SYNTOCINON INJECTION 1ML
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Introduction About SYNTOCINON
SYNTOCINON contains Oxytocin which belongs to the group of medicines called Uterine Stimulants. It is used to induce labor pain among full-term pregnant women.
It strengthens uterine contractions among full-term pregnant women who aim for a successful vaginal delivery when the labour is not progressing at a desired rate or when the mother’s body does not initiate uterine contractions on its own.
It is also used to induce labour pain among mothers who require an immediate delivery due to health complications such as preeclampsia, maternal diabetes, etc., and helps in the management of inevitable or incomplete miscarriages (abortion).
It also speeds up the delivery of placenta, once after childbirth and can control excessive bleeding after delivering the baby. Before receiving SYNTOCINON inform your doctor if you have any problems in your kidneys or heart.
You must also inform your doctor if you have any problems in blood circulation or previously had a caesarean section delivery or any other surgeries on the uterus as a precaution. SYNTOCINON should not be used in women for whom vaginal delivery (normal delivery) is not advisable (such as due to inappropriate baby’s position or placenta’s position, baby’s head is too large to fit in your pelvis, cord around the neck of the baby, etc.,)
During management with SYNTOCINON, you must inform your doctor immediately if your contractions does not increase or becomes mild (or less strong) after administering this medicine. The most common side effects of receiving SYNTOCINON are nausea, vomiting, headache, and irregular pulse. Consult your doctor if any of these side effect troubles you.
Uses Of SYNTOCINON
- Strengthens uterine contractions and induces labor pain among pregnant women
- Helps in the management of miscarriage
- Speeds up the delivery of placenta after childbirth
- Prevents and controls excessive bleeding after childbirth
How SYNTOCINON Works
SYNTOCINON is a uterine stimulant. It induces labour pain among pregnant women by strengthening the uterine contractions and by making the uterus release more amount of pain-causing chemicals (such as prostaglandins). Once after childbirth, it contracts the uterus which helps in managing and controlling excessive postpartum bleeding.
How to use SYNTOCINON
SYNTOCINON will be given to you only by a doctor or a nurse into the vein (intravenously) or into the muscle (intramuscularly). Your doctor will decide the correct dose for you depending upon your body weight and health condition.
Side Effects Of SYNTOCINON
Common
- nausea, vomiting
- headache
- fast, slow or irregular heartbeat
Rare
- Skin rashes
Consult your doctor immediately if you experience any of the following side effects after receiving SYNTOCINON:
- signs of severe allergic reactions (such as skin rash, itching, swelling of the face, lips, throat or tongue causing difficulty in breathing or swallowing, low blood pressure, dizziness, fainting, nausea, cold clammy skin or fast or weak pulse)
How To Manage Side Effects
Headache
Rest and relax. Applying a pain-relieving balm on your forehead can be beneficial. Consult your doctor if your headache worsens.
Warning & Precautions
Pregnancy
SafeThe available data suggests that SYNTOCINON would not be a risk to the growing baby when used correctly to induce labour pain. However, your doctor will administer this medicine only if it is considered necessary.
Breastfeeding
SafeSYNTOCINON may be found in the breast milk, but it is not expected to be harmful as it is quickly inactivated by the baby’s digestive system. However, consult your doctor for advice.
Driving and Using Machines
RiskySYNTOCINON can stimulate uterine contractions and induce labour pain. Therefore, it is not advisable to drive or handle heavy machines after receiving this medicine.
Kidney
Use with CautionSYNTOCINON should be used with caution in patients with kidney problems. Therefore, inform your doctor before receiving it.
Allergy
ContraindicatedTalk to your doctor before receiving SYNTOCINON if you are allergic to Oxytocin.
Heart Disease
Consult your doctorSYNTOCINON is not recommended for use in pregnant women with severe heart problems. It should be used with caution in women with hypertension, irregular heartbeat or any other pre-existing heart conditions. Therefore, inform your doctor before receiving it.
Use In Pediatrics
Consult your doctorSYNTOCINON is not intended for use in children and in adolescents (aged below 18 years). However, consult your doctor for advice.
Use In Geriatrics
Consult your doctorSYNTOCINON is not intended for use in the elderly patients. However, consult your doctor for advice.
Others
SYNTOCINON is not recommended for use if:
- you already have stronger uterine contractions
- you have any obstruction in the genital tract that hinders vaginal delivery
- you are at risk of developing foetal hypoxia (low oxygen levels to the foetus)
- vaginal delivery is not advisable (due to inappropriate baby’s position or placenta’s position, baby’s head is too large to fit in your pelvis, low oxygen supply to the baby, cord around the neck of the baby, separation of placenta before childbirth, rupture of uterine membranes, or due to previous caesarean section or other surgery in the uterus)
- your contractions do not increase with the management even after using for 6 hours
- have severe pre-eclampsia (high blood pressure during pregnancy)
- have severe problems with blood circulation
Before receiving SYNTOCINON, inform your doctor if you:
- have problems in blood circulation
- previously had a caesarean section delivery
- are aged more than 35 years
- are more than 40 weeks pregnant
- previously had any complications during your pregnancy
Interactions
A. Drug-Drug Interactions:
Before receiving SYNTOCINON, inform your doctor if you are taking any of the following medicine:
- prostaglandins (used to start labour or to manage stomach ulcers)
- general anaesthetics (used to create loss of consciousness) such as halothane, cyclopropane, sevoflurane or desflurane
- local anaesthetics (used to cause loss of sensation at the region where it is applied) such as lignocaine
B. Drug - Food interaction:
While administering SYNTOCINON, your doctor may ask you to minimize your fluid intake as a precaution.
Overdosage:
SYNTOCINON will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor if you experience any unusual symptoms.
Synopsis
| Drug | : | Oxytocin |
| Pharmacological Category | : | Oxytocics |
| Therapeutic Indication | : | Labour and delivery |
| Dosage Forms | : | Injection, Pessary |
More Information
- Keep SYNTOCINON out of reach of children
- Store SYNTOCINON at room temperature or in the refrigerator (between 2-8°C) based on the instructions mentioned in the product label
FAQs About SYNTOCINON
Q: What are the side effects of SYNTOCINON?
A: The most common side effects of receiving SYNTOCINON are nausea, vomiting, headache, and irregular pulse. Consult your doctor if any of these side effect troubles you.
Q: Is SYNTOCINON safe for the baby?
A: The available data suggests that SYNTOCINON would not be a risk to the growing baby when used correctly to induce labour pain. However, your doctor will administer this medicine only if it is considered necessary.
Q: Why my doctor prescribed me SYNTOCINON?
A: SYNTOCINON is usually prescribed to induce labor pain among full-term pregnant women who aim for a successful vaginal delivery when the labour is not progressing at a desired rate or when the mother’s body does not initiate uterine contractions on its own. It is also used to induce labor pain among mothers who require an immediate delivery due to health complications such as preeclampsia, maternal diabetes, etc., and helps in the management of inevitable or incomplete miscarriages (abortion). It also speeds up the delivery of placenta, once after childbirth and can control excessive bleeding after delivering the baby.
Q: How SYNTOCINON helps in stopping bleeding after childbirth?
A: Once after childbirth, SYNTOCINON contracts the uterus which helps in managing and controlling excessive postpartum bleeding.
Q: Why my doctor has injected SYNTOCINON once the baby is born?
A: After childbirth, SYNTOCINON can be used to speed up the delivery of placenta and can control excessive bleeding after delivering the baby.
Q: Can the use of SYNTOCINON cause edema?
A: SYNTOCINON can cause water retention (edema) when used in patients with kidney disease. Therefore, inform your doctor before receiving it.
Q: Will the use of SYNTOCINON affect the unborn baby?
A: The available data suggests that SYNTOCINON would not be a risk to the growing baby when used correctly to induce labour pain. However, your doctor will administer this medicine only if it is considered necessary.
References
1. KD. Tripathi. Oxytocin and other drugs acting on uterus. Essentials of Medical Pharmacology. 7th Edition. 2013. Page – 329.
2. Eva V. Osilla; Sandeep Sharma. Oxytocin. StatPearls. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. July 2022. [Accessed on 21st March 2023] https://www.ncbi.nlm.nih.gov/books/NBK507848/#:~:text=Oxytocin%20is%20indicated%20and%20approved,vaginal%20delivery%20of%20the%20fetus.
3. Pinewood Laboratories Ltd. Oxytocin 10 IU/ml Concentrate for Solution for Infusion. Electronic Medicines Compendium (EMC). [Revised in July 2019]. [Accessed on 21st March 2023] https://www.medicines.org.uk/emc/files/pil.1769.pdf
4. Hikma Pharmaceuticals USA Inc. Oxytocin injection. Dailymed.com. [Revised in December 2019]. [Accessed on 21st March 2023] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a9b62187-4141-487c-a9da-f42ad7f9b408
5. Taj Lifesciences. Oxytocin injection USP. [Accessed on 21st March 2023] https://tajlifesciences.com/portfolio/oxytocin-injection-usp-10-iu-ml/
Useful Diagnostic Tests
- Complete Blood Count
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