TOFADOZ Gel 15g

Introduction About TOFADOZ GEL

TOFADOZ GEL is used to manage mild to moderate atopic dermatitis (AD), such as dry, itchy, swollen, and red skin. It contains Tofacitinib, which belongs to the group of medicines called Janus Kinase Inhibitors. It suppresses an overactive immune system by inhibiting certain enzymes called Janus kinases (JAKs). Thus, TOFADOZ GEL blocks the production of pro-inflammatory substances (including cytokines) that contribute to the development of inflammation and other symptoms of atopic dermatitis.

Apply TOFADOZ GEL to the affected area as directed by your doctor to get the most benefit. Prior to the initiation of this medicine, your doctor may order blood tests to understand and monitor your existing condition.

TOFADOZ GEL is not recommended for use in pregnant women and breastfeeding women. Consult your doctor before using it.

TOFADOZ GEL is not recommended for use if you have active tuberculosis (TB) or severe liver disease. Consult your doctor before using it.

TOFADOZ GEL should be used with caution in patients with a history of chronic lung disease or in those who develop interstitial lung disease due to the increased risk of infections. Consult your doctor before using it.

The safety and efficacy of TOFADOZ GEL in children are not established. Consult your child’s doctor for advice.

The most common side effects of using TOFADOZ GEL are application site eczema, application site itching, and fever. Consult your doctor if any of the side effects worsen.

Uses Of TOFADOZ GEL

It is used to:

• manage mild to moderate atopic dermatitis

How TOFADOZ GEL Works

TOFADOZ GEL suppresses an overactive immune system by inhibiting certain enzymes called Janus kinases (JAKs). Thus, TOFADOZ GEL blocks the production of pro-inflammatory substances (including cytokines) that contribute to the development of inflammation and other symptoms of atopic dermatitis.

How to use TOFADOZ GEL

Apply TOFADOZ GEL as advised by your doctor. It is for external use only. Apply TOFADOZ GEL as a thin layer to the affected area as directed by your doctor to get the most benefit. Your doctor will decide the correct dose and duration of TOFADOZ GEL for you depending upon your age, body weight, and disease condition.

Overdose

If you or anyone else accidentally swallows too much of TOFADOZ GEL, consult your doctor immediately or visit the nearby hospital.

Side Effects Of TOFADOZ GEL

Common side effects of TOFADOZ GEL:

• Application site eczema
• Application site itching
• Fever

Stop taking TOFADOZ GEL and contact your physician immediately if you experience any of the following side effects:

• Serious infection, an opportunistic infection, or sepsis
• Serious allergic reactions such as urticaria and angioedema
• Signs of myocardial infarction or stroke

How To Manage Side Effects

Skin rash Or Itching

Keep the affected area clean and dry and avoid scratching to prevent further irritation or infection. Apply calamine lotion to help reduce itching and inflammation. Applying cool compresses and wearing loose, breathable clothing can also provide relief. If the itching persists, consult your doctor.

Warning & Precautions

Pregnancy

Contraindicated

TOFADOZ GEL is not recommended for use by pregnant women. Women of childbearing potential should be advised to use effective contraception during management with TOFADOZ GEL and for at least 4 weeks after the last dose. Consult your doctor before using it.

Breastfeeding

Contraindicated

TOFADOZ GEL is not recommended for use by breastfeeding women. Consult your doctor before using it.

Driving and Using Machines

Use with Caution

TOFADOZ GEL has no influence on the ability to drive or operate machinery.

Liver

Contraindicated

TOFADOZ GEL is not recommended for use if you have severe liver disease. Consult your doctor before using it.

Allergy

Contraindicated

Do not use TOFADOZ GEL if you are allergic to tofacitinib or any of the other ingredients in this medicine.

Lungs

Consult your doctor

TOFADOZ GEL is not recommended for use if you have active tuberculosis (TB). It should be used with caution in patients with a history of chronic lung disease or in those who develop interstitial lung disease due to the increased risk of infections. Consult your doctor before using it.

Use In Pediatrics

Consult your doctor

The safety and efficacy of TOFADOZ GEL in children are not established. Consult your child’s doctor for advice.

Other Warnings for TOFADOZ GEL

Before using TOFADOZ GEL, inform your doctor if you:

• Have a chronic or recurrent infection
• Have been exposed to tuberculosis
• History of a serious or an opportunistic infection
• Have resided or travelled in areas of endemic tuberculosis or endemic mycoses
• Have underlying conditions that may predispose to infections
• Have a decrease in white blood cell count
• Have herpes zoster (due to virus reactivation)
• Have an increased risk of thrombosis (blood clots)

Who should not take TOFADOZ GEL

TOFADOZ GEL is not recommended for use if you:

• Have serious infections, such as sepsis, or opportunistic infections
• Have a low white blood cell count
• Have low levels of haemoglobin

Drug - Drug interaction

• Antifungals (Ex. ketoconazole, fluconazole)
• Anti-tubercular agent (Ex. rifampicin)
• Immunosuppressants (Ex. tacrolimus, ciclosporin)
• Live vaccines

Synopsis

More Information

References

1. Purohit VS, Ports WC, Wang C, Riley S. Systemic Tofacitinib Concentrations in Adult Patients With Atopic Dermatitis Treated With 2% Tofacitinib Ointment and Application to Pediatric Study Planning. NIH, National Library of Medicine. National Centre for Biotechnology Information. PubMed Central. [Revised in December 2018] [Accessed on 21st July 2026]

2. MSN Laboratories Private Limited. Tofacitinib. [Revised in September 2023] [Accessed on 21st July 2026]

Useful Diagnostic Tests

• Complete Blood Count (CBC)

Author Details

Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)

Reviewed For Accuracy By Dr. Janet. C - Pharm.D

Last updated on 21 Jul 2026 | 12:53 PM(IST)