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Introduction About TOROXX A TABLET
TOROXX A TABLET is used to relieve pain and reduce redness and swelling (inflammation) in patients suffering from osteoarthritis (arthritis of the joints), rheumatoid arthritis (an autoimmune disorder that causes chronic inflammation of the joints), and ankylosing spondylitis (arthritis of the spine, which can lead to fusion of the vertebrae).
It contains Aceclofenac, which belongs to the group of medicines called Non-steroidal anti-inflammatory drugs, which work by blocking the release of prostaglandins, which are responsible for pain and inflammation.
TOROXX A TABLET is not recommended for use in patients with a stomach ulcer, severe kidney disease, heart disease (heart attack), cerebrovascular disease (such as stroke or transient ischemic attack) or blockage of blood vessels to the heart or brain, peripheral arterial disease (poor blood circulation to extremities of the body), severe liver failure, and blood clotting disorders.
Before taking TOROXX A TABLET, inform your doctor if you have diabetes, raised cholesterol or triglyceride levels, a rare inherited disorder like porphyria, systemic lupus erythematous, or other connective tissue disorders, and if you are recovering from major surgery or have a habit of smoking.
TOROXX A TABLET is not recommended for use in pregnant and breastfeeding women unless advised by the doctor. Consult your doctor before taking this medicine.
TOROXX A TABLET is not recommended for use in children and adolescents (under 18 years of age). TOROXX A TABLET should be used with caution in elderly patients due to the increased risk of serious side effects.
The most common side effects of taking TOROXX A TABLET are dizziness, nausea, and diarrhea. Consult your doctor if any of the side effects worsen.
Uses Of TOROXX A TABLET
TOROXX A TABLET is used to relieve pain and reduce redness and swelling (inflammation) in patients suffering from:
- Osteoarthritis (arthritis of the joints)
- Rheumatoid arthritis (an autoimmune disease that causes chronic inflammation of joints)
- Ankylosing spondylitis (arthritis of the spine)
How TOROXX A TABLET Works
TOROXX A TABLET works by exhibiting anti-inflammatory and painkiller properties by blocking the enzyme cyclo-oxygenase, which is involved in the production of prostaglandins, which are responsible for causing pain and inflammation (swelling).
How to use TOROXX A TABLET
Take TOROXX A TABLET as advised by your physician. It can be taken with or after food.
For Tablet, Capsule: Swallow TOROXX A TABLET with a glass of water. Do not crush or chew the medicine.
For Dispersible Tablet: Disperse the medicine in the specified quantity of water as mentioned on the label. Consume the medicine immediately after reconstitution.
Your doctor will decide the correct dose and duration for you depending on your age, body weight, and disease condition.
Side Effects Of TOROXX A TABLET
Common
- Dizziness
- Nausea, diarrhoea
- Increased liver enzymes in the blood
Uncommon
- Inflammation or irritation of the lining of the stomach (gastritis), vomiting
- Flatulence, constipation
- Mouth ulcers
- Itching, rash, and inflammation of the skin
- Red, itchy, stinging, or burning patches on the skin (hives)
- Elevated blood urea or creatinine levels
Rare
- Hypersensitivity (allergic reaction)
- Visual disturbance
- Shortness of breath
- Heart failure
- High blood pressure
- Bleeding from the stomach or bowel
- Stomach or bowel ulceration
Stop taking TOROXX A TABLET and contact your doctor immediately if you experience any of the following side effects:
- Severe allergic reaction (signs include fever, difficulty breathing, wheezing, abdominal pain, vomiting, and swelling of the face and throat)
- Severe skin rashes, such as Stevens-Johnson syndrome, and toxic epidermal necrosis symptoms, such as fever, headache, and aching of the joints, skin peeling, and blisters
- Meningitis (signs include high fever, headache, vomiting, blotchy red rashes, neck stiffness, sensitivity, and intolerance to light)
- Kidney failure
- Passing blood in your faeces (stools or motions) or passing black tarry stools, blood vomiting
- Indigestion, heartburn, or abdominal pain
- Blood disorders such as reduced production of blood cells, abnormal breakdown of red blood cells (hemolytic anemia), low content of iron in the blood, low level of white blood cells, decreased platelet count, and increased potassium levels (signs include being extremely tired, breathlessness, aching of the joints, and being prone to getting repeated infections and bruising)
How To Manage Side Effects
Constipation
Increase fiber intake through fruits, vegetables, and whole grains. Stay hydrated by drinking plenty of water. Maintain regular meal times and avoid skipping meals. Exercise regularly to promote bowel movements. Establish a bathroom routine and avoid ignoring the urge to go. Avoid processed foods and prioritize probiotic-rich foods for gut health. Consult your doctor if constipation persists.
Diarrhea
Drink plenty of clear fluids, like water, diluted fruit juices, or oral rehydration solutions, to stay hydrated. Avoid caffeinated or alcoholic beverages, as they can worsen dehydration. Gradually take bland, low-fiber foods like bananas, rice, applesauce, and toast to help firm up stools. Probiotics, found in yogurt or supplements, may help restore the balance of gut bacteria. Practice good hand hygiene to prevent the spread of infection. Consult your doctor if diarrhea worsens.
Dizziness Or Drowsiness
Ensure proper hydration, as dehydration can cause dizziness. Avoid excessive caffeine, alcohol, and high-sodium foods, which can exacerbate symptoms. Engage in physical therapy or vestibular rehabilitation exercises designed to improve balance and reduce dizziness. Move slowly when changing positions, such as standing up or lying down, to avoid triggering dizziness. Practice relaxation techniques such as deep breathing, meditation, or yoga to manage stress, which can contribute to dizziness. Consult your doctor if dizziness persists.
Nausea And Vomiting
Stay hydrated with small sips of clear fluids like water, ginger ale, or electrolyte solutions. Avoid consuming large meals; instead, opt for bland, easy-to-digest foods. Ginger, peppermint, or chamomile tea may help soothe the stomach. Rest in a comfortable position, preferably with your head elevated, to ease symptoms. Consult your doctor if nausea and vomiting persist.
Stomach Pain
Avoid spicy or fatty foods, caffeine, or alcohol that may exacerbate symptoms. Eat a bland diet consisting of easily digestible foods like rice, bananas, applesauce, and toast. Applying a heating pad or taking a warm bath can also help soothe abdominal muscles and alleviate discomfort. Drink plenty of fluids to stay hydrated, but avoid excessive consumption to prevent further irritation. If stomach pain persists, consult your doctor.
Warning & Precautions
Pregnancy
Monitoring requiredTOROXX A TABLET is not recommended for use by pregnant women unless advised by the doctor. It must not be used during the last three months of pregnancy. Consult your doctor before taking TOROXX A TABLET.
Breastfeeding
Consult your doctorTOROXX A TABLET is not recommended for use in breastfeeding women unless advised by the doctor, as it is not known if it passes through the breast milk. Consult your doctor before taking TOROXX A TABLET.
Driving and Using Machines
Use with CautionDo not drive or operate any machines if you feel dizziness, drowsiness, vertigo, tiredness, or any visual disturbances after taking TOROXX A TABLET.
Kidney
Consult your doctorTOROXX A TABLET is not recommended for use in patients with severe kidney disease. It should be used with caution in patients with kidney disease. Consult your doctor before taking TOROXX A TABLET.
Liver
Consult your doctorTOROXX A TABLET is not recommended for use in patients with severe liver failure. It should be used with caution in patients with liver disease. Consult your doctor before taking TOROXX A TABLET.
Allergy
ContraindicatedDo not take TOROXX A TABLET if you are allergic to aceclofenac, aspirin, or any other nonsteroidal anti-inflammatory drugs (NSAIDs) (such as ibuprofen, naproxen, or diclofenac).
Lungs
Use with CautionTOROXX A TABLET should be used with caution in patients with asthma or breathing problems. Consult your doctor before taking TOROXX A TABLET.
Heart Disease
Consult your doctorTOROXX A TABLET is not recommended for use in patients with heart attacks and blockages to the blood vessels of the heart. It should be used with caution in patients with angina (chest pain) and high blood pressure. Consult your doctor before taking TOROXX A TABLET.
Use In Pediatrics
ContraindicatedTOROXX A TABLET is not recommended for use in children and adolescents (under 18 years of age). Consult your child’s doctor for advice.
Use In Geriatrics
Use with CautionTOROXX A TABLET should be used with caution in elderly patients due to the increased risk of serious side effects. Your doctor will initiate management with the lowest effective dose for a shorter duration. Consult your doctor before taking TOROXX A TABLET.
Others
TOROXX A TABLET is not recommended for use if you have:
- Stomach ulcer, blood vomiting, or passing blood in your faeces (black tarry stools)
- Cerebrovascular diseases such as stroke or mini-stroke (TIA)
- Blockages of blood vessels to the brain
- An operation to clear or bypass blockages
- Blood circulation (peripheral arterial disease)
- Suffer from bleeding or any type of blood clotting disorders
- Acute rhinitis or urticaria
- Active peptic ulcer
Before taking TOROXX A TABLET, inform your doctor if you:
- Have stomach or gut/bowel disorders such as inflammatory bowel disease (ulcerative colitis), chronic inflammatory bowel disease (Crohn’s disease), ulceration, bleeding, or perforation of the stomach or bowel
- Have problems with blood circulation to the brain
- Have a rare inherited disorder like porphyria
- Are smoker
- Have diabetes
- Have blood clots, raised cholesterol, or raised triglycerides
- Are suffering from systemic lupus erythematous (autoimmune disorder) or other connective tissue disorders
- Are infected with chicken pox
- Are recovering from major surgery
Interactions
A. Drug-drug interactions:
- Antidepressants (Ex. citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline) or lithium
- Cardiovascular agents (Ex. digoxin, enalapril, lisinopril, losartan, candesartan, hydralazine, methyldopa, clonidine, and propranolol)
- Anti-infectives (Ex. ciprofloxacin, ofloxacin, levofloxacin, and moxifloxacin)
- diuretics (Ex. thiazides, furosemide, and amiloride)
- Anticoagulants (Ex. warfarin, heparin)
- Antimetabolites (Ex. methotrexate)
- Anti-progestational steroids (Ex. mifepristone)
- Corticosteroids (Ex. hydrocortisone, prednisolone)
- Immunosuppressants (Ex. cyclosporine or tacrolimus)
- Antiviral (Ex. zidovudine)
- Antidiabetics (Ex. glibenclamide, gliclazide, and tolbutamide)
- Non-steroidal anti-inflammatory drugs (Ex. aspirin, ibuprofen, naproxen, celecoxib, and etoricoxib)
- Antiplatelet (Ex. clopidogrel)
Overdosage:
If you or anyone else accidentally takes too much of TOROXX A TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of an overdose are low blood pressure, gastrointestinal irritation, respiratory depression, and convulsions.
Synopsis
|
Drug |
: |
Aceclofenac |
|
Pharmacological Category |
: |
Non-steroidal anti-inflammatory drugs |
|
Therapeutic Indication |
|
Osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis |
|
Dosage Forms |
: |
Tablet, dispersible tablet, capsule, injection |
More Information
Storage
- Keep TOROXX A TABLET out of the sight and reach of children
- Store TOROXX A TABLET at room temperature
FAQs About TOROXX A TABLET
Q: What is TOROXX A TABLET used for?
A: TOROXX A TABLET is used to relieve pain and reduce redness and swelling (inflammation) in patients suffering from osteoarthritis (arthritis of the joints), rheumatoid arthritis (an autoimmune disorder that causes chronic inflammation of the joints), and ankylosing spondylitis (arthritis of the spine, which can lead to fusion of the vertebrae).
Q: How does TOROXX A TABLET work?
A: TOROXX A TABLET works by exhibiting anti-inflammatory and painkiller properties by blocking the enzyme cyclo-oxygenase, which is involved in the production of prostaglandins, which are responsible for causing pain and inflammation (swelling).
Q: What are the side effects of taking TOROXX A TABLET?
A: The most common side effects of taking TOROXX A TABLET are dizziness, nausea, and diarrhea. Consult your doctor if any of the side effects worsen.
Q: Does TOROXX A TABLET cause ulcers?
A: Yes, TOROXX A TABLET may cause ulcers when used for a long time. Painkillers like aceclofenac can lead to ulcers in the stomach and duodenum. But this risk can be reduced by taking the medication with food or immediately after food. Consult your doctor before taking TOROXX A TABLET.
Q: Can I use TOROXX A TABLET daily?
A: Take TOROXX A TABLET as advised by your doctor. Do not exceed the recommended dosage advised by your doctor, as it may cause severe bleeding when taken for a long time.
Q: Can TOROXX A TABLET be used in pregnant women?
A: TOROXX A TABLET is not recommended for use in pregnant women unless advised by the doctor. It must not be used during the last three months of pregnancy. Consult your doctor before taking TOROXX A TABLET if you are pregnant or planning to get pregnant.
Q: Who should avoid taking TOROXX A TABLET?
A: TOROXX A TABLET is not recommended for use in patients having stomach ulcers or having blood vomiting or passed blood in the faeces (black tarry stools), heart diseases, stroke, blockages to blood vessels of the heart or brain, problems with blood circulation (peripheral arterial disease), severe kidney disease or liver failure, ulcerative colitis, Crohn’s disease, and bleeding or blood clotting disorders.
Q: Is TOROXX A TABLET safe to use in patients with kidney disease?
A: TOROXX A TABLET is not recommended for use in patients with severe kidney disease. It should be used with caution in patients with kidney disease. Your doctor may monitor your kidney functioning before and during management with TOROXX A TABLET to manage the risk of any unusual effects or kidney damage. Consult your doctor before taking TOROXX A TABLET.
Q: Can TOROXX A TABLET be used with elderly patients?
A: TOROXX A TABLET should be used with caution in elderly patients due to the increased risk of serious side effects. Your doctor will initiate management with the lowest effective dose for a shorter duration. Consult your doctor before taking TOROXX A TABLET.
Q: Can I use TOROXX A TABLET with children?
A: TOROXX A TABLET is not recommended for use in children and adolescents (under 18 years of age). Consult your child’s doctor for advice.
Q: Is TOROXX A TABLET safe for asthma patients?
A: TOROXX A TABLET should be used with caution in patients with asthma or breathing problems. Consult your doctor before taking TOROXX A TABLET.
References
1. K.D Tripathi. Nonsteroidal Anti-inflammatory Drugs and Antipyretic-Analgesics. Essentials of Medical Pharmacology. Seventh Edition. 2013. Page – 204.
2. Parvati B. Patel and Tejas K. Patel. Efficacy and safety of aceclofenac in osteoarthritis: A meta-analysis of randomized controlled trials. NIH. National Library of Medicine, National Center for Biotechnology Information. PubMed Central. March 2017. [Accessed on 4th June 2024] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335881/
3. Daewon Pharmaceutical Co., Ltd. Phase IV Clinical Trial to Evaluate the Efficacy and Safety of PlbCR and Aceclofenac in the Treatment of Patients With Osteoarthritis of the Knee. NIH, U.S. National Library of Medicine. ClinicalTrials.gov. [Revised in October 2016] [Accessed on 4th June 2024] https://clinicaltrials.gov/ct2/show/NCT02682524
4. Rivopharm UK Ltd. Electronic Medicines Compendium (EMC). [Revised in March 2023] [Accessed on 4th June 2024] https://www.medicines.org.uk/emc/files/pil.2389.pdf
5. LABORATORI FUNDACIÓ DAU. Health Products Regulatory Authority (HPRA). [Revised in March 2024] [Accessed on 4th June 2024] https://www.hpra.ie/img/uploaded/swedocuments/269c05e5-6329-4bb4-a68b-f50ebcb9e979.pdf
6. United Douglas Pharm, Inc. Aceclofenac tablet. [Revised in November 2011] [Accessed on 4th June 2024] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8a023942-01e8-4849-aa3c-1a640ffc7fd3
Useful Diagnostic Tests
- Complete Blood Count (CBC)/ Hemogram
- Kidney Function Test (KFT)
- Liver Function Test (LFT)
- Basic Arthritis Care
- Comprehensive Bone Care
- Ra Test Rheumatoid Arthritis Factor, Quantitative
- Extended Arthritis Care Plan
- Frequent Pain Check Package
- Advanced Arthritis Care
- Autoimmune Arthritis Panel
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