TRUBOSE PLUS Tablet 10's

Introduction About TRUBOSE PLUS TABLET

TRUBOSE PLUS TABLET is a combination of Metformin, Nateglinide, and Voglibose, which belongs to the group of medicines called Antidiabetic agents. It is used in the management of diabetes mellitus.

During management with TRUBOSE PLUS TABLET, your doctor will conduct a blood test to check your kidney function.

TRUBOSE PLUS TABLET is not recommended for use if you have liver disease, severe kidney disease, acute heart failure, a recent history of heart attack, severe problems with blood circulation (such as shock) or breathing difficulties. Consult your doctor before taking it.

TRUBOSE PLUS TABLET is not recommended for use during pregnancy or in breastfeeding women, as it may pass through the breast milk. Consult your doctor before taking it.

The most common side effects of taking TRUBOSE PLUS TABLET are nausea, vomiting, diarrhea, abdominal pain, heartburn, indigestion, constipation, flatulence, loss of appetite, changes in taste, and low blood sugar levels. Consult your doctor if any of the side effects worsen.

Uses Of TRUBOSE PLUS TABLET

• To manage type II diabetes mellitus

How TRUBOSE PLUS TABLET Works

TRUBOSE PLUS TABLET effectively controls blood glucose levels, where metformin works by decreasing glucose production in the liver and the amount of glucose absorbed by the stomach and intestine. It also helps to restore the body’s response to insulin. Nateglinide works by stimulating the pancreas to produce more insulin quickly, which helps to control blood sugar levels. Voglibose works by inhibiting the alpha-glucosidase enzyme, which breaks down complex carbohydrates into simple sugars. Thus, voglibose slows down the digestion and absorption of carbohydrates in the small intestine and improves blood glucose levels.

How to use TRUBOSE PLUS TABLET

Take TRUBOSE PLUS TABLET, preferably with meals or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight, and disease condition. Do not stop taking this medicine without informing your doctor. Otherwise, it may raise blood sugar levels.

Side Effects Of TRUBOSE PLUS TABLET

How To Manage Side Effects

Bloating

Eat smaller and more frequent meals. Eat and drink slowly, and exercise regularly. If the bloating does not improve, contact your doctor.

Constipation

Include fiber-rich foods in your diet, such as fresh fruits, vegetables, and whole-grain cereals, and drink plenty of fluids. Exercise more regularly and stay active. Contact your doctor if constipation persists.

Diarrhea

Drink lots of fluids, such as water or fruit juices, to keep yourself hydrated. Do not take any medicine on your own to manage diarrhea. Contact your doctor if your diarrhea does not improve.

Nausea And Vomiting

Take TRUBOSE PLUS TABLET with a meal. Stick to simple meals. Avoid eating oily or spicy food. Contact your doctor if your nausea and vomiting do not improve.

Stomach Pain

Rest and relax. Eat and drink slowly or try to have smaller and more frequent meals. Keep a heating pad on your stomach. Do not self-manage on your own, consult your doctor if the symptom does not improve on its own.

Warning & Precautions

Pregnancy

Contraindicated

TRUBOSE PLUS TABLET is not recommended for use during pregnancy since it may cause harm to the foetus. Consult your doctor before taking TRUBOSE PLUS TABLET.

Breastfeeding

Contraindicated

TRUBOSE PLUS TABLET is not recommended for use in breastfeeding women as it may pass through the breast milk. Consult your doctor before taking TRUBOSE PLUS TABLET.

Driving and Using Machines

Use with Caution

Do not drive or operate any machinery if you have weakness, dizziness, increased sweating, a fast heartbeat, visual problems, or difficulty in concentration after taking TRUBOSE PLUS TABLET.

Alcohol

Use with Caution

Avoid excessive consumption of alcohol, as it may increase the risk of lactic acidosis.

Kidney

Contraindicated

TRUBOSE PLUS TABLET is not recommended for use if you have severe kidney disease. Consult your doctor before taking the medicine.

Liver

Contraindicated

TRUBOSE PLUS TABLET is not recommended for use if you have liver disease. Consult your doctor before taking the medicine.

Allergy

Contraindicated

Do not take TRUBOSE PLUS TABLET if you are allergic to metformin, nateglinide, voglibose, or any other ingredients of this medicine.

Heart Disease

Contraindicated

TRUBOSE PLUS TABLET is not recommended for use if you are managed for acute heart failure, a recent history of heart attack, or severe problems with blood circulation (such as shock) or have breathing difficulties. Consult your doctor before taking it.

Use In Pediatrics

Contraindicated

TRUBOSE PLUS TABLET is not recommended for use in children and adolescents (aged below 18 years) as the safety and effectiveness of the medicine are not established. Consult your doctor before taking it.

Use In Geriatrics

Use with Caution

TRUBOSE PLUS TABLET should be used with caution in elderly patients (aged 65 years and above). Consult your doctor before taking TRUBOSE PLUS TABLET.

Interactions

A. Drug-drug interactions:

Before taking TRUBOSE PLUS TABLET, inform your doctor if you are taking any of the following medicines:

• medicines that increase urine production (diuretics) Ex. chlorothiazide, furosemide
• beta-2 agonists such as salbutamol or terbutaline (used to manage asthma)
• corticosteroids (used to manage inflammatory conditions) Ex. prednisone and cortisone
• verapamil, ranolazine (medicine used to manage blood pressure and angina)
• rifampicin (a medicine used to manage tuberculosis)
• cimetidine (medicine used to manage stomach problems)
• dolutegravir (a medicine used to manage viral infections)
• trimethoprim (a medicine used to manage bacterial infections)
• vandetanib, crizotinib, and olaparib (medicines used to manage cancer)
• medicine used to manage fungal infections Ex. fluconazole, isavuconazole
• medicines used to manage pain and inflammation (NSAIDs and COX-2-inhibitors) Ex. ibuprofen, celecoxib, and aspirin
• medicines for the management of high blood pressure and heart problems (ACE inhibitors, angiotensin II receptor antagonists, and betablockers) Ex. losartan, enalapril, and atenolol
• monoamine oxidase inhibitors (used to manage depression) Ex. selegiline
• gemfibrozil (used to manage dyslipidemia)
• sulfinpyrazone (used to manage chronic gout)
• sympathomimetics, Ex. ephedrine (medicine used to manage asthma)
• anabolic hormones Ex. methandrostenolone (medicine used for increasing physical performance)
• John’s Wort (an herbal medicine used to manage depression)
• somatropin (a growth hormone)
• somatostatin analogues such as lanreotide and octreotide (used to manage acromegaly)
• phenytoin (used to manage fits)
• sulfonylurea or biguanide, or with insulin, Ex. glimepiride (other medicines used to manage diabetes mellitus)
• alpha blockers Ex. prazosin, doxazosin (medicines used to manage benign prostate hypertrophy)
• warfarin (medicine used to manage blood clots)
• epinephrine (medicine used in emergency conditions)
• adrenocortical hormone
• thyroid hormone Ex. levothyroxine (medicine used to manage hypothyroidism)

Overdosage:

If you or anyone else accidentally took more TRUBOSE PLUS TABLET, consult your doctor immediately or visit the nearby hospital. Overdosage may cause lactic acidosis, and symptoms include vomiting, abdominal pain with muscle cramps, a general feeling of not being well with severe tiredness, and difficulty in breathing. Further symptoms include a reduced body temperature and heartbeat. Overdosage may also cause abdominal discomfort, diarrhea, and a severe hypoglycemic attack (which may lead to loss of consciousness or fits).

Synopsis

More Information

• Keep TRUBOSE PLUS TABLET out of the sight and reach of children
• Store TRUBOSE PLUS TABLET below 30°C

FAQs About TRUBOSE PLUS TABLET

Q: What if I forget to take TRUBOSE PLUS TABLET?

A: If you forgot to take a dose of TRUBOSE PLUS TABLET, take it as soon as you remember. However, if it is time for the next dose of TRUBOSE PLUS TABLET, skip the missed dose and take the next one regularly. Do not take a double dose of TRUBOSE PLUS TABLET to compensate for the missed ones.

Q: Is TRUBOSE PLUS TABLET safe in pregnancy?

A: TRUBOSE PLUS TABLET is not recommended for use during pregnancy since it may cause harm to the foetus. Inform your doctor if you are pregnant or planning for pregnancy before taking this medicine.

Q: What are the side effects of taking TRUBOSE PLUS TABLET?

The most common side effects of taking TRUBOSE PLUS TABLET are nausea, vomiting, diarrhea, abdominal pain, heartburn, indigestion, constipation, flatulence, loss of appetite, changes in taste, and low blood sugar levels. Consult your doctor if any of the side effects worsen.

Q: Can I take alcohol while using TRUBOSE PLUS TABLET?

A: No. Avoid consumption of alcohol while taking TRUBOSE PLUS TABLET, as it may increase the risk of lactic acidosis.

Q: Can I use TRUBOSE PLUS TABLET with other diabetic medications?

A: Your doctor may advise TRUBOSE PLUS TABLET with or without other medications to control your blood sugar levels. However, it is advised to maintain a proper diet and exercise to achieve controlled blood sugar levels while using this medicine with or without other antidiabetic medications.

Q: Who should not take TRUBOSE PLUS TABLET?

A: TRUBOSE PLUS TABLET is not recommended for use if you have liver disease, severe kidney disease, acute heart failure, a recent history of heart attack, or severe problems with blood circulation (such as shock), or have breathing difficulties, dehydration, severe infections, uncontrolled diabetes with lactic acidosis, ketoacidosis, or diabetic pre-coma, or have gastrointestinal obstruction. Consult your doctor before taking it.

References

1. KD. Tripathi. Insulin, Oral Antidiabetic Drugs and Glucagon. Essentials of medical pharmacology. Eight edition. 2019. Page – 297, 299, 301.

2. John M, Gopinath D, Kalra S. Triple fixed drug combinations in type 2 diabetes. Indian J Endocrinol Metab. 2015. [Accessed on 8th January 2024]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366766/

3. Brown & Burk UK Ltd. Electronic Medicines Compendium (EMC) [Revised in May 2022] [Accessed on 8th January 2024]. https://www.medicines.org.uk/emc/files/pil.10759.pdf

4. Novartis Farma S.p.A.. Electronic Medicines Compendium (EMC) [Revised in May 2018] [Accessed on 8th January 2024]. https://www.medicines.org.uk/emc/files/pil.1320.pdf

5. Blue Cross Laboratories Pvt Ltd. Voglibose. [Revised in April 2021] [Accessed on 8th January 2024[. https://bluecrosslabs.com/wp-content/uploads/2023/02/K-VOG_Tablets_PI.pdf

6. Nateglinide+Voglibose+Metformin. Atlantis Formulations Pvt Ltd. [Accessed on 8th January 2024]. https://atlantisformulations.com/diacardo

7. Nateglinide+Metformin+Voglibose. Aar Ess Remedies Pvt Ltd. [Accessed on 8th January 2024]. http://www.aaressremedies.com/productpage/trubose-forte/

Useful Diagnostic Tests

• HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin
• Blood Glucose Fasting (FBS)
• Random Blood Sugar (RBS)
• Post Prandial Blood Sugar (PPBS)
• Insulin – Fasting
• Insulin Postprandial (PP)
• Vital Diabetes Care
• Extended Diabetes Care
• Advance Diabetes Care
• Comprehensive Diabetes Care

Author Details

Written By Dr. N. Sai Swaroop - Pharm.D

Reviewed For Accuracy By Dr. Jaya Prabakaran - MBBS, MD (Diabetology and Family Medicine)

Last updated on 10 Jan 2024 | 11:55 AM(IST)