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Introduction About TROFAME XR CAPSULE
TROFAME XR CAPSULE contains Trospium which belongs to the group of medicines called Antimuscarinics. TROFAME XR CAPSULE is used to relax muscles of urinary bladder which helps in managing symptoms associated with involuntary loss of urine (wetting) and/or increased frequency/urgency to urinate in patients affected with overactive urinary bladder (syndrome that cause sudden/unstoppable need to urinate).
TROFAME XR CAPSULE is not recommended for use in patients allergic to Trospium. It is also not recommended for use in patients suffering from urinary retention due to blockage of urinary tract. The medicine is also not indicated for use in patients suffering from narrow-angle glaucoma (eye disorder that cause increased intraocular pressure in the eye), myasthenia gravis (weak muscle), severe digestive tract conditions (such as toxic megacolon), fast/abnormal heart beats, severe liver disease, and/or kidney disorders.
Before taking TROFAME XR CAPSULE, inform your doctor if you suffer from any type of stomach/intestine obstruction, impaired urine flow, nerve damage, overactive thyroid, and/or heart problems (such as coronary artery disease/congestive heart failure).
TROFAME XR CAPSULE should be used with caution in pregnant and breastfeeding women only if it is clearly necessary.
The medicine is not recommended for use in children and adolescents (aged below 18 years) and is advised to be used with caution in elderly patients (aged 75-years and above) after consulting the doctor.
The most common side effects of taking TROFAME XR CAPSULE are dry mouth, constipation, nausea, abdominal pain, indigestion, dry eyes, and/or dry nose. Consult your doctor if any of these symptoms worsen.
Uses Of TROFAME XR CAPSULE
- Relaxes muscles of urinary bladder which helps in managing symptoms associated with involuntary loss of urine (wetting) and/or increased frequency/urgency to urinate in patients with an overactive urinary bladder
How TROFAME XR CAPSULE Works
TROFAME XR CAPSULE works by relaxing muscles of the urinary bladder which helps in managing frequent, urgent, and/or uncontrolled urge/need to urinate in patients with overactive urinary bladder.
How to use TROFAME XR CAPSULE
Take TROFAME XR CAPSULE as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of TROFAME XR CAPSULE
Common
- dry mouth, constipation, nausea, stomach pain, indigestion
- dry eyes and nose
Uncommon
- flatulence
Rare
- urinary retention, difficulty emptying the bladder
- fast heart rate, racing/pounding heartbeat
- difficulty seeing objects at a closer view
- rash
- feeling generally weak
Stop taking TROFAME XR CAPSULE and contact your doctor immediately if you experience any of the following side effects:
- swelling of face, tongue, throat, and/or windpipe that cause breathing in breathing
- sudden allergic reaction with breathlessness, rash, wheezing, and/or drop in blood pressure
How To Manage Side Effects
Dry mouth:
Try to drink plenty of cold water and sip on cold unsweetened drinks and use lip balm if your lips are dry. Brush your teeth twice a day and use mouthwash. Consult and inform your doctor if the symptom gets worse.
Constipation:
Try to eat high-fiber foods such as vegetables, cereals, fresh fruit, and drink plenty of water. Involve in regular exercise (going for a daily walk or run) and if this does not help, consult and inform your doctor for receiving alternate managements for constipation.
Nausea:
Take TROFAME XR CAPSULE with/just after a meal. Stick to simple meals. Avoid eating oil rich/spicy foods, sugary snacks and drinks. Avoid drinking too much liquid along with your meals, and drink slowly in between meals. Consult your doctor if the condition worsens.
Indigestion:
Try to have smaller and more frequent meals and drink slowly. Reduce consumption of coffee, cola, tea, or alcohol and lose weight if you are obese. Try to avoid smoking and don’t have rich, fatty or spicy foods. Consult your doctor and inform if the symptom does not improve.
Warning & Precautions
Pregnancy
TROFAME XR CAPSULE should be used with caution in pregnant women only if it is clearly necessary. Consult your doctor before taking the medicine.
Breastfeeding
TROFAME XR CAPSULE should be used with caution in breastfeeding women only if it is clearly necessary. Consult your doctor before taking the medicine.
Driving and Using Machines
Do not drive or operate any machines if you experience impaired vision after taking TROFAME XR CAPSULE.
Kidney
TROFAME XR CAPSULE is not recommended for use in patients with kidney disorders. Consult your doctor before taking TROFAME XR CAPSULE.
Liver
TROFAME XR CAPSULE is not recommended for use in patients with severe liver problems. Consult your doctor before taking TROFAME XR CAPSULE.
Allergy
Do not take TROFAME XR CAPSULE if you are allergic to Trospium, and/or any other ingredients of this medicine.
Heart Disease
TROFAME XR CAPSULE is not recommended for use in patients with heart problems such as abnormal/faster heart beats. It should be used with caution in patients with other heart problems such as coronary artery disease/congestive heart failure. Consult your doctor before taking TROFAME XR CAPSULE.
Others
TROFAME XR CAPSULE is not recommended for use if you:
- suffer from urinary retention due to blockage of urinary tract
- have narrow-angle glaucoma (eye disorder that cause increased intraocular pressure in the eye)
- suffer from myasthenia gravis (weak muscle)
- suffer from severe digestive tract conditions (such as toxic megacolon)
Before taking TROFAME XR CAPSULE, inform your doctor if you:
- have any type of stomach/intestine obstruction
- have an impaired urine flow
- suffer from neuropathy (nerve damage)
- suffer from hiatus hernia related to reflux oesophagitis (heartburn which worsens on bending/lying down)
- suffer from overactive thyroid
Use in Pediatrics:
TROFAME XR CAPSULE is not recommended for use in children and adolescents (aged below 18 years). Consult your doctor before taking the medicine.
Use in Geriatrics:
TROFAME XR CAPSULE should be used with caution in elderly patients (aged above 75 years). Consult your doctor before taking the medicine.
Interactions
A. Drug-Drug interactions:
Before taking TROFAME XR CAPSULE, inform your doctor if you are taking any of the following medicine:
- antidepressants (medicines used to manage depression) Ex. amitryptiline, imipramine
- medicines used to manage asthma (Ex. salbutamol, tolbutamide)
- amantadine (used to manage Parkinson’s disease)
- metoclopramide (used for nausea and vomiting)
- medicines used to decrease blood fat levels (Ex. colestipol, colestyramine)
Overdosage:
If you or anyone else accidentally takes too much of TROFAME XR CAPSULE, consult your doctor immediately or visit the nearby hospital to manage overdose symptoms.
Synopsis
| Drug | : | Trospium |
| Pharmacological Category | : | Antimuscarinics |
| Therapeutic Indication | : | Symptoms related to overactive bladder |
| Dosage Forms | : | Capsule, Tablet |
More Information
- Keep TROFAME XR CAPSULE out of reach of children
- Store TROFAME XR CAPSULE at room temperature
FAQs About TROFAME XR CAPSULE
Q. What is TROFAME XR CAPSULE used for?
A. TROFAME XR CAPSULE is used to relax muscles of urinary bladder which helps in managing symptoms associated with involuntary loss of urine (wetting) and/or increased frequency/urgency to urinate in patients affected with overactive urinary bladder (syndrome that cause sudden/unstoppable need to urinate).
Q. What are the side effects of TROFAME XR CAPSULE?
A. The most common side effects of taking TROFAME XR CAPSULE are dry mouth, constipation, nausea, abdominal pain, indigestion, dry eyes, and/or dry nose. Consult your doctor if any of these symptoms worsen.
Q. How TROFAME XR CAPSULE is taken?
A. TROFAME XR CAPSULE works by relaxing muscles of the urinary bladder which helps in managing frequent, urgent, and/or uncontrolled urge/need to urinate in patients with overactive urinary bladder.
Q. What happens if TROFAME XR CAPSULE is taken more than its required dosage?
A. If you or anyone else accidentally takes too much of TROFAME XR CAPSULE, consult your doctor immediately or visit the nearby hospital to manage overdose symptoms.
Q. How TROFAME XR CAPSULE works?
A. TROFAME XR CAPSULE works by relaxing muscles of the urinary bladder which helps in managing frequent, urgent, and/or uncontrolled urge/need to urinate in patients with overactive urinary bladder.
References
1. Tilo Grosser, Emer Smyth and Garret A. FitzGerald. Drugs Acting at Synaptic and Neuroeffector Junctional Sites. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 196.
2. Peter K Sand, Theodore M Johnson Ii, Eric S Rovner, Pamela I Ellsworth, Michael G Oefelein, David R Staskin. Trospium chloride once-daily extended release is efficacious and tolerated in elderly subjects (aged ≥ 75 years) with overactive bladder syndrome. NIH National Library of Medicine. National center for biotechnology information. PubMed.gov. February 2011. [Accessed on 10th June 2022] https://pubmed.ncbi.nlm.nih.gov/20707790/
3. Trospium. NIH National Library of Medicine. National Center for Biotechnology Information. PubChem. June 2022. [Accessed on 10th June 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Trospium#section=Biological-Half-Life
4. Madaus GmbH. Electronic Medicines Compendium (EMC). [Revised in September 2020] [Accessed on 10th June 2022] https://www.medicines.org.uk/emc/files/pil.6644.pdf
Useful Diagnostic Tests
- Uroflowmetry
- Urodynamic tests
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