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Introduction About TACPRO
TACPRO contains Tacrolimus which belongs to the group of medicines called Immunosuppressants. It is used to manage moderate to severe atopic dermatitis (eczema) when other conventional therapies fail to provide adequate results.
Atopic dermatitis is an allergic skin condition that makes your skin itchy, red, dry and irritated. It is characterized by small, raised bumps on the skin with pus accompanied by severe skin itching, redness and inflammation.
TACPRO is suitable for use both in adults and in children (aged 2 years or older). Apply a thin layer of TACPRO on the affected skin areas. You may use your regular skin moisturizer and/or other skin lotions along with TACPRO, but make sure to apply them after 2 hours of applying TACPRO.
Do not use TACPRO for more than the stipulated duration recommended by your doctor. Regularly visit your doctor (once a year or as instructed) for reviewing your condition even if your condition remains under control.
Before using TACPRO inform your doctor if you have any other skin disease apart from eczema such as skin cancer, skin infections or lesions at the application site, any inherited skin barrier disease or generalised erythroderma (severe skin redness and scaling).
You must also inform your doctor if you have a weak immune system, liver problems or any autoimmune disease conditions. Consult your doctor before using TACPRO if you are pregnant or breastfeeding.
While undergoing therapy with TACPRO, avoid exposing your skin towards direct sunlight or towards any artificial light sources. Wear protective loose-fitting clothes and apply sunscreen while going outdoors. Also, avoid consumption of alcohol as it may make your skin look more flushed.
The most common side effects of applying TACPRO are skin irritation, burning sensation, redness or warmth at the site of application. Consult your doctor if this side effect troubles you.
Uses Of TACPRO
It is used in adults and in children (aged 2 years or older) to manage and prevent:
- Moderate to severe atopic dermatitis (eczema)
How TACPRO Works
TACPRO is an immunosuppressive agent. It works by blocking the release of certain chemicals in the body (such as T-cells) that cause allergic and inflammatory reactions. When applied topically, it suppresses the immune system and manages the abnormal immune response towards allergens. This reduces skin dryness, redness, itching and inflammation associated with auto-immune skin conditions.
How to use TACPRO
Apply a small amount of TACPRO into the affected skin areas or directed by the physician. It is for topical use only. Wash your hands before and after application unless your hands are also managed.
Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight and health condition. Do not stop using or overuse TACPRO without consulting your doctor.
Avoid contact of TACPRO with your eyes, mouth, ears, nose or with open wounds. Do not cover the application site with bandages, dressings or clothes.
Side Effects Of TACPRO
Common
- itching or burning sensation at the site of application
- skin redness, flushing or pain
- increased skin sensitivity towards heat or cold
- skin infections
- inflamed or infected hair follicles on the skin
- facial flushing among alcoholics
Uncommon
- acne (pimples)
Rare
Stop using TACPRO and contact your doctor immediately if you experience any of the following side effects such as:
- enlarged or swollen lymph nodes
- changes in skin colour
How To Manage Side Effects
Application Site Reactions:
Place an icepack on the affected skin areas to ease the irritation. Avoid using harsh chemicals or soaps on the affected areas. Wear protective loose-fitting clothes while going outdoors. Regularly moisturize your skin. Avoid exposing your skin towards direct sunlight. If the condition did not improve, contact your doctor.
Warning & Precautions
Pregnancy
TACPRO should be used in pregnant women only if considered necessary by the physician. Therefore, consult your doctor before using it.
Breastfeeding
TACPRO should be used in breastfeeding women only if considered necessary by the physician. Therefore, consult your doctor before using it.
Driving and Using Machines
TACPRO is unlikely to affect your ability for driving and using machinery. However, do not drive or handle any heavy tools or machines if your ability is affected by TACPRO.
Alcohol
Avoid consumption of alcohol while using TACPRO as it may make your skin look more flushed.
Liver
TACPRO should be used with caution in patients with liver problems (such as liver failure). Therefore, consult your doctor before using it.
Allergy
Talk to your doctor before using TACPRO if you are allergic to Tacrolimus or to any macrolide antibiotics (such as erythromycin, azithromycin).
Others
Before using TACPRO inform your doctor if you:
- have skin cancer
- have a weak immune system
- have any skin conditions that hinders absorption through skin (such as Netherton’s syndrome or lamellar ichthyosis)
- have generalised erythroderma (severe skin redness and scaling)
- have any autoimmune diseases
- have cutaneous graft versus host disease (immune reactions on the skin caused due to bone marrow transplantation)
- have swollen lymph nodes
- have any skin infections or lesions at the site of application
- are undergoing any light therapy
Use in pediatrics:
TACPRO should be used in children and adolescents (aged 2 years or older) only if prescribed by the physician. It is not recommended for use in children aged below 2 years. Therefore, consult your doctor before using it.
Use in geriatrics:
TACPRO should be used with caution in the elderly patients. Therefore, consult your doctor before taking it.
Interactions
A. Drug – drug interaction:
Before using TACPRO inform your doctor if you are taking following medicines such as:
- erythromycin (a medicine used to manage bacterial infections)
- medicines used to manage fungal infection (Ex. ketoconazole, itraconazole)
- diltiazem (a medicine used to manage heart problems)
- cimetidine (a medicine used to manage stomach ulcers)
- corticosteroids (used to manage pain and inflammation) Ex. cortisone
Overdosage:
If you or anyone else accidentally swallowed TACPRO, consult your doctor for advice or visit the nearby hospital.
Synopsis
| Drug | : | Tacrolimus |
| Pharmacological Category | : | Calcineurin Inhibitors |
| Therapeutic Indication | : | Atopic dermatitis |
| Dosage Forms | : | Capsules, Tablets, Ointment, Lotion, solution, Topical Solution, Oral gel, eye ointment |
More Information
- Keep TACPRO out of reach of children
- Store TACPRO at room temperature
FAQs About TACPRO
What is the use of TACPRO?
TACPRO is used to manage moderate to severe atopic dermatitis (eczema) when other conventional therapies fail to provide adequate results.
How TACPRO works?
TACPRO is an immunosuppressive agent. It works by blocking the release of certain chemicals in the body (such as T-cells) that cause allergic and inflammatory reactions. When applied topically, it suppresses the immune system and manages the abnormal immune response towards allergens. This reduces skin dryness, redness, itching and inflammation associated with auto-immune skin conditions.
How to use TACPRO?
Apply a small amount of TACPRO into the affected skin areas or directed by the physician. It is for topical use only. Wash your hands before and after application unless your hands are also managed.
What precautions must be followed while using TACPRO?
TACPRO is for topical use only. Avoid contact of TACPRO with your eyes, mouth, ears, nose or with open wounds. Do not cover the application site with bandages, dressings or clothes. Wash your hands before and after application. Before using TACPRO inform your doctor if you have any other skin disease apart from eczema such as skin cancer, skin infections or any inherited skin barrier disease. Consult your doctor before using TACPRO if you are pregnant or breastfeeding. Avoid exposing your skin towards direct sunlight and wear protective loose-fitting clothes and sunscreen while going outdoors.
Is TACPRO safe?
TACPRO may cause skin irritation, burning sensation, redness and warmth at the site of application. Consult your doctor if this bothers you.
What are the common side effects of using TACPRO?
The most common side effects of applying TACPRO are skin irritation, burning sensation, redness or warmth at the site of application. Consult your doctor if this side effect troubles you.
What to do if I forgot to apply TACPRO?
If you forgot to apply a dose of TACPRO, apply it as soon as you remember. However, if it is time for the next dose of TACPRO, skip the missed dose and apply the next one regularly. Do not apply a double dose of TACPRO to compensate for the missed ones.
How long will it take for TACPRO to heal my condition?
You need to apply TACPRO as long as your doctor prescribes you the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
Can I use other topical medicines while using TACPRO?
Avoid using any other topical medicines along with TACPRO without consulting your doctor.
Can TACPRO be used in pregnant women?
TACPRO should be used in pregnant women only if considered necessary by the physician. Therefore, consult your doctor before using it.
Can TACPRO be used in children?
TACPRO should be used in children and adolescents (aged between 2-18 years) only if prescribed by the physician. It is not recommended for use in children aged below 2 years. However, consult your doctor for advice.
Can I use TACPRO for psoriasis?
TACPRO is usually prescribed for the management of eczema. Consult your doctor for advice if you are wishing to use this medicine to manage psoriasis.
Can I use TACPRO for my 4-year-old son?
TACPRO can be used in children aged 2 years or older. However, consult your paediatrician before using them in young children.
References
1. KD Tripathi. Autocoids and related drugs. Essentials of Medical Pharmacology. 8th edition. 2019. Page – 940-941.
2. Mamitaro Ohtsuki, Hiroshi Morimoto and Hidemi Nakagawa. Tacrolimus ointment for the treatment of adult and pediatric atopic dermatitis: Review on safety and benefits. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. August 2018. [Accessed on 25th October 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099320/
3. Astellas Ireland Co. Ltd. Electronic Medicines Compendium (EMC). [Revised in June 2021] [Accessed on 25th October 2022] https://www.medicines.org.uk/emc/files/pil.1612.pdf
4. Astellas Toyama Co., Ltd. U.S. Food and Drug Administration. [Revised in November 2011]. [Accessed on 26th October 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/050777s018lbl.pdf
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