Trajenta 5mg Tablet 10'S

Introduction About TRAJENTA 5MG TABLET

Trajenta 5mg Tablet (Linagliptin) is an oral medication formulated to support adults living with Type 2 Diabetes in managing their blood glucose levels effectively. It works as part of a comprehensive care approach that includes diet and physical activity. Trajenta is often recommended for individuals whose blood sugar control requires additional support beyond lifestyle changes alone. Its once-daily dosing makes it a convenient option for maintaining consistent blood sugar balance throughout the day.    

This medication is especially suitable for adult patients with Type 2 Diabetes who may be managing their condition with other oral medicines like metformin or insulin. It belongs to a class known as DPP-4 inhibitors, which work by enhancing the body’s natural ability to regulate glucose levels after meals. Linagliptin’s unique elimination pathway means it typically does not require dose adjustments in patients with kidney concerns, making it a preferred choice for those with renal challenges.     

Trajenta 5mg is taken orally once daily, with or without food ideally at the same time each day to help maintain steady levels in the bloodstream. Patients should follow their healthcare provider’s directions closely and maintain regular monitoring of blood glucose levels. It is important to inform the doctor about any other medications being taken to avoid potential interactions. While Trajenta is generally well tolerated, patients should watch for signs such as allergic reactions or persistent digestive discomfort and report these promptly.    

Trajenta 5mg is not recommended during pregnancy or breastfeeding due to limited safety data, so alternative options are usually considered for those periods. Common side effects reported include mild headaches, nasal congestion or upper respiratory tract symptoms. If unusual or severe symptoms occur, it is crucial to consult a healthcare professional. This balanced profile makes Trajenta 5mg a valuable component in the personalized management of Type 2 Diabetes.

Uses Of TRAJENTA 5MG TABLET

• Supports blood sugar control in Type 2 Diabetes

Benefits of TRAJENTA 5MG TABLET

Benefits of taking Trajenta 5mg for Type 2 diabetes

Trajenta 5mg supports adults with Type 2 Diabetes by helping maintain more stable blood sugar levels throughout the day. It works by enhancing the body’s natural processes to regulate glucose after meals, which can contribute to better overall glycemic balance. When combined with a healthy diet and regular physical activity, Trajenta offers a convenient once-daily oral option that fits well into daily routines. Its safety profile, including a low risk of causing low blood sugar episodes, makes it a preferred choice in diabetes care plans.

Trajenta 5mg for managing post-meal sugar spikes

One of the key ways Trajenta helps is by assisting in the reduction of blood sugar rises following meals. This effect is important because controlling post-meal glucose fluctuations can support long-term blood sugar stability and reduce strain on the body. Trajenta works by prolonging the activity of natural hormones that help regulate insulin release and glucose levels after eating. Taking the tablet consistently every day can contribute to smoother sugar level curves, helping patients maintain steady energy and reduce discomfort associated with sudden sugar spikes.

Benefits of Trajenta in renal-impaired patients

Trajenta 5mg (Linagliptin) has a unique advantage for patients with kidney concerns as it is primarily eliminated through non-renal pathways. This means that unlike many other glucose-supporting medicines, it usually does not require dose adjustments for patients with mild to moderate kidney impairment. This feature makes Trajenta a valuable option for individuals managing Type 2 Diabetes alongside renal challenges, offering effective blood sugar support without placing additional strain on kidney function. As always, medical supervision and regular monitoring remain essential during treatment.

How TRAJENTA 5MG TABLET Works

How does Trajenta 5mg regulate blood sugar

Trajenta support the body's natural ability to manage blood sugar levels, especially after meals. Linagliptin works by slowing the breakdown of incretin hormones—these hormones stimulate the release of insulin when blood sugar rises and reduce the amount of sugar produced by the liver. By enhancing this natural process, Trajenta helps maintain more stable blood glucose levels throughout the day, contributing to overall blood sugar balance in adults with Type 2 Diabetes.

How to use TRAJENTA 5MG TABLET

Trajenta 5mg recommended dose for adults        

• Standard adult dose: One 5mg tablet once daily
• Fixed-dose; no routine dose adjustment needed
• To be taken exactly as advised by the healthcare provider

When to take Trajenta for best results

• Can be taken at any time of the day
• Preferably taken at the same time each day
• Helps maintain consistent blood levels and improves adherence

Trajenta 5mg administration with or without food

• Can be taken with or without meals
• Suitable for patients with variable eating schedules
• Swallow the tablet whole with water; do not crush or chew

Adjusting Trajenta dose in kidney impairment

• No dose adjustment needed in mild to severe renal impairment
• Linagliptin is eliminated primarily through non-renal pathways
• Still important to consult a doctor for personalized monitoring

What if I forgot to take TRAJENTA 5MG TABLET

If you forget to take a dose of Trajenta 5mg, take it as soon as you remember, unless it is almost time for your next scheduled dose. In such cases, skip the missed dose and continue with your regular daily schedule. Do not take two doses at the same time to make up for the missed one. Missing an occasional dose may not cause immediate issues, but regular intake is important for maintaining consistent blood sugar control. Setting a daily reminder or linking the dose with a routine activity like breakfast can help improve adherence.

Overdose

Accidental or intentional overuse of Trajenta 5mg should be avoided. While the risk of serious side effects from a single extra dose is low, taking more than the prescribed amount may increase the chance of experiencing side effects such as headache, dizziness or gastrointestinal discomfort. In rare cases, overdosage may lead to elevated enzyme levels or interactions with other medications. If an overdose is suspected, it is important to seek medical advice immediately. Always follow your healthcare provider’s instructions and avoid self-adjusting the dose without guidance.

Side Effects Of TRAJENTA 5MG TABLET

Common Side Effects of Trajenta 5mg Tablet:

• Stuffy or runny nose
• Sore throat
• Cough
• Diarrhoea

When to Seek Medical Attention?

Stop taking TRAJENTA 5MG TABLET and contact your doctor immediately if you experience any of the following side effects:

• Signs of low blood sugar (hypoglycaemia) (such as trembling, sweating, anxiety, blurred vision, tingling lips, paleness, mood change or confusion, headache, drowsiness, weakness, dizziness, irritability, hunger, fast heartbeat, shaking or feeling jittery)
• Signs of serious allergic reactions (such as swelling of your face, lips, tongue, throat, and other areas on skin, difficulty with swallowing or breathing, raised red areas on the skin (hives), skin rash, itching, flaking or peeling of the skin)
• Signs of inflamed pancreas (pancreatitis) (such as severe and persistent stomach pain, nausea and vomiting)
• Bullous pemphigoid (blisters or breakdown of the outer skin layer (erosion))
• Heart failure symptoms (such as increasing shortness of breath or trouble breathing, especially when you lie down, swelling or fluid retention, especially in the feet, ankles or legs, an unusually fast increase in weight, unusual tiredness)

How To Manage Side Effects

Diarrhea

• Drink plenty of fluids like water or oral rehydration solutions to prevent dehydration.
• Eat light, bland foods such as rice, bananas, or toast.
• Avoid fatty, spicy, or dairy-based foods until symptoms resolve.

Sore Throat

• Gargle with warm salt water several times a day.
• Drink warm fluids like herbal teas or clear broths to soothe irritation.
• Use throat lozenges for temporary relief, if advised by a doctor.

Warning & Precautions

Pregnancy

Contraindicated

TRAJENTA 5MG TABLET is generally not recommended for use in pregnant women as it is unknown if it is harmful to the unborn child. Consult your doctor before taking it.

Breastfeeding

Consult your doctor

It is not known if TRAJENTA 5MG TABLET passes though breast milk. Consult your doctor before taking it.

Driving and Using Machines

Use with Caution

TRAJENTA 5MG TABLET has no or negligible effect on the ability to drive or use machines. Consult your doctor if you feel any side effects during management that may stop you from driving or using machines.

Alcohol

Use with Caution

TRAJENTA 5MG TABLET should be used with caution in patients with a history of alcoholism. Consult your doctor before taking it.

Kidney

Use with Caution

TRAJENTA 5MG TABLET should be taken with caution in patients with kidney problems. Consult your doctor before taking it.

Allergy

Contraindicated

Do not take TRAJENTA 5MG TABLET if you are allergic to Linagliptin. Inform your doctor if you had an allergic reaction to any other medicines that you take to control blood sugar levels.

Heart Disease

Use with Caution

TRAJENTA 5MG TABLET should be taken with caution in patients with a history of heart failure. Consult your doctor before taking it.

Use In Pediatrics

Contraindicated

TRAJENTA 5MG TABLET is not recommended for use in children and adolescents (under 18 years of age). Consult your child’s doctor for advice.

Use In Geriatrics

Use with Caution

TRAJENTA 5MG TABLET should be used with caution in elderly patients (aged 65 years and above). Consult your doctor before taking it.

Other Warnings for TRAJENTA 5MG TABLET

Before taking TRAJENTA 5MG TABLET, inform your doctor if you:

• Have type 1 diabetes (body does not produce any insulin)
• Have diabetic ketoacidosis (complication of diabetes with high blood sugar, rapid weight loss, nausea or vomiting)
• Have or had a disease of the pancreas
• Have diabetic skin lesions

Safety Advice

Important precautions before taking Trajenta 5mg

Before starting Trajenta 5mg, it is important to inform your healthcare provider about your complete medical history. Individuals with a history of inflammation of the pancreas (pancreatitis), heart disease, or liver concerns should be closely monitored. Let your doctor know about all the medicines you are currently taking, including those for high blood pressure, cholesterol, or other blood sugar-lowering agents, to avoid possible interactions. It’s also advisable to mention if you are planning any surgery or if you are experiencing severe dehydration, as these conditions may require temporary adjustments to your treatment plan.

Who Should Avoid Taking Trajenta?

Trajenta 5mg may not be suitable for everyone. It is not typically recommended for individuals with Type 1 diabetes or for managing diabetic ketoacidosis. Those with a known allergy to linagliptin or any inactive ingredients in the tablet should not use this medicine. Caution is also advised in people with a history of chronic or recurrent pancreatitis. Pregnant or breastfeeding individuals should consult their doctor to evaluate potential risks and determine if alternative options may be more appropriate.

Trajenta 5mg safety considerations during routine use

When used consistently as directed, Trajenta 5mg is generally well-tolerated and integrates easily into daily routines. It is designed to be taken once daily, with or without food, offering flexibility for users. While dose adjustments are not typically required in cases of kidney impairment, ongoing monitoring by a healthcare provider is recommended, especially for those with multiple health conditions. Patients should continue to maintain a healthy lifestyle, including a balanced diet and regular physical activity, to support overall blood sugar management alongside medication use.

Diet and Lifestyle Advice

Recommended Diet

• Choose Low-Glycemic Index (GI) Foods
  Opt for whole grains, legumes, non-starchy vegetables and fiber-rich fruits. These foods release glucose more slowly, supporting more stable post-meal sugar levels.
• Limit Simple Carbohydrates and Added Sugars
  Avoid sugary drinks, sweets and processed snacks that can cause glucose spikes and work against your diabetes care routine.
• Include Lean Proteins and Healthy Fats
  Add foods like fish, nuts, seeds, tofu and olive oil. These help with satiety and have minimal effect on blood glucose.
• Stay Hydrated
  Drink plenty of water throughout the day to support metabolism and digestion.
• Practice Portion Control
  Keep meal sizes consistent, especially with carbohydrates, to help manage blood sugar more predictably.

Lifestyle Practices

• Regular Physical Activity
  Engage in moderate exercise like walking, cycling or yoga for at least 30 minutes a day 5 days a week. This enhances insulin sensitivity and supports better glucose regulation.
• Maintain a Healthy Weight
  Weight management plays a supportive role in overall blood sugar control and cardiovascular health.
• Sleep and Stress Management
  Aim for 7–8 hours of quality sleep. Practice mindfulness or stress-reduction activities like deep breathing or meditation, as stress can affect blood sugar levels.
• Avoid Smoking and Limit Alcohol
  These can interfere with metabolic processes and blood glucose balance. If alcohol is consumed, it should be done in moderation and with food.
• Stick to Routine
  Take Trajenta 5mg at the same time each day. Consistent meal and activity timings improve predictability in glucose patterns.

Trajenta 5mg vs metformin – what's the difference?

Stabilizing Blood Sugar After Illness: How Trajenta 5mg Supports Routine Diabetes Management

Trajenta 5mg Tablet (Linagliptin) plays a valuable role in managing blood sugar levels in adults with Type 2 diabetes, especially during the recovery phase after an illness. This period often brings unexpected glucose fluctuations due to physical stress, changes in eating patterns, reduced activity or the temporary use of medications such as corticosteroids.

With its once-daily dosing and kidney-safety profile, Trajenta 5mg Tablet is often included in diabetes care plans where consistency and ease of use are important. Its mode of action—inhibiting the DPP-4 enzyme—enhances the body’s natural incretin response, which helps in better handling post-meal glucose surges and improving overall glycemic control.

Trajenta 5mg Tablet is considered a suitable option for those who need a gentle glucose-lowering medicine with minimal risk of hypoglycemia, particularly when not used alongside sulfonylureas or insulin. It is also well tolerated in individuals who experience digestive discomfort with other oral agents, making it a convenient choice during recovery when patient comfort and adherence are critical.

As part of a holistic diabetes management routine, Trajenta 5mg Tablet can be integrated with a balanced diet, regular physical activity, and routine blood sugar monitoring to support blood sugar stabilization and long-term well-being after illness.

Drug - Drug interaction

When managing Type 2 diabetes, it's essential to consider how Trajenta 5mg Tablet may interact with other medications. Certain drugs can alter its effect or increase the risk of low blood sugar. Understanding these interactions helps support safe and effective use. Always consult a healthcare provider before combining therapies.

1. Sulfonylureas (e.g., Glimepiride, Glipizide)

• Interaction: Co-administration may increase the risk of low blood sugar (hypoglycemia).
• Management: Blood glucose levels should be monitored closely. A dose adjustment of the sulfonylurea may be necessary to reduce hypoglycemia risk.

2. Insulin or Insulin Analogs

• Interaction: When used with Trajenta, there may be a higher likelihood of hypoglycemia.
• Management: Doctors may consider lowering the insulin dose and regularly reviewing blood glucose readings.

3. Rifampin (Antibiotic)

• Interaction: May reduce the effectiveness of Linagliptin by increasing its breakdown in the liver.
• Management: Blood sugar levels should be monitored. An alternate diabetes support option may be considered if needed.

4. Carbamazepine, Phenytoin, Phenobarbital (Anti-seizure medications)

• Interaction: These may decrease the levels of Linagliptin in the blood, reducing its intended glucose-lowering effect.
• Management: Periodic evaluation of blood glucose and possible adjustment in therapy may be advised.

5. Strong CYP3A4 Inducers (e.g., St. John’s Wort)

• Interaction: May lower plasma concentration of Linagliptin, impacting its action.
• Management: Avoid concurrent use or monitor glycemic control closely.

6. ACE Inhibitors (e.g., Enalapril, Ramipril)

• Interaction: Combined use may enhance the risk of hypoglycemia, especially when used with other diabetes medications.
• Management: Monitor blood glucose and adjust therapy if needed.     

Drug - Food interaction

1. High-Carbohydrate or High-Glycemic Meals

• Interaction: Such meals may cause blood sugar spikes which can challenge the body’s glucose balance even when on medication.
• Management: Prefer balanced meals with low to moderate glycemic index. Pairing carbs with fiber, protein or healthy fats may support better glucose response.

2. Alcohol

• Interaction: Alcohol can increase the risk of hypoglycemia especially if consumed in excess or on an empty stomach.
• Management: Limit or avoid alcohol while using Trajenta. If consumed it should be taken with food and blood sugar should be monitored closely.

Synopsis

More Information

FAQs About TRAJENTA 5MG TABLET

References

1.KD Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of Medical Pharmacology. seventh edition.2013. Page-275.

2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th edition. Philadelphia, PA: Wolters Kluwer Health; 2015. Page 2247-2248.

3. Dipeptidyl Peptidase IV (DPP IV) Inhibitors. Statpearls. Revised on 22nd May 2023. [Accessed on 16th May 2025]             

4. Boehringer Ingelheim Hellas Single Member S.A. Electronic Medicines Compendium (EMC). [Revised in January 2022] [Accessed on 16th May 2025] 

5.Boehringer Ingelheim Pharmaceuticals, Inc. U.S. Food & Drug Administration. [Revised in June 2023] [Accessed on 16th May 2025] 

Useful Diagnostic Tests

• Diabetes Profile- Comprehensive
• Advance Diabetes Care
• HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin

Author Details

Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)

Reviewed For Accuracy By Dr. Jaya Prabakaran - MBBS, MD (Diabetology and Family Medicine)

Last updated on 17 May 2025 | 05:06 PM(IST)