SYNCA LS Eye Drops 5ml

Introduction About SYNCA LS EYE DROPS

SYNCA LS EYE DROPS is indicated for the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. It is typically used in patients who are not responding well to therapy with single agents. It is a combination of Brimonidine and brinzolamide, which belongs to the group of medicines called Ophthalmic anti-glaucoma agents. It works by decreasing the production of excessive eye fluids (aqueous humour) while simultaneously increasing their drainage. As a result, it reduces strain on the eyes, which therefore reduces elevated intraocular pressure.

SYNCA LS EYE DROPS is for ophthalmic use only. Instill a few drops of this medicine into the affected eye(s). Do not touch the tip of the dropper with your eye or with other body surfaces to avoid contamination. If you wear soft contact lenses, remove the lens before using SYNCA LS EYE DROPS and wait for at least 15 minutes before reinsertion.

Before using SYNCA LS EYE DROPS, inform your doctor if you have any liver, kidney, or heart problems. You must also inform your doctor if you have low or high blood pressure, narrow-angle glaucoma, dry eyes, depression, or poor blood circulation in your body as a precaution.

SYNCA LS EYE DROPS is generally not recommended for use in pregnant and breastfeeding women unless considered necessary by the physician. Therefore, consult your doctor before using it. The most common side effects of using SYNCA LS EYE DROPS are eye pain, redness, discomfort, irritation, itching or inflammation, blurred vision, and bad taste. Consult your doctor if they trouble you.

Uses Of SYNCA LS EYE DROPS

• Manage open-angle glaucoma or ocular hypertension in adults

How SYNCA LS EYE DROPS Works

SYNCA LS EYE DROPS works by decreasing the production of excessive eye fluids (aqueous humour) while simultaneously increasing their drainage. As a result, it reduces strain on the eyes, which therefore reduces elevated intraocular pressure.

How to use SYNCA LS EYE DROPS

Use SYNCA LS EYE DROPS as advised by your doctor. It is for ophthalmic use only. Wash your hands before use. Instill a few drops of SYNCA LS EYE DROPS into the affected eye. Close your eyes and press the corner of your eye with your finger for a minute.

Do not touch the tip of the dropper with your eye or with other body surfaces to avoid contamination. After applying SYNCA LS EYE DROPS, leave a time gap of at least 5 minutes before applying other eye drops or ointments. If you wear soft contact lenses, remove the lens before applying SYNCA LS EYE DROPS and wait for at least 15 minutes before reinsertion.

Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight, and disease condition. Do not stop using SYNCA LS EYE DROPS without consulting your doctor, as the pressure within the eye may rise once again.

Side Effects Of SYNCA LS EYE DROPS

How To Manage Side Effects

Dizziness Or Drowsiness

Ensure proper hydration, as dehydration can cause dizziness. Avoid excessive caffeine, alcohol, and high-sodium foods, which can exacerbate symptoms. Engage in physical therapy or vestibular rehabilitation exercises designed to improve balance and reduce dizziness. Move slowly when changing positions, such as standing up or lying down, to avoid triggering dizziness. Practice relaxation techniques such as deep breathing, meditation, or yoga to manage stress, which can contribute to dizziness. Consult your doctor if dizziness persists.

Eye irritation Or Itching

Wash your eyes with plain, cold water. Place an ice pack on your eye to ease the irritation. Avoid straining your eyes by looking at mobile phones, laptops, or televisions. Wear protective eyeglasses while going outdoors.

Visual Disturbances

Close your eyes and relax. Do not strain your eyes by looking at mobile phones, laptops, or televisions. Avoid driving or operating any heavy tools or machines while your vision is blurry. Consult your doctor if you experience blurred vision for a prolonged period.

Warning & Precautions

Pregnancy

Monitoring required

There are no adequate and well-controlled studies on pregnant women. The combination should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Therefore, consult your doctor before using it. Women of childbearing age should use the proper contraceptive method to avoid pregnancy while undergoing therapy with SYNCA LS EYE DROPS.

Breastfeeding

Monitoring required

SYNCA LS EYE DROPS is generally not recommended for use by breastfeeding women unless considered necessary by the physician. Therefore, consult your doctor before using it.

Driving and Using Machines

Use with Caution

Do not drive or operate any heavy tools or machines if you experience blurred vision, drowsiness, or tiredness after using SYNCA LS EYE DROPS.

Alcohol

Consult your doctor

Avoid the consumption of alcohol while using SYNCA LS EYE DROPS, as it may increase the risk of side effects.

Kidney

Contraindicated

SYNCA LS EYE DROPS is not recommended for use in patients with severe kidney problems. Therefore, consult your doctor before using it.

Liver

Use with Caution

SYNCA LS EYE DROPS should be used with caution in patients with liver problems. Therefore, consult your doctor before using it.

Allergy

Contraindicated

Do not take SYNCA LS EYE DROPS if you are allergic to brimonidine, brinzolamide, sulphonamides (such as glipizide and gliclazide), or diuretics (such as furosemide).

Heart Disease

Use with Caution

SYNCA LS EYE DROPS should be used with caution in patients with heart diseases (such as coronary heart disease or heart failure). Therefore, consult your doctor before using it.

Use In Pediatrics

Contraindicated

SYNCA LS EYE DROPS is not recommended for use in children under the age of 2 years. Therefore, consult your doctor before using it.

Use In Geriatrics

Use with Caution

SYNCA LS EYE DROPS should be used with caution with elderly patients. Therefore, consult your doctor before using it.

Interactions

A. Drug-Drug interactions:

• Antidepressants (Ex. citalopram, escitalopram, fluoxetine, sertraline, amitriptyline, nortriptyline, moclobemide, selegiline, phenelzine, isocarboxazid, clomipramine, mianserin, venlafaxine, nefazodone, and duloxetine)
• Sedative-hypnotics (Ex. alprazolam, midazolam, and phenobarbital)
• Antipsychotics (Ex. chlorpromazine, methylphenidate, and reserpine)
• Antihypertensives (Ex. enalapril, ramipril)
• Cardiac glycosides (Ex. digoxin)
• Anaesthetics (Ex. lidocaine)
• Other anti-glaucoma agents (Ex. acetazolamide, dorzolamide, diclofenamide, and ethoxzolamide)
• Antivirals (such as ritonavir, nelfinavir, atazanavir, boceprevir, indinavir, lopinavir, nelfinavir, saquinavir, telaprevir, darunavir, delavirdine, and fosamprenavir)
• Antifungals (such as ketoconazole, fluconazole, itraconazole, posaconazole, and voriconazole)
• Antibacterials (such as amoxicillin, cefixime, azithromycin, clarithromycin, and telithromycin)
• Anti-diuretic hormone (Ex. conivaptan)
• High-Dose Salicylate Therapy

Overdosage:

If you or anyone else accidentally used more SYNCA LS EYE DROPS, rinse your eye with warm water. If irritation persists, consult your doctor.

If you or anyone else accidentally swallowed this medicine, contact your doctor immediately. Symptoms of an overdose might include electrolyte imbalance, the development of an acidotic state, a slow heartbeat, low or high blood pressure, difficulty breathing, and confusion or nerve problems.

Synopsis

More Information

FAQs About SYNCA LS EYE DROPS

Q: How does SYNCA LS EYE DROPS work?

A: SYNCA LS EYE DROPS works by decreasing the production of excessive eye fluids (aqueous humour) while simultaneously increasing their drainage. As a result, it reduces strain on the eyes, which therefore reduces elevated intraocular pressure.

Q: Can the use of SYNCA LS EYE DROPS cause blurred vision?

A: Yes. SYNCA LS EYE DROPS may cause blurred vision after application. If your vision becomes blurry, close your eyes for some time and rest. Do not strain your eyes by looking at mobile phones, laptops, or televisions. Avoid driving or operating any heavy tools or machines while your vision is blurry. Consult your doctor if you experience blurred vision for a prolonged period.

Q: Can I use other eye medicines while using SYNCA LS EYE DROPS?

A: Yes. You can use other eye medicines while undergoing therapy with SYNCA LS EYE DROPS. But make sure to leave a time gap of at least 5 minutes before applying other eye drops or ointments.

Q: Who should avoid using SYNCA LS EYE DROPS?

A: Do not take SYNCA LS EYE DROPS if you are allergic to brimonidine, brinzolamide, sulphonamides (such as glipizide and gliclazide), or diuretics (such as furosemide), or if you have severe kidney problems, hyperchloremic acidosis (a condition where there is too much acidity in the blood), or acute angle-closure glaucoma. Consult your doctor before using it.

Q: What precautions must be taken while using SYNCA LS EYE DROPS?

A: SYNCA LS EYE DROPS should be used with caution in patients with liver problems, heart diseases (such as coronary heart disease or heart failure), dry eyes or problems in your cornea (including corneal edema), narrow angle glaucoma (a type of rapid increase in pressure within the eye), high or low blood pressure, depression, poor blood circulation in the body (such as Raynaud’s disease), or have reduced blood supply to the brain or reduced mental capacity, or if you are wearing soft contact lenses. Consult your doctor before using it.

Q: How do I use SYNCA LS EYE DROPS?

A: Use SYNCA LS EYE DROPS as advised by your physician. It is for ophthalmic use only. Instill a few drops of the medicine into the affected eye(s). Close your eyes and press the corner of your eye with your finger for a minute. Use one drop in the affected eye three times daily or as directed by the physician. If you wear soft contact lenses, remove the lens before applying SYNCA LS EYE DROPS and wait for at least 15 minutes before reinsertion.

Q: What is the use of SYNCA LS EYE DROPS?

A: SYNCA LS EYE DROPS is a prescription medicine used in adults to manage glaucoma and ocular hypertension.

Q: How long does it take for SYNCA LS EYE DROPS to work?

A: It may take about 1 to 4 weeks for SYNCA LS EYE DROPS to show the results. Therefore, continue to use SYNCA LS EYE DROPS as prescribed by your physician.

Q: What are the side effects of SYNCA LS EYE DROPS?

A: The most common side effects of using SYNCA LS EYE DROPS are eye pain, redness, discomfort, irritation, itching or inflammation, blurred vision, and bad taste. Consult your doctor if they trouble you.

Q: Can I use SYNCA LS EYE DROPS while wearing contact lenses?

A: If you wear soft contact lenses, remove the lens before applying SYNCA LS EYE DROPS and wait for at least 15 minutes before reinsertion. This is because SYNCA LS EYE DROPS contains preservatives that may interact with your contact lens and cause your lens to discolour.

Q: Can I stop using SYNCA LS EYE DROPS without consulting my doctor?

A: Do not stop using SYNCA LS EYE DROPS without consulting your doctor, as the pressure within the eye may raise once again. If you think that you are feeling better or if you wish to stop using SYNCA LS EYE DROPS, contact your doctor for advice. Your doctor will check your condition and gradually withdraw the dose.

Q: Is SYNCA LS EYE DROPS safe for pregnant and breastfeeding women?

A: SYNCA LS EYE DROPS is generally not recommended for use in pregnant and breastfeeding women unless considered necessary by the physician. Therefore, consult your doctor before using it.

Q: Can I drive or ride a bike after using SYNCA LS EYE DROPS?

A: Do not drive if you feel dizzy or experience blurred vision after using SYNCA LS EYE DROPS.

Q: What if I miss a dose of SYNCA LS EYE DROPS?

A: If you missed a dose of SYNCA LS EYE DROPS, apply it as soon as you remember. However, if it is time for the next dose, skip the missed dose and apply the regular dose. Do not apply a double dose to compensate for the missed dose.

References

1. KD. Tripathi. Anti-Adrenergic Drugs Acting on ANS. Essentials of Medical Pharmacology. Seventh Edition. 2013. Page – 154.

2. Robert F. Reilly and Edwin K. Jackson. Regulation of Renal volume and vascular volume. Goodman and Gilman’s The Pharmacological Basis of Therapeutics. 12th Edition. Page – 680.

3. Jed Asher Lusthaus, Ivan Goldberg. Brimonidine and brinzolamide for treating glaucoma and ocular hypertension; a safety evaluation. NIH. National Library of Medicine. National Center of Biotechnology Information. Pubmed.gov. September 2017. [Accessed on 13th June 2024] https://pubmed.ncbi.nlm.nih.gov/28656780/

4. Alcon-Couvreur N.V. Electronic Medicines Compendium (EMC). [Revised in May 2022]. [Accessed on 13th June 2024] https://www.medicines.org.uk/emc/files/pil.3290.pdf

5. ALCON LABORATORIES, INC. U.S. Food & Drug Administration. [Revised in April 2013]. [Accessed on 13th June 2024] https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/204251s000lbl.pdf

6. Central Drugs Standard Control Organization (CDSCO). Brinzolamide 10mg Brimonidine Tartrate eq. to Brimonidine 2mg Ophthalmic suspension. March 2016. [Accessed on 13th June 2024] https://cdsco.gov.in/opencms/resources/UploadCDSCOWeb/2018/UploadApprovalNewDrugs/dciApprovedfdc.pdf

Useful Diagnostic Tests

• Tonometry
• Complete Blood Count (CBC)/ Hemogram
• Men Health Checkup – Advanced
• Complete Women Checkup
• Elderly Checkup – Female
• Elderly Checkup - Male
• Full Body Checkup – Silver

Author Details

Written By Dr. N. Sai Swaroop - Pharm.D

Reviewed For Accuracy By Dr. Purvi Raghuvanshi - MBBS, ENT

Last updated on 13 Jun 2024 | 12:51 PM(IST)