Tazloc Trio 40mg Tablet 10'S

Introduction About TAZLOC TRIO 40MG TABLET

Tazloc Trio 40mg is a fixed-dose combination containing Amlodipine (a calcium channel blocker), Telmisartan (an angiotensin II receptor blocker), and Hydrochlorothiazide (a thiazide diuretic). This triple-action formulation is designed for individuals whose blood pressure is not adequately controlled with single or dual therapy. It works by relaxing blood vessels, reducing fluid retention, and easing the heart’s workload, thereby helping maintain healthy blood pressure levels. This makes it particularly suitable for patients with persistent hypertension requiring multi-drug therapy to achieve target readings and reduce the long-term strain on the cardiovascular system.

Tazloc Trio 40mg is generally advised for adults diagnosed with high blood pressure who may also have associated risks such as left ventricular hypertrophy, early-stage kidney involvement, or a history of cardiovascular events. The triple combination allows for improved control in patients who have not achieved sufficient results with two medications alone, while potentially reducing the pill burden. The dose is usually taken once daily at the same time each day, preferably in the morning, with or without food, as directed by the healthcare provider. Skipping or abruptly stopping the medicine may cause a sudden rise in blood pressure, so regular use is important.

Before starting Tazloc Trio 40mg, patients should inform their doctor about any history of kidney or liver disease, electrolyte imbalances, heart rhythm problems, or dehydration. The medicine should be used with caution alongside other drugs that affect potassium levels or kidney function. Alcohol intake should be limited, as it may enhance the blood pressure-lowering effect. This combination is not recommended during pregnancy, especially in the second and third trimesters, as it may affect fetal development. It should also be avoided during breastfeeding due to the risk of the components passing into breast milk.

Commonly reported side effects include dizziness, ankle swelling, fatigue, muscle cramps, headache, and frequent urination. These are usually mild and transient, but persistent or severe symptoms should be reported to a healthcare professional. In rare cases, significant changes in electrolyte levels or kidney function may occur, so periodic monitoring is advised. By combining three proven antihypertensive agents into a single tablet, Tazloc Trio 40mg provides a comprehensive and convenient approach to managing difficult-to-control blood pressure.

Uses Of TAZLOC TRIO 40MG TABLET

• Used to manage Hypertension

Benefits of TAZLOC TRIO 40MG TABLET

Tazloc Trio 40mg for Hypertension Control

Tazloc Trio 40mg is a fixed-dose combination containing Telmisartan, Amlodipine, and Hydrochlorothiazide, designed for individuals whose blood pressure is not adequately managed with single or dual therapy. It helps relax blood vessels, reduce excess fluid, and ease the workload on the heart, which supports maintaining optimal blood pressure levels. This triple-action approach can be useful in patients with persistent or resistant hypertension, providing convenience by reducing the number of tablets needed daily. Regular monitoring and consistent intake are important to ensure effective blood pressure control.

Tazloc Trio 40mg for Cardiovascular Support

By controlling high blood pressure effectively, Tazloc Trio 40mg can help lower the strain on the heart and blood vessels, thereby reducing the risk of complications such as heart strain, stroke, or vessel damage. The combination of Telmisartan (ARB) and Amlodipine (calcium channel blocker) helps maintain smooth blood flow, while Hydrochlorothiazide assists in preventing fluid overload. This makes it a suitable option for patients needing long-term cardiovascular protection under medical supervision, particularly those with multiple risk factors.

Tazloc Trio 40mg for Diuretic Action

One of the components of Tazloc Trio 40mg, Hydrochlorothiazide, works as a thiazide diuretic. It helps the body eliminate excess sodium and water through urine, which can lower blood volume and contribute to reduced blood pressure. This diuretic action not only supports hypertension management but also helps reduce swelling or fluid retention in certain patients. Adequate hydration and regular lab monitoring are advised to ensure electrolyte levels remain balanced during use.

How TAZLOC TRIO 40MG TABLET Works

Tazloc Trio 40mg Mechanism

The triple-action mechanism of Tazloc Trio 40mg targets high blood pressure through three pathways:

1. Telmisartan (Angiotensin II Receptor Blocker) – Prevents angiotensin II from narrowing the blood vessels, reducing vascular resistance.
2. Amlodipine (Calcium Channel Blocker) – Stops calcium from entering smooth muscle cells of blood vessels, causing them to relax and dilate.
3. Hydrochlorothiazide (Thiazide Diuretic) – Promotes the excretion of excess salt and water, lowering blood volume and reducing pressure on vessel walls.

Action of Tazloc Trio 40mg on Smooth Muscle and Blood Flow

Tazloc Trio 40mg combines Telmisartan, Amlodipine, and Hydrochlorothiazide, each working in a complementary way to improve blood vessel function. Amlodipine relaxes the smooth muscles in the walls of arteries, allowing them to widen (vasodilation), which eases the passage of blood and lowers resistance. Telmisartan blocks the effects of angiotensin II, a chemical that normally causes blood vessels to tighten, further aiding in smooth muscle relaxation. As a result, blood flows more freely, the heart pumps with less effort, and oxygen delivery to tissues improves.

How to use TAZLOC TRIO 40MG TABLET

• Take Tazloc Trio 40mg exactly as advised by your doctor, usually once daily.
• Swallow the tablet whole with a glass of water, without crushing or chewing.
• It can be taken with or without food but try to take it at the same time each day for best results.
• Follow the prescribed dosage carefully and do not adjust the dose on your own.
• If you miss a dose, take it as soon as you remember unless it’s almost time for your next dose.
• Avoid double-dosing to make up for a missed tablet.
• Continue the medication even if you feel well, as blood pressure control requires regular use.
• Keep regular doctor check-ups to monitor blood pressure and kidney function while using this medicine.

What if I forgot to take TAZLOC TRIO 40MG TABLET

• Take the Missed Dose as Soon as You Remember: If it’s not close to the time for your next scheduled dose, you can take it when you remember.
• Skip the Missed Dose If It’s Almost Time for the Next One: Do not take two doses together to make up for the missed dose.
• Resume Your Regular Schedule: Continue with your usual dosing routine from the next dose onward.
• Avoid Double Dosing: Taking extra medicine can increase the risk of low blood pressure, dizziness, or other side effects.
• Set a Reminder: Use alarms, phone notifications, or a pill organizer to help avoid missing future doses.
• Inform Your Doctor if You Miss Doses Frequently: Consistent intake is important for optimal blood pressure support.

Overdose

Exceeding the recommended dose can cause serious effects like intense dizziness, fainting, or a sharp fall in blood pressure. If an overdose is suspected, contact a healthcare professional immediately or go to the nearest emergency facility

Side Effects Of TAZLOC TRIO 40MG TABLET

Common Side Effects of Tazloc Trio 40mg

• Headache and Dizziness
• Fatigue and Tiredness
• Taste Changes
• Flushing or a warm sensation in the face
• Frequent micturition
• Diarrhea and Flu-Like Symptoms
• Sinusitis (Nasal Congestion)
• Peripheral edema
• Muscle Weakness and Cramps
• Dry Mouth and Increased Thirst

When to Seek Medical Attention?

Stop taking TAZLOC TRIO 40MG TABLET and consult your doctor immediately if you experience any of the following side effects:

• Allergic Reactions: symptoms like rash, itching, swelling (especially of the face, tongue, or throat), severe dizziness or difficulty in breathing.
• Low Blood Pressure (Hypotension): May lead to a feeling of extreme dizziness, light headedness, or occasional fainting, particularly when getting up quickly from a sitting or lying position.
• Electrolyte Imbalance: Can cause symptoms like muscle weakness, irregular heartbeat, confusion, or dehydration, which may result from increased urination.

How To Manage Side Effects

Diarrhea

• Stay Hydrated: Drink plenty of water, clear soups, or oral rehydration solutions (ORS) to replace lost fluids and electrolytes.
• Eat a BRAT Diet: Include bananas, rice, applesauce, and toast, which are gentle on the stomach and help firm stools.
• Avoid Irritants: Stay away from spicy, oily, and fatty foods until bowel movements return to normal.

Dry Mouth

• Stay Hydrated: Sip water frequently throughout the day to keep your mouth moist.
• Chew Sugar-Free Gum or Suck on Sugar-Free Lozenges: This helps stimulate saliva production naturally.
• Rinse with a Mild Saltwater or Alcohol-Free Mouthwash: Helps keep the mouth fresh and reduce dryness.
• Use a Humidifier: Adding moisture to indoor air can reduce dryness, especially at night.

Headache

• Stay Hydrated: Drink plenty of water, as dehydration is a common cause of headaches.
• Cold or Warm Compress: Apply a cold pack to the forehead for tension headaches or a warm compress on the back of the neck for muscle-related discomfort.
• Rest in a Quiet, Dark Room: Short breaks in a calm environment can help reduce headache intensity.
• Gentle Neck and Shoulder Massage: Light massages can improve blood flow and ease muscle tension.

Warning & Precautions

Pregnancy

Contraindicated

TAZLOC TRIO 40mg Tablet is not considered safe during pregnancy. Its components, such as telmisartan and amlodipine, may pose a risk to the developing foetus, particularly in the second and third trimesters.
If you are pregnant, planning pregnancy, or think you might be pregnant, inform your doctor immediately. Safer alternatives for blood pressure management should be discussed with your healthcare provider.

Breastfeeding

Contraindicated

This medicine can pass into breast milk, and its effect on nursing infants is not well established. Therefore, TAZLOC TRIO 40mg Tablet is not recommended for breastfeeding women. Always consult your healthcare provider for suitable alternatives.

Driving and Using Machines

Use with Caution

If you experience dizziness or light headedness after taking TAZLOC TRIO 40mg, avoid driving, operating heavy machinery, or handling sharp tools until you feel normal.

Alcohol

Consult your doctor

Alcohol consumption may increase dizziness or lower blood pressure further while using this medicine. It is advisable to avoid or limit alcohol and seek your doctor’s advice.

Kidney

Consult your doctor

TAZLOC TRIO 40mg is not recommended for individuals with severe kidney disease or very low urine output (anuria).

Mild to moderate kidney issues: Usually no dose adjustment is required but consult your doctor before starting.

Liver

Consult your doctor

This medicine is not recommended in severe liver disease.

Mild liver problems: It should be started at a lower dose and adjusted gradually under medical supervision.

Allergy

Contraindicated

Do not take TAZLOC TRIO 40mg if you are allergic to telmisartan, amlodipine, hydrochlorothiazide, or any other ingredient in the tablet.

Lungs

Use with Caution

If you have a history of allergies or bronchial asthma, take this medicine with caution, as it may increase the risk of allergic reactions.

Heart Disease

Use with Caution

Patients with severe coronary artery disease, congestive heart failure, or volume depletion should use TAZLOC TRIO 40mg carefully.

Sudden changes in blood pressure may worsen angina or affect kidney function, so regular monitoring is essential.

Use In Pediatrics

Consult your doctor

This medicine is not typically recommended for children as its safety and effectiveness in paediatric patients have not been established.
Doctors may recommend alternative medicines for managing blood pressure in children.

Use In Geriatrics

Use with Caution

Elderly patients should take this medicine under medical supervision because they may be more sensitive to blood pressure changes. Dose adjustments may be needed.

Other Warnings for TAZLOC TRIO 40MG TABLET

Before taking TAZLOC TRIO 40MG TABLET, tell your doctor if you:

• Have diabetes
• Have eye disorders like acute myopia and acute closed-angle glaucoma
• Have systemic lupous erythematosus
• Had sympathectomy

Safety Advice

• Monitor Blood Pressure Regularly: Keep track of your readings to notice any unusual fluctuations.
• Rise Slowly from Sitting or Lying Positions: This helps reduce sudden dizziness or fainting caused by low blood pressure.
• Maintain Adequate Hydration: Drink enough fluids daily, unless advised otherwise by your doctor, to support kidney function.
• Limit High-Salt and High-Potassium Foods: Check with your doctor about dietary adjustments to maintain electrolyte balance.
• Avoid Over-the-Counter NSAIDs (like ibuprofen) Without Advice: These can affect kidney function or reduce the effectiveness of blood pressure medicines.
• Inform Your Doctor Before Any Surgery or Dental Procedure: Some anaesthesia medicines may interact with blood pressure medications.
• Regular Lab Tests May Be Required: Your doctor might monitor kidney function, electrolytes, and blood pressure response.
• Do Not Stop the Medicine Suddenly: Abruptly discontinuing may cause sudden changes in blood pressure always consult your doctor first.
• Check for Swelling in Ankles or Feet: Report persistent swelling to your healthcare provider for assessment.

Diet and Lifestyle Advice

•  Include High-Fiber Foods: Whole grains, beans, and vegetables support digestion and overall cardiovascular health.
•  Avoid Excess Caffeine: Limit coffee, energy drinks, and caffeinated sodas as they may affect blood pressure levels.
•  Prefer Fresh Home-Cooked Meals: Reduces hidden salt, sugar, and unhealthy fats found in packaged foods.
•  Check Food Labels for Sodium Content: Even snacks and sauces may contain high amounts of salt.
•  Eat Small, Frequent Meals: Helps maintain stable energy levels and may reduce dizziness associated with blood pressure changes.
•  Limit Pickles and Processed Meats: These are often high in sodium and preservatives, which can affect blood pressure.
•  Incorporate Omega-3 Rich Foods: Flaxseeds, walnuts, and fatty fish may support heart health.
•  Practice Post-Meal Walking: Gentle activity after meals can improve blood circulation and digestion.
•  Avoid Extreme Dieting or Fasting: Sudden changes in diet can affect blood pressure stability.
•  Schedule Regular Medical Check-ups: Combine healthy habits with medical supervision for better long-term outcomes.

1.Difference Between Tazloc Trio 40mg and Tazloc 40mg

2.Tazloc Trio 40mg vs Amlodipine + Hydrochlorothiazide for Resistant Hypertension

Interactions

Drug - Drug interaction

1. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

Examples: Ibuprofen, Naproxen, Diclofenac

• Interaction: NSAIDs may reduce the blood pressure-lowering effect of telmisartan and may increase the risk of kidney problems, especially in dehydrated patients or the elderly.
• Management: Avoid frequent or long-term NSAID use. Monitor kidney function and blood pressure if NSAIDs are needed occasionally.

2. Potassium Supplements or Potassium-Sparing Diuretics

Examples: Spironolactone, Amiloride, Eplerenone, Potassium chloride

• Interaction: Telmisartan can increase potassium levels in the blood. Combining it with potassium-rich supplements or potassium-sparing diuretics may cause hyperkalaemia, which can affect heart rhythm.
• Management: Avoid unnecessary potassium supplements. Monitor blood potassium levels regularly if these medicines must be used together.

3. Lithium

• Interaction: Hydrochlorothiazide can reduce lithium clearance, leading to lithium toxicity, which may cause tremors, confusion, or kidney damage.
• Management: Avoid combining with lithium whenever possible. If unavoidable, monitor lithium levels frequently under medical supervision.

4. Other Antihypertensive Medicines

Examples: Beta-blockers (Metoprolol), ACE inhibitors (Enalapril), ARBs, Calcium channel blockers

• Interaction: Combining these with Tazloc Trio 40mg may enhance blood pressure-lowering effects, increasing the risk of dizziness, fainting, or hypotension.
• Management: Doctors may adjust the dose and monitor blood pressure closely when used together.

5. Diabetic Medications

Examples: Insulin, Metformin, Glimepiride

• Interaction: Hydrochlorothiazide can affect blood sugar levels, and telmisartan may enhance the blood sugar-lowering effect of some medicines.
• Management: Monitor blood sugar regularly and adjust diabetes medication doses as advised by your doctor.

6. Digitalis Glycosides (Digoxin)

• Interaction: Hydrochlorothiazide may lower potassium or magnesium levels, which can increase the risk of digoxin toxicity and irregular heart rhythms.
• Management: Monitor electrolytes and watch for symptoms like palpitations or dizziness if used together.

7.CYP3A4 Inhibitors or Inducers

• Interaction: amlodipine levels may be altered by drugs that strongly inhibit or induce the CYP3A4 enzyme (e.g., ketoconazole, rifampicin, clarithromycin).
   
• Management: Monitor blood pressure and side effects; dose adjustments of amlodipine may be required.

Drug - Food interaction

1.Grapefruit and Grapefruit Juice

• Interaction: Grapefruit can increase the level of amlodipine in the blood, potentially leading to excessive blood pressure lowering or swelling.
• Management: Avoid grapefruit and grapefruit juice while on Tazloc Trio 40mg.

2. High-Potassium Foods (e.g., bananas, oranges, coconut water)

• Interaction: Telmisartan can raise potassium levels in the blood. Eating too many potassium-rich foods may increase the risk of hyperkalemia, especially in patients with kidney problems.
• Management: Limit excessive intake of high-potassium foods; follow your doctor’s dietary advice and monitor potassium levels if recommended.

3. High-Sodium Diet (salty snacks, processed foods)

• Interaction: High sodium intake can reduce the blood pressure-lowering effect of the medicine and increase fluid retention.
• Management: Reduce salt intake by avoiding processed and high-salt foods; opt for fresh, home-cooked meals.

4. Licorice (Black Licorice)

• Interaction: Natural licorice can lower potassium levels, which may worsen the potassium loss caused by hydrochlorothiazide, increasing the risk of muscle weakness or irregular heartbeat.
• Management: Avoid excessive intake of natural licorice products.

5. Large Amounts of Caffeine (coffee, energy drinks)

• Interaction: Caffeine may cause a temporary rise in blood pressure, counteracting the medicine’s effect.
• Management: Moderate caffeine consumption; avoid excessive intake, especially close to medication timing.

Synopsis

More Information

FAQs About TAZLOC TRIO 40MG TABLET

Q: What is Tazloc Trio 40mg Tablet?

A: Tazloc Trio 40mg is a triple-combination tablet containing telmisartan, amlodipine, and hydrochlorothiazide. It is commonly prescribed for managing high blood pressure when single or dual medicines are not sufficient. The combination works by relaxing blood vessels, improving blood flow, and reducing fluid retention. It is usually taken once daily, as advised by a healthcare professional. This combination helps in maintaining consistent blood pressure control and may reduce the number of tablets a patient needs to take daily.

Q: Can I take Tazloc Trio 40mg with food?

A: Yes, Tazloc Trio 40mg can be taken with or without food. However, taking it at the same time each day ensures better blood pressure control. If you experience mild stomach discomfort, taking it with a light meal can help. Avoid very salty meals, as high sodium intake can affect blood pressure management. Your doctor may guide you on the best diet to follow while using this medicine.

Q: What are the common side effects of Tazloc Trio 40mg?

A: Some people may experience dizziness, headache, swelling of ankles, tiredness, increased urination, or mild stomach upset. These effects are usually temporary and improve as your body adjusts to the medicine. Drinking enough water and avoiding sudden position changes can reduce dizziness. If side effects are persistent or unusual, consult your healthcare professional for advice.

Q: Can Tazloc Trio 40mg be stopped suddenly?

A: Do not stop taking Tazloc Trio 40mg abruptly without consulting your doctor. Sudden discontinuation may cause fluctuations in blood pressure, which can affect heart health. If your doctor decides to stop the medicine, they may reduce the dose gradually to avoid sudden changes.

Q: How long does it take for Tazloc Trio 40mg to work?

A: Tazloc Trio 40mg usually starts supporting blood pressure control within a few hours of the first dose. However, full benefits may take 1–2 weeks of regular use. Consistency in taking the medicine and following lifestyle advice helps in achieving better results.

Q: Can I take Tazloc Trio 40mg with other medicines?

A: Tazloc Trio 40mg may interact with certain medicines, including other blood pressure drugs, diuretics, NSAIDs, and potassium supplements. Always share your medication list with your doctor to avoid interactions. Do not start or stop any medicine without medical advice.

Q: What diet should I follow while taking Tazloc Trio 40mg?

A: A low-salt, balanced diet with fresh fruits, vegetables, whole grains, and lean protein is recommended. Limit processed foods, pickles, and excess caffeine. Stay hydrated and avoid alcohol and smoking. Your doctor may also suggest moderate potassium intake based on your kidney function.

Q: What should I do in case of overdose?

A: Taking more than the prescribed dose may cause severe dizziness, fainting, or a sharp drop in blood pressure. Seek immediate medical attention or go to the nearest emergency centre if an overdose is suspected.

Q: How often should I check my blood pressure?

A: Regular monitoring is important. Your doctor may recommend daily or weekly checks, especially when starting or adjusting the dose. Keep a log of your readings to discuss during medical visits.

Q: Does Tazloc Trio 40mg cause frequent urination?

A: Yes, due to hydrochlorothiazide, the medicine may increase urination, especially during the day. This effect helps reduce excess fluid and lower blood pressure. Avoid taking the medicine late at night to prevent sleep disturbances.

Q: Can I take Tazloc Trio 40mg for a long time?

A: Yes, it can be taken long term under medical supervision. Regular check-ups, kidney function tests, and blood pressure monitoring are important for safety. Do not stop or change the dose without your doctor’s advice.

References

1.Antihypertensive Drugs.K.D. Tripathi, Essentials of Medical Pharmacology, 7th Edition, Jaypee Brothers Medical Publishers, 2013, Page 561.

2. Jitsuo Higaki, Issei Komuro, Kosuke Shiki, Ganghyuck Lee, Atsushi Taniguchi, Hiroshi Ikeda, Daisuke Kuroki, Seiichiro Nishimura, and Toshio Ogihara. Effect of hydrochlorothiazide in addition to telmisartan/amlodipine combination for treating hypertensive patients uncontrolled with telmisartan/amlodipine: a randomized, double-blind study. Hypertens Res. [Revised in March 2017]. [Accessed on 4th August 2025] 

3. Sanofi India Limited. Amlodipine, Hydrochlorothiazide, and Telmisartan. [Revised in 20th December 2020] [Accessed on 4th August 2025] 

Useful Diagnostic Tests

• Electrolytes Serum/ Electrolytes Profile
• Kidney Function Test (KFT)

Author Details

Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)

Reviewed For Accuracy By Dr. Thamada Manikanta Praveen - MBBS, MD (General Medicine)

Last updated on 20 Aug 2025 | 09:34 AM(IST)