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Introduction About TOPCEF DC TABLET
TOPCEF DC TABLET is a combination of Cefixime and Dicloxacillin which belongs to the group of medicines called Antibiotics. It is used to manage bacterial infections such as ear (otitis media), nose (sinusitis), throat (tonsillitis, pharyngitis), chest and lung infections such as (bronchitis, pneumonia), uncomplicated urinary tract infections such as cystitis and kidney infections and uncomplicated gonorrhoea (cervical/urethral infections).
Before taking TOPCEF DC TABLET inform your doctor if you have lung diseases such as asthma, liver, kidney or heart disease.
TOPCEF DC TABLET should be used with caution in pregnant women. Contact your doctor before taking. TOPCEF DC TABLET is not recommended for use in breast feeding women as it may pass through the breast milk. Contact your doctor before taking.
TOPCEF DC TABLET is not recommended for use in children under 10 years of age. Contact our doctor before taking.
TOPCEF DC TABLET should be used with caution in elderly patients aged 65 years or above. Contact your doctor before taking.
The most common side effects of this medicine are nausea, vomiting, stomach pain, diarrhea, indigestion or headache, dizziness. Contact your doctor if any of the side effects worsen.
Uses Of TOPCEF DC TABLET
It is used to manage bacterial infections such as:
- ear (otitis media), nose (sinusitis), throat (tonsillitis, pharyngitis)
- chest and lungs (bronchitis, pneumonia)
- uncomplicated urinary tract infections (cystitis and kidney infections)
- uncomplicated gonorrhoea (cervical/urethral infections)
How TOPCEF DC TABLET Works
TOPCEF DC TABLET helps to manage bacterial infections, where Cefixime and Dicloxacillin belongs to cephalosporin and penicillin antibiotics respectively. They, works by binding to penicillin-binding proteins, located inside the bacterial cell walls (which are responsible for the formation of bacterial cell wall) and inhibit the synthesis of bacterial cell wall, leading to bacterial cell death.
How to use TOPCEF DC TABLET
Take this medicine as advised by your physician. Swallow this medicine as whole with a glass of water and do not crush or chew the medicine. Your doctor will give the right dose depends on your age, body weight and disease condition.
Side Effects Of TOPCEF DC TABLET
Common
- nausea, vomiting
- stomach pain
- diarrhoea
- indigestion
- headache
- dizziness
- genital or vaginal area itching
Uncommon
- change in kidney and liver function
- blood clot
Rare
Stop taking TOPCEF DC TABLET and contact your doctor immediately if you experience any of the following side effects:
- allergic reaction such as rash, joint pains, swelling of face, lips, tongue or throat causing difficulty in swallowing or breathing or anaphylactic reactions
- Stevens Johnson Syndrome or Toxic Epidermal Necrolysis symptoms such as blistering, peeling or bleeding from the lips, eyes, mouth, nose, genitals, hands or feet
- DRESS (Drug Rash with Eosinophilia and Systemic symptoms) symptoms may include flu-like symptoms and a widespread rash, high fever and enlarged lymph nodes
- abnormal blood test values may include increased levels of liver enzymes and an increase in a type of white blood cell (eosinophilia) and enlarged lymph nodes
- AGEP (Acute generalized exanthematous pustulosis) symptoms such as red, scaly, widespread rash with fever, bumps under the skin or skin folds, chest, abdomen, back and arms and blisters
- skin rash or lesions with a reddish or pink ring and a pale centre, with itching, scaly or filled with fluid
- signs of infections
- bruise or bleed more easily
- nose bleed, bleeding gums, chills, tiredness, pale skin, and shortness of breath
- blood in urine
- fits
- convulsions, feeling confused, decreased alertness or aware of things than usual, abnormal muscle movements or stiffness
- symptoms of pseudomembranous colitis such as severe watery diarrhoea, fever and weakness
How To Manage Side Effects
Headache:
Rest and relax. Drink plenty of fluids such as water or electrolytes and apply a pain-relieving balm on the head if necessary. Do not consume alcohol. Contact your doctor if the symptom did not improve.
Nausea or Vomiting:
Take this medicine with, or just after meals. Stick to simple meals. Avoid eating oily or spicy foods.
Diarrhoea:
Drink lots of fluids, such as water or fruit juices to keep you hydrated. Do not take any medicine on your own for managing diarrhea. Contact your doctor if the symptom did not improve.
Indigestion:
Eat smaller meals but take frequently. Eat and exercise regularly. Contact your doctor if the symptom did not improve.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operate any machines while you are feeling dizzy. Do not consume alcohol, as it can aggravate your dizziness. Contact your doctor if the symptom did not improve.
Stomach pain:
Try to rest and relax. Eat small meals but take frequently. Keep a heat pad on your stomach. Contact your doctor if the symptom did not improve.
Warning & Precautions
Pregnancy
TOPCEF DC TABLET should be used with caution in pregnant women. Contact your doctor before taking.
Breastfeeding
TOPCEF DC TABLET is generally not recommended for use in breastfeeding women as it may pass through the breast milk. Consult your doctor before taking it.
Driving and Using Machines
Do not drive or operate any machines if you have fits (convulsions), feeling confused, decreased alertness or aware of things than usual, abnormal muscle movements or stiffness after taking [GBNEYWORD].
Kidney
TOPCEF DC TABLET should be used caution in patients with kidney disease. Consult your doctor before taking.
Liver
TOPCEF DC TABLET should be used with caution in patients with liver disease. Contact your doctor before taking.
Allergy
Do not take TOPCEF DC TABLET if you are allergic to Cefixime, Dicloxacillin, or to Beta lactam antibiotics like cephalosporins, penicillin or to any of the other ingredients of this medicine.
Lungs
TOPCEF DC TABLET should be used with caution in patients with lung disease like asthma. Contact your doctor before taking.
Heart Disease
TOPCEF DC TABLET should be used caution in patients with cardio spasm. Contact your doctor before taking.
Others
Before taking TOPCEF DC TABLET, inform your doctor if you have:
- colitis
- clostridium difficle associated diarrhea (CDAD)
- coagulation disorders
- poor nutrition
- urine test for ketones, glucose
- coombs test
- phenylketonuria
- severe illness
Use in pediatrics:
TOPCEF DC TABLET is not recommended for use in children under 10 years of age. Contact your doctor before taking.
Use in geriatrics:
TOPCEF DC TABLET should be used with caution in elderly patients (aged 65 years or above). Contact your doctor before taking.
Interactions
A. Drug-Drug interactions:
Inform your physician if you are taking:
- medicines used to thin the blood (Ex. warfarin, dicumarol)
- carbamazepine (medicines used to manage epilepsy)
- probenecid (medicines used to manage gout)
- medicines used to manage bacterial infections (amikacin, gentamycin and tetracyclines like doxycycline, demeclocycline)
Overdosage:
If you or anyone else accidentally took too much of this medicine, consult your doctor immediately or visit the nearby hospital.
Synopsis
| Drug | : | Cefixime, Dicloxacillin |
| Pharmacological Category | : | Cephalosporins, Penicillin Antibiotics |
| Therapeutic Indication | : | Bacterial infections |
| Dosage Forms | : | Tablet |
More Information
- Keep out of reach of children
- Store TOPCEF DC TABLET below 25°C
FAQs About TOPCEF DC TABLET
How TOPCEF DC TABLET work?
TOPCEF DC TABLET helps to manage bacterial infections, where Cefixime and Dicloxacillin belongs to cephalosporin and penicillin antibiotics respectively. They, works by binding to penicillin-binding proteins, located inside the bacterial cell walls (which are responsible for the formation of bacterial cell wall) and inhibit the synthesis of bacterial cell wall, leading to bacterial cell death.
Who should avoid taking TOPCEF DC TABLET?
TOPCEF DC TABLET is not recommended for use in patients with allergic history to Cefixime, Dicloxacillin, or to Beta lactam antibiotics like cephalosporins, penicillins or cephamycins, in breast feeding women and in children under 10 years of age. Contact your doctor before taking.
Can I use TOPCEF DC TABLET to manage cold?
No. TOPCEF DC TABLET is not used to manage viral infections like common cold. Contact your doctor before taking.
For what conditions TOPCEF DC TABLET is used?
TOPCEF DC TABLET is used to manage bacterial infections such as ear (otitis media), nose (sinusitis), throat (tonsillitis, pharyngitis), chest and lung infections such as (bronchitis, pneumonia), uncomplicated urinary tract infections such as cystitis and kidney infections and uncomplicated gonorrhoea (cervical/urethral infections). Contact your doctor before taking.
Does TOPCEF DC TABLET cause fits?
Yes. TOPCEF DC TABLET may cause fits. Stop taking TOPCEF DC TABLET and contact your doctor if you have unusual symptoms like fits.
References
1. K.D.Tripathi. Beta-lactam Antibiotics. Essentials of medical pharmacology. Seventh edition. 2013. Page- 728, 721.
2. Famar Lyon. Electronic Medicines Compendium (EMC). [Revised on April 2021] [Accessed on 6th June 2022] https://www.medicines.org.uk/emc/files/pil.5534.pdf
3. Lupin Limited. U.S. Food & Drug Administration. [Revised on May 2012] [Accessed on 6th June 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/203195s000lbl.pdf
4. Orchid Europe Limited. Health Products Regulatory Authority (HPRA). [Revised on November 2018] [Accessed on 6th June 2022] https://www.hpra.ie/img/uploaded/swedocuments/Licence_PA1335-002-001_23112018135013.pdf
5. Lupin Pharmaceuticals, Inc. Cefixime. [Revised on November 2019] [Accessed on 6th June 2022] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d0fd45bd-7d52-4fa6-a5f7-f46d5651ffa2
6. Sandoz Inc. Dicloxacillin. [Revised on November 2020] [Accessed on 6th June 2022] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=65c3e99b-ec77-416c-ad70-596d6f0a9c31
7. Teva Pharmaceuticals USA, Inc. Dicloxacillin. [Revised on July 2018] [Accessed on 6th June 2022] https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=8478f242-c715-4984-ac1d-dc79dc28665e
8. Dicloxacillin. mims.com. [Accessed on 6th June 2022] https://www.mims.com/philippines/drug/info/dicloxacillin?mtype=generic
Useful Diagnostic Tests
- Complete blood count
- Peripheral smear examination
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