick to simple meals. Avoid eating oily or spicy foods.

Warning & Precautions

Pregnancy

Contraindicated

TRUDOL PLUS TABLET is not recommended for use in pregnant women. Consult your doctor before taking it.

Breastfeeding

Contraindicated

TRUDOL PLUS TABLET is not recommended in breastfeeding women as it may pass through the breast milk. Consult your doctor before taking it.

Driving and Using Machines

Use with Caution

Do not drive or operate any machines if you feel dizzy after taking TRUDOL PLUS TABLET.

Alcohol

Contraindicated

Consumption of alcohol is not recommended while taking TRUDOL PLUS TABLET because it might make you dizzier.

Kidney

Consult your doctor

TRUDOL PLUS TABLET is not recommended in patients with kidney failure. It should be used with caution in patients with mild to moderate kidney problems. Consult your doctor for advice.

Liver

Consult your doctor

TRUDOL PLUS TABLET is not recommended in patients with liver failure. It should be used with caution in patients with mild to moderate liver problems. Consult your doctor for advice.

Allergy

Contraindicated

Do not take TRUDOL PLUS TABLET if you are allergic to Diclofenac, Tramadol, or any of the other ingredients of this medicine.

Lungs

Use with Caution

TRUDOL PLUS TABLET should be used with caution in patients who have asthma and chronic pulmonary diseases. Consult your doctor for advice.

Heart Disease

Consult your doctor

TRUDOL PLUS TABLET is not recommended in patients with severe heart failure. It should be used with caution in patients with high blood pressure. Consult your doctor for advice.

Use In Pediatrics

Contraindicated

TRUDOL PLUS TABLET is not recommended for use in children and adolescents below 12 years of age. Consult your doctor before taking it.

Use In Geriatrics

Use with Caution

TRUDOL PLUS TABLET should be used with caution in elderly (above 65 years of age). Consult your doctor for advice.

Interactions

A. Drug-Drug interactions:

Before taking TRUDOL PLUS TABLET, inform your doctor if you are taking any of the following medicine:

• medicines used against infections. (Ex. ketoconazole, flucloxacillin, erythromycin)
• medicine used to reduce cholesterol in the blood (Ex. cholestyramine)
• HIV medications (Ex. indinavir, nelfinavir, ritonavir) 
• medicines used to manage abnormal heart rhythms (Ex. quinidine)
• medicine used in the management of depression or Parkinson’s disease (Ex. monoamine oxidase inhibitors)
• antidepressants (Ex. amitriptyline)
• blood pressure-lowering agents (Ex. hydrochlorothiazide)
• medicines that affect the state of mind, used to help stop smoking (Ex. bupropion)
• blood thinning medicines (Ex. warfarin)
• painkillers (Ex. nimesulide, oxyphenbutazone)
• medicine used to manage epilepsy or some types of pain (Ex. carbamazepine)
• opioid-type pain relievers (Ex. buprenorphine, nalbuphine or pentazocine)

Overdosage:

If you or anyone else accidentally takes too much of TRUDOL PLUS TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms may include headache, nausea, pain abdominal, vomiting, bleeding intestinal or stomach, drowsiness, excitation, diarrhoea, disorientation, rarely convulsions may occur.

Synopsis

More Information

• Keep TRUDOL PLUS TABLET out of reach of children
• Store at room temperature

FAQs About TRUDOL PLUS TABLET

Q: What are the uses of TRUDOL PLUS TABLET?

A: TRUDOL PLUS TABLET is used in the management moderate to severe pain. Tramadol and Diclofenac in combination, have a faster action and provide quick relief from pain.

Q: Can we use TRUDOL PLUS TABLET for pregnant and breastfeeding women?

A: TRUDOL PLUS TABLET is not recommended in pregnant women. TRUDOL PLUS TABLET is excreted into breast milk so it not recommended in breastfeeding women. Consult your doctor before taking it.

Q: Can TRUDOL PLUS TABLET lead to kidney damage?

A: Yes, prolonged use of TRUDOL PLUS TABLET may cause kidney damage as pain killers reduce prostaglandin levels (a chemical), which protects the kidneys from damage and helps in its normal functioning. So, TRUDOL PLUS TABLET is mostly prescribed as a short-term medication to avoid any kidney damage. Consult your doctor before taking it.

Q: Can TRUDOL PLUS TABLET be taken daily?

A: Take TRUDOL PLUS TABLET as advised by your physician. If there is no improvement in your condition or if symptoms worsen, contact your doctor.

Q: What if I forget to take TRUDOL PLUS TABLET?

A: Take the medicine as soon as you remember it, however, if it is time for the next scheduled dose, skip the missed dose and follow your usual regime. Do not double the dose.

References

1. KD. Tripathi. Opioid Analgesics and Antagonists. Essentials of medical pharmacology. seventh edition. 2017. Page – 469.

2. Shah DD, Sorathia ZH. Tramadol/Diclofenac Fixed-Dose Combination: A Review of Its Use in Severe Acute Pain. National Library of Medicine.  February 2020. [Accessed on 8th March 2023] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203365/

3. Tramadol/Diclofenac Fixed-dose Combination Phase III Trial in Acute Pain After Third Molar Extraction. National Library of Medicine. Diclofenac and Tramadol. [Accessed on 8th March 2023] https://clinicaltrials.gov/ct2/show/NCT03714672

4. Abbott Pharmaceuticals. Diclofenac and Tramadol. [Accessed on 8th March 2023] https://www.abbott.in/products/therapy-areas.painmgmt.html#tabsComp

5. Dexcel Pharma Ltd. Diclofenac. [Revised in April 2021] [Accessed on 8th March 2023] https://www.medicines.org.uk/emc/files/pil.2660.pdf

6. APL Swift Services (Malta) Limited. Tramadol. [Revised in September 2021] [Accessed on 8th March 2023] https://www.medicines.org.uk/emc/files/pil.7123.pdf

Author Details

Written By Dr. Janet.C - Pharm.D

Reviewed For Accuracy By Dr. Sankara Babu Gorle - MBBS, MD (Pharmacology)

Last updated on 09 Mar 2023 | 10:00 AM(IST)