Triptolol Tablet 10'S

Introduction About TRIPTOLOL TABLET

TRIPTOLOL TABLET is a combination of Amitriptyline and Propranolol which belongs to the group of medicines called Tricyclic antidepressants and Beta blockers respectively. It is used to manage migraine with co-morbid conditions like insomnia, neuralgic pain, hypertension, and anxiety.

Migraine is a neurological condition characterized by intense, throbbing head pain and, typically, includes other physical symptoms such as nausea, vomiting, and sensitivity to light, sound, or smell.

Insomnia is a common sleep disorder that can make it hard to fall asleep, hard to stay asleep, or cause you to wake up too early and not be able to get back to sleep.

Neuropathic pain is caused by damage or injury to the nerves that transfer information between the brain and spinal cord from the skin, muscles, and other parts of the body.

Hypertension is a condition in which the force of the blood against the artery walls is too high.

Anxiety is an emotion characterized by feelings of tension, worried thoughts, and physical changes like increased blood pressure.

Before taking this medicine, inform your doctor if you have any kidney or liver problems or heart problems or high blood pressure.

Pregnant or breastfeeding women should consult their doctor before taking this medicine. The most common side effects are weight gain, dry mouth, blurred vision, constipation, drowsiness. Contact your doctor if any of the symptoms worsen.

Uses Of TRIPTOLOL TABLET

• Used to manage migraine with co-morbid conditions like insomnia, neuralgic pain, hypertension and anxiety

How TRIPTOLOL TABLET Works

TRIPTOLOL TABLET is a combination of Amitriptyline and Propranolol. Amitriptyline belongs to tricyclic antidepressant which stops the movement of pain signals from nerves to the brain thereby relieving pain. Propranolol widens the blood vessels in the body for better blood flow.  

How to use TRIPTOLOL TABLET

Take TRIPTOLOL TABLET as advised by your physician. Swallow the medicine with a glass of water, do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

Side Effects Of TRIPTOLOL TABLET

How To Manage Side Effects

Constipation:

Eat fiber rich foods such as fresh fruits, vegetables and cereals and drink plenty of water. Try to exercise more regularly. Consult your doctor if the symptom did not improve on its own.

Drowsiness:

Get up and move around to feel awake. Take a nap to take the edge off sleepiness. Give your eyes a break to avoid fatigue.

Warning & Precautions

Pregnancy

There is no proper information regarding the use of TRIPTOLOL TABLET in pregnant women. Consult your doctor before taking this medicine.

Breastfeeding

There is no proper information regarding the use of TRIPTOLOL TABLET in breast feeding women. Consult your doctor before taking this medicine.

Driving and Using Machines

Do not drive or use any machines if you experience mental alertness, and motor coordination after taking TRIPTOLOL TABLET.

Alcohol

Consumption of alcohol is not recommended during management with TRIPTOLOL TABLET. Because it may cause excessive drowsiness.

Kidney

TRIPTOLOL TABLET should be used with caution in patients with renal dysfunction. Consult your doctor before taking this medicine.

Liver

TRIPTOLOL TABLET is not recommended for use in patients with severe hepatic dysfunction. Consult your doctor before taking this medicine.

Allergy

Do not take TRIPTOLOL TABLET if you are allergic to Amitriptyline, Propranolol or any other ingredients of this medicine.

Lungs

TRIPTOLOL TABLET is not recommended for use in patients with bronchial asthma. Consult your doctor before taking this medicine.

Heart Disease

TRIPTOLOL TABLET is not recommended for use in patients with cardiogenic shock, sinus bradycardia and greater than first degree block. Consult your doctor before taking this medicine.

Interactions

A. Drug-Drug interactions:

Before taking TRIPTOLOL TABLET, inform your doctor if you are taking any of the following medicine:

• duloxetine, citalopram, fluoxetine, topiramate, tramadol, sertraline, cyclobenzaprine, and trazodone
• pregabalin, levothyroxine, alprazolam
• medicines used to manage irregular heartbeat, as well as other heart medications
• disulfiram (used to help people with alcoholism avoid from drinking)
• atropine, phenobarbital
• warfarin (used for blood thinners)
• bromocriptine
• cimetidine, metoclopramide (used to manage heartburn/ulcer medication)
• clonidine, labetalol (used to manage high blood pressure)
• delavirdine (used to manage HIV infection)
• diphenoxylate (used to manage diarrhoea)
• imatinib and procarbazine (used for chemotherapy)
• levodopa (used to manage Parkinson's disease)
• donepezil, galantamine, tacrine (used to manage Alzheimer's)
• medicines used to manage epilepsy and seizure
• levothyroxine
• antiarrhythmics medicine such as propafenone, amiodarone
• quinidine
• digitalis glycosides
• calcium channel blockers

Overdosage:

If you or anyone else accidentally takes too much of TRIPTOLOL TABLET, consult your doctor immediately or visit the nearby hospital.

Synopsis

More Information

• Keep TRIPTOLOL TABLET out of reach of children
• Store at room temperature

FAQs About TRIPTOLOL TABLET

Q: Can I consume alcohol while taking [GBBNKEYWORD]?

A: No, avoid consumption of alcohol while taking this medicine. Because it may cause excessive drowsiness.

Q: Can you crush TRIPTOLOL TABLET?

A: No, Swallow the medicine as a whole and do not crush or chew the medicine. Consult your doctor for advice.

Q: Is TRIPTOLOL TABLET effective?

A: Yes, it is effective if used in the dose and duration directed by your physician. Consult your doctor for advice.

Q: Can I take TRIPTOLOL TABLET if I have liver disease?

A: TRIPTOLOL TABLET is not recommended for use in patients with severe hepatic dysfunction. Consult your doctor before taking this medicine.

Q: Is TRIPTOLOL TABLET cause Constipation?

A: Yes, this medicine may cause constipation in some individuals. Eat fiber rich foods such as fresh fruits, vegetables and cereals and drink plenty of water. Try to exercise more regularly. Consult your doctor if the symptom did not improve on its own.

References

1. KD. Tripathi. 5-Hydroxytryptamine, its Antagonists and Drug Therapy of Migraine & Antiarrhythmic Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 180 & 532.

2. M. Rafieian-Kopaei, J. Mehvari and H. Shirzadeh. Different Profile of Propranolol and Amitriptyline Effects on Migraine Prophylaxis. [Accessed 13 Apr 2022] https://scialert.net/abstract/?doi=ijp.2005.366.368

3. D K Ziegler 1, A Hurwitz, S Preskorn, R Hassanein, J Seim. Propranolol and amitriptyline in prophylaxis of migraine. Pharmacokinetic and therapeutic effects. NIH: National Library of Medicine, National center of biotechnology Information Pubmed.gov. Aug 1993. [Accessed 13 Apr 2022] https://pubmed.ncbi.nlm.nih.gov/8352668/

4. XENON PHARMA PVT LTD. [Revised on Jan 2021] [Accessed 13 Apr 2022] https://www.centaurpharma.com/downloads/neurology/Triptolol.pdf

Author Details

Written By Dr. Janet.C - Pharm.D

Reviewed For Accuracy By Dr. Sankara Babu Gorle - MBBS, MD (Pharmacology)

Last updated on 30 Dec 2022 | 09:45 AM(IST)