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Introduction About TENETIS MF TABLET
TENETIS MF TABLET is used to manage high blood sugar levels in people with type 2 diabetes mellitus. It is a combination of Metformin and Teneligliptin which belongs to the group of medicines called Antidiabetic agents.
Before taking TENETIS MF TABLET inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have low potassium levels in blood or are severely dehydrated due to excessive vomiting or diarrhea recently. During therapy with TENETIS MF TABLET, your doctor might regularly monitor blood sugar levels and kidney functions to avoid the risk of unwanted side effects.
TENETIS MF TABLET is not recommended for use in patients with severe uncontrollable diabetes. It is also not suitable for use in patients with alcoholism and in patients with severe systemic infections. The most common side effects of taking TENETIS MF TABLET are low blood sugar levels, stomach upset, constipation, flatulence and altered taste sensations. Consult your doctor if any of the above side effects bother you.
Uses Of TENETIS MF TABLET
- Used to manage type II diabetes mellitus
How TENETIS MF TABLET Works
TENETIS MF TABLET contains Metformin and Teneligliptin. Metformin works by lowering glucose production in the liver, delaying glucose absorption from intestines and increasing the body’s sensitivity to insulin. Teneligliptin is a dipeptidyl peptidase-4 inhibitor which works by increasing the release of insulin from pancreas and decreasing the hormones that raise blood sugar levels. This reduces both fasting and post-meal sugar levels. Together, they provide better control of blood sugar.
How to use TENETIS MF TABLET
- Take TENETIS MF TABLET preferably after meals or as advised by your physician
- Swallow the medicine with a glass of water. Do not crush or chew the medicine
- Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition
- Do not stop taking TENETIS MF TABLET unless your doctor advice you to stop
Side Effects Of TENETIS MF TABLET
Common side effects of TENETIS MF TABLET:
- hypoglycemia
- flatulence, diarrhea, constipation, stomach pain, loss of appetite
- changes in taste
Stop taking TENETIS MF TABLET and consult your doctor immediately if you experience any of the following side effects:
- serious allergic reaction (hives, swelling of the face, lips, tongue or throat causing difficulty in breathing or swallowing)
- severe skin rashes with redness and blistering of the skin
- signs of lactic acidosis (cold hands or feet, dizziness or light-headedness, slow or irregular heartbeat, weakness or tiredness, unusual muscle pain, trouble breathing, sleepiness or drowsiness, stomach pains, nausea or vomiting)
- signs of liver damage (tiredness, loss of appetite, weight loss, with or without yellowing of the skin or whites of the eyes)
Warning & Precautions
Pregnancy
Monitoring requiredTENETIS MF TABLET should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Safe use of the medicine during pregnancy has not been established.
Breastfeeding
ContraindicatedTENETIS MF TABLET is not recommended for use in breastfeeding mother.
Driving and Using Machines
Use with CautionDo not drive or operate any machines if you feel dizzy after taking TENETIS MF TABLET.
Alcohol
Consult your doctorAvoid consumption of alcohol while taking TENETIS MF TABLET as it may increase the risk of unwanted side effects.
Kidney
ContraindicatedTENETIS MF TABLET is not recommended for use in patients with severely reduced kidney functions.
Liver
Consult your doctorTENETIS MF TABLET is not recommended for use in patients with severe liver problems. It should be used with caution in patients with gall stones.
Allergy
ContraindicatedDo not take TENETIS MF TABLET if you are allergic to Metformin or Teneligliptin or any other ingredients of this medicine.
Lungs
ContraindicatedTENETIS MF TABLET is not recommended for use in patients with severe infections of the lungs or respiratory tract.
Heart Disease
ContraindicatedTENETIS MF TABLET is not recommended for use in patients with severe heart problems (such as acute heart failure, recent heart attack, arrythmia, prolonged QT interval).
Use In Pediatrics
Consult your doctorThe safety and effectiveness of TENETIS MF TABLET have not been established in infants, children and adolescents (aged below 18 years).
Use In Geriatrics
Consult your doctorThe safety and effectiveness of TENETIS MF TABLET have not been established in elderly patients (aged 65 years or above).
Others
TENETIS MF TABLET is not recommended for use if you:
- have severe, uncontrollable diabetes
- have lactic acidosis or ketoacidosis
- are dehydrated (due to drinking less fluid or had severe vomiting or diarrhea during the recent days)
- have any severe systemic infection
- have shock or problems in blood circulation
Before taking TENETIS MF TABLET, inform your doctor if you:
- have pituitary insufficiency or adrenal insufficiency
- are malnourished, starved, on an irregular diet, or feeling weak
- perform extreme muscle exercises
- have a history of abdominal operation or intestinal obstruction
- have hypokalaemia
- have type I diabetes mellitus
- have severe traumatic conditions
Interactions
A. Drug-Drug interactions:
Before taking TENETIS MF TABLET, inform your doctor if you are taking any of the following medicines such as:
- Anti-diabetics (Ex. glimepiride, glyburide, gliclazide, rosiglitazone, pioglitazone)
- iodine contrast medium (used during X-rays)
- Bronchodilators (Ex. salbutamol or terbutaline)
- Corticosteroids (Ex. hydrocortisone, prednisolone)
- diuretics (Ex. furosemide, hydrochlorothiazide)
- Non-steroidal anti-inflammatory agents (Ex. ibuprofen and celecoxib)
- Antihypertensives (such as atenolol, propranolol, captopril, enalapril, ramipril, lisinopril, losartan, valsartan, olmesartan, telmisartan)
- H2 blockers (Ex. cimetidine)
- Anti-viral agents (Ex. dolutegravir)
- Calcium-channel blockers (Ex. verapamil)
- Antimicrobial (Ex. rifampicin)
- Anti-anginals (Ex. ranolazine)
- Antibiotics (Ex. trimethoprim)
- Anti-cancer agents (Ex. vandetanib, crizotinib and Olaparib)
- Anti-fungal (Ex. isavuconazole)
- Keratolytic agents (Ex. salicylic acid)
- Antidepressants (Ex. phenelzine, selegiline)
- Sympathomimetic agents (Ex. adrenaline)
- Thyroid hormones (Ex. levothyroxine, liothyronine)
- Cardiac glycosides (Ex. quinidine, procainamide, amiodarone, sotalol)
Overdosage:
If you or anyone else accidentally took more of TENETIS MF TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are feeling cold, severe nausea or vomiting, stomach pain, unexplained weight loss, muscular cramps and fast breathing.
Synopsis
| Drug | : | Metformin, Teneligliptin |
| Pharmacological Category | : | Biguanides, DPP-4 Inhibitors |
| Therapeutic Indication | : | Type II Diabetes mellitus |
| Dosage Forms | : | Tablet |
More Information
FAQs About TENETIS MF TABLET
Q: What is TENETIS MF TABLET used for?
A: TENETIS MF TABLET is used as an adjunct to diet and exercise to control blood sugar levels in patients with type II diabetes mellitus.
Q: How and when to take TENETIS MF TABLET?
A: Take TENETIS MF TABLET preferably after meals or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.
Q: How long should I take TENETIS MF TABLET?
A: You need to take TENETIS MF TABLET as long as your doctor prescribes you the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
Q: What is the best time to take TENETIS MF TABLET?
A: TENETIS MF TABLET must be taken with meals to avoid gastrointestinal side effects.
Q: What to do if I forgot to take a dose of TENETIS MF TABLET?
A: If you forgot to take a dose of TENETIS MF TABLET, take it as soon as you remember. However, if it is time for the next dose of TENETIS MF TABLET, skip the missed dose and take the next one regularly. Do not take a double dose of TENETIS MF TABLET to compensate the missed ones.
Q: What are the most common side effects of taking TENETIS MF TABLET?
A: The most common side effects of taking TENETIS MF TABLET are low blood sugar levels, stomach upset, constipation, flatulence, metallic taste in mouth, sore throat, stuffy nose and joint pain. Consult your doctor if they bother you.
Q: Can I stop taking TENETIS MF TABLET without consulting your doctor?
A: No. You should not stop taking TENETIS MF TABLET without consulting your doctor because it may lead to reversal of symptoms.
Q: Will taking a higher dose of TENETIS MF TABLET be more effective?
A: No, taking a higher dose of TENETIS MF TABLET will not be effective it can lead to toxicity. Always take the dose prescribed by your doctor.
Q: What precautions do I need to follow while taking TENETIS MF TABLET?
A: Before taking TENETIS MF TABLET inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have severe systemic infections or are severely dehydrated due to excessive vomiting or diarrhea recently.
Q: Can I take medication for high blood pressure along with TENETIS MF TABLET?
A: Consult your doctor before taking any antihypertensive such as beta blockers (Ex. atenolol, propranolol) along with TENETIS MF TABLET as they have known interactions with this medicine.
Q: What should I do if I experience low blood sugar after taking TENETIS MF TABLET?
A: Low blood sugar is a common side effect of taking TENETIS MF TABLET. If you experience any signs of low blood sugar levels (such as increased hunger, sweating, shakiness, weakness or an irregular heartbeat), consume a sugary snack or sugar drink immediately. Consult your doctor if the symptom did not improve.
Q: Can TENETIS MF TABLET be taken with insulin?
A: Co-administration of TENETIS MF TABLET with insulin is considered risky as they are increased chances of hypoglycemia (decreased blood sugar levels).
Q: Can TENETIS MF TABLET be used in pregnant women?
A: TENETIS MF TABLET should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Safe use of the medicine during pregnancy has not been established.
Q: Can TENETIS MF TABLET cause constipation?
A: Yes. Constipation is a common side effect of using TENETIS MF TABLET. Eat plenty of fiber rich foods such as fresh fruits, vegetables, cereals as well as drink plenty of water and exercise more regularly while taking this medicine.
References
1. KD. Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 274 & 275.
2. Linong Ji, Ling Li, Jianhua Ma, Xuefeng Li, Dongmei Li, Bangzhu Meng, Weiping Lu, Jiao Sun, Yanmei Liu, Gen Takayanagi and Yi Wang. Efficacy and safety of teneligliptin added to metformin in Chinese patients with type 2 diabetes mellitus inadequately controlled with metformin: A phase 3, randomized, double-blind, placebo-controlled study. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. January 2021. [Accessed on 27th October 2022] click here
3. Rx Farma Limited. Electronic Medicines Compendium (EMC). [Revised in September 2019] [Accessed on 27th October 2022] click here
4. Torrent Pharmaceutical Ltd. Teneligliptin. [Revised in April 2021] [Accessed on 27th October April 2022] click here
5. Centaur Pharmaceuticals Pvt Ltd. TEN20 – M. [Accessed on 27th October 2022] click here
6. Johnlee Pharmaceuticals Pvt Ltd. TENALIP-M 1000. [Accessed on 27th October 2022] click here
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