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Introduction About THE TRIGLYNASE 2 TABLET
Triglynase 2 Tablet supports in the management of Type II Diabetes mellitus when diet and exercise alone are insufficient. It is a combination of Glimepiride, Metformin and Pioglitazone which belongs to the group of medicines called Antidiabetic agents.
Take Triglynase 2 Tablet as directed by your healthcare provider. Swallow whole with water at a fixed time daily. Do not exceed the recommended daily dose.
Triglynase 2 Tablet is not recommended for children. Consult your doctor if you are pregnant, breastfeeding, or have liver, kidney, or heart conditions. Avoid alcohol consumption. Monitor for symptoms of low blood sugar such as dizziness, sweating, or confusion.
Triglynase 2 Tablet is strictly not recommended for use in patients with type I diabetes mellitus, bladder cancer, severe heart failure or lactic acidosis.
The possible side effects of taking Triglynase 2 Tablet are low blood sugar (hypoglycemia), nausea, headache, stomach upset and dizziness. Consult your doctor if any of the above side effects worsen or persists for a longer duration.
Store at room temperature, away from moisture and direct sunlight. Keep out of reach of children.
Uses Of THE TRIGLYNASE 2 TABLET
- Used to manage Type II Diabetes mellitus
Benefits of THE TRIGLYNASE 2 TABLET
- Glimepiride (2 mg), Metformin Hydrochloride (500 mg), Pioglitazone (15 mg)
- Supports blood sugar management in type 2 diabetes
- Combination of three well-researched antidiabetic agents
- Patient-friendly oral tablet
How THE TRIGLYNASE 2 TABLET Works
Mechanism of Action: Triglynase 2 Tablet Explained
Triglynase 2 Tablet works in type 2 diabetes mellitus by combining three active ingredients namely Glimepiride, Metformin, and Pioglitazone each of which targets different aspects of blood sugar management.
1. Glimepiride: Stimulates the beta cells in the pancreas to release more insulin, which helps move sugar (glucose) from the blood into the body’s cells.
2. Metformin: It reduces the amount of glucose produced by the liver and decreases glucose absorption from the intestines. It also increases the sensitivity of muscle cells to insulin, allowing them to use glucose more efficiently.
3. Pioglitazone: Improves the body’s sensitivity to insulin in the liver, muscle, and fat cells. This helps these tissues remove glucose from the blood more effectively and decreases the amount of glucose produced by the liver.
How Glimepiride, Metformin, and Pioglitazone work together?
Together, these three components work synergistically to lower blood sugar levels, improve insulin sensitivity and reduce the risk of diabetes-related complications.
How to use THE TRIGLYNASE 2 TABLET
- Take Triglynase 2 Tablet as directed by your healthcare provider. Swallow whole with water at a fixed time daily. Do not exceed the recommended daily dose.
- Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition
- Do not stop taking Triglynase 2 Tablet unless your doctor advice you to stop
What if I forgot to take THE TRIGLYNASE 2 TABLET
- If you miss a dose of Triglynase 2 Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule
- Do not double the dose to make up for the missed one, as this can increase the risk of side effects such as low blood sugar (hypoglycemia) or other adverse reactions
- If you are unsure or frequently miss doses, consult your doctor for advice on how best to manage your medication regimen
Overdose
If you or anyone else accidentally took more Triglynase 2 Tablet you may experience the signs of hypoglycemia (such as increased hunger, sweating, headache, feeling clammy, restless or aggressive, shakiness, fast heartbeat and confusion).
Side Effects Of THE TRIGLYNASE 2 TABLET
Common side effects of THE TRIGLYNASE 2 TABLET:
- hypoglycemia (low blood sugar levels)
- diarrhea
- stomach pain
- loss of appetite
- flatulence
- changes in taste
- metallic taste
- joint pain
- back pain
- muscle pain
When to consult a doctor?
- signs of lactic acidosis (cold hands or feet, dizziness or light-headedness, slow or irregular heartbeat, weakness or tiredness, unusual muscle pain, trouble breathing, sleepiness or drowsiness, stomach pains, nausea or vomiting)
- unusual shortness of breath or trouble in breathing, rapid increase in weight or localized swelling (oedema), especially in the ankles or legs, unusual tiredness)
- blood in your urine, pain while urinating or urgent need to pee
- increased risk of fractures (especially in the bones of hand, upper arm, or foot in women)
- blurred vision due to swelling at the back of the eye or worsening of existing blurred vision
- serious allergic reaction (hives, swelling of the face, lips, tongue or throat causing difficulty in breathing or swallowing)
- signs of liver problems (nausea or vomiting, stomach pain, unusual or unexplained tiredness, loss of appetite, dark urine, yellowing of the skin or the whites of the eyes)
Warning & Precautions
Pregnancy
Consult your doctorThere are no adequate human data to determine the safety of Triglynase 2 Tablet during pregnancy.
Breastfeeding
Consult your doctorIt is not known if Triglynase 2 Tablet passes into human milk and if it can harm your baby. Talk to your doctor about the best way to control your blood glucose levels while breastfeeding.
Driving and Using Machines
Use with CautionDo not drive or operate any heavy tools or machines if your ability is affected by Triglynase 2 Tablet.
Alcohol
Consult your doctorAvoid consumption of alcohol while taking Triglynase 2 Tablet as it may increase the risk of unwanted side effects.
Kidney
Consult your doctorTriglynase 2 Tablet is not recommended for use in patients with severe kidney problems. It should be used with caution in patients with other kidney problems.
Liver
Consult your doctorTriglynase 2 Tablet is not recommended for use in patients with severe liver problems. It should be used with caution in patients with other liver problems.
Allergy
ContraindicatedDo not take Triglynase 2 Tablet if you are allergic to Glimepiride, Metformin, Pioglitazone or to any other ingredients of this medicine.
Heart Disease
Consult your doctorTriglynase 2 Tablet is not recommended for use in patients with severe heart problems (such as heart failure). It should be used with caution in patients with other heart problems.
Use In Pediatrics
ContraindicatedTriglynase 2 Tablet is not recommended for use in children and in adolescents (aged below 18 years).
Use In Geriatrics
Use with CautionTriglynase 2 Tablet should be used with caution in elderly patients (aged above 65 years).
Other Warnings for THE TRIGLYNASE 2 TABLET
Before taking Triglynase 2 Tablet inform your doctor if you:
- are recovering from any injury, operation, infections or from any form of stress
- have G6PD deficiency
- are on fasting or malnourished, starved, on an irregular diet, or feeling weak
- perform extreme physical exercises without proper carbohydrate intake
- are severely dehydrated
- have hormonal problems
- have edema (swelling of body parts)
- smoke
- have special type of diabetic eye disease called macular oedema
- have cysts on your ovaries (polycystic ovarian syndrome)
- previously had stroke
- have anemia
- have any bone problems or at risk of developing bone fractures
- are a premenopausal woman
- have thyroid problems
Who should not take [GBNKEYWORD
It is not recommended for use if you:
- have type I diabetes mellitus (insulin dependent diabetes)
- have lactic acidosis (build-up of lactic acid in the body)
- have diabetic ketoacidosis
- have bladder cancer
- pass bloody urine
Safety Advice
How to use Triglynase 2 Tablet 10's Safely
- Take as directed: Always take the tablet exactly as prescribed by your doctor. Do not exceed the recommended dose or duration
- Swallow whole: Swallow the tablet whole with a glass of water. Do not crush, chew, or break the medicine
- Take with food: Take the tablet with food to help manage stomach upset and improve absorption
- Fixed timing: Take the tablet at the same time each day for optimal results
- Missed Dose: If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. Never double the dose to compensate for a missed one
- Monitor Blood Sugar: Regularly monitor your blood sugar levels, especially when starting the medication or if you have symptoms of low blood sugar (hypoglycemia), such as dizziness, sweating, or confusion
- Avoid Alcohol: Do not consume alcohol while taking this medication, as it can increase the risk of certain side effects, including lactic acidosis and hypoglycemia
- Inform Your Doctor: Let your doctor know about any existing kidney, liver, or heart problems. Regular kidney function tests may be required
- Pregnancy and Breastfeeding: Do not use this medication if you are pregnant or breastfeeding unless specifically advised by your doctor
- Watch for side effects: Common side effects include nausea, diarrhea, stomach pain, headache, low blood sugar, and respiratory tract infections. Report any persistent or severe symptoms to your doctor
- Carry emergency sugar: If you experience symptoms of low blood sugar, have a quick source of sugar (like candy, glucose tablets, or juice) available and seek medical advice
Precautions for Triglynase 2 Tablet users
- Do not use this tablet if you are allergic to Glimepiride, Metformin, Pioglitazone, or any other ingredients in the medication
- Liver and Kidney Issues: It is not recommended for patients with severe liver or kidney problems. Use with caution if you have mild to moderate liver or kidney issues, and inform your doctor about any such conditions before starting treatment
- Heart Conditions: Avoid use if you have severe heart problems such as heart failure. Use with caution if you have other heart conditions
- Children and Adolescents: Not recommended for individuals under 18 years of age
- Elderly Patients: Use with caution in elderly patients (aged above 65 years), as they may be more sensitive to side effects
- Blood Sugar Monitoring: Regularly monitor your blood sugar levels, especially when starting the medication or if you experience symptoms of low blood sugar (hypoglycemia)
- Other Medications: Inform your doctor about all other medicines, supplements, or herbal products you are taking, as certain drugs may interact with Triglynase 2 Tablet
- Driving and Machinery: Use caution if you experience dizziness, visual disturbances, or low blood sugar, as these may affect your ability to drive or operate machinery
Drug - Drug interaction
|
Drug/Category |
Interaction Effect |
|
Insulin and other antidiabetic drugs |
Increased risk of hypoglycemia, dose adjustment and monitoring needed |
|
Antifungals (e.g., fluconazole) |
Can lead to severe hypoglycemia |
|
Beta blockers |
May mask symptoms of hypoglycemia and affect blood sugar control |
|
Diuretics (e.g., furosemide) |
May affect blood sugar control and electrolyte balance |
|
Antithyroid drugs (e.g., levothyroxine) |
Potential interaction affecting thyroid and blood sugar levels |
|
Anticonvulsants (e.g., pregabalin) |
Possible interaction affecting blood sugar control |
|
Anabolic steroids and androgens |
May affect blood sugar levels and medication effectiveness |
|
Angiotensin converting enzyme (ACE) inhibitors |
May enhance hypoglycemic effect |
|
Atypical antipsychotic medications |
May affect blood sugar control and increase risk of side effects |
|
Chloramphenicol |
Potential interaction affecting medication metabolism |
Synopsis
|
Drug |
: |
Glimepiride, Metformin, Pioglitazone |
|
Pharmacological Category |
: |
Sulfonylureas, Biguanides, PPAR-gamma and PPAR-alpha agonist |
|
Therapeutic Indication |
: |
Type II diabetes mellitus |
|
Dosage Forms |
: |
Tablet |
More Information
Storage
- Keep out of reach of children
- Store at room temperature
FAQs About THE TRIGLYNASE 2 TABLET
Q: What is Triglynase 2 Tablet used for?
A: Triglynase 2 Tablet is an antidiabetic medicine used to manage type II diabetes mellitus when diet, exercise and management with single agent does not result in adequate response.
Q: How and when to take Triglynase 2 Tablet?
A: Take Triglynase 2 Tablet preferably after meals or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
Q: How long should I take Triglynase 2 Tablet?
A: You need to take Triglynase 2 Tablet as long as your doctor or physician prescribes you the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
Q: What is the best time to take Triglynase 2 Tablet?
A: Triglynase 2 Tablet must be taken with meals to avoid gastrointestinal side effects.
Q: What to do if I forgot to take a dose of Triglynase 2 Tablet?
A: If you forgot to take a dose of Triglynase 2 Tablet, take it as soon as you remember. However, if it is time for the next dose of Triglynase 2 Tablet, skip the missed dose and take the next one regularly.
Q: Can I stop taking Triglynase 2 Tablet without consulting your doctor?
A: No. You should not stop taking Triglynase 2 Tablet without consulting your doctor because it may lead to reversal of symptoms.
Q: Will taking a higher dose of Triglynase 2 Tablet be more effective?
A: No, taking a higher dose of Triglynase 2 Tablet will not be effective, rather it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.
Q: Can I take medication for high blood pressure along with THE TRIGLYNASE 2 TABLET?
A: It is not advisable to take medicines to control blood pressure while taking Triglynase 2 Tablet without consulting your doctor, as they have known interactions with Triglynase 2 Tablet.
Q: How to manage the side effects of Triglynase 2 Tablet?
A: Low blood sugar is a common side effect of taking Triglynase 2 Tablet. Try to have sugar rich food items such as fruit juice, glucose tablets or gel, soft drinks, honey or sugary candy. Check your blood sugar after 10 minutes. If not gained optimum level, take another sugary snack, or drink, and check the blood sugar levels once again. If your condition did not improve, consult your doctor immediately.
Q: Can Triglynase 2 Tablet be taken with insulin?
A: Co-administration of Triglynase 2 Tablet with insulin is considered risky as they can increase the chances of hypoglycemia (low blood sugar levels). Therefore, consult your doctor before taking it.
Q: How Triglynase 2 Tablet works in diabetes?
A: Triglynase 2 Tablet works by combining three active ingredient Glimepiride, Metformin, and Pioglitazone each targeting different mechanisms to manage type 2 diabetes mellitus. Together, they improve blood sugar control through complementary actions. Glimepiride (2mg) stimulates the pancreas to release more insulin, which helps move sugar from the blood into cells for energy. Metformin (500mg) reduces glucose production in the liver and decreases sugar absorption from the intestines. It also improves insulin sensitivity in muscle cells, allowing them to use blood sugar more effectively and Pioglitazone (15mg) enhances insulin sensitivity in the liver, muscle, and fat cells, helping these tissues remove glucose from the blood more efficiently. It also reduces glucose production by the liver and supports insulin-producing cells in the pancreas.
Q: Does Triglynase 2 Tablet cause weight gain?
A: Yes. Triglynase 2 Tablet may cause weight gain in some individuals. To avoid this, follow a healthy diet and regular physical activity as advised by your physician. However, if you experience any weight gain due to swelling of body parts (such as in face, legs, or hands), consult your doctor immediately.
Q: What are the side effects of taking Triglynase 2 Tablet?
A: The most common side effects of taking Triglynase 2 Tablet are low blood sugar levels, nausea, stomach upset, constipation, sore throat, muscle pain, headache, dizziness and weight gain. Consult your doctor if any of these side effect worsens.
Q: Can I stop taking Triglynase 2 Tablet if my blood sugar is controlled?
A: Consult your healthcare provider before making any changes to your medication regimen.
Q: What should I do if I miss a dose of Triglynase 2 Tablet?
A: Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double the dose.
References
1. KD. Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 270, 275 & 277.
2. Jeong Mi Kim, Sang Soo Kim, Jong Ho Kim, Mi Kyung Kim, Tae Nyun Kim, Soon Hee Lee, Chang Won Lee, Ja Young Park, Eun Sook Kim, Kwang Jae Lee, Young Sik Choi, Duk Kyu Kim and In Joo Kim. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. July 2019. [Accessed on 21st June 2025] 
3. Brown & Burk UK Limited. Electronic Medicines Compendium (EMC). [Revised in December 2020] [Accessed on 21st June 2025] 
4. Milpharm Limited. Electronic Medicines Compendium (EMC). [Revised in June 2020] [Accessed on 21st June 2025]
5. Rx Farma Limited. Electronic Medicines Compendium (EMC). [Revised in September 2019] [Accessed on 21st June 2025]
6. Gerard Laboratories. Electronic Medicines Compendium (EMC). [Revised in August 2020] [Accessed on 21st June 2025]
7. Cipla Ltd. TRIEXER ER Tablets (Glimepiride + Pioglitazone hydrochloride + Metformin hydrochloride). Ciplamed. [Revised in September 2020] [Accessed on 21st June 2025]
8. Central Drugs Standard Control Organization. FDC of Glimepiride (1mg/2mg) + Pioglitazone (15mg) + Metformin (500mg E.R) Tablet. August 2005. [Accessed on 21st June 2025]
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